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Volumn , Issue , 2011, Pages 23-46

Pulmonary Delivery of Peptides and Proteins

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EID: 84882499572     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-384935-9.10002-1     Document Type: Chapter
Times cited : (14)

References (113)
  • 1
    • 0004122931 scopus 로고    scopus 로고
    • Orlando, USA: Harcourt Brace & Company
    • M.K. Campbell (1999) Biochemistry. Orlando, USA: Harcourt Brace & Company
    • (1999) Biochemistry
    • Campbell, M.K.1
  • 5
    • 0031646537 scopus 로고    scopus 로고
    • Safety of inhaled proteins for therapeutic use
    • R.K. Wolff (1998) Safety of inhaled proteins for therapeutic use. J. Aerosol Med. 11 197-219.
    • (1998) J. Aerosol Med. , vol.11 , pp. 197-219
    • Wolff, R.K.1
  • 7
    • 0003577140 scopus 로고    scopus 로고
    • New York, USA: John Willey & Sons
    • W.C. Hinds (1999) Aerosol Technology. New York, USA: John Willey & Sons
    • (1999) Aerosol Technology
    • Hinds, W.C.1
  • 9
    • 0020607763 scopus 로고
    • Levels of elastase activity in bronchoalveolar lavage fluids of healthy smokers and nonsmokers
    • A. Janoff, L. Raju and R. Dearing (1983) Levels of elastase activity in bronchoalveolar lavage fluids of healthy smokers and nonsmokers. Am. Rev. Respir. Dis. 127 540-544.
    • (1983) Am. Rev. Respir. Dis. , vol.127 , pp. 540-544
    • Janoff, A.1    Raju, L.2    Dearing, R.3
  • 10
    • 0021884164 scopus 로고
    • Extracellular elastolytic activity in human lung lavage: A comparative study between smokers and non-smokers
    • S.F. Smith, A. Guz, N.T. Cooke, G.H. Burton and T.D. Tetley (1985) Extracellular elastolytic activity in human lung lavage: A comparative study between smokers and non-smokers. Clin. Sci. 69 17-27.
    • (1985) Clin. Sci. , vol.69 , pp. 17-27
    • Smith, S.F.1    Guz, A.2    Cooke, N.T.3    Burton, G.H.4    Tetley, T.D.5
  • 11
    • 0025374343 scopus 로고
    • Evaluation of elastase and antielastase balance in patients with chronic bronchitis and pulmonary emphysema
    • J. Fujita, N.L. Nelson, D.M. Daughton, C.A. Dobry, J.R. Spurzem, S. Irino, et al. (1990) Evaluation of elastase and antielastase balance in patients with chronic bronchitis and pulmonary emphysema. Am. Rev. Respir. Dis. 142 57-62.
    • (1990) Am. Rev. Respir. Dis. , vol.142 , pp. 57-62
    • Fujita, J.1    Nelson, N.L.2    Daughton, D.M.3    Dobry, C.A.4    Spurzem, J.R.5    Irino, S.6
  • 12
    • 0019469755 scopus 로고
    • Proteolytic enzymes in bronchopulmonary lavage fluids: Cathepsin B-like activity and prolyl endopeptidase
    • M. Orlowski, J. Orlowski, M. Lesser and K.H. Kilburn (1981) Proteolytic enzymes in bronchopulmonary lavage fluids: Cathepsin B-like activity and prolyl endopeptidase. J. Lab. Clin. Med. 97 467-476.
    • (1981) J. Lab. Clin. Med. , vol.97 , pp. 467-476
    • Orlowski, M.1    Orlowski, J.2    Lesser, M.3    Kilburn, K.H.4
  • 14
    • 0024461541 scopus 로고
    • Peptidase enzymes of the pulmonary vascular surface
    • J.W. Ryan (1989) Peptidase enzymes of the pulmonary vascular surface. Am. J. Physiol.-Lung Cell. Mol. Physiol. 257 L53-L60.
    • (1989) Am. J. Physiol.-Lung Cell. Mol. Physiol. , vol.257 , pp. L53-L60
    • Ryan, J.W.1
  • 15
  • 16
    • 0027249865 scopus 로고
    • High levels of exopeptidase activity are present in rat and canine bronchoalveolar lavage fluid
    • D.A. Wall and A.T. Lanutti (1993) High levels of exopeptidase activity are present in rat and canine bronchoalveolar lavage fluid. Int. J. Pharm. 97 171-181.
    • (1993) Int. J. Pharm. , vol.97 , pp. 171-181
    • Wall, D.A.1    Lanutti, A.T.2
  • 17
    • 0021919760 scopus 로고
    • Elastases and emphysema
    • A. Janoff (1985) Elastases and emphysema. Am. Rev. Respir. Dis. 132 417-433.
    • (1985) Am. Rev. Respir. Dis. , vol.132 , pp. 417-433
    • Janoff, A.1
  • 18
    • 0015160590 scopus 로고
    • Intestinal transport of dipeptides in man: Relative importance of hydrolysis and intact absorption
    • S.A. Adibi and E.L. Morse (1971) Intestinal transport of dipeptides in man: Relative importance of hydrolysis and intact absorption. J. Clin. Invest. 50 2266-2275.
    • (1971) J. Clin. Invest. , vol.50 , pp. 2266-2275
    • Adibi, S.A.1    Morse, E.L.2
  • 19
    • 0022592643 scopus 로고
    • Aminopeptidase activity in homogenates of various absorptive mucosae m the albino rabbit: Implications in peptide delivery
    • R.E. Stratford Jr. and V.H.L. Lee (1986) Aminopeptidase activity in homogenates of various absorptive mucosae m the albino rabbit: Implications in peptide delivery. Int. J. Pharm. 30 73-82.
    • (1986) Int. J. Pharm. , vol.30 , pp. 73-82
    • Stratford, R.E.1    Lee, V.H.L.2
  • 20
    • 0342899772 scopus 로고
    • Peptide metabolism by lung and airway peptidases
    • G.H. Caughey (1992) Peptide metabolism by lung and airway peptidases. J. Biopharm. Sci. 3 233-240.
