Selective suppression of cytochrome P450 gene expression by the medicinal herb, Thonningia sanguinea in rat liver

Life Sciences

Volumn 74, Issue 14, 2004, Pages 1723-1737

  Gyamfi, Maxwell Afari ^a,b   Tanaka, Tatsuo ^a   Aniya, Yoko ^a  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Antioxidant; Cytochrome P450; Gene expression; Inhibition; Medicinal herb; T. sanguinea; Time course

Indexed keywords

4 NITROPHENOL HYDROXYLASE; 7 METHOXYRESORUFIN O DEMETHYLASE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 3A2; ENZYME; ERYTHROMYCIN N DEMETHYLASE; GLUTATHIONE TRANSFERASE; OXYGENASE; PLANT EXTRACT; THONNINGIA SANGUINEA EXTRACT; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME METABOLISM; GENE EXPRESSION; HERB; LIVER; MALE; MEDICINAL PLANT; NONHUMAN; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

THONNINGIA; THONNINGIA SANGUINEA;

EID: 1642523775     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2003.07.049     Document Type: Article

References (45)

1. Bailey D.G., Arnold J.M., Bend J.R., Tran L.T., Spence J.D. Grapefruit juice-felodipine interaction: reproducibility and characterization with the extended release drug formulation. British Journal of Clinical Pharmacology. 40:1995;135-140.
2. Beigneux A.P., Moser A.H., Shigenaga J.K., Grunfeld C., Feingold K.R. Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response. Biochemical and Biophysical Research Communications. 293:2002;145-149.
3. Brady J.F., Ishizaki H., Fukuto J.M., Lin M.C., Fadel A., Gapac J.M., Yang C.S. Inhibition of cytochrome P-450 2E1 by diallyl sulfide and its metabolites. Chemical Research in Toxicology. 4:1991;642-647.
4. Casper R.F., Quesne M., Rogers I.M., Shirota T., Jolivet A., Milgrom E., Savoret J.F. Resveratrol has antagonist activity on the aryl hydrocarbon receptor: implications for prevention of dioxin toxicity. Molecular Pharmacology. 56:1999;784-790.
5. Chun Y.J., Kim M.Y., Guengerich F.P. Resveratrol is a selective human cytochrome P450 1A1 inhibitor. Biochemical and Biophysical Research Communications. 262:1999;20-24.
6. Chung K.T., Wong T.Y., Wei C.I., Huang Y.W., Lin Y. Tannins and human health: a review. Critical Reviews in Food Science and Nutrition. 38:1998;421-464.
7. Ciolino H.P., Daschner P.J., Yeh G.C. Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially. The Biochemical Journal. 340:1999;715-722.
8. Goodwin B., Redinbo M.R., Kliewer S.A. Regulation of cyp3a gene transcription by the pregnane x receptor. Annual Review of Pharmacology and Toxicology. 42:2002;1-23.
9. Goosen T.C., Mills D.E., Hollenberg P.F. Effects of benzyl isothiocyanate on rat and human cytochromes P450: identification of metabolites formed by P450 2B1. Journal of Pharmacology and Experimental Therapeutics. 296:2001;198-206.
10. Guengerich F.P., Shimada T. Activation of procarcinogens by human cytochrome P450 enzymes. Mutation Research. 400:1998;201-213.
11. Gyamfi M.A., Aniya Y. Medicinal herb, Thonningia Sanguinea protects against aflatoxin B1 acute hepatotoxicity in Fischer 344 rats. Human and Experimental Toxicology. 17:1998;418-423.
12. Gyamfi M.A., Yonamine M., Aniya Y. Free radical scavenging action of medicinal herbs from Ghana. Thonningia sanguinea on experimentally induced liver injuries. General Pharmacology. 32:1999;661-667.
13. Gyamfi M.A., Hokama N., Oppong-Boachie K., Aniya Y. Inhibitory effects of the medicinal herb, Thonningia sanguinea, on liver drug metabolizing enzymes of rats. Human and Experimental Toxicology. 19:2000;623-631.
14. Gyamfi M.A., Aniya Y. Antioxidant properties of Thonningianin A, isolated from the African medicinal herb, Thonningia sanguinea. Biochemical Pharmacology. 63:2002;1725-1737.
15. Habig W.H., Pabst M.J., Jakoby W.B. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. Journal of Biological Chemistry. 249:1974;7130-7139.
16. Hayes J.D., Pulford D.J. The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Critical Reviews in Biochemistry and Molecular Biology. 30:1995;445-600.
17. Hesse I.F. Knowledge of asthma and its management in newly qualified doctors in Accra, Ghana. Respiratory Medicine. 89:1995;35-39.
18. Hodek P., Trefil P., Stiborova M. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chemico-Biological Interactions. 139:2002;1-21.
19. Kliewer S.A., Moore J.T., Wade L., Staudinger J.L., Watson M.A., Jones S.A., McKee D.D., Oliver B.B., Willson T.M., Zetterstrom R.H., Perlmann T., Lehmann J.M. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell. 92:1998;73-82.
20. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227(259):1970;680-685.
21. Lamb D.C., Kelly D.E., Manning N.J., Kaderbhai M.A., Kelly S.L. Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction. FEBS Letters. 462:1999;283-288.
