Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: A proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope

Journal of Biological Chemistry

Volumn 286, Issue 27, 2011, Pages 24046-24056

  Zheng, Yuxiang ^a   Yin, Huiyong ^a   Boeglin, William E ^a   Elias, Peter M ^b   Crumrine, Debra ^b   Beier, David R ^c   Brash, Alan R ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

12R-LOX; BARRIER FORMATION; BIOCHEMICAL PATHWAY; CERAMIDES; DRY LAND; EPIDERMAL BARRIER; ESSENTIAL FATTY ACIDS; ESTER HYDROLYSIS; HPLC-UV; IN-BUILDINGS; LIPOXYGENASES; MOUSE SKIN; MULTIPLE COMPONENTS; STEREOSPECIFIC; TRANSEPIDERMAL WATER LOSS; WATER LOSS;

AMIDES; ESTERIFICATION; ESTERS; HYDROLYSIS; KETONES; MAMMALS; NANOCAPSULES; OXYGENATION; OXYGENATORS; POLYUNSATURATED FATTY ACIDS; PROTEINS; SCAFFOLDS (BIOLOGY);

FATTY ACIDS;

ARACHIDONATE 12 LIPOXYGENASE; CERAMIDE DERIVATIVE; FATTY ACID; HYDROXYPEROXYLINOLEOYL OMEGA HYDROXYCERAMIDE; LIPID ENVELOPE; LIPOXYGENASE; LIPOXYGENASE III; O LINOLEOYL OMEGA HYDROXYCERAMIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORNEOCYTE; EPIDERMIS; FATTY ACID OXIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; LIQUID CHROMATOGRAPHY; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; MOUSE; NONHUMAN; OXYGENATION; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN BINDING; PROTON NUCLEAR MAGNETIC RESONANCE; SKIN; SKIN CELL; SWINE; WATER LOSS;

ANIMALS; ARACHIDONATE 12-LIPOXYGENASE; CERAMIDES; EPIDERMIS; FATTY ACIDS, ESSENTIAL; LIPOXYGENASE; MICE; OXIDATION-REDUCTION; SWINE;

MAMMALIA; MUS; SUIDAE;

EID: 79959906412     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.251496     Document Type: Article

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