    • (1992) J. Biopharm. Sci. , vol.3 , pp. 233-240
    • Caughey, G.H.1
  • 21
    • 0006619826 scopus 로고    scopus 로고
    • Pulmonary absorption and metabolism of peptides and proteins
    • R.N. Dalby, P.R. Byron, S.J. Farr (Eds), Bufflao Grove, IL, USA: Interpharm Press
    • J.S. Patton, S. Nagarajan and A. Clark (1998) Pulmonary absorption and metabolism of peptides and proteins. R.N. Dalby, P.R. Byron, S.J. Farr (Eds) Respiratory Drug Delivery VI Bufflao Grove, IL, USA: Interpharm Press 17-24.
    • (1998) Respiratory Drug Delivery VI , pp. 17-24
    • Patton, J.S.1    Nagarajan, S.2    Clark, A.3
  • 22
    • 42949106073 scopus 로고    scopus 로고
    • Dry powder inhalation systems for pulmonary delivery of therapeutic peptides and proteins
    • S. Onoue, N. Hashimoto and S. Yamada (2008) Dry powder inhalation systems for pulmonary delivery of therapeutic peptides and proteins. Expert Opin. Ther. Patents 18 429-442.
    • (2008) Expert Opin. Ther. Patents , vol.18 , pp. 429-442
    • Onoue, S.1    Hashimoto, N.2    Yamada, S.3
  • 23
    • 0026501192 scopus 로고
    • (C) Means to enhance penetration: (4) Delivery systems for penetration enhancement of peptide and protein drugs: Design considerations
    • U.B. Kompella and V.H.L. Lee (1992) (C) Means to enhance penetration: (4) Delivery systems for penetration enhancement of peptide and protein drugs: Design considerations. Adv. Drug Deliv. Rev. 8 115-162.
    • (1992) Adv. Drug Deliv. Rev. , vol.8 , pp. 115-162
    • Kompella, U.B.1    Lee, V.H.L.2
  • 25
    • 0035132126 scopus 로고    scopus 로고
    • Localization of the peptide transporter PEPT2 in the lung: Implications for pulmonary oligopeptide uptake
    • D.A. Groneberg, M. Nickolaus, J. Springer, F. Döring, H. Daniel and F. Axel (2001) Localization of the peptide transporter PEPT2 in the lung: Implications for pulmonary oligopeptide uptake. Am. J. Pathol. 158 707-714.
    • (2001) Am. J. Pathol. , vol.158 , pp. 707-714
    • Groneberg, D.A.1    Nickolaus, M.2    Springer, J.3    Döring, F.4    Daniel, H.5    Axel, F.6
  • 26
    • 0034049133 scopus 로고    scopus 로고
    • Systematic investigations of the influence of molecular structure on the transport of peptides across cultured alveolar cell monolayers
    • A.N.O. Dodoo, S. Bansal, D.J. Barlow, F.C. Bennet, R.C. Hider, A.B. Lansley, et al. (2000) Systematic investigations of the influence of molecular structure on the transport of peptides across cultured alveolar cell monolayers. Pharm. Res. 17 7-14.
    • (2000) Pharm. Res. , vol.17 , pp. 7-14
    • Dodoo, A.N.O.1    Bansal, S.2    Barlow, D.J.3    Bennet, F.C.4    Hider, R.C.5    Lansley, A.B.6
  • 27
    • 0026688443 scopus 로고
    • Clearance of different-sized proteins from the alveolar space in humans and rabbits
    • R.H. Hastings, M. Grady, T. Sakuma and M.A. Matthay (1992) Clearance of different-sized proteins from the alveolar space in humans and rabbits. J. Appl. Physiol. 73 1310-1316.
    • (1992) J. Appl. Physiol. , vol.73 , pp. 1310-1316
    • Hastings, R.H.1    Grady, M.2    Sakuma, T.3    Matthay, M.A.4
  • 28
    • 0343058935 scopus 로고    scopus 로고
    • Mechanisms of macromolecule absorption by the lungs
    • J.S. Patton (1996) Mechanisms of macromolecule absorption by the lungs. Adv. Drug Deliv. Rev. 19 3-36.
    • (1996) Adv. Drug Deliv. Rev. , vol.19 , pp. 3-36
    • Patton, J.S.1
  • 29
    • 0028332685 scopus 로고
    • Transport of thyrotropin-releasing hormone across rat alveolar epithelial cell monolayers
    • K. Morimoto, H. Yamahara, V.H.L. Lee and K.-J. Kim (1994) Transport of thyrotropin-releasing hormone across rat alveolar epithelial cell monolayers. Life Sci. 54 2083-2092.
    • (1994) Life Sci. , vol.54 , pp. 2083-2092
    • Morimoto, K.1    Yamahara, H.2    Lee, V.H.L.3    Kim, K.-J.4
  • 31
    • 0029055776 scopus 로고
    • Susceptibility of insulin to proteolysis in rat lung homogenate and its protection from proteolysis by various protease inhibitors
    • Y. Fukuda, T. Tsuji, T. Fujita, A. Yamamoto and S. Muranishi (1995) Susceptibility of insulin to proteolysis in rat lung homogenate and its protection from proteolysis by various protease inhibitors. Biol. Pharm. Bull. 18 891-894.
    • (1995) Biol. Pharm. Bull. , vol.18 , pp. 891-894
    • Fukuda, Y.1    Tsuji, T.2    Fujita, T.3    Yamamoto, A.4    Muranishi, S.5
  • 32
    • 0026620518 scopus 로고
    • Intratracheal delivery of insulin absorption from solution and aerosol by rat lung
    • K. Okumura, S. Iwakawa, T. Yoshida, T. Seki and F. Komada (1992) Intratracheal delivery of insulin absorption from solution and aerosol by rat lung. Int. J. Pharm 88 63-73.
