-
1
-
-
0031589944
-
Ion channels-basic science and clinical disease
-
Ackerman MJ, Clapham DE (1997) Ion channels-basic science and clinical disease. N Engl J Med 336(22):1575-1586.
-
(1997)
N Engl J Med
, vol.336
, Issue.22
, pp. 1575-1586
-
-
Ackerman, M.J.1
Clapham, D.E.2
-
2
-
-
74749088503
-
Spending on new drug development1
-
Adams CP, Brantner VV (2010) Spending on new drug development1. Health Econ 19(2):130-141.
-
(2010)
Health Econ
, vol.19
, Issue.2
, pp. 130-141
-
-
Adams, C.P.1
Brantner, V.V.2
-
3
-
-
85028501780
-
-
National Biotech Conference, 2008
-
Anandakumar R, Harn NR, Sathish HA, LeachWL, Oliver CN, Bishop SM (2008) American Association of Pharmaceutical Scientist, National Biotech Conference, 2008.
-
(2008)
American Association of Pharmaceutical Scientist
-
-
Anandakumar, R.1
Harn, N.R.2
Sathish, H.A.3
Leach, W.L.4
Oliver, C.N.5
Bishop, S.M.6
-
4
-
-
0030926366
-
Targeted anti-cancer therapy using rituximab, a chimaeric anti-CD20 antibody (IDEC-C2B8) in the treatment of non-Hodgkin's B-cell lymphoma
-
Anderson DR, Grillo-Lopez A, Varns C, Chambers KS, Hanna N (1997) Targeted anti-cancer therapy using rituximab, a chimaeric anti-CD20 antibody (IDEC-C2B8) in the treatment of non-Hodgkin's B-cell lymphoma. Biochem Soc Trans 25(2):705-708.
-
(1997)
Biochem Soc Trans
, vol.25
, Issue.2
, pp. 705-708
-
-
Anderson, D.R.1
Grillo-Lopez, A.2
Varns, C.3
Chambers, K.S.4
Hanna, N.5
-
5
-
-
34848814457
-
A high-throughput method for detection of protein selfassociation and second virial coefficient using size-exclusion chromatography through simultaneous measurement of concentration and scattered light intensity
-
Bajaj H, Sharma VK, Kalonia DS (2007) A high-throughput method for detection of protein selfassociation and second virial coefficient using size-exclusion chromatography through simultaneous measurement of concentration and scattered light intensity. Pharm Res 24(11):2071-2083.
-
(2007)
Pharm Res
, vol.24
, Issue.11
, pp. 2071-2083
-
-
Bajaj, H.1
Sharma, V.K.2
Kalonia, D.S.3
-
6
-
-
0032100706
-
Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate
-
Batista FD, Neuberger MS (1998) Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate. Immunity 8(6):751-759.
-
(1998)
Immunity
, vol.8
, Issue.6
, pp. 751-759
-
-
Batista, F.D.1
Neuberger, M.S.2
-
7
-
-
67650812831
-
Response of a concentrated monoclonal antibody formulation to high shear
-
Bee JS, Stevenson JL, Mehta B, Svitel J, Pollastrini J, Platz R, Freund E, Carpenter JF, Randolph TW (2009) Response of a concentrated monoclonal antibody formulation to high shear. Biotechnol Bioeng 103(5):936-943.
-
(2009)
Biotechnol Bioeng
, vol.103
, Issue.5
, pp. 936-943
-
-
Bee, J.S.1
Stevenson, J.L.2
Mehta, B.3
Svitel, J.4
Pollastrini, J.5
Platz, R.6
Freund, E.7
Carpenter, J.F.8
Randolph, T.W.9
-
8
-
-
80052263787
-
The effects of shear flow on protein structure and function
-
Bekard IB, Asimakis P, Bertolini J, Dunstan DE (2011) The effects of shear flow on protein structure and function. Biopolymers 95(11):733-745.
-
(2011)
Biopolymers
, vol.95
, Issue.11
, pp. 733-745
-
-
Bekard, I.B.1
Asimakis, P.2
Bertolini, J.3
Dunstan, D.E.4
-
9
-
-
35348827271
-
Determining antibody stability: creation of solid-liquid interfacial effects within a high shear environment
-
Biddlecombe JG, Craig AV, Zhang H, Uddin S, Mulot S, Fish BC, Bracewell DG (2007) Determining antibody stability: creation of solid-liquid interfacial effects within a high shear environment. Biotechnol Prog 23(5):1218-1222.
