Absence of 2-hydroxylated sphingolipids is compatible with normal neural development but causes late-onset axon and myelin sheath degeneration

Journal of Neuroscience

Volumn 28, Issue 39, 2008, Pages 9741-9754

  Zöller, Inge ^a   Meixner, Marion ^a   Hartmann, Dieter ^a   Büssow, Heinrich ^a   Meyer, Rainer ^a   Gieselmann, Volkmar ^a   Eckhardt, Matthias ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Axonal degeneration; Fatty acid 2 hydroxylase; Galactosylceramide; Myelin; Oligodendrocyte; Schwann cell; Sphingolipids

Indexed keywords

2 HYDROXYLATED SPHINGOLIPID; GALACTOSYLCERAMIDE; MYELIN; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PROTEOLIPID PROTEIN; SPHINGOLIPID; UNCLASSIFIED DRUG; AMIDASE; BETA GALACTOSIDASE; FATTY ACID AMIDASE; FATTY-ACID AMIDE HYDROLASE; MYELIN BASIC PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CELL DIFFERENTIATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; FA2H GENE; FEMALE; GENE; HISTOLOGY; IN SITU HYBRIDIZATION; MALE; MOUSE; MYELIN SHEATH; MYELINATION; NERVE CELL DIFFERENTIATION; NERVE CONDUCTION; NERVE FIBER DEGENERATION; NONHUMAN; OLIGODENDROGLIA; PERIPHERAL NERVE; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; RNA PROBE; SCIATIC NERVE; SPINAL CORD; AGE; ANIMAL; ANIMAL BEHAVIOR; C57BL MOUSE; EXPLORATORY BEHAVIOR; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; LIPID METABOLISM; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; MOUSE MUTANT; NERVE DEGENERATION; NERVE FIBER; NEWBORN; OPTIC NERVE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

AGE FACTORS; AMIDOHYDROLASES; ANIMALS; ANIMALS, NEWBORN; AXONS; BEHAVIOR, ANIMAL; BETA-GALACTOSIDASE; CELL DIFFERENTIATION; CENTRAL NERVOUS SYSTEM; EXPLORATORY BEHAVIOR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; LIPID METABOLISM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, TRANSMISSION; MYELIN BASIC PROTEINS; MYELIN SHEATH; NERVE DEGENERATION; NEURAL CONDUCTION; OLIGODENDROGLIA; OPTIC NERVE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPHINGOLIPIDS;

EID: 55749103552     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0458-08.2008     Document Type: Article

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