    • (1992) Int. J. Pharm , vol.88 , pp. 63-73
    • Okumura, K.1    Iwakawa, S.2    Yoshida, T.3    Seki, T.4    Komada, F.5
  • 34
    • 0030922813 scopus 로고    scopus 로고
    • 1,7)-eel calcitonin by various absorption enhancers and their pulmonary toxicity in rats
    • A. Yamamoto, S. Okumura, Y. Fukuda, M. Fukui, K. Takahashi and S. Muranishi (1997) Improvement of the pulmonary absorption of (Asu1,7)-eel calcitonin by various absorption enhancers and their pulmonary toxicity in rats. J. Pharm. Sci. 86 1144-1147.
    • (1997) J. Pharm. Sci. , vol.86 , pp. 1144-1147
    • Yamamoto, A.1    Okumura, S.2    Fukuda, Y.3    Fukui, M.4    Takahashi, K.5    Muranishi, S.6
  • 35
    • 0027965843 scopus 로고
    • Study on pulmonary delivery of salmon calcitonin in rats: Effects of protease inhibitors and absorption enhancers
    • S. Kobayashi, S. Kondo and K. Juni (1994) Study on pulmonary delivery of salmon calcitonin in rats: Effects of protease inhibitors and absorption enhancers. Pharm. Res. 11 1239-1243.
    • (1994) Pharm. Res. , vol.11 , pp. 1239-1243
    • Kobayashi, S.1    Kondo, S.2    Juni, K.3
  • 36
    • 0029918843 scopus 로고    scopus 로고
    • Pulmonary delivery of salmon calcitonin dry powders containing absorption enhancers in rats
    • S. Kobayashi, S. Kondo and K. Juni (1996) Pulmonary delivery of salmon calcitonin dry powders containing absorption enhancers in rats. Pharm. Res. 13 80-83.
    • (1996) Pharm. Res. , vol.13 , pp. 80-83
    • Kobayashi, S.1    Kondo, S.2    Juni, K.3
  • 37
    • 21744457648 scopus 로고    scopus 로고
    • Carrier-based strategies for targeting protein and peptide drugs to the lungs
    • S.-A. Cryan (2005) Carrier-based strategies for targeting protein and peptide drugs to the lungs. AAPS J. 7 E20-E41.
    • (2005) AAPS J. , vol.7 , pp. E20-E41
    • Cryan, S.-A.1
  • 38
    • 0027398639 scopus 로고
    • Pulmonary delivery of free and liposomal insulin
    • F.-Y. Liu, Z. Shao, D.O. Kildsig and A.K. Mitra (1993) Pulmonary delivery of free and liposomal insulin. Pharm. Res. 10 228-232.
    • (1993) Pharm. Res. , vol.10 , pp. 228-232
    • Liu, F.-Y.1    Shao, Z.2    Kildsig, D.O.3    Mitra, A.K.4
  • 39
    • 0033386038 scopus 로고    scopus 로고
    • Pharmacokinetics of liposomal aerosolized cyclosporine A for pulmonary immunosuppression
    • G.V. Letsou, H.J. Safi, M.J. Reardon, M. Ergenoglu, Z. Li, C.N. Kolonaris, et al. (1999) Pharmacokinetics of liposomal aerosolized cyclosporine A for pulmonary immunosuppression. Ann. Thorac. Surg. 68 2044-2048.
    • (1999) Ann. Thorac. Surg. , vol.68 , pp. 2044-2048
    • Letsou, G.V.1    Safi, H.J.2    Reardon, M.J.3    Ergenoglu, M.4    Li, Z.5    Kolonaris, C.N.6
  • 40
    • 0029912238 scopus 로고    scopus 로고
    • Aerosol delivery of interleukin 2 liposomes is nontoxic and biologically effective: Canine studies
    • C. Khanna, D.E. Hasz, J.S. Klausner and P.M. Anderson (1996) Aerosol delivery of interleukin 2 liposomes is nontoxic and biologically effective: Canine studies. Clin. Cancer Res. 2 721-734.
    • (1996) Clin. Cancer Res. , vol.2 , pp. 721-734
    • Khanna, C.1    Hasz, D.E.2    Klausner, J.S.3    Anderson, P.M.4
  • 41
    • 0033523046 scopus 로고    scopus 로고
    • Comparison of the quality of protection elicited by toxoid and peptide liposomal vaccine formulations against ricin as assessed by markers of inflammation
    • G.D. Griffiths, G.J. Phillips and S.C. Bailey (1999) Comparison of the quality of protection elicited by toxoid and peptide liposomal vaccine formulations against ricin as assessed by markers of inflammation. Vaccine 17 2562-2568.
    • (1999) Vaccine , vol.17 , pp. 2562-2568
    • Griffiths, G.D.1    Phillips, G.J.2    Bailey, S.C.3
  • 42
    • 0028137062 scopus 로고
    • Cyclodextrins as mucosal absorption promoters of insulin. II. Effects of β-cyclodextrin derivatives on α-chymotryptic degradation and enteral absorption of insulin in rats
    • Z. Shao, Y. Li, T. Chermak and A.K. Mitra (1994) Cyclodextrins as mucosal absorption promoters of insulin. II. Effects of β-cyclodextrin derivatives on α-chymotryptic degradation and enteral absorption of insulin in rats. Pharm. Res. 11 1174-1179.
    • (1994) Pharm. Res. , vol.11 , pp. 1174-1179
    • Shao, Z.1    Li, Y.2    Chermak, T.3    Mitra, A.K.4
  • 43
    • 0142105943 scopus 로고    scopus 로고
    • Pulmonary absorption of insulin mediated by tetradecyl-β-maltoside and dimethyl-β-cyclodextrin
    • A. Hussain, T. Yang, A.-A. Zaghloul and F. Ahsan (2003) Pulmonary absorption of insulin mediated by tetradecyl-β-maltoside and dimethyl-β-cyclodextrin. Pharm. Res. 20 1551-1557.
    • (2003) Pharm. Res. , vol.20 , pp. 1551-1557
    • Hussain, A.1    Yang, T.2    Zaghloul, A.-A.3    Ahsan, F.4
  • 44
    • 0000121902 scopus 로고    scopus 로고
    • Sustained efficacy and pulmonary safety of inhaled insulin during 2-years of outpatient therapy
    • W.T. Cefalu, C.C. Balagtas, W.H. Lanschultz and R.A. Gelfand (2000) Sustained efficacy and pulmonary safety of inhaled insulin during 2-years of outpatient therapy. Diabetes 49 A101.