-
(2007)
Biotechnol Prog
, vol.23
, Issue.5
, pp. 1218-1222
-
-
Biddlecombe, J.G.1
Craig, A.V.2
Zhang, H.3
Uddin, S.4
Mulot, S.5
Fish, B.C.6
Bracewell, D.G.7
-
10
-
-
0034718615
-
Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity
-
Boder ET, Midelfort KS, Wittrup KD (2000) Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity. Proc Natl Acad Sci USA 97(20):10701-10705.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, Issue.20
, pp. 10701-10705
-
-
Boder, E.T.1
Midelfort, K.S.2
Wittrup, K.D.3
-
11
-
-
79955666020
-
Introduction to current and future protein therapeutics: a protein engineering perspective
-
Carter PJ (2011) Introduction to current and future protein therapeutics: a protein engineering perspective. Exp Cell Res 317(9):1261-1269.
-
(2011)
Exp Cell Res
, vol.317
, Issue.9
, pp. 1261-1269
-
-
Carter, P.J.1
-
12
-
-
34248549336
-
Protein aggregation in silico
-
Cellmer T, Bratko D, Prausnitz JM, Blanch HW (2007) Protein aggregation in silico. Trends Biotechnol 25(6):254-261.
-
(2007)
Trends Biotechnol
, vol.25
, Issue.6
, pp. 254-261
-
-
Cellmer, T.1
Bratko, D.2
Prausnitz, J.M.3
Blanch, H.W.4
-
13
-
-
77951529848
-
Therapeutic antibodies for autoimmunity and inflammation
-
Chan AC, Carter PJ (2010) Therapeutic antibodies for autoimmunity and inflammation. Nat Rev Immunol 10(5):301-316.
-
(2010)
Nat Rev Immunol
, vol.10
, Issue.5
, pp. 301-316
-
-
Chan, A.C.1
Carter, P.J.2
-
14
-
-
70449112652
-
Long- and short-range electrostatic interactions affect the rheology of highly concentrated antibody solutions
-
Chari R, Jerath K, Badkar AV, Kalonia DS (2009) Long- and short-range electrostatic interactions affect the rheology of highly concentrated antibody solutions. Pharm Res 26(12):2607-2618.
-
(2009)
Pharm Res
, vol.26
, Issue.12
, pp. 2607-2618
-
-
Chari, R.1
Jerath, K.2
Badkar, A.V.3
Kalonia, D.S.4
-
15
-
-
67749111952
-
Design of therapeutic proteins with enhanced stability
-
Chennamsetty N, Voynov V, Kayser V, Helk B, Trout BL (2009a) Design of therapeutic proteins with enhanced stability. Proc Natl Acad Sci USA 106(29):11937-11942.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.29
, pp. 11937-11942
-
-
Chennamsetty, N.1
Voynov, V.2
Kayser, V.3
Helk, B.4
Trout, B.L.5
-
16
-
-
67650683480
-
Aggregation-prone motifs in human immunoglobulin G
-
Chennamsetty N, Helk B, Voynov V, Kayser V, Trout BL (2009b) Aggregation-prone motifs in human immunoglobulin G. J Mol Biol 391(2):404-413.
-
(2009)
J Mol Biol
, vol.391
, Issue.2
, pp. 404-413
-
-
Chennamsetty, N.1
Helk, B.2
Voynov, V.3
Kayser, V.4
Trout, B.L.5
-
17
-
-
0141567459
-
Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation
-
Chi EY, Krishnan S, Randolph TW, Carpenter JF (2003a) Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation. Pharm Res 20(9):1325-1336.
-
(2003)
Pharm Res
, vol.20
, Issue.9
, pp. 1325-1336
-
-
Chi, E.Y.1
Krishnan, S.2
Randolph, T.W.3
Carpenter, J.F.4
-
18
-
-
0242515822
-
Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony-stimulating factor
-
Chi EY, Krishnan S, Kendrick BS, Chang BS, Carpenter JF, Randolph TW (2003b) Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony-stimulating factor. Protein Sci 12(5):903-913.
-
(2003)
Protein Sci
, vol.12
, Issue.5
, pp. 903-913
-
-
Chi, E.Y.1
Krishnan, S.2
Kendrick, B.S.3
Chang, B.S.4
Carpenter, J.F.5
Randolph, T.W.6
-
19
-
-
33745823893
-
Modulation of the effector functions of a human IgG1 through engineering of its hinge region
-
Dall'Acqua WF, Cook KE, Damschroder MM, Woods RM, Wu H (2006a) Modulation of the effector functions of a human IgG1 through engineering of its hinge region. J Immunol 177(2):1129-1138.
