Enantiomers of naringenin as pleiotropic, stereoselective inhibitors of cytochrome P450 isoforms

Chirality

Volumn 23, Issue 10, 2011, Pages 891-896

  Lu, Wenjie Jessie ^a   Ferlito, Valentina ^b   Xu, Cong ^a   Flockhart, David Alastair ^a   Caccamese, Salvatore ^b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CATANIA   (Italy)

Author keywords

CYP19; CYP2C19; CYP2C9; CYP3A; drug metabolism; enantioselectivity; flavonoid; food drug interaction

Indexed keywords

AROMATASE; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 INHIBITOR; ISOENZYME; NARINGENIN; RECOMBINANT ENZYME; CYTOCHROME P450; FLAVANONE DERIVATIVE;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENANTIOMER; ENANTIOSELECTIVITY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; LIVER MICROSOME; PLEIOTROPY; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; ENZYME SPECIFICITY; METABOLISM; STEREOISOMERISM;

CYTOCHROME P-450 ENZYME INHIBITORS; CYTOCHROME P-450 ENZYME SYSTEM; FLAVANONES; HUMANS; ISOENZYMES; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 80053928122     PISSN: 08990042     EISSN: 1520636X     Source Type: Journal    
DOI: 10.1002/chir.21005     Document Type: Article

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