    • (2000) Diabetes , vol.49 , pp. A101
    • Cefalu, W.T.1    Balagtas, C.C.2    Lanschultz, W.H.3    Gelfand, R.A.4
  • 45
    • 0034096243 scopus 로고    scopus 로고
    • Oxygen radical-mediated pulmonary toxicity induced by some cationic liposomes
    • S. Dokka, D. Toledo, X. Shi, V. Castranova and Y. Rojanasakul (2000) Oxygen radical-mediated pulmonary toxicity induced by some cationic liposomes. Pharm. Res. 17 521-525.
    • (2000) Pharm. Res. , vol.17 , pp. 521-525
    • Dokka, S.1    Toledo, D.2    Shi, X.3    Castranova, V.4    Rojanasakul, Y.5
  • 46
    • 85007764407 scopus 로고    scopus 로고
    • Why is Exubera being withdrawn?
    • C.J. Bailey and A.H. Barnett (2007) Why is Exubera being withdrawn? Br. Med. J. 335 1156.
    • (2007) Br. Med. J. , vol.335 , pp. 1156
    • Bailey, C.J.1    Barnett, A.H.2
  • 47
    • 17444417143 scopus 로고    scopus 로고
    • Liquid-spray or dry-powder systems for inhaled delivery of peptide and proteins?
    • L. Garcia-Contreras and H.D.C. Smyth (2005) Liquid-spray or dry-powder systems for inhaled delivery of peptide and proteins? Am. J. Drug Deliv. 3 29-45.
    • (2005) Am. J. Drug Deliv. , vol.3 , pp. 29-45
    • Garcia-Contreras, L.1    Smyth, H.D.C.2
  • 50
    • 85017339835 scopus 로고    scopus 로고
    • Ultrasonic and electrohydrodynamic methods for aerosol generation
    • A.J. Hickey (Eds), New York, USA: Informa Healthcare USA
    • B.J. Greenspan (2007) Ultrasonic and electrohydrodynamic methods for aerosol generation. A.J. Hickey (Eds) Inhalation Aerosols: Physical and Biological Basis for Therapy New York, USA: Informa Healthcare USA
    • (2007) Inhalation Aerosols: Physical and Biological Basis for Therapy
    • Greenspan, B.J.1
  • 51
    • 0028118736 scopus 로고
    • Assessment of aerosol delivery systems for recombinant human deoxyribonuclease
    • D.C. Cipolla, A.R. Clark, H.-K. Chan, I. Gonda and S.J. Shire (1994) Assessment of aerosol delivery systems for recombinant human deoxyribonuclease. STP Pharma. Sci. 4 50-62.
    • (1994) STP Pharma. Sci. , vol.4 , pp. 50-62
    • Cipolla, D.C.1    Clark, A.R.2    Chan, H.-K.3    Gonda, I.4    Shire, S.J.5
  • 53
  • 54
    • 0028332576 scopus 로고
    • Protein nebulization: I. Stability of lactate dehydrogenase and recombinant granulocyte-colony stimulating factor to air-jet nebulizaion
    • R.W. Niven, A.Y. Ip, S.D. Mittelman, C. Farrar, T. Arakawa and S.J. Prestrelski (1994) Protein nebulization: I. Stability of lactate dehydrogenase and recombinant granulocyte-colony stimulating factor to air-jet nebulizaion. Int. J. Pharm. 109 17-26.
    • (1994) Int. J. Pharm. , vol.109 , pp. 17-26
    • Niven, R.W.1    Ip, A.Y.2    Mittelman, S.D.3    Farrar, C.4    Arakawa, T.5    Prestrelski, S.J.6
  • 55
    • 1642433360 scopus 로고    scopus 로고
    • Effect of excipients on the stability and aerosol performance of nebulised aviscumine
    • H. Steckel, F. Eskander and K. Witthohn (2003) Effect of excipients on the stability and aerosol performance of nebulised aviscumine. J. Aerosol Med. 16 417-432.
    • (2003) J. Aerosol Med. , vol.16 , pp. 417-432
    • Steckel, H.1    Eskander, F.2    Witthohn, K.3
  • 56
    • 0038015539 scopus 로고    scopus 로고
    • Effect of cryoprotectants on the stability and aerosol performance of nebulized aviscumine, a 57-kDa protein
    • H. Steckel, F. Eskander and K. Witthohn (2003) Effect of cryoprotectants on the stability and aerosol performance of nebulized aviscumine, a 57-kDa protein. Eur. J. Pharm. Biopharm. 56 11-21.
    • (2003) Eur. J. Pharm. Biopharm. , vol.56 , pp. 11-21
    • Steckel, H.1    Eskander, F.2    Witthohn, K.3
  • 57
    • 0037433846 scopus 로고    scopus 로고
    • The effect of formulation variables on the stability of nebulised aviscumine
    • H. Steckel, F. Eskander and K. Witthohn (2003) The effect of formulation variables on the stability of nebulised aviscumine. Int. J. Pharm. 257 181-194.
    • (2003) Int. J. Pharm. , vol.257 , pp. 181-194
    • Steckel, H.1    Eskander, F.2    Witthohn, K.3
  • 58
    • 85147063983 scopus 로고    scopus 로고
    • Consumer Medicine Information, Roche Products Pty Ltd, Dee Why, NSW, Australia,
    • Pulmozyme® Consumer Medicine Information, Roche Products Pty Ltd, Dee Why, NSW, Australia, 2008.
    • (2008) Pulmozyme®
  • 59
    • 0037695175 scopus 로고    scopus 로고
    • Deoxyribonuclease inhalation
    • A.L. Adjei, P.K. Gupta (Eds), New York, USA: Marcel Dekker
    • I. Gonda (1997) Deoxyribonuclease inhalation. A.L. Adjei, P.K. Gupta (Eds) Inhalation Delivery of Therapeutic Peptides and Proteins New York, USA: Marcel Dekker 355-365.
