Deficiency of PPARβ/σ in the epidermis results in defective cutaneous permeability barrier homeostasis and increased inflammation

Journal of Investigative Dermatology

Volumn 128, Issue 2, 2008, Pages 370-377

  Man, Mao Qiang ^a   Barish, Grant D ^b   Schmuth, Matthias ^a   Crumrine, Debra ^a   Barak, Yaacov ^b   Chang, Sandra ^a   Jiang, Yan ^a   Evans, Ronald M ^b   Elias, Peter M ^a   Feingold, Kenneth R ^a,c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS ANTIGEN; FILAGGRIN; INVOLUCRIN; LORICRIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PHORBOL 13 ACETATE 12 MYRISTATE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DNA BINDING; EPIDERMIS; HOMEOSTASIS; HYDRATION; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KERATINOCYTE; LIPOGENESIS; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; SKIN INJURY; SKIN PERMEABILITY; STRATUM CORNEUM; ACUTE DISEASE; ANIMAL; CELL DIVISION; CHEMISTRY; CYTOLOGY; DERMATITIS; GENETICS; IMMUNOLOGY; INJURY; METABOLISM; MOUSE MUTANT; MOUSE STRAIN; PATHOLOGY; PERMEABILITY; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; WOUND HEALING;

ACUTE DISEASE; ANIMALS; CELL DIVISION; DERMATITIS; EPIDERMIS; HOMEOSTASIS; KERATINOCYTES; MALE; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; PERMEABILITY; PPAR GAMMA; PPAR-BETA; PROTEIN STRUCTURE, TERTIARY; WOUND HEALING;

EID: 38149033573     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5701026     Document Type: Article

References (43)

