Sex difference in inhibition of in vitro mexazolam metabolism by various 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors in rat liver microsomes

Drug Metabolism and Disposition

Volumn 30, Issue 8, 2002, Pages 904-910

  Ishigami, Michi ^a,b,c   Takasaki, Wataru ^a,b,c   Ikeda, Toshihiko ^a,b,c   Komai, Toru ^a,b,c   Ito, Kiyomi ^a,b,c   Sugiyama, Yuichi ^a,b,c  

^a DAIICHI SANKYO CO   (Japan)

^b KITASATO UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; CERIVASTATIN; CYTOCHROME P450 3A4; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ITRACONAZOLE; MEXAZOLAM; PRAVASTATIN; SIMVASTATIN;

ANIMAL TISSUE; ARTICLE; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; DRUG INHIBITION; DRUG METABOLISM; DRUG POTENCY; ENZYME METABOLISM; FEMALE; IN VITRO STUDY; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEX DIFFERENCE;

ANIMALS; ANTI-ANXIETY AGENTS; BENZODIAZEPINES; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; DRUG INTERACTIONS; FEMALE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; ITRACONAZOLE; KINETICS; MALE; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; SEX FACTORS;

ANIMALIA;

EID: 0036329182     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.30.8.904     Document Type: Article

References (10)

1. Regulation of two members of the steroid-inducible cytochrome P450 subfamily (3A) in rats
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4. A comparison of the effects of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors on the CYP3A4-dependent oxidation of mexazolam in vitro
5. Drug interaction between simvastatin and itraconazole in male and female rats
6. Sex difference of cytochrome P-450 in the rat: Purification, characterization and quantification of constitutive forms of cytochrome P-450 from liver microsomes of male and female rats
7. Cytochrome P-450 as a determinant of sex difference of drug metabolism in the rat
8. P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature
9. Mexazolam metabolism by cDNA-expressed human cytochrome P450 isoforms using a recombinant vaccinia virus
10. Quantitative prediction of metabolic inhibition of midazolam by itraconazole and ketoconazole in rats: Implication of concentrative uptake of inhibitors into liver