-
(2006)
J Immunol
, vol.177
, Issue.2
, pp. 1129-1138
-
-
Dall'Acqua, W.F.1
Cook, K.E.2
Damschroder, M.M.3
Woods, R.M.4
Wu, H.5
-
20
-
-
33747631571
-
Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn)
-
Dall'Acqua WF, Kiener PA, Wu H (2006b) Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn). J Biol Chem 281(33):23514-23524.
-
(2006)
J Biol Chem
, vol.281
, Issue.33
, pp. 23514-23524
-
-
Dall'Acqua, W.F.1
Kiener, P.A.2
Wu, H.3
-
21
-
-
34548324706
-
The cost of biopharmaceutical R&D: is biotech different?
-
DiMasi JA, Grabowski HG (2007) The cost of biopharmaceutical R&D: is biotech different? Manag Decis Econ 28(4-5):469-479.
-
(2007)
Manag Decis Econ
, vol.28
, Issue.4-5
, pp. 469-479
-
-
DiMasi, J.A.1
Grabowski, H.G.2
-
22
-
-
39049173446
-
Thermodynamically stable aggregation-resistant antibody domains through directed evolution
-
Famm K, Hansen L, Christ D, Winter G (2008) Thermodynamically stable aggregation-resistant antibody domains through directed evolution. J Mol Biol 376(4):926-931.
-
(2008)
J Mol Biol
, vol.376
, Issue.4
, pp. 926-931
-
-
Famm, K.1
Hansen, L.2
Christ, D.3
Winter, G.4
-
23
-
-
80051668855
-
Whole-molecule antibody engineering: generation of a high-affinity anti-IL-6 antibody with extended pharmacokinetics
-
Finch DK, Sleeman MA, Moisan J, Ferraro F, Botterell S, Campbell J, Cochrane D, Cruwys S, England E, Lane S, Rendall E, Sinha M, Walker C, Rees G, Bowen MA, Schneider A, Liang M, Faggioni R, Fung M, Mallinder PR, Wilkinson T, Kolbeck R, Vaughan T, Lowe DC (2011) Whole-molecule antibody engineering: generation of a high-affinity anti-IL-6 antibody with extended pharmacokinetics. J Mol Biol 411(4):791-807.
-
(2011)
J Mol Biol
, vol.411
, Issue.4
, pp. 791-807
-
-
Finch, D.K.1
Sleeman, M.A.2
Moisan, J.3
Ferraro, F.4
Botterell, S.5
Campbell, J.6
Cochrane, D.7
Cruwys, S.8
England, E.9
Lane, S.10
Rendall, E.11
Sinha, M.12
Walker, C.13
Rees, G.14
Bowen, M.A.15
Schneider, A.16
Liang, M.17
Faggioni, R.18
Fung, M.19
Mallinder, P.R.20
Wilkinson, T.21
Kolbeck, R.22
Vaughan, T.23
Lowe, D.C.24
more..
-
24
-
-
0029653368
-
Kinetic and affinity limits on antibodies produced during immune responses
-
Foote J, Eisen HN (1995) Kinetic and affinity limits on antibodies produced during immune responses. Proc Natl Acad Sci USA 92(5):1254-1256.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, Issue.5
, pp. 1254-1256
-
-
Foote, J.1
Eisen, H.N.2
-
25
-
-
22544466953
-
Rational design of aggregationresistant bioactive peptides: reengineering human calcitonin
-
Fowler SB, Poon S, Muff R, Chiti F, Dobson CM, Zurdo J (2005) Rational design of aggregationresistant bioactive peptides: reengineering human calcitonin. Proc Natl Acad Sci USA 102(29):10105-10110.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, Issue.29
, pp. 10105-10110
-
-
Fowler, S.B.1
Poon, S.2
Muff, R.3
Chiti, F.4
Dobson, C.M.5
Zurdo, J.6
-
26
-
-
67649872364
-
Engineered protein scaffolds as next-generation antibody therapeutics
-
Gebauer M, Skerra A (2009) Engineered protein scaffolds as next-generation antibody therapeutics. Curr Opin Chem Biol 13(3):245-255.
-
(2009)
Curr Opin Chem Biol
, vol.13
, Issue.3
, pp. 245-255
-
-
Gebauer, M.1
Skerra, A.2
-
27
-
-
0001279457
-
Predicting protein crystallization from a dilute solution property
-
George A, Wilson WW (1994) Predicting protein crystallization from a dilute solution property. Acta Crystallogr D Biol Crystallogr 50(Pt 4):361-365.