1. Akiyama M (2006) Harlequin ichthyosis and other autosomal recessive congenital ichthyoses: the underlying genetic defects and pathomechanism. J Dermatol Sci 42:83-9
2. Barak Y, Liao D, He W, Ong ES, Nelson MC, Olefsky JM et al. (2002) Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc Natl Acad Sci USA 99:303-8
3. Bilal H, Handra-Luca A, Bertrand JC, Fouret PJ (2003) P63 is expressed in basal and myoepithelial cells of human normal and tumor salivary gland tissues. J Histochem Cytochem 51:133-9
4. Braissant O, Foufelle F, Scotto C, Dauca M, Wahli W (1996) Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in adult rat. Endocrinology 137:354-66
5. Braissant O, Wahli W (1998) Differential expression of peroxisome proliferator-activated receptor-alpha, -beta, and -gamma during rat embryonic development. Endocrinology 139:2748-54
6. Chawla A, Repa JJ, Evans RM, Mangelsdorf DJ (2001) Nuclear receptors and lipid physiology: opening the X-files. Science 294:1866-70
7. Demerjian M, Man MQ, Choi EH, Brown BE, Crumrine D, Chang S et al. (2006) Topical treatment with thiazolidinediones, activators of peroxisome proliferator-activated receptor-gamma, normalizes epidermal homeostasis in a murine hyperproliferative disease model. Exp Dermatol 15:154-60
8. Di-Poi N, Ng CY, Tan NS, Yang Z, Hemmings BA, Desvergne B et al. (2005) Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor β/δ during hair follicle development. Mol Cell Biol 25:1696-712
9. Ellis CN, Varani J, Fisher GJ, Zergler ME, Pershadsingh HA, Benson SC et al. (2000) Troglitazone improves psoriasis and normalizes models of proliferative skin disease: ligands for peroxisome proliferator activatored receptor-gamma inhibit keratinocyte proliferation. Arch Dermatol 136:609-16
10. Feingold KR, Man MQ, Menon GK, Cho SS, Brown BE, Elias PM (1990) Cholesterol synthesis is required for cutaneous barrier function in mice. J Clin Invest 86:1738-45
11. Hanley K, Jiang Y, He SS, Friedman M, Elias PM, Bikle DD et al. (1998) Keratinocyte differentiation is stimulated by activators of the nuclear hormone receptor PPARalpha. J Invest Dermatol 110:368-75
12. Holleran WM, Man MQ, Gao W, Menon GK, Elias PM, Feingold KR (1991) Sphingolipids are required for mammalian barrier function: inhibition of sphingolipid synthesis delays barrier recovery after acute perturbation. J Clin Invest 88:1338-45
13. Holleran WM, Takagi Y, Menon GK, Legler G, Feingold KR, Elias PM (1993) Processing of epidermal glucosylceramides is required for optimal mammalian cutaneous permeability barrier function. J Clin Invest 91:1656-64
14. Hou SY, Mitra AK, White SH, Menon GK, Ghadially R, Elias PM (1991) Membrane structures in normal and essential fatty acid-deficient stratum corneum: characterization by ruthenium tetroxide staining and X-ray diffraction. J Invest Dermatol 96:215-23
15. Hovnanian A (2005) Harquin ichthyosis unmasked: a defect of lipid transport. J Clin Invest 115:708-10
16. Jiang YJ, Lu B, Kim P, Elias PM, Feingold KR (2006) Regulation of ABCA1 expression in human keratinocyte and murine epidermis. J Lipid Res 47:2248-58
17. Kersten S, Desvergne B, Wahli W (2000) Roles of PPARs in health and disease. Nature 405:421-4
18. Kim DJ, Bility MT, Billin AN, Willson TM, Gonzalez FJ, Peters JM (2006) PPARbeta/delta selectively induces differentiation and inhibits cell proliferation. Cell Death Differ 13:53-60
19. Kim DJ, Murray IA, Burns AM, Gonzalez FJ, Perdew GH, Peters JM (2005) Peroxisome proliferator-activated receptor-beta/delta inhibits epidermal cell proliferation by downregulation of kinase activity. J Biol Chem 280:9519-27
20. Kippenberger S, Loitsch SM, Grundmann-Kollmann M, Simon S, Dang TA, Hard-Weinelt K et al. (2001) Activators of peroxisome proliferator-activated receptors protect human skin from ultraviolet-B-light- induced inflammation. J Invest Dermatol 117:1430-6
21. Komuves LG, Hanley K, Jiang Y, Elias PM, Williams ML, Feingold KR (1998) Ligands and activators of nuclear hormone receptors regulate epidermal differentiation during fetal rat skin development. J Invest Dermatol 111:429-33
22. Komuves LG, Hanley K, Lefebvre AM, Man MQ, Ng DC, Bikle DD et al. (2000a) Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo. J Invest Dermatol 115:353-60
23. Komuves LG, Hanley K, Man MQ, Elias PM, Williams ML, Feingold KR (2000b) Keratinocyte differentiation in hyperproliferative epidermis: topical application of PPARalpha activators restores tissue homeostasis. J Invest Dermatol 115:361-7
24. Lee SS, Pincau T, Drago J, Lee EJ, Owens JW, Kroeta DL et al. (1995) Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol 15:3012-22
25. Lefevre C, Audebert S, Jobard F, Bouadjar B, Lakhdar H, Boughdene-Stambouli O et al. (2003) Mutations in the transporter ABCA12 are associated with lamellar ichthyosis type 2. Hum Mol Genet 12:2369-78
26. Man MQ, Choi EH, Schmuth M, Crumrine D, Uchida Y, Elias PM et al. (2006) Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processing. J Invest Dermatol 126:386-92
27. Man MQ, Feingold K, Wang FS, Thornfeldt CR, Elias PM (1997a) A natural lipid mixture improves barrier function and skin hydration in both human and murine skin. J Soc Cosmet Chem 47:157-66
28. Man MQ, Fowler AJ, Schmuth M, Lau P, Chang S, Brown BE et al. (2004) Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation. J Invest Dermatol 123:305-12
29. Man MQ, Mauro T, Warren R, Elias P, Feingold K (1997b) Calcium and potassium inhibit barrier recovery after disruption by detergents, independent of the type of insult in hairless mice. Experimental Dermatol 6:36-40
30. Mangelsdorf DJ, Evans RM (1995) The RXR heterodimers and orphan receptors. Cell 83:841-50
31. Mao-Qiang M, Elias PM, Feingold KR (1993) Fatty acids are required for permeability barrier homeostasis. J Clin Invest 92:791-8
32. Matsuura H, Adachi H, Smart RC, Xu X, Arata J, Jetten AM (1999) Correlation between expression of peroxisome proliferator-activated receptor beta and sequamous differentiation in epidermal and tracheobronchial epithelial cells. Mol Cell Endocrinol 147:85-92
33. Menon GK, Feingold KR, Elias PM (1992) Lamellar body secretory response to barrier disruption. J Invest Dermatol 98:279-89
34. Michalik L, Desvergne B, Tan NS, Basu-Modak S, Escher P, Rieusset J et al. (2001) Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice. J Cell Biol 154:799-814
35. Mikaelian I, Hovick K, Silva KA, Burzenski LM, Shultz LD, Ackert-Bicknell CL et al. (2006) Expression of terminal differentiation proteins defines stages of mouse mammary gland development. Vet Pathol 43:36-49
36. Peters JM, Lee SS, Li W, Ward JM, Gavrilova O, Everett C et al. (2000) Growth, adipose, brain, and skin alternations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor β(δ). Mol Cell Biol 20:5119-28
37. Rivier M, Safonova I, Lebrun P, Griffiths CE, Ailhaud G, Michel S (1998) Differential expression of peroxisome proliferator-activated receptor subtypes during the differentiation of human keratinocytes. J Invest Dermatol 111:1116-21
38. Schmuth M, Haqq CM, Cairns WJ, Holder JC, Dorsam S, Chang S et al. (2004) Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes. J Invest Dermatol 122:971-83. Erratum in: J Invest Dermatol. 123(4):806
39. Schmuth M, Schoonjians K, Yu QC, Fluhr JW, Crumrine D, Hachem JP et al. (2002) Role of peroxisome proliferator-activated receptor alpha in epidermal development in utero. J Invest Dermatol 119:1298-303
40. Sheu MY, Fowler AJ, Kao J, Schmuth M, Schoonjans K, Auwerx J et al. (2002) Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models. J Invest Dermatol 118:94-101
41. Tan NS, Michalik L, Noy N, Yasmin R, Pacot C, Heim M et al. (2001) Critical roles of PPAR beta/delta in keratinocyte response to inflammation. Genes Dev 15:3263-77
42. Westergaard M, Henningsen J, Johansen C, Rasmussen S, Svendsen ML, Jensen UB et al. (2003) Expression and localization of peroxisome proliferator activated receptor and nuclear factor B in normal and lesional psoriatic skin. J Invest Dermatol 121:1104-17
43. Westergaard M, Henningsen J, Svendsen ML, Johansen C, Jensen UB, Schroder HD et al. (2001) Modulation of keratinocyte gene expression and differentiation by PPAR-selective ligands and tetradecylthioacetic acid. J Invest Dermatol 116:702-12