A Molecular Caliper Mechanism for Determining Very Long-Chain Fatty Acid Length

Cell

Volumn 130, Issue 4, 2007, Pages 663-677

  Denic, Vladimir ^a   Weissman, Jonathan S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

PROTEINS

Indexed keywords

FATTY ACID ELONGASE; HYDROLYASE; LYSINE; MEMBRANE ENZYME; OXIDOREDUCTASE; UNCLASSIFIED DRUG; VERY LONG CHAIN FATTY ACID;

ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME STRUCTURE; FATTY ACID SYNTHESIS; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEOLIPOSOME;

EID: 34547947625     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2007.06.031     Document Type: Article

References (50)

1. Alberts B., Johnson A., Lewis M., Raff M., Roberts K., and Walter P. Molecular Biology of the Cell. Fourth Edition (2002), Garland Science, Taylor & Francis Group, New York, NY
2. Beaudoin F., Michaelson L.V., Hey S.J., Lewis M.J., Shewry P.R., Sayanova O., and Napier J.A. Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway. Proc. Natl. Acad. Sci. USA 97 (2000) 6421-6426
3. Beaudoin F., Gable K., Sayanova O., Dunn T., and Napier J.A. A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase. J. Biol. Chem. 277 (2002) 11481-11488
4. Bellec Y., Harrar Y., Butaeye C., Darnet S., Bellini C., and Faure J.D. Pasticcino2 is a protein tyrosine phosphatase-like involved in cell proliferation and differentiation in Arabidopsis. Plant J. 32 (2002) 713-722
5. Browse J., McCourt P.J., and Somerville C.R. Fatty acid composition of leaf lipids determined after combined digestion and fatty acid methyl ester formation from fresh tissue. Anal. Biochem. 152 (1986) 141-145
6. Cane D.E., Walsh C.T., and Khosla C. Harnessing the biosynthetic code: combinations, permutations, and mutations. Science 282 (1998) 63-68
7. Cinti D.L., Cook L., Nagi M.N., and Suneja S.K. The fatty acid chain elongation system of mammalian endoplasmic reticulum. Prog. Lipid Res. 31 (1992) 1-51
8. Da Costa M., Bach L., Landrieu I., Bellec Y., Catrice O., Brown S., De Veylder L., Lippens G., Inze D., and Faure J.D. Arabidopsis PASTICCINO2 is an antiphosphatase involved in regulation of cyclin-dependent kinase A. Plant Cell 18 (2006) 1426-1437
9. Denic V., Quan E.M., and Weissman J.S. A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation. Cell 126 (2006) 349-359
10. Dickson R.C., Sumanasekera C., and Lester R.L. Functions and metabolism of sphingolipids in Saccharomyces cerevisiae. Prog. Lipid Res. 45 (2006) 447-465
11. Ferrer J.L., Jez J.M., Bowman M.E., Dixon R.A., and Noel J.P. Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis. Nat. Struct. Biol. 6 (1999) 775-784
12. Graham I.A., Larson T., and Napier J.A. Rational metabolic engineering of transgenic plants for biosynthesis of omega-3 polyunsaturates. Curr. Opin. Biotechnol. 18 (2007) 142-147
13. Han G., Gable K., Kohlwein S.D., Beaudoin F., Napier J.A., and Dunn T.M. The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase. J. Biol. Chem. 277 (2002) 35440-35449
14. Ivessa A.S., Schneiter R., and Kohlwein S.D. Yeast acetyl-CoA carboxylase is associated with the cytoplasmic surface of the endoplasmic reticulum. Eur. J. Cell Biol. 74 (1997) 399-406
15. Jakobsson A., Westerberg R., and Jacobsson A. Fatty acid elongases in mammals: their regulation and roles in metabolism. Prog. Lipid Res. 45 (2006) 237-249
16. Jenni S., Leibundgut M., Boehringer D., Frick C., Mikolasek B., and Ban N. Structure of fungal fatty acid synthase and implications for iterative substrate shuttling. Science 316 (2007) 254-261