-
(1994)
Acta Crystallogr D Biol Crystallogr
, vol.50
, pp. 361-365
-
-
George, A.1
Wilson, W.W.2
-
28
-
-
79951895571
-
Formulation development of therapeutic monoclonal antibodies using high-throughput fluorescence and static light scattering techniques:role of conformational and colloidal stability
-
Goldberg DS, Bishop SM, Shah AU, Sathish HA (2011) Formulation development of therapeutic monoclonal antibodies using high-throughput fluorescence and static light scattering techniques:role of conformational and colloidal stability. J Pharm Sci 100:1306-1315.
-
(2011)
J Pharm Sci
, vol.100
, pp. 1306-1315
-
-
Goldberg, D.S.1
Bishop, S.M.2
Shah, A.U.3
Sathish, H.A.4
-
30
-
-
77649185864
-
High-throughput dynamic light scattering method for measuring viscosity of concentrated protein solutions
-
He F, Becker GW, Litowski JR, Narhi LO, Brems DN, Razinkov VI (2010) High-throughput dynamic light scattering method for measuring viscosity of concentrated protein solutions. Anal Biochem 399(1):141-143.
-
(2010)
Anal Biochem
, vol.399
, Issue.1
, pp. 141-143
-
-
He, F.1
Becker, G.W.2
Litowski, J.R.3
Narhi, L.O.4
Brems, D.N.5
Razinkov, V.I.6
-
31
-
-
79955665534
-
Engineering the variable region of therapeutic IgG antibodies
-
Igawa T, Tsunoda H, Kuramochi T, Sampei Z, Ishii S, Hattori K (2011) Engineering the variable region of therapeutic IgG antibodies. MAbs 3(3):243-252.
-
(2011)
MAbs
, vol.3
, Issue.3
, pp. 243-252
-
-
Igawa, T.1
Tsunoda, H.2
Kuramochi, T.3
Sampei, Z.4
Ishii, S.5
Hattori, K.6
-
32
-
-
4444302074
-
Aggregation-resistant domain antibodies selected on phage by heat denaturation
-
Jespers L, Schon O, Famm K, Winter G (2004) Aggregation-resistant domain antibodies selected on phage by heat denaturation. Nat Biotechnol 22(9):1161-1165.
-
(2004)
Nat Biotechnol
, vol.22
, Issue.9
, pp. 1161-1165
-
-
Jespers, L.1
Schon, O.2
Famm, K.3
Winter, G.4
-
33
-
-
58549106756
-
High-throughput self-interaction chromatography:applications in protein formulation prediction
-
Johnson DH, Parupudi A, Wilson WW, DeLucas LJ (2009) High-throughput self-interaction chromatography:applications in protein formulation prediction. Pharm Res 26(2):296-305.
-
(2009)
Pharm Res
, vol.26
, Issue.2
, pp. 296-305
-
-
Johnson, D.H.1
Parupudi, A.2
Wilson, W.W.3
DeLucas, L.J.4
-
34
-
-
21844472999
-
Reduction of irreversible protein adsorption on solid surfaces by protein engineering for increased stability
-
Karlsson M, Ekeroth J, Elwing H, Carlsson U (2005) Reduction of irreversible protein adsorption on solid surfaces by protein engineering for increased stability. J Biol Chem 280(27):25558-25564.
-
(2005)
J Biol Chem
, vol.280
, Issue.27
, pp. 25558-25564
-
-
Karlsson, M.1
Ekeroth, J.2
Elwing, H.3
Carlsson, U.4
-
35
-
-
78651275679
-
Glycosylation influences on the aggregation propensity of therapeutic monoclonal antibodies
-
Kayser V, Chennamsetty N, Voynov V, Forrer K, Helk B, Trout BL (2011) Glycosylation influences on the aggregation propensity of therapeutic monoclonal antibodies. Biotechnol J 6(1):38-44.
-
(2011)
Biotechnol J
, vol.6
, Issue.1
, pp. 38-44
-
-
Kayser, V.1
Chennamsetty, N.2
Voynov, V.3
Forrer, K.4
Helk, B.5
Trout, B.L.6
-
36
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates?
-
Kola I, Landis J (2004) Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov 3(8):711-715.
