Interaction of Liposomal and Polycationic Transfection Complexes with Pulmonary Surfactant

Journal of Gene Medicine

Volumn 1, Issue 5, 1999, Pages 331-340

  Ernst, Nicola ^a   Ulrichskötter, Sonja ^a   Schmalix, Wolfgang A ^a   Rädler, Joachim ^b   Galneder, Reinhard ^b   Mayer, Elfriede ^a   Gersting, Soeren ^a   Plank, Christian ^b   Reinhardt, Dietrich ^a   Rosenecker, Joseph ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Cystic fibrosis; Dendrimer; DNase; Gene therapy; Gene transfer; Lipofection; Polyethylenimine; Polyfection; Surfactant

Indexed keywords

BOVINAE; SUIDAE;

1 PALMITOYL 2 OLEOYLGLYCERO 3 PHOSPHOGLYCEROL; 1-PALMITOYL-2-OLEOYLGLYCERO-3-PHOSPHOGLYCEROL; DEOXYRIBONUCLEASE; DIPALMITOYLPHOSPHATIDYLCHOLINE; DNA; FATTY ALCOHOL; LIPID; LIPOSOME; LUCIFERASE; LUNG SURFACTANT; MACROGOL DERIVATIVE; PHOSPHATIDYLGLYCEROL; PHOSPHOLIPID; PHOSPHORYLCHOLINE; POLYAMINE; POLYCATIONS; SF RI 1, BOVINE SURFACTANT PREPARATION; SF-RI 1, BOVINE SURFACTANT PREPARATION;

ANIMAL; ARTICLE; CATTLE; CELL CULTURE; CELL LINE; CELL STRAIN COS1; DRUG COMBINATION; DRUG EFFECT; GENE THERAPY; GENETIC TRANSFECTION; GENETICS; HUMAN; LUNG; METABOLISM; SWINE;

ANIMALS; CATTLE; CELL LINE; CELLS, CULTURED; COS CELLS; DEOXYRIBONUCLEASES; DNA; DRUG COMBINATIONS; FATTY ALCOHOLS; GENE THERAPY; HUMANS; LIPIDS; LIPOSOMES; LUCIFERASES; LUNG; PHOSPHATIDYLGLYCEROLS; PHOSPHOLIPIDS; PHOSPHORYLCHOLINE; POLYAMINES; POLYETHYLENE GLYCOLS; PULMONARY SURFACTANTS; SWINE; TRANSFECTION;

EID: 0346250724     PISSN: 1099498X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-2254(199909/10)1:5<331::AID-JGM60>3.0.CO;2-8     Document Type: Article

References (15)

1. Stribling R, Brunette E, Liggitt D, Gaensler K, Debs R. Aerosol gene delivery in vivo. Proc Natl Acad Sci U S A 1992; 89: 11277-11281.
2. Meyer KB, Thompson MM, Levy MY, Barron LG, Szoka FC, Jr. Intratracheal gene delivery to the mouse airway: characterization of plasmid DNA expression and pharmacokinetics. Gene Ther 1995; 2: 450-2460.
3. Duncan JE, Whitsett JA, Horowitz AD. Pulmonary surfactant inhibits cationic liposome-mediated gene delivery to respiratory epithelial cells in vitro. Hum Gene Ther 1997; 8: 431-438.
4. Xu Y, Szoka FC, Jr. Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection. Biochemistry 1996; 35: 5616-5623.
5. Haensler J, Szoka FC, Jr. Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjug Chem 1993; 4: 372-379.
6. Yamaya M, Finkbeiner WE, Chun SY, Widdicombe JH. Differentiated structure and function of cultures from human tracheal epithelium. Am J Physiol 1992; 262: L713-L724.
7. de Wet JR, Wood KV, DeLuca M, Helinski DR, Subramani S. Firefly luciferase gene: structure and expression in mammalian cells. Mol Cell Biol 1987; 7: 725-737.
8. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254.
9. Tang MX, Szoka FC. The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes. Gene Ther 1997; 4: 823-832.
10. Cheng SH, Marshall J, Scheule RK, Smith AE. Cationic lipid formulations for intracellular gene delivery of cystic fibrosis transmembrane conductance regulator to airway epithelia. Methods Enzymol 1998; 292: 697-717.
11. Jobe AH, Ueda T, Whitsett JA, Trapnell BC, Ikegami M. Surfactant enhances adenovirus-mediated gene expression in rabbit lungs. Gene Ther 1996; 3: 775-779.
12. Tsan MF, Tsan GL, White JE. Surfactant inhibits cationic liposome-mediated gene transfer. Hum Gene Ther 1997; 8: 817-825.
13. Zelphati O, Szoka FC, Jr. Mechanism of oligonucleotide release from cationic liposomes. Proc Natl Acad Sci U S A 1996; 93: 11493-11498.
14. Radler JO, Koltover I, Salditt T, Safinya CR. Structure of DNA-cationic liposome complexes: DNA intercalation in multilamellar membranes in distinct interhelical packing regimes [see comments]. Science 1997; 275: 810-814.
15. Raczka E, Kukowska-Latallo JF, Rymaszewski M, Chen C, Baker JR Jr. The effect of synthetic surfactant Exosurf on gene transfer in mouse lung in vivo. Gene Ther 1998; 5: 1333-1339.