17. Kemp S., Valianpour F., Denis S., Ofman R., Sanders R.J., Mooyer P., Barth P.G., and Wanders R.J. Elongation of very long-chain fatty acids is enhanced in X-linked adrenoleukodystrophy. Mol. Genet. Metab. 84 (2005) 144-151
18. Kim H., Melen K., Osterberg M., and von Heijne G. A global topology map of the Saccharomyces cerevisiae membrane proteome. Proc. Natl. Acad. Sci. USA 103 (2006) 11142-11147
19. Kniazeva M., Crawford Q.T., Seiber M., Wang C.Y., and Han M. Monomethyl branched-chain fatty acids play an essential role in Caenorhabditis elegans development. PLoS Biol. 2 (2004) E257 10.1371/journal.pbio.0020257
20. Kohlwein S.D., Eder S., Oh C.S., Martin C.E., Gable K., Bacikova D., and Dunn T. Tsc13p is required for fatty acid elongation and localizes to a novel structure at the nuclear-vacuolar interface in Saccharomyces cerevisiae. Mol. Cell. Biol. 21 (2001) 109-125
21. Kunst L., and Samuels A.L. Biosynthesis and secretion of plant cuticular wax. Prog. Lipid Res. 42 (2003) 51-80
22. Lee S.H., Stephens J.L., Paul K.S., and Englund P.T. Fatty acid synthesis by elongases in trypanosomes. Cell 126 (2006) 691-699
23. Leonard A.E., Kelder B., Bobik E.G., Chuang L.T., Lewis C.J., Kopchick J.J., Mukerji P., and Huang Y.S. Identification and expression of mammalian long-chain PUFA elongation enzymes. Lipids 37 (2002) 733-740
24. Leonard A.E., Pereira S.L., Sprecher H., and Huang Y.S. Elongation of long-chain fatty acids. Prog. Lipid Res. 43 (2004) 36-54
25. Lester R.L., and Dickson R.C. High-performance liquid chromatography analysis of molecular species of sphingolipid-related long chain bases and long chain base phosphates in Saccharomyces cerevisiae after derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate. Anal. Biochem. 298 (2001) 283-292
26. Livore V.I., Tripodi K.E., and Uttaro A.D. Elongation of polyunsaturated fatty acids in trypanosomatids. FEBS J. 274 (2007) 264-274
27. Lomakin I.B., Xiong Y., and Steitz T.A. The Crystal Structure of Yeast Fatty Acid Synthase, a Cellular Machine with Eight Active Sites Working Together. Cell 129 (2007) 319-332
28. Matsuoka K., and Schekman R. The use of liposomes to study COPII- and COPI-coated vesicle formation and membrane protein sorting. Methods 20 (2000) 417-428
29. McMahon A., Butovich I.A., Mata N.L., Klein M., Ritter III R., Richardson J., Birch D.G., Edwards A.O., and Kedzierski W. Retinal pathology and skin barrier defect in mice carrying a Stargardt disease-3 mutation in elongase of very long chain fatty acids-4. Mol. Vis. 13 (2007) 258-272
30. Moon Y.A., Shah N.A., Mohapatra S., Warrington J.A., and Horton J.D. Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins. J. Biol. Chem. 276 (2001) 45358-45366
31. Nugteren D.H. The enzymic chain elongation of fatty acids by rat-liver microsomes. Biochim. Biophys. Acta 106 (1965) 280-290
32. Oh C.S., Toke D.A., Mandala S., and Martin C.E. ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation. J. Biol. Chem. 272 (1997) 17376-17384
33. Paul S., Gable K., Beaudoin F., Cahoon E., Jaworski J., Napier J.A., and Dunn T.M. Members of the Arabidopsis FAE1-like 3-Ketoacyl-CoA synthase gene family substitute for the Elop proteins of Saccharomyces cerevisiae. J. Biol. Chem. 281 (2006) 9018-9029
34. Pecoul B. New drugs for neglected diseases: from pipeline to patients. PLoS Med. 1 (2004) e6 10.1371/journal.pmed.001006