-
(2004)
Nat Rev Drug Discov
, vol.3
, Issue.8
, pp. 711-715
-
-
Kola, I.1
Landis, J.2
-
37
-
-
0037474543
-
Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity
-
Krapp S, Mimura Y, Jefferis R, Huber R, Sondermann P (2003) Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity. J Mol Biol 325(5):979-989.
-
(2003)
J Mol Biol
, vol.325
, Issue.5
, pp. 979-989
-
-
Krapp, S.1
Mimura, Y.2
Jefferis, R.3
Huber, R.4
Sondermann, P.5
-
38
-
-
70149086034
-
Engineered therapeutic antibodies with improved effector functions
-
Kubota T, Niwa R, Satoh M, Akinaga S, Shitara K, Hanai N (2009) Engineered therapeutic antibodies with improved effector functions. Cancer Sci 100(9):1566-1572.
-
(2009)
Cancer Sci
, vol.100
, Issue.9
, pp. 1566-1572
-
-
Kubota, T.1
Niwa, R.2
Satoh, M.3
Akinaga, S.4
Shitara, K.5
Hanai, N.6
-
39
-
-
82255192512
-
Developability index: a rapid in silico tool for the screening of antibody aggregation propensity
-
Lauer TM, Agrawal NJ, Chennamsetty N, Egodage K, Helk B, Trout BL (2012) Developability index: a rapid in silico tool for the screening of antibody aggregation propensity. J Pharm Sci 101(1):102-115.
-
(2012)
J Pharm Sci
, vol.101
, Issue.1
, pp. 102-115
-
-
Lauer, T.M.1
Agrawal, N.J.2
Chennamsetty, N.3
Egodage, K.4
Helk, B.5
Trout, B.L.6
-
40
-
-
77951652786
-
A critical evaluation of self- interaction chromatography as a predictive tool for the assessment of protein-protein interactions in protein formulation development: a case study of a therapeutic monoclonal antibody
-
Le Brun V, Friess W, Bassarab S, Muhlau S, Garidel P (2010) A critical evaluation of self- interaction chromatography as a predictive tool for the assessment of protein-protein interactions in protein formulation development: a case study of a therapeutic monoclonal antibody. Eur J Pharm Biopharm 75(1):16-25.
-
(2010)
Eur J Pharm Biopharm
, vol.75
, Issue.1
, pp. 16-25
-
-
Le Brun, V.1
Friess, W.2
Bassarab, S.3
Muhlau, S.4
Garidel, P.5
-
41
-
-
27644477360
-
Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution
-
Liu J, Nguyen MD, Andya JD, Shire SJ (2005) Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution. J Pharm Sci 94(9):1928-1940.
-
(2005)
J Pharm Sci
, vol.94
, Issue.9
, pp. 1928-1940
-
-
Liu, J.1
Nguyen, M.D.2
Andya, J.D.3
Shire, S.J.4
-
42
-
-
12344250438
-
Structural genomics of GPCRs
-
Lundstrom K (2005) Structural genomics of GPCRs. Trends Biotechnol 23(2):103-108.
-
(2005)
Trends Biotechnol
, vol.23
, Issue.2
, pp. 103-108
-
-
Lundstrom, K.1
-
44
-
-
84856561419
-
Correlation of second virial coefficient with solubility for proteins in salt solutions
-
Mehta CM, White ET, Litster JD (2012) Correlation of second virial coefficient with solubility for proteins in salt solutions. Biotechnol Prog 28(1):163-170.
-
(2012)
Biotechnol Prog
, vol.28
, Issue.1
, pp. 163-170
-
-
Mehta, C.M.1
White, E.T.2
Litster, J.D.3
-
45
-
-
0035081693
-
The influence of glycosylation on the thermal stability and effector function expression of human IgG1-Fc: properties of a series of truncated glycoforms
-
Mimura Y, Church S, Ghirlando R, Ashton PR, Dong S, Goodall M, Lund J, Jefferis R (2000) The influence of glycosylation on the thermal stability and effector function expression of human IgG1-Fc: properties of a series of truncated glycoforms. Mol Immunol 37(12-13):697-706.
-
(2000)
Mol Immunol
, vol.37
, Issue.12-13
, pp. 697-706
-
-
Mimura, Y.1
Church, S.2
Ghirlando, R.3
Ashton, P.R.4
Dong, S.5
Goodall, M.6
Lund, J.7
Jefferis, R.8
-
46
-
-
25444487734
-
Influence of macromolecular crowding upon the stability and state of association of proteins: predictions and observations
-
Minton AP (2005) Influence of macromolecular crowding upon the stability and state of association of proteins: predictions and observations. J Pharm Sci 94(8):1668-1675.
