Influence of carrier on the performance of dry powder inhalers

International Journal of Pharmaceutics

Volumn 334, Issue 1-2, 2007, Pages 85-91

  Saint Lorant, G ^a   Leterme, P ^a   Gayot, A ^a   Flament, M P ^a  

^a UNIV LILLE   (France)

Author keywords

Adhesion; Aerodynamic behaviour; Carrier; Drug; Dry powder inhalers

Indexed keywords

DRUG CARRIER; FORMOTEROL FUMARATE; LACTOPRESS; LACTOSE; MALTISORB; MALTITOL; MANNITOL; PEARLITOL; TERBUTALINE SULFATE; UNCLASSIFIED DRUG;

ADHESION; ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRY POWDER; MOLECULAR INTERACTION; MOLECULAR STABILITY; PARTICLE SIZE; POWDER INHALER; PRIORITY JOURNAL; SPRAY DRYING; SURFACE PROPERTY; VIBRATION;

ADHESIVENESS; ADMINISTRATION, INHALATION; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG STABILITY; ETHANOLAMINES; EXCIPIENTS; LACTOSE; MALTOSE; MANNITOL; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE; POWDERS; SUGAR ALCOHOLS; TERBUTALINE; VIBRATION;

EID: 33947109116     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.10.028     Document Type: Article

References (19)

1. Aiache J.M. Les préparations pour inhalation. S. T. P. Pharma. 6 10 (1990) 753-761
2. Bell J. Dry powder inhalation technology. Pharm. Manuf. Int. (1994) 179-182
3. Bérard V., Lesniewska E., Andrès C., Pertuy D., Laroche C., and Pourcelot Y. Dry powder inhaler: influence of humidity on topology and adhesion studied by AFM. Int. J. Pharm. 232 (2002) 213-224
4. Ferron G.A. Aerosol properties and lung deposition. Eur. Respir. J. 7 (1994) 1392-1394
5. Flament M.P., Leterme P., and Gayot A. The influence of carrier roughness on adhesion, content uniformity and the in vitro deposition of terbutaline sulphate from dry powder inhalers. Int. J. Pharm. 275 (2004) 201-209
6. Ganderton D. The generation of respirable clouds from coarse powder aggregates. J. Biopharm. Sci. 3 (1992) 101-105
7. Hersey J.A. Ordered mixing: a new concept in powder mixing practice. Powder Technol. 11 (1975) 41-44
8. Kassem N.M. Generation of deeply inspirable dry powders (1990), University of London, UK
9. Louey M.D., Mulvaney P., and Stewart P. Characterisation of adhesional properties of lactose carriers using atomic force microscopy. J. Pharm. Biomed. Anal. 25 (2001) 559-567
10. Podczeck F., and Newton J.M. Development of an ultracentrifuge technique to determine the adhesion and friction properties between particles and surfaces. J. Pharm. Sci. 84 (1995) 1067-1071
11. Podczeck F. Optimization of the operation conditions of an Andersen-Cascade impactor and the relationship to centrifugal adhesion measurements to aid the development of dry powder inhalations. Int. J. Pharm. 149 (1997) 51-61
12. Podczeck F. Investigations into the reduction of powder adhesion to stainless steel surfaces by surface modification to aid capsule filling. Int. J. Pharm. 178 (1999) 93-100
13. Prime D., Atkins P.J., Slater A., and Sumby B. Review of dry powder inhalers. Adv. Drug. Deliv. Rev. 26 (1997) 51-58
14. Shimada Y., Sunada M., Mizuno M., Yonezawa Y., Sunada H., Yokosuka M., Kimura H., and Takebayashi H. Measurement of the adhesive force of fine particles on tablet surfaces and method of their removal. Drug Dev. Ind. Pharm. 26 (2000) 149-158
15. Steckel H., and Bolzen N. Alternative sugars as potential carriers for dry powder inhalations. Int. J. Pharm. 270 (2004) 297-306
16. Tee S.K., Marriott C., Zeng X.M., and Martin G.P. The use of different sugars as fine and coarse carriers for aerosolised salbutamol sulphate. Int. J. Pharm. 208 (2000) 111-123
17. Timsina M.P., Martin G.P., Marriott C., Ganderton D., and Yianneskis M. Drug delivery to the respiratory tract using dry powder inhalers. Int. J. Pharm. 101 (1994) 1-13
18. Zeng X.M., Martin G.P., Marriott C., and Pritchard J. The influence of carrier morphology on drug delivery by dry powder inhalers. Int. J. Pharm. 200 (2000) 93-106
19. Zeng X.M., Martin G.P., and Marriott C. Particulate Interactions in Dry Powder Formulations for Inhalation (2001), Taylor & Francis, London