Effective endogenous gene silencing mediated by pH responsive peptides proceeds via multiple pathways

Journal of Controlled Release

Volumn 158, Issue 2, 2012, Pages 293-303

  Lam, Jenny K W ^a,b   Liang, Wanling ^b   Lan, Yun ^a,b   Chaudhuri, Poulami ^a   Chow, Michael Y T ^b   Witt, Katarzyna ^a   Kudsiova, Laila ^a   Mason, A James ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Endocytosis; GAPDH; Gene silencing; pH responsive peptides; siRNA

Indexed keywords

A549 CELLS; ACIDIC PH; AMPHIPATHIC; CLATHRIN-DEPENDENT ENDOCYTOSIS; DNA TRANSFER; ENDOCYTOSIS; ENDOGENOUS GENES; ENDOSOMES; GAPDH; GENE ACTIVITIES; GENE DELIVERY; GENE SILENCING; LIVE-CELL IMAGING; MULTIPLE PATHWAYS; NONVIRAL VECTORS; PH-RESPONSIVE; PLASMID DNA; SELECTIVE REDUCTION; SIRNA; SIRNA DELIVERY;

AMINO ACIDS; BIOMOLECULES; DRUG THERAPY; GENE TRANSFER; GENES; RNA;

PEPTIDES;

CLATHRIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; PEPTIDE DERIVATIVE; PLASMID DNA; PLASMID VECTOR; SMALL INTERFERING RNA;

ACIDITY; ARTICLE; CELL STRAIN; CELL STRAIN A549; CELL STRAIN MCF 7; CONTROLLED STUDY; DNA TRANSFER; ENDOCYTOSIS; ENDOSOME; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; PH; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

CELL LINE, TUMOR; CELL SURVIVAL; DNA; GENE SILENCING; GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE (NADP+); HUMANS; HYDROGEN-ION CONCENTRATION; PEPTIDES; PLASMIDS; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84858701389     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.11.024     Document Type: Article

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