CYP4F22 is highly expressed at the site and timing of onset of keratinization during skin development

Journal of Dermatological Science

Volumn 65, Issue 2, 2012, Pages 156-158

  Sasaki, Kaori ^a   Akiyama, Masashi ^a,b   Yanagi, Teruki ^a   Sakai, Kaori ^a   Miyamura, Yuki ^a   Sato, Megumi ^a   Shimizu, Hiroshi ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Ichthyosis; Keratinization; Skin barrier

Indexed keywords

CALCIUM ION; CYTOCHROME P450; CYTOCHROME P450 4F22; LIPOXYGENASE; LIPOXYGENASE III; MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN NIPAL4; UNCLASSIFIED DRUG;

CALCIUM CELL LEVEL; CELL CULTURE; CELLULAR DISTRIBUTION; CYP4F22 GENE; DEVELOPMENT; EPIDERMIS; GENE; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; HUMAN; IMMUNOBLOTTING; IMMUNOFLUORESCENCE TEST; KERATINIZATION; LETTER; LIPOXYGENASE 3 GENE; MARKER GENE; NIPAL4 GENE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN DEVELOPMENT; TISSUE DISTRIBUTION; UPREGULATION;

CALCIUM; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GESTATIONAL AGE; HUMANS; KERATINS; LIPOXYGENASE; RECEPTORS, CELL SURFACE; RNA, MESSENGER; SKIN;

EID: 84856478248     PISSN: 09231811     EISSN: 1873569X     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2011.12.006     Document Type: Letter

References (10)

1. Akiyama M. Updated molecular genetics and pathogenesis of ichthyoses. Nagoya J Med Sci 2011, 73:79-90.
2. Epp N., Fürstenberger G., Müller K., de Juanes S., Leitges M., Hausser I., et al. 12R-lipoxygenase deficiency disrupts epidermal barrier function. J Cell Biol 2007, 177:173-182.
3. Wajid M., Kurban M., Shimomura Y., Christiano A.M. NIPAL4/ichthyin is expressed in the granular layer of human epidermis and mutated in two Pakistani families with autosomal recessive ichthyosis. Dermatology 2010, 220:8-14.
4. Yamanaka Y., Akiyama M., Sugiyama-Nakagiri Y., Sakai K., Goto M., McMillan J.R., et al. Expression of keratinocyte lipid transporter ABCA12 in developing and reconstituted human epidermis. Am J Pathol 2007, 171:43-52.
5. Eckl K.M., Krieg P., Küster W., Traupe H., André F., Wittstruck N., et al. Mutation spectrum and functional analysis of epidermis-type lipoxygenases in patients with autosomal recessive congenital ichthyosis. Hum Mutat 2005, 26:351-361.
6. Holtzman M.J., Turk J., Pentland A. A regiospecific monooxygenase with novel stereopreference is the major pathway for arachidonic acid oxygenation in isolated epidermal cells. J Clin Invest 1989, 84:1446-1453.
7. Boeglin W.E., Kim R.B., Brash A.R. A 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expression. Proc Natl Acad Sci USA 1998, 95:6744-6749.
8. Woollard P.M. Stereochemical difference between 12-hydroxy-5,8,10,14-eicosatetraenoic acid in platelets and psoriatic lesions. Biochem Biophys Res Commun 1986, 136:169-176.
9. Zheng Y., Yin H., Boeglin W.E., Elias P.M., Crumrine D., Beier D.R., et al. Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation. A proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope. J Biol Chem 2011, 286:24046-24056.
10. Nilsson T., Ivanov I.V., Oliw E.H. LC-MS/MS analysis of epoxyalcohols and epoxides of arachidonic acid and their oxygenation by recombinant CYP4F8 and CYP4F22. Arch Biochem Biophys 2010, 494:64-71.