-
(2005)
J Pharm Sci
, vol.94
, Issue.8
, pp. 1668-1675
-
-
Minton, A.P.1
-
47
-
-
77952561651
-
Extracellular ion channel inhibitor antibodies
-
Naylor J, Beech DJ (2009) Extracellular ion channel inhibitor antibodies. Open Drug Discov J 1:36-42.
-
(2009)
Open Drug Discov J
, vol.1
, pp. 36-42
-
-
Naylor, J.1
Beech, D.J.2
-
48
-
-
77957361348
-
Development trends for human monoclonal antibody therapeutics
-
Nelson AL, Dhimolea E, Reichert JM (2010) Development trends for human monoclonal antibody therapeutics. Nat Rev Drug Discov 9(10):767-774.
-
(2010)
Nat Rev Drug Discov
, vol.9
, Issue.10
, pp. 767-774
-
-
Nelson, A.L.1
Dhimolea, E.2
Reichert, J.M.3
-
49
-
-
0022781496
-
Adsorption of proteins from solution at the solid-liquid interface
-
Norde W (1986) Adsorption of proteins from solution at the solid-liquid interface. Adv Colloid Interface Sci 25(4):267-340.
-
(1986)
Adv Colloid Interface Sci
, vol.25
, Issue.4
, pp. 267-340
-
-
Norde, W.1
-
50
-
-
39149106011
-
Structural characterization of a mutated, ADCC-enhanced human Fc fragment
-
Oganesyan V, Damschroder MM, Leach W, Wu H, Dall'Acqua WF (2008) Structural characterization of a mutated, ADCC-enhanced human Fc fragment. Mol Immunol 45(7):1872-1882.
-
(2008)
Mol Immunol
, vol.45
, Issue.7
, pp. 1872-1882
-
-
Oganesyan, V.1
Damschroder, M.M.2
Leach, W.3
Wu, H.4
Dall'Acqua, W.F.5
-
51
-
-
33749470157
-
Second virial coefficient determination of a therapeutic peptide by selfinteraction chromatography
-
Payne RW, Nayar R, Tarantino R, Del Terzo S, Moschera J, Di J, Heilman D, Bray B, Manning MC, Henry CS (2006) Second virial coefficient determination of a therapeutic peptide by selfinteraction chromatography. Biopolymers 84(5):527-533.
-
(2006)
Biopolymers
, vol.84
, Issue.5
, pp. 527-533
-
-
Payne, R.W.1
Nayar, R.2
Tarantino, R.S.D.T.3
Moschera, J.4
Di, J.5
Heilman, D.6
Bray, B.7
Manning, M.C.8
Henry, C.S.9
-
52
-
-
77951566536
-
Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis
-
Pepinsky RB, Silvian L, Berkowitz SA, Farrington G, Lugovskoy A, Walus L, Eldredge J, Capili A, Mi S, Graff C, Garber E (2010) Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis. Protein Sci 19(5):954-966.
-
(2010)
Protein Sci
, vol.19
, Issue.5
, pp. 954-966
-
-
Pepinsky, R.B.1
Silvian, L.2
Berkowitz, S.A.3
Farrington, G.4
Lugovskoy, A.5
Walus, L.6
Eldredge, J.7
Capili, A.8
Mi, S.9
Graff, C.10
Garber, E.11
-
53
-
-
80053303946
-
HuCAL PLATINUM, a synthetic Fab library optimized for sequence diversity and superior performance in mammalian expression systems
-
Prassler J, Thiel S, Pracht C, Polzer A, Peters S, Bauer M, Norenberg S, Stark Y, Kolln J, Popp A, Urlinger S, Enzelberger M (2011) HuCAL PLATINUM, a synthetic Fab library optimized for sequence diversity and superior performance in mammalian expression systems. J Mol Biol 413(1):261-278.
-
(2011)
J Mol Biol
, vol.413
, Issue.1
, pp. 261-278
-
-
Prassler, J.1
Thiel, S.2
Pracht, C.3
Polzer, A.4
Peters, S.5
Bauer, M.6
Norenberg, S.7
Stark, Y.8
Kolln, J.9
Popp, A.10
Urlinger, S.11
Enzelberger, M.12
-
54
-
-
48549105161
-
Molecular engineering and design of therapeutic antibodies
-
Presta LG (2008) Molecular engineering and design of therapeutic antibodies. Curr Opin Immunol 20(4):460-470.