    • (1997) Inhalation Delivery of Therapeutic Peptides and Proteins , pp. 355-365
    • Gonda, I.1
  • 60
    • 84882476450 scopus 로고    scopus 로고
    • Novel aerosol peptide drug delivery systems
    • A.L. Adjei, P.K. Gupta (Eds), New York, USA: Marcel Dekker
    • R. Rubsamen (1997) Novel aerosol peptide drug delivery systems. A.L. Adjei, P.K. Gupta (Eds) Inhalation Delivery of Therapeutic Peptides and Proteins New York, USA: Marcel Dekker 703-731.
    • (1997) Inhalation Delivery of Therapeutic Peptides and Proteins , pp. 703-731
    • Rubsamen, R.1
  • 61
    • 33646187665 scopus 로고    scopus 로고
    • Delivery of rhDNase by the AERx® pulmonary delivery system
    • R.N. Dalby, P.R. Byron, S. Farr, J. Peart (Eds), Raleigh, NC, USA: Serentec Press
    • S. Mudumba, M. Khossravi, D. Yim, T. Rossi, D. Pearce, M. Hughes, et al. (2000) Delivery of rhDNase by the AERx® pulmonary delivery system. R.N. Dalby, P.R. Byron, S. Farr, J. Peart (Eds) Respiratory Drug Delivery VII Raleigh, NC, USA: Serentec Press 329-332.
    • (2000) Respiratory Drug Delivery VII , pp. 329-332
    • Mudumba, S.1    Khossravi, M.2    Yim, D.3    Rossi, T.4    Pearce, D.5    Hughes, M.6
  • 62
    • 0038248885 scopus 로고    scopus 로고
    • Inhaled insulin using the AERx Insulin Diabetes Management System in healthy and asthmatic subjects
    • R.R. Henry, S.R.D. Mudaliar, W.C. Howland III, N. Chu, D. Kim, B. An, et al. (2003) Inhaled insulin using the AERx Insulin Diabetes Management System in healthy and asthmatic subjects. Diabetes Care 26 764-769.
    • (2003) Diabetes Care , vol.26 , pp. 764-769
    • Henry, R.R.1    Mudaliar, S.R.D.2    Howland, W.C.3    Chu, N.4    Kim, D.5    An, B.6
  • 63
    • 0010495811 scopus 로고    scopus 로고
    • Technical development of AERx® Diabetes Management System: Essential characteristics for diabetes treatment with pulmonary insulin
    • R.N. Dalby, P.R. Byron, J. Peart, S. Farr (Eds), Raleigh, NC, USA: Davis Horwood International
    • S. Farr, D. Reynolds, A. Nat, S. Srinivasan, M. Roach, S. Jensen, et al. (2002) Technical development of AERx® Diabetes Management System: Essential characteristics for diabetes treatment with pulmonary insulin. R.N. Dalby, P.R. Byron, J. Peart, S. Farr (Eds) Respiratory Drug Delivery VIII Raleigh, NC, USA: Davis Horwood International 51-60.
    • (2002) Respiratory Drug Delivery VIII , pp. 51-60
    • Farr, S.1    Reynolds, D.2    Nat, A.3    Srinivasan, S.4    Roach, M.5    Jensen, S.6
  • 64
    • 0034891605 scopus 로고    scopus 로고
    • Aerosolized protein delivery in asthma: Gamma camera analysis of regional deposition and perfusion
    • S. Sangwan, J.M. Agosti, L.A. Bauer, B.A. Otulana, R.J. Morishige, D.C. Cipolla, et al. (2001) Aerosolized protein delivery in asthma: Gamma camera analysis of regional deposition and perfusion. J. Aerosol Med. 14 185-195.
    • (2001) J. Aerosol Med. , vol.14 , pp. 185-195
    • Sangwan, S.1    Agosti, J.M.2    Bauer, L.A.3    Otulana, B.A.4    Morishige, R.J.5    Cipolla, D.C.6
  • 66
    • 0032768740 scopus 로고    scopus 로고
    • Protein conformational stability in the hydrofluoroalkane propellants tetrafluoroethane and heptafluoropropane analysed by Fourier transform Raman spectroscopy
    • É.Á. Quinn, R.T. Forbes, A.C. Williams, M.J. Oliver, L. McKenzie and T.S. Purewal (1999) Protein conformational stability in the hydrofluoroalkane propellants tetrafluoroethane and heptafluoropropane analysed by Fourier transform Raman spectroscopy. Int. J. Pharm. 186 31-41.
    • (1999) Int. J. Pharm. , vol.186 , pp. 31-41
    • Quinn, É.Á.1    Forbes, R.T.2    Williams, A.C.3    Oliver, M.J.4    McKenzie, L.5    Purewal, T.S.6
  • 67
    • 0031442496 scopus 로고    scopus 로고
    • Tetrafluoroethane (HFC 134A) propellant-driven aerosols of proteins
    • A.R. Brown and D.W. George (1997) Tetrafluoroethane (HFC 134A) propellant-driven aerosols of proteins. Pharm. Res. 14 1542-1547.
    • (1997) Pharm. Res. , vol.14 , pp. 1542-1547
    • Brown, A.R.1    George, D.W.2
  • 68
    • 0032935231 scopus 로고    scopus 로고
    • Formulation of a protein with propellant HFA 134a for aerosol delivery
    • R.O. Williams III and J. Liu (1998) Formulation of a protein with propellant HFA 134a for aerosol delivery. Eur. J. Pharm. Sci. 7 137-144.
    • (1998) Eur. J. Pharm. Sci. , vol.7 , pp. 137-144
    • Williams, R.O.1    Liu, J.2
  • 69
    • 33746897692 scopus 로고    scopus 로고
    • Inhaled insulin as adjunctive therapy in subjects with type 2 diabetes failing oral agents: A controlled proof-of-concept study
    • M. Hausmann, S. Dellweg, C. Osborn, L. Heinemann, A. Buchwald, R. Rosskamp, et al. (2006) Inhaled insulin as adjunctive therapy in subjects with type 2 diabetes failing oral agents: A controlled proof-of-concept study. Diabetes Obes. Metab. 8 574-580.
