Effect of simvastatin and naringenin coadministration on rat liver DNA fragmentation and cytochrome P450 activity: An in vivo and in vitro study

Journal of Physiology and Biochemistry

Volumn 70, Issue 1, 2014, Pages 225-237

  Motawi, T K ^a   Teleb, Z A ^b   El Boghdady, N A ^a   Ibrahim, S A ^b  

^a CAIRO UNIVERSITY   (Egypt)

^b NATIONAL ORGANIZATION FOR DRUG CONTROL AND RESEARCH NODCAR   (Egypt)

Author keywords

CYP2E1; CYP3A1 2; DNA fragmentation; Oxidative stress markers

Indexed keywords

ALBUMIN; CATALASE; CYTOCHROME P450; CYTOCHROME P450 2E1; CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; DNA; GLUTATHIONE; GLUTATHIONE TRANSFERASE; LACTATE DEHYDROGENASE; NARINGENIN; PROTEIN; SIMVASTATIN; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA FRAGMENTATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; LIPID PEROXIDATION; LIVER FUNCTION; LIVER LEVEL; LIVER MICROSOME; LIVER PROTECTION; NONHUMAN; OXIDATIVE STRESS; RAT; TOXIC HEPATITIS;

ALANINE TRANSAMINASE; ANIMALS; ANTICHOLESTEREMIC AGENTS; ANTIOXIDANTS; ASPARTATE AMINOTRANSFERASES; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 CYP3A; DNA FRAGMENTATION; DRUG EVALUATION, PRECLINICAL; DRUG INTERACTIONS; DRUG-INDUCED LIVER INJURY; FEMALE; FLAVANONES; GLUTATHIONE; LIVER; MALONDIALDEHYDE; MICROSOMES, LIVER; RATS; RATS, WISTAR; SIMVASTATIN; SUPEROXIDE DISMUTASE;

EID: 84896352743     PISSN: 11387548     EISSN: 18778755     Source Type: Journal    
DOI: 10.1007/s13105-013-0296-x     Document Type: Article

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