A variant human IgG1-Fc mediates improved ADCC

Protein Engineering, Design and Selection

Volumn 24, Issue 9, 2011, Pages 671-678

  Stewart, Ross ^a   Thom, George ^a   Levens, Michaela ^a   Güler Gane, Gülin ^a   Holgate, Robert ^a,c   Rudd, Pauline M ^b   Webster, Carl ^a   Jermutus, Lutz ^a   Lund, John ^a  

^a MEDIMMUNE   (United States)

^b NATIONAL INSTITUTE FOR BIOPROCESSING RESEARCH AND TRAINING   (Ireland)

^c Antitope Ltd   (United Kingdom)

Author keywords

ADCC; Fc receptors; fucosylation; IgG; ribosome display

Indexed keywords

ADCC; ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITIES; ERROR PRONES; FC REGION; FUCOSYLATION; GLYCOSYLATED; HUMAN IMMUNOGLOBULIN; IGG; N-ACETYLGLUCOSAMINE; NATURAL KILLER CELLS; RIBOSOME DISPLAY; WILD TYPES;

CARBOHYDRATES; MACROMOLECULES; OLIGOSACCHARIDES; POLYMERASE CHAIN REACTION;

ANTIBODIES;

ALANINE; FC RECEPTOR; FC RECEPTOR IIIA; FUCOSE; HISTIDINE; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G1 ANTIBODY; LEUCINE; N ACETYLGLUCOSAMINE; OLIGOSACCHARIDE; PHENYLALANINE; PROLINE; RECEPTOR SUBTYPE; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; CELL STRAIN HEK293; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GLYCOSYLATION; HUMAN; HUMAN CELL; MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN VARIANT; RADIOIMMUNOASSAY; RIBOSOME; RIBOSOME DISPLAY; SCREENING; WILD TYPE;

ANTIBODY-DEPENDENT CELL CYTOTOXICITY; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONING, MOLECULAR; FUCOSE; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; MUTATION; OLIGOSACCHARIDES; PROTEIN BINDING; PROTEIN ENGINEERING; RECEPTORS, IGG; RIBOSOMES;

EID: 80052305702     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzr015     Document Type: Article

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