    • (2006) Diabetes Obes. Metab. , vol.8 , pp. 574-580
    • Hausmann, M.1    Dellweg, S.2    Osborn, C.3    Heinemann, L.4    Buchwald, A.5    Rosskamp, R.6
  • 72
    • 47049128164 scopus 로고    scopus 로고
    • Dry powder inhalers (DPIs) – A review of device reliability and innovation
    • N. Islam and E. Gladki (2008) Dry powder inhalers (DPIs) – A review of device reliability and innovation. Int. J. Pharm. 360 1-11.
    • (2008) Int. J. Pharm. , vol.360 , pp. 1-11
    • Islam, N.1    Gladki, E.2
  • 73
    • 0031596775 scopus 로고    scopus 로고
    • Solid state characterization of spray-dried powders of recombinant human deoxyribonuclease (rhDNase)
    • H.-K. Chan and I. Gonda (1998) Solid state characterization of spray-dried powders of recombinant human deoxyribonuclease (rhDNase). J. Pharm. Sci. 87 647-654.
    • (1998) J. Pharm. Sci. , vol.87 , pp. 647-654
    • Chan, H.-K.1    Gonda, I.2
  • 74
    • 0001848965 scopus 로고    scopus 로고
    • The balance between biochemical and physical stability for inhalation protein powders: rhDNase as an example
    • R.N. Dalby, P.R. Byron, S. Farr (Eds), Buffalo Grove, IL, USA: Interpharm Press
    • A.R. Clark, N. Dasovich, I. Gonda and H.-K. Chan (1996) The balance between biochemical and physical stability for inhalation protein powders: rhDNase as an example. R.N. Dalby, P.R. Byron, S. Farr (Eds) Resiratory Drug Delivery V Buffalo Grove, IL, USA: Interpharm Press 167-174.
    • (1996) Resiratory Drug Delivery V , pp. 167-174
    • Clark, A.R.1    Dasovich, N.2    Gonda, I.3    Chan, H.-K.4
  • 75
    • 0032962882 scopus 로고    scopus 로고
    • The effect of formulation excipients on protein stability and aerosol performance of spray-dried powders of a recombinant humanized anti-IgE monoclonal antibody
    • J.D. Andya, Y.-F. Maa, H.R. Constantino, P.-A. Nguyen, N. Dasovich, T.D. Sweeney, et al. (1999) The effect of formulation excipients on protein stability and aerosol performance of spray-dried powders of a recombinant humanized anti-IgE monoclonal antibody. Pharm. Res. 16 350-358.
    • (1999) Pharm. Res. , vol.16 , pp. 350-358
    • Andya, J.D.1    Maa, Y.-F.2    Constantino, H.R.3    Nguyen, P.-A.4    Dasovich, N.5    Sweeney, T.D.6
  • 78
    • 0028316923 scopus 로고
    • Long-term stabilization of biologicals
    • F. Frank (1994) Long-term stabilization of biologicals. Biotechnol. 12 253-256.
    • (1994) Biotechnol. , vol.12 , pp. 253-256
    • Frank, F.1
  • 79
    • 0027337054 scopus 로고
    • Decreased protein-stabilizing effects of cryoprotectants due to crystallization
    • K.-I. Izutsu, S. Yoshioka and T. Terao (1993) Decreased protein-stabilizing effects of cryoprotectants due to crystallization. Pharm. Res. 10 1232-1237.
    • (1993) Pharm. Res. , vol.10 , pp. 1232-1237
    • Izutsu, K.-I.1    Yoshioka, S.2    Terao, T.3
  • 80
    • 0025793265 scopus 로고
    • The effects of formulation variables on the stability of freeze-dried human growth hormone
    • M.J. Pikal, K.M. Dellerman, M.L. Roy and R.M. Riggin (1991) The effects of formulation variables on the stability of freeze-dried human growth hormone. Pharm. Res. 8 427-436.
    • (1991) Pharm. Res. , vol.8 , pp. 427-436
    • Pikal, M.J.1    Dellerman, K.M.2    Roy, M.L.3    Riggin, R.M.4
  • 81
    • 0032078387 scopus 로고    scopus 로고
    • Application of infrared spectroscopy to development of stable lyophilized protein formulations
    • J.F. Carpenter, S.J. Prestrelski and A. Dong (1998) Application of infrared spectroscopy to development of stable lyophilized protein formulations. Eur. J. Pharm. Biopharm. 45 231-238.
    • (1998) Eur. J. Pharm. Biopharm. , vol.45 , pp. 231-238
    • Carpenter, J.F.1    Prestrelski, S.J.2    Dong, A.3
  • 83
    • 0032425197 scopus 로고    scopus 로고
    • A solid-state NMR study of protein hydration and stability
    • F. Separovic, Y.H. Lam, X. Ke and H.-K. Chan (1998) A solid-state NMR study of protein hydration and stability. Pharm. Res. 15 1816-1821.
    • (1998) Pharm. Res. , vol.15 , pp. 1816-1821
    • Separovic, F.1    Lam, Y.H.2    Ke, X.3    Chan, H.-K.4
  • 84
    • 0032915277 scopus 로고    scopus 로고
    • Development of a mathematical model for the water distribution in freeze-dried solids
    • H.-K. Chan, K.-L. Au-Yeung and I. Gonda (1999) Development of a mathematical model for the water distribution in freeze-dried solids. Pharm. Res. 16 660-665.
    • (1999) Pharm. Res. , vol.16 , pp. 660-665
    • Chan, H.-K.1    Au-Yeung, K.-L.2    Gonda, I.3
  • 85
    • 84985233962 scopus 로고
    • Plasticizing effect of water on thermal behavior and crystallization of amorphous food models
    • Y. Roos and M. Karel (1991) Plasticizing effect of water on thermal behavior and crystallization of amorphous food models. J. Food Sci. 56 38-43.
