Comparison of simvastatin with Eugenia Jambolana fruit pulp in their effects on alanine transferase, aspartate aminotransferase and creatinine phosphokinase levels of hyperlipidaemic rats

Journal of the Pakistan Medical Association

Volumn 61, Issue 12, 2011, Pages 1190-1194

  Bilal, Rabiea ^a   Zakaria, Manzar ^b   Usman, Ahmad ^c   Zia, Azam ^d  

^a National Institute of Heart Diseases National University of Medical Sciences   (Pakistan)

^b AGA KHAN UNIVERSITY HOSPITAL   (Pakistan)

^c Army Cardiac Centre   (Pakistan)

^d RAWALPINDI MEDICAL COLLEGE   (Pakistan)

Author keywords

Eugenia jambolana; Rats; Simvastatin; Traditional medicine

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; CREATINE KINASE; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; SIMVASTATIN; SYZYGIUM CUMINI EXTRACT; TRIACYLGLYCEROL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; FRUIT; HYPERLIPIDEMIA; LIPOPROTEIN BLOOD LEVEL; LIVER PROTECTION; LIVER TOXICITY; MALE; MUSCLE INJURY; NONHUMAN; RAT; TRIACYLGLYCEROL BLOOD LEVEL;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CREATINE KINASE; EUGENIA; FRUIT; HYPERLIPIDEMIAS; MALE; PHYTOTHERAPY; PLANT EXTRACTS; RANDOM ALLOCATION; RATS; RATS, WISTAR; SIMVASTATIN; TREATMENT OUTCOME;

EID: 81855187058     PISSN: 00309982     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Gaziano JM. Global burden of cardiovascular disease. In: Braunwald E, Bonow R, Libby P, Zipes D, eds. Braunwald's Heart Disease. Philadelphia:Elsevier Saunders 2005; 7: 1-19.
2. No author listed. Choice of lipid lowering drugs. Med Lett Drugs Ther 1998; 40: 117-22.
3. Mahley RW, Bersot TP. Drug therapy for hypercholesterolemia and dyslipidemia. In: Brunton, LL (eds). Goodman and Gillman's. The Pharmacological Basis of Therapeutics. New York: McGrawHill 2006; pp 933-66.
4. Evans M, Rees A. Effects of HMG-CoA reductase inhibitors on skeletal muscle:are all statins the same? Drug Saf 2002; 25: 649-63.
5. Arora R, Maxlieboand, Maldonado F. Statin induced myopathy: The two faces of janus. J Cardiovasc Pharmacol Ther 2006; 11: 105-12.
6. A Császár.Hepatotoxicity of statins. Orv Hetil 2009; 150: 1754-5.
7. Thapa BR, Walia A. Liver Function Tests and their Interpretation. Indian J Pediatr 2007; 74: 663-71.
8. Brahmachari HD, Augusti KT, Hypoglycemic agents from Indian Indigenous plants. J Pharmacy Pharmacol (JPP) 1961; 12: 381-2.
9. Bilal R, Usman A, Aftab S. Manzar Z, Zia A. Antihyperlipidemic effects of Eugenia Jambolana fruit in diet induced hyperlipidemic rats. JPMA 2011; 61: 433-7.
10. Das S, Sarma G. Study of the Hepatoprotective Activity of the Ethanolic Extract of the Pulp of Eugenia Jambolana (Jamun) In Albino Rats. JCDR 2009; 3: 1466-74.
11. Curtis AD, Murzilli S, Castelnuovd AD, et al. Alcohol free red wine prevents arterial thrombosis in dietary-induced hypercholestrolemic rats: Experimental support for French Paradox. J Thrombosis Haemostasis 2005; 3: 346.
12. Akpanabiatu M1, Umoh 1B, Udoh AE, Edet EF. Rats serum electrolytes, lipid profile and cardiovascular activity on Nuclea Latifolia leaf extract administration. Indian J Clin Biochemistr 2005; 20: 29-34.
13. Pari. Antihyperlipidemic and antiperoxidative effects of Diarulin, a polyherbal formulation in alloxan induced hyperglyceuric rats. BMC Complement Alternat Med 2005; 5: 14.
14. Bhattaram VA, Ceraefe M, Kohlest C, Vest M, Deundorf H. Pharmacokinetic and bioavailability of herbal medicinal products. Phytomed 2002; 9: 1-36.
15. Angulo P. Nonalcoholic Fatty Liver Disease. N Engl J Med 2002; 346: 1221-31.
16. Sharma B, Vishwanath G, Salunke R, Roy P. Effects of flavonoid-rich extract from seeds of Eugenia jambolana (L.) on carbohydrate and lipid metabolism in diabetic mice. Foodchem 2008; 110: 697-705.
17. Sultana B, Anwar F, Przybylski R. Antioxidant activity of phenolic components present in barks of Azadirachta indica, Terminalia arjuna, Acacia nilotica, and Eugenia jambolana Lam. Trees. Foodchem 2007; 104: 1106-14.
18. Galisteo M, Suarez A, Montilla MP, Navarroa MC. Protective effects of Rosmarinus tomentosus ethanol extract on thioacetamide-induced liver cirrhosis in rats. Phytomedicine 2006; 13: 101-8.
19. Venkateswarlu G. On the nature of the clouring matter of the jambul fruit (Eugenia jambolana). Phcog Mag 2006; 2: 103.
20. Peluso MR. Flavonoids Attenuate Cardiovascular Disease, Inhibit Phosphodiesterase, and Modulate Lipid Homeostasis in Adipose Tissue and Liver. Exp Biol Med 2006; 231: 1287-99.
21. Gershovich OE, Lyman AE. Liver function test and pruritis in patients treated with atrovastatin: case report and review of literature. Pharmacotherapy 2004; 24: 150-4.
22. Rasheed S, Tahir M, Sami W, Munir B. Histological effects of Eugenia Jambolana seed extract on liver of adult albino rats. J Ayub Med Coll Abbottabad 2009; 21.