-
(2008)
Curr Opin Immunol
, vol.20
, Issue.4
, pp. 460-470
-
-
Presta, L.G.1
-
55
-
-
14444277713
-
Interleukin-1 receptor (IL-1R) liquid formulation development using differential scanning calorimetry
-
Remmele RL Jr, Nightlinger NS, Srinivasan S, Gombotz WR (1998) Interleukin-1 receptor (IL-1R) liquid formulation development using differential scanning calorimetry. Pharm Res 15(2):200-208.
-
(1998)
Pharm Res
, vol.15
, Issue.2
, pp. 200-208
-
-
Remmele, R.L.1
Nightlinger, N.S.2
Srinivasan, S.3
Gombotz, W.R.4
-
56
-
-
73949139940
-
Understanding and modulating opalescence and viscosity in a monoclonal antibody formulation
-
Salinas BA, Sathish HA, Bishop SM, Harn N, Carpenter JF, Randolph TW (2010) Understanding and modulating opalescence and viscosity in a monoclonal antibody formulation. J Pharm Sci 99(1):82-93.
-
(2010)
J Pharm Sci
, vol.99
, Issue.1
, pp. 82-93
-
-
Salinas, B.A.1
Sathish, H.A.2
Bishop, S.M.3
Harn, N.4
Carpenter, J.F.5
Randolph, T.W.6
-
57
-
-
44449108578
-
Nature and consequences of protein-protein interactions in high protein concentration solutions
-
Saluja A, Kalonia DS (2008) Nature and consequences of protein-protein interactions in high protein concentration solutions. Int J Pharm 358(1-2):1-15.
-
(2008)
Int J Pharm
, vol.358
, Issue.1-2
, pp. 1-15
-
-
Saluja, A.1
Kalonia, D.S.2
-
58
-
-
77957843464
-
Intermolecular interactions of IgG1 monoclonal antibodies at high concentrations characterized by light scattering
-
Scherer TM, Liu J, Shire SJ, Minton AP (2010) Intermolecular interactions of IgG1 monoclonal antibodies at high concentrations characterized by light scattering. J Phys Chem B 114(40):12948-12957.
-
(2010)
J Phys Chem B
, vol.114
, Issue.40
, pp. 12948-12957
-
-
Scherer, T.M.1
Liu, J.2
Shire, S.J.3
Minton, A.P.4
-
59
-
-
21244462685
-
Protein structural perturbation and aggregation on homogeneous surfaces
-
Sethuraman A, Belfort G (2005) Protein structural perturbation and aggregation on homogeneous surfaces. Biophys J 88(2):1322-1333.
-
(2005)
Biophys J
, vol.88
, Issue.2
, pp. 1322-1333
-
-
Sethuraman, A.1
Belfort, G.2
-
60
-
-
67749109890
-
Effect of protein structure on deamidation rate in the Fc fragment of an IgG1 monoclonal antibody
-
Sinha S, Zhang L, Duan S, Williams TD, Vlasak J, Ionescu R, Topp EM (2009) Effect of protein structure on deamidation rate in the Fc fragment of an IgG1 monoclonal antibody. Protein Sci 18(8):1573-1584.
-
(2009)
Protein Sci
, vol.18
, Issue.8
, pp. 1573-1584
-
-
Sinha, S.1
Zhang, L.2
Duan, S.3
Williams, T.D.4
Vlasak, J.5
Ionescu, R.6
Topp, E.M.7
-
61
-
-
80052305702
-
A variant human IgG1-Fc mediates improved ADCC
-
Stewart R, Thom G, Levens M, Guler-Gane G, Holgate R, Rudd PM, Webster C, Jermutus L, Lund J (2011) A variant human IgG1-Fc mediates improved ADCC. Protein Eng Des Sel 24(9):671-678.
-
(2011)
Protein Eng Des Sel
, vol.24
, Issue.9
, pp. 671-678
-
-
Stewart, R.1
Thom, G.2
Levens, M.3
Guler-Gane, G.4
Holgate, R.5
Rudd, P.M.6
Webster, C.7
Jermutus, L.8
Lund, J.9
-
62
-
-
80053382151
-
Highthroughput analysis of concentration-dependent antibody self-association
-
Sule SV, Sukumar M, Weiss WF, Marcelino-Cruz AM, Sample T, Tessier PM (2011) Highthroughput analysis of concentration-dependent antibody self-association. Biophys J 101(7):1749-1757.
