Formulation development of therapeutic monoclonal antibodies using high-throughput fluorescence and static light scattering techniques: Role of conformational and colloidal stability

Journal of Pharmaceutical Sciences

Volumn 100, Issue 4, 2011, Pages 1306-1315

  Goldberg, Deborah S ^a,b   Bishop, Steven M ^a   Shah, Ambarish U ^a   Sathish, Hasige A ^a  

^a MEDIMMUNE   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

Author keywords

Calorimetry (DSC); Colloidal stability; Conformational stability; Fluorescence spectroscopy; Formulation; High throughput screening stability; Light scattering; Monoclonal antibody; Protein aggregation

Indexed keywords

FLUORESCENT DYE; MONOCLONAL ANTIBODY; PROTEIN AGGREGATE;

ARTICLE; COLLOID; CONFORMATION; COST EFFECTIVENESS ANALYSIS; DENATURATION; DIFFERENTIAL SCANNING FLUORESCENCE; DIFFERENTIAL STATIC LIGHT SCATTERING; FLUORESCENCE; HEAT; HIGH THROUGHPUT SCREENING; LABORATORY; LIGHT SCATTERING; MELTING POINT; PROTEIN AGGREGATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN STABILITY; STRESS; TEMPERATURE; CHEMISTRY; LIGHT; MEDICINAL CHEMISTRY; PROTEIN CONFORMATION; RADIATION SCATTERING; SPECTROFLUOROMETRY;

ANTIBODIES, MONOCLONAL; CHEMISTRY, PHARMACEUTICAL; HIGH-THROUGHPUT SCREENING ASSAYS; LIGHT; PROTEIN AGGREGATES; PROTEIN CONFORMATION; PROTEIN STABILITY; SCATTERING, RADIATION; SPECTROMETRY, FLUORESCENCE;

EID: 79951895571     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22371     Document Type: Article

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