    • (1991) J. Food Sci. , vol.56 , pp. 38-43
    • Roos, Y.1    Karel, M.2
  • 86
    • 0029015405 scopus 로고
    • Molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures
    • B.C. Hancock, S.L. Shamblin and G. Zografi (1995) Molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures. Pharm. Res. 12 799-806.
    • (1995) Pharm. Res. , vol.12 , pp. 799-806
    • Hancock, B.C.1    Shamblin, S.L.2    Zografi, G.3
  • 88
    • 0000658833 scopus 로고    scopus 로고
    • Effect of humidity on the dispersion of dry powers
    • R.N. Dalby, P.R. Byron, S. Farr, J. Peart (Eds), Raleigh, NC, USA: Serentec Press
    • N.Y.K. Chew and H.-K. Chan (2000) Effect of humidity on the dispersion of dry powers. R.N. Dalby, P.R. Byron, S. Farr, J. Peart (Eds) Respiratory Drug Delivery VII Raleigh, NC, USA: Serentec Press 615-618.
    • (2000) Respiratory Drug Delivery VII , pp. 615-618
    • Chew, N.Y.K.1    Chan, H.-K.2
  • 89
    • 0038498927 scopus 로고    scopus 로고
    • A novel formulation of dry powder for inhalation of peptides and proteins
    • R.N. Dalby, P.R. Byron, S. Farr (Eds), Buffalo Grove, IL, USA: Interpharm Press
    • C. Yamashita, T. Nishibayashi, S. Akashi, H. Toguchi and M. Odomi (1996) A novel formulation of dry powder for inhalation of peptides and proteins. R.N. Dalby, P.R. Byron, S. Farr (Eds) Respiratory Drug Delivery V Buffalo Grove, IL, USA: Interpharm Press 483-486.
    • (1996) Respiratory Drug Delivery V , pp. 483-486
    • Yamashita, C.1    Nishibayashi, T.2    Akashi, S.3    Toguchi, H.4    Odomi, M.5
  • 90
    • 0031008878 scopus 로고    scopus 로고
    • Spray dried powders and powder blends of recombinant human deoxyribonuclease (rhDNase) for aerosol delivery
    • H.-K. Chan, A. Clark, I. Gonda, M. Mumenthaler and C. Hsu (1997) Spray dried powders and powder blends of recombinant human deoxyribonuclease (rhDNase) for aerosol delivery. Pharm. Res. 14 431-437.
    • (1997) Pharm. Res. , vol.14 , pp. 431-437
    • Chan, H.-K.1    Clark, A.2    Gonda, I.3    Mumenthaler, M.4    Hsu, C.5
  • 92
  • 93
    • 0034001190 scopus 로고    scopus 로고
    • Novel lipid-based hollow-porous microparticles as a platform for immunoglobulin delivery to the respiratory tract
    • A.I. Bot, T.E. Tarara, D.J. Smith, S.R. Bot, C.M. Woods and J.G. Weers (2000) Novel lipid-based hollow-porous microparticles as a platform for immunoglobulin delivery to the respiratory tract. Pharm. Res. 17 275-283.
    • (2000) Pharm. Res. , vol.17 , pp. 275-283
    • Bot, A.I.1    Tarara, T.E.2    Smith, D.J.3    Bot, S.R.4    Woods, C.M.5    Weers, J.G.6
  • 94
    • 52449131110 scopus 로고    scopus 로고
    • The influence of drug morphology on the aerosolisation efficiency of dry powder inhaler formulations
    • H. Adi, D. Traini, H.-K. Chan and P.M. Young (2008) The influence of drug morphology on the aerosolisation efficiency of dry powder inhaler formulations. J. Pharm. Sci. 97 2780-2788.
    • (2008) J. Pharm. Sci. , vol.97 , pp. 2780-2788
    • Adi, H.1    Traini, D.2    Chan, H.-K.3    Young, P.M.4
  • 96
    • 0034750024 scopus 로고    scopus 로고
    • Use of solid corrugated particles to enhance powder aerosol performance
    • N.Y.K. Chew and H.K. Chan (2001) Use of solid corrugated particles to enhance powder aerosol performance. Pharm. Res. 18 1570-1577.
    • (2001) Pharm. Res. , vol.18 , pp. 1570-1577
    • Chew, N.Y.K.1    Chan, H.K.2
  • 97
    • 17644394959 scopus 로고    scopus 로고
    • How much particle surface corrugation is sufficient to improve aerosol performance of powders?
    • N.Y.K. Chew, P. Tang, H.K. Chan and J.A. Raper (2005) How much particle surface corrugation is sufficient to improve aerosol performance of powders? Pharm. Res. 22 148-152.
    • (2005) Pharm. Res. , vol.22 , pp. 148-152
    • Chew, N.Y.K.1    Tang, P.2    Chan, H.K.3    Raper, J.A.4
  • 98
    • 0027972452 scopus 로고
    • Feasibility study on spray-drying protein pharmaceuticals: Recombinant human growth hormone and tissue-type plasminogen activator
    • M. Mumenthaler, C.C. Hsu and R. Pearlman (1994) Feasibility study on spray-drying protein pharmaceuticals: Recombinant human growth hormone and tissue-type plasminogen activator. Pharm. Res. 11 12-20.
    • (1994) Pharm. Res. , vol.11 , pp. 12-20
    • Mumenthaler, M.1    Hsu, C.C.2    Pearlman, R.3
  • 99
    • 0031914743 scopus 로고    scopus 로고
    • Spray-drying of air–liquid interface sensitive recombinant human growth hormone
    • Y.-F. Maa, P.-A.T. Nguyen and S.W. Hsu (1998) Spray-drying of air–liquid interface sensitive recombinant human growth hormone. J. Pharm. Sci. 87 152-159.
