Oxidative stress mediated hepatotoxicity produced by simvastatin

Pharmacologyonline

Volumn 3, Issue , 2008, Pages 495-503

  Vaghasiya, Jitendra D ^a   Bhalodia, Yagnik S ^a   Manek, Ravi A ^a   Gohil, Tushar A ^a   Rathod, Shivkumar P ^b  

^a SNDT Women's University   (India)

^b M S UNIVERSITY OF BARODA   (India)

Author keywords

Hepatotoxicity; Oxidative stress; Simvastatin

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; BILIRUBIN GLUCURONIDE; CATALASE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; LACTATE DEHYDROGENASE; PROTEIN; SIMVASTATIN; SUPEROXIDE DISMUTASE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; ENZYME BLOOD LEVEL; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HISTOPATHOLOGY; IN VIVO STUDY; LACTATE DEHYDROGENASE BLOOD LEVEL; LIPID PEROXIDATION; LIVER FUNCTION; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; PROTEIN DEPLETION; RAT; TISSUE LEVEL; WISTAR RAT;

EID: 58049087970     PISSN: None     EISSN: 18278620     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Zimmerman H. Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. 2nd ed. Philadelphia: Lippincott, Williams & Wilkins, 1999.
2. Kaplowitz N. Biochemical and cellular mechanisms of toxic liver injury. Semin Liver Dis. 2002; 22:137-44.
3. Frei, B, Kim M., Ames B. Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proc. Natl. Acad. Sci. U. S. A. 1990;87:4879-4883.
4. Stocker R., Bowry VW, Frei B. Ubiquinone-10 protects low density lipoprotein more efficiently against lipid peroxidation than does alphatocopherol. Proc. Natl. Acad. Sci. U.S.A. 1991; 88:1646-1650.
5. Temple RJ, Himmel MH. Safety of newly approved drugs: implications for prescribing. JAMA. 2002; 287:2273-2275.
6. S. Tavintharan, CN Ong, K. Jeyaseelan, et al. Reduced mitochondrial coenzyme Q10 levels in HepG2 cells treated with high-dose simvastatin: A possible role in statin-induced hepatotoxicity? Toxicology and Applied Pharmacology 2007; 223:173-179
7. Slater TF, Sawyer BC. The stimulatory effects of carbon tetrachloride and other halogenoalkanes or peroxidative reactions in liver fractions in vitro. Biochem J, 1971; 123:805-814.
8. Moran MS, Depierre JW, Mannervik B. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochimica et Biophysica ACTA. 1979; 582: 67
9. Misra HP, Fridovich I. The role of superoxide anion in the autooxidation of epinephrine and a simple assay of SOD. J Biol.Chem, 1972; 247:3170.
10. Colowick SP, Kaplan NO, Packer L. Methods in Enzymology, 105. Academic Press. London, 1984; 121.
11. Forsmark-Andree, P, Ernster L. Evidence for a protective effect of endogenous ubiquinol against oxidative damage to mitochondrial protein and DNA during lipid peroxidation. Mol. Aspects Med. 1994; 15:S73-S81.
12. Lass A., Sohal RS. Electron transport-linked ubiquinone-dependent recycling of atocopherol inhibits autooxidation of mitochondrial membranes. Arch. Biochem. Biophys. 1998 3; 52:229-236.
13. Masters BA, Palmoski MJ, Flint OP, et al. In vitro myotoxicity of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, pravastatin, lovastatin, and simvastatin, using neonatal rat skeletal myocytes. Toxicol. Appl. Pharmacol. 1995; 131 (1): 163-174.
14. Johnson TE, Zhang X, Bleicher KB, et al. Umbenhauer, D.R. Statins induce apoptosis in rat and human myotube cultures by inhibiting protein geranylgeranylation but not ubiquinone. Toxicol. Appl. Pharmacol 2004; 200 (3): 237-250.
15. Rosen HR, Keefe EB. Evaluation of abnormal liver enzymes, use of liver tests and the serology of viral hepatitis. Liver disease, diagnosis and management. 1st ed. New York; Churchill livingstone publishers, 2000; 24-35.
16. Friedman SF, Martin P, Munoz JS. Laboratory evaluation of the patient with liver disease. Hepatology, a textbook of liver disease. Philedelphia; Saunders publication, 2003; 1: 661-709.
17. Simko V. Alkaline phosphatases in biology and medicine. Dig Dis 1991; 9: 189-193.
18. Chenoweth MB, Hake CL. The smaller halogenated aliphatic hydrocarbons. Ann. Rev. Pharmacol. 1962; 2:363-398.
19. Green RM, Flamm S. AGA techinal review of evaluation of liver chemistry tests. Gastroenterology 2002; 123: 1367-1384.