22. Langouet S., Furge L.L., Kerriguy N., Nakamura K., Guillouzo A., Guengerich F.P. Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane. Chemical Research in Toxicology. 4:2000;245-252.
23. Lee I.J., Jeong K.S., Roberts B.J., Kallarakal A.T., Fernandez-Salguero P., Gonzalez F.J., Song B.J. Transcriptional induction of the cytochrome P4501A1 gene by a thiazolium compound, YH439. Molecular Pharmacology. 49:1996;980-988.
24. Long W.P., Pray-Grant M., Tsai J.C., Perdew G.H. Protein kinase C activity is required for aryl hydrocarbon receptor pathway-mediated signal transduction. Molecular Pharmacology. 53:1998;691-700.
25. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with Folin phenol reagent. Journal of Biological Chemistry. 193:1951;265-275.
26. Lu Y.F., Santostefano M., Cunningham B.D., Threadgill M.D., Safe S. Substituted flavones as aryl hydrocarbon (Ah) receptor agonists and antagonists. Biochemical Pharmacology. 51:1996;1077-1087.
27. Miwa G.T., West S.B., Lu A.Y. Studies on the rate-limiting enzyme component in the microsomal monooxygenase system. Incorporation of purified NADPH-cytochrome c reductase and cytochrome P-450 into rat liver microsomes. Journal of Biological Chemistry. 253:1978;1921-1929.
28. Moore L.B., Goodwin B., Jones S.A., Wisely G.B., Serabjit-Singh C.J., Willson T.M., Collins J.L., Kliewer S.A. St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. Proceedings of the National Academy of Sciences of the United States of America. 97:2000;7500-7502.
29. Morgan E.T., Thomas K.B., Swanson R., Vales T., Hwang J., Wright K. Selective suppression of cytochrome P-450 gene expression by interleukins 1 and 6 in rat liver. Biochimica et Biophysica Acta. 1219:1994;475-483.
30. Nyarko A.K., Addy M.E. In vitro screening for the anti-anaphylactic agent in Thonningia sanguinea. Journal of Ethnopharmacology. 41:1994;45-51.
31. Ohtani I.I., Gotoh N., Tanaka J., Higa T., Gyamfi M.A., Aniya Y. Thonningianins A and B, new antioxidants from the African medicinal herb Thonningia sanguinea. Journal of Natural Products. 63:2000;676-679.
32. Omura T., Sato R. The carbon-monoxide-binding pigment of liver microsomes: I. Evidence for its hemoprotein nature. Journal of Biological Chemistry. 239:1964;2370-2378.
33. Pan J., Hong J.Y., Ma B.L., Ning S.M., Paranawithana S.R., Yang C.S. Transcriptional activation of cytochrome P450 2B1/2 genes in rat liver by diallyl sulfide, a compound derived from garlic. Archives of Biochemistry and Biophysics. 302:1993;337-342.
34. Phillips A.V., Langdon R.G. Hepatic triphosphopyridine nucleotide-cytochrome c reductase: Isolation, characterization, and kinetic studies. Journal of Biological Chemistry. 237:1962;2652-2660.
35. Ruschitzka F., Meier P.J., Turina M., Luscher T.F., Noll G. Acute heart transplant rejection due to Saint John's wort. Lancet. 355(9203):2000;548-549.
36. Sohn D.H., Yun Y.P., Park K.S., Veech R.L., Song B.J. Post-translational reduction of cytochrome P450IIE by CCl4, its substrate. Biochemical and Biophysical Research Communications. 179:1991;449-454.
37. Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proceedings of the National Academy of Sciences of the United States of America. 76:1979;4350-4354.
38. Ueng Y.F., Wang J.J., Lin L.C., Park S.S., Chen C.F. Induction of cytochrome P450-dependent monooxygenase in mouse liver and kidney by rutaecarpine, an alkaloid of the herbal drug Evodia rutaecarpa. Life Sciences. 70:2001;207-217.
39. Wargovich M.J., Imada O., Stephens L.C. Initiation and post-initiation chemopreventive effects of diallyl sulfide in esophageal carcinogenesis. Cancer Letters. 64:1992;39-42.
40. Waxman D.J., Lapenson D.P., Aoyama T., Gelboin H.V., Gonzalez F.J., Korzekwa K. Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s. Archives of Biochemistry and Biophysics. 290:1991;160-166.
41. Waxman D.J. P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR. Archives of Biochemistry and Biophysics. 369:1999;11-23.
42. Yamazaki H., Hiroki S., Urano T., Inoue K., Shimada T. Effects of roxithromycin, erythromycin and troleandomycin on their N-demethylation by rat and human cytochrome P450 enzymes. Xenobiotica. 26:1996;1143-1153.
43. Yamazaki H., Nakano M., Gillam E.M., Bell L.C., Guengerich F.P., Shimada T. Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes. Biochemical Pharmacology. 52:1996;301-309.
44. Yang C.S., Smith T.J., Hong J.Y. Cytochrome P-450 enzymes as target for chemoprevention against carcinogenesis and toxicity: opportunities and limitations. Cancer Research. 54:1994;1982s-1986s. (Suppl).
45. Yun C.H., Jeong H.G., Jhoun J.W., Guengerich F.P. Non-specific inhibition of cytochrome P450 activities by chlorophyllin in human and rat liver microsomes. Carcinogenesis. 16:1995;1437-1440.