35. Pele M., Tiret L., Kessler J.L., Blot S., and Panthier J.J. SINE exonic insertion in the PTPLA gene leads to multiple splicing defects and segregates with the autosomal recessive centronuclear myopathy in dogs. Hum. Mol. Genet. 14 (2005) 1417-1427
36. Poulos A., Beckman K., Johnson D.W., Paton B.C., Robinson B.S., Sharp P., Usher S., and Singh H. Very long-chain fatty acids in peroxisomal disease. Adv. Exp. Med. Biol. 318 (1992) 331-340
37. Puyaubert J., Garcia C., Chevalier S., and Lessire R. Acyl-CoA elongase, a key enzyme in the development of high-erucic acid rapeseed?. Eur. J. Lipid Sci. Technol. 107 (2005) 263-267
38. Rossler H., Rieck C., Delong T., Hoja U., and Schweizer E. Functional differentiation and selective inactivation of multiple Saccharomyces cerevisiae genes involved in very-long-chain fatty acid synthesis. Mol. Genet. Genomics 269 (2003) 290-298
39. Schneiter R., Hitomi M., Ivessa A.S., Fasch E.V., Kohlwein S.D., and Tartakoff A.M. A yeast acetyl coenzyme A carboxylase mutant links very-long-chain fatty acid synthesis to the structure and function of the nuclear membrane-pore complex. Mol. Cell. Biol. 16 (1996) 7161-7172
40. Schneiter R., Brugger B., Amann C.M., Prestwich G.D., Epand R.F., Zellnig G., Wieland F.T., and Epand R.M. Identification and biophysical characterization of a very-long-chain-fatty-acid-substituted phosphatidylinositol in yeast subcellular membranes. Biochem. J. 381 (2004) 941-949
41. Schuldiner M., Collins S.R., Thompson N.J., Denic V., Bhamidipati A., Punna T., Ihmels J., Andrews B., Boone C., Greenblatt J.F., et al. Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 123 (2005) 507-519
42. Shanklin J., Whittle E., and Fox B.G. Eight histidine residues are catalytically essential in a membrane-associated iron enzyme, stearoyl-CoA desaturase, and are conserved in alkane hydroxylase and xylene monooxygenase. Biochemistry 33 (1994) 12787-12794
43. Smith S., Witkowski A., and Joshi A.K. Structural and functional organization of the animal fatty acid synthase. Prog. Lipid Res. 42 (2003) 289-317
44. Toulmay A., and Schneiter R. Lipid-dependent surface transport of the proton pumping ATPase: a model to study plasma membrane biogenesis in yeast. Biochimie 89 (2007) 249-254
45. Tsuji S., Ohno T., Miyatake T., Suzuki A., and Yamakawa T. Fatty acid elongation activity in fibroblasts from patients with adrenoleukodystrophy (ALD). J. Biochem. (Tokyo) 96 (1984) 1241-1247
46. Van Gilst M.R., Hadjivassiliou H., Jolly A., and Yamamoto K.R. Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans. PLoS Biol. 3 (2005) e53 10.1371/journal.pbio.0030053
47. Vasireddy V., Uchida Y., Salem Jr. N., Kim S.Y., Mandal M.N., Reddy G.B., Bodepudi R., Alderson N.L., Brown J.C., Hama H., et al. Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death. Hum. Mol. Genet. 16 (2007) 471-482
48. Welch J.W., and Burlingame A.L. Very long-chain fatty acids in yeast. J. Bacteriol. 115 (1973) 464-466
49. Westerberg R., Mansson J.E., Golozoubova V., Shabalina I.G., Backlund E.C., Tvrdik P., Retterstol K., Capecchi M.R., and Jacobsson A. ELOVL3 is an important component for early onset of lipid recruitment in brown adipose tissue. J. Biol. Chem. 281 (2006) 4958-4968
50. Wu G., Truksa M., Datla N., Vrinten P., Bauer J., Zank T., Cirpus P., Heinz E., and Qiu X. Stepwise engineering to produce high yields of very long-chain polyunsaturated fatty acids in plants. Nat. Biotechnol. 23 (2005) 1013-1017