-
(2011)
Biophys J
, vol.101
, Issue.7
, pp. 1749-1757
-
-
Sule, S.V.1
Sukumar, M.2
Weiss, W.F.3
Marcelino-Cruz, A.M.4
Sample, T.5
Tessier, P.M.6
-
63
-
-
80053564368
-
Interparticle interactions in concentrated suspensions and their bulk (rheological) properties
-
Tadros T (2011) Interparticle interactions in concentrated suspensions and their bulk (rheological) properties. Adv Colloid Interface Sci 168(1-2):263-277.
-
(2011)
Adv Colloid Interface Sci
, vol.168
, Issue.1-2
, pp. 263-277
-
-
Tadros, T.1
-
64
-
-
41449114608
-
Self-interaction nanoparticle spectroscopy: a nanoparticle-based protein interaction assay
-
Tessier PM, Jinkoji J, Cheng YC, Prentice JL, Lenhoff AM (2008) Self-interaction nanoparticle spectroscopy: a nanoparticle-based protein interaction assay. J Am Chem Soc 130(10):3106-3112.
-
(2008)
J Am Chem Soc
, vol.130
, Issue.10
, pp. 3106-3112
-
-
Tessier, P.M.1
Jinkoji, J.2
Cheng, Y.C.3
Prentice, J.L.4
Lenhoff, A.M.5
-
65
-
-
79951768234
-
Effects of shear on proteins in solution
-
Thomas CR, Geer D (2011) Effects of shear on proteins in solution. Biotechnol Lett 33(3):443-456.
-
(2011)
Biotechnol Lett
, vol.33
, Issue.3
, pp. 443-456
-
-
Thomas, C.R.1
Geer, D.2
-
66
-
-
31344474356
-
Colloidal behavior of proteins:effects of the second virial coefficient on solubility, crystallization and aggregation of proteins in aqueous solution
-
Valente JJ, Payne RW, Manning MC, Wilson WW, Henry CS (2005) Colloidal behavior of proteins:effects of the second virial coefficient on solubility, crystallization and aggregation of proteins in aqueous solution. Curr Pharm Biotechnol 6(6):427-436.
-
(2005)
Curr Pharm Biotechnol
, vol.6
, Issue.6
, pp. 427-436
-
-
Valente, J.J.1
Payne, R.W.2
Manning, M.C.3
Wilson, W.W.4
Henry, C.S.5
-
67
-
-
79955656236
-
Fragmentation of monoclonal antibodies
-
Vlasak J, Ionescu R (2011) Fragmentation of monoclonal antibodies. MAbs 3(3):253-263.
-
(2011)
MAbs
, vol.3
, Issue.3
, pp. 253-263
-
-
Vlasak, J.1
Ionescu, R.2
-
68
-
-
4644335636
-
Reduced protein adsorption at solid interfaces by sugar excipients
-
Wendorf JR, Radke CJ, Blanch HW (2004) Reduced protein adsorption at solid interfaces by sugar excipients. Biotechnol Bioeng 87(5):565-573.
-
(2004)
Biotechnol Bioeng
, vol.87
, Issue.5
, pp. 565-573
-
-
Wendorf, J.R.1
Radke, C.J.2
Blanch, H.W.3
-
69
-
-
0642373290
-
Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma
-
Weng WK, Levy R (2003) Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma. J Clin Oncol 21(21):3940-3947.
-
(2003)
J Clin Oncol
, vol.21
, Issue.21
, pp. 3940-3947
-
-
Weng, W.K.1
Levy, R.2
-
70
-
-
79952453101
-
Use of dynamic light scattering to determine second virial coefficient in a semidilute concentration regime
-
Yadav S, Scherer TM, Shire SJ, Kalonia DS (2011) Use of dynamic light scattering to determine second virial coefficient in a semidilute concentration regime. Anal Biochem 411(2):292-296.
-
(2011)
Anal Biochem
, vol.411
, Issue.2
, pp. 292-296
-
-
Yadav, S.1
Scherer, T.M.2
Shire, S.J.3
Kalonia, D.S.4
-
71
-
-
84855891967
-
Viscosity behavior of high-concentration monoclonal antibody solutions: correlation with interaction parameter and electroviscous effects
-
Yadav S, Shire SJ, Kalonia DS (2012) Viscosity behavior of high-concentration monoclonal antibody solutions: correlation with interaction parameter and electroviscous effects. J Pharm Sci 101(3):998-1011.
-
(2012)
J Pharm Sci
, vol.101
, Issue.3
, pp. 998-1011
-
-
Yadav, S.1
Shire, S.J.2
Kalonia, D.S.3
|