Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity

Journal of Molecular Biology

Volumn 325, Issue 5, 2003, Pages 979-989

  Krapp, S ^a   Mimura, Y ^b,c   Jefferis, R ^b   Huber, R ^a   Sondermann, P ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Antibody; Crystal structure; Effector functions; Fc fragment; Glycosylation

Indexed keywords

FC RECEPTOR; IMMUNOGLOBULIN; IMMUNOGLOBULIN FC FRAGMENT; MANNOSE; N ACETYLGLUCOSAMINE; OLIGOSACCHARIDE; POLYPEPTIDE;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOHYDRATE ANALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN STRUCTURE;

EID: 0037474543     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)01250-0     Document Type: Article

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