    • (1998) J. Pharm. Sci. , vol.87 , pp. 152-159
    • Maa, Y.-F.1    Nguyen, P.-A.T.2    Hsu, S.W.3
  • 100
    • 0032734092 scopus 로고    scopus 로고
    • Formulation and physical characeterization of large porous particles for inhalation
    • R. Vanbever, J.D. Mintzes, J. Wang, J. Nice, D. Chen, R. Batycky, et al. (1999) Formulation and physical characeterization of large porous particles for inhalation. Pharm. Res. 16 1735-1742.
    • (1999) Pharm. Res. , vol.16 , pp. 1735-1742
    • Vanbever, R.1    Mintzes, J.D.2    Wang, J.3    Nice, J.4    Chen, D.5    Batycky, R.6
  • 102
    • 0034495097 scopus 로고    scopus 로고
    • Generation of micro-particles of proteins for aerosol delivery using high pressure modified carbon dioxide
    • R.T. Bustami, H.-K. Chan, F. Dehghani and N.R. Foster (2000) Generation of micro-particles of proteins for aerosol delivery using high pressure modified carbon dioxide. Pharm. Res. 17 1360-1366.
    • (2000) Pharm. Res. , vol.17 , pp. 1360-1366
    • Bustami, R.T.1    Chan, H.-K.2    Dehghani, F.3    Foster, N.R.4
  • 103
    • 2942638774 scopus 로고    scopus 로고
    • Aerosol delivery of protein powders processed by supercritical fluid technology
    • R.N. Dalby, P.R. Byron, S. Farr, J. Peart (Eds), Raleigh, NC, USA: Serentec Press
    • R.T. Bustami, H.-K. Chan and N.R. Foster (2000) Aerosol delivery of protein powders processed by supercritical fluid technology. R.N. Dalby, P.R. Byron, S. Farr, J. Peart (Eds) Respiratory Drug Delivery VII Raleigh, NC, USA: Serentec Press 611-614.
    • (2000) Respiratory Drug Delivery VII , pp. 611-614
    • Bustami, R.T.1    Chan, H.-K.2    Foster, N.R.3
  • 107
    • 38549145278 scopus 로고    scopus 로고
    • Evaluation on the use of the confined liquid impinging jets for the synthesis of nanodrug particles
    • H. Chiou, H.-K. Chan, R.K. Prud'homme and J.A. Raper (2008) Evaluation on the use of the confined liquid impinging jets for the synthesis of nanodrug particles. Drug Dev. Ind. Pharm. 34 59-64.
    • (2008) Drug Dev. Ind. Pharm. , vol.34 , pp. 59-64
    • Chiou, H.1    Chan, H.-K.2    Prud'homme, R.K.3    Raper, J.A.4
  • 108
    • 43649096146 scopus 로고    scopus 로고
    • A novel production method for inhalable cyclosporine A powders by confined liquid impinging jet precipitation
    • H. Chiou, H.-K. Chan, D. Heng, R.K. Prud'homme and J.A. Raper (2008) A novel production method for inhalable cyclosporine A powders by confined liquid impinging jet precipitation. J. Aerosol Sci. 39 500-509.
    • (2008) J. Aerosol Sci. , vol.39 , pp. 500-509
    • Chiou, H.1    Chan, H.-K.2    Heng, D.3    Prud'homme, R.K.4    Raper, J.A.5
  • 110
    • 0033814073 scopus 로고    scopus 로고
    • A self-complementary, self-assembling microsphere system: Application for intravenous delivery of the antiepileptic and neuroprotectant compound felbamate
    • H. Lian, S.S. Steiner, R.D. Sofia, J.H. Woodhead, H.H. Wolf, H.S. White, et al. (2000) A self-complementary, self-assembling microsphere system: Application for intravenous delivery of the antiepileptic and neuroprotectant compound felbamate. J. Pharm. Sci. 89 867-875.
    • (2000) J. Pharm. Sci. , vol.89 , pp. 867-875
    • Lian, H.1    Steiner, S.S.2    Sofia, R.D.3    Woodhead, J.H.4    Wolf, H.H.5    White, H.S.6
  • 111
    • 0346352236 scopus 로고    scopus 로고
    • Pulmonary delivery of novel insulin microspheres
    • R.N. Dalby, P.R. Byron, J. Peart, S. Farr (Eds), Raleigh, NC, USA: Davis Horwood International
    • L.R. Brown, J. Rashba-Step, T.L. Scott, Y. Qin, P.W. Rulon, J. McGeehan, et al. (2002) Pulmonary delivery of novel insulin microspheres. R.N. Dalby, P.R. Byron, J. Peart, S. Farr (Eds) Respiratory Drug Delivery VIII Raleigh, NC, USA: Davis Horwood International 431-434.
    • (2002) Respiratory Drug Delivery VIII , pp. 431-434
    • Brown, L.R.1    Rashba-Step, J.2    Scott, T.L.3    Qin, Y.4    Rulon, P.W.5    McGeehan, J.6
  • 112
    • 0031780284 scopus 로고    scopus 로고
    • Effect of spray drying and subsequent processing conditions on residual moisture content and physical/biochemical stability of protein inhalation powders
    • Y.-F. Maa, P.-A. Nguyen, J.D. Andya, N. Dasovich, T.D. Sweeney, S.J. Shire, et al. (1998) Effect of spray drying and subsequent processing conditions on residual moisture content and physical/biochemical stability of protein inhalation powders. Pharm. Res. 15 768-775.
    • (1998) Pharm. Res. , vol.15 , pp. 768-775
    • Maa, Y.-F.1    Nguyen, P.-A.2    Andya, J.D.3    Dasovich, N.4    Sweeney, T.D.5    Shire, S.J.6
  • 113
    • 85147064684 scopus 로고    scopus 로고
    • Guidance for industry: Metered Dose Inhaler (MDI) and Dry Powder Inhaler (DPI) Drug Products
    • Rockville, MD, USA,
    • Food and Drug Administration, Guidance for industry: Metered Dose Inhaler (MDI) and Dry Powder Inhaler (DPI) Drug Products. Chemistry, Manufacturing, and Controls Documentation, Food and Drug Administration, Rockville, MD, USA, 1998.
    • (1998) Chemistry, Manufacturing, and Controls Documentation, Food and Drug Administration


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