메뉴 건너뛰기




Volumn 57, Issue 5, 2012, Pages 1122-1129

Sorafenib for treatment of hepatocellular carcinoma: A systematic review

Author keywords

Cirrhosis; Hepatocellular carcinoma; Sorafenib; Systematic review; Transarterial chemoembolization

Indexed keywords

DOXORUBICIN; FLUOROURACIL; SORAFENIB; BENZENESULFONIC ACID DERIVATIVE; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; PYRIDINE DERIVATIVE; RAF PROTEIN;

EID: 84863606957     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-012-2136-1     Document Type: Review
Times cited : (107)

References (51)
  • 2
    • 25144500506 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: A clinical update
    • Pons-Renedo F, Llovet JM. Hepatocellular carcinoma: a clinical update. Med Gen Med. 2003;5:11.
    • (2003) Med Gen Med. , vol.5 , pp. 11
    • Pons-Renedo, F.1    Llovet, J.M.2
  • 3
    • 80955160714 scopus 로고    scopus 로고
    • Cancer Facts and Figures 2010
    • American Cancer Society
    • American Cancer Society. Cancer Facts and Figures 2010. Atlanta: American Cancer Society; 2010.
    • (2010) Atlanta: American Cancer Society
  • 4
    • 40949109774 scopus 로고    scopus 로고
    • Epidemiology of hepatocellular carcinoma in USA
    • El-Serag HB. Epidemiology of hepatocellular carcinoma in USA. Hepatol Res. 2007;37:S88-S94.
    • (2007) Hepatol Res. , vol.37
    • El-Serag, H.B.1
  • 5
    • 0642303165 scopus 로고    scopus 로고
    • The continuing increase in the incidence of hepatocellular carcinoma in the United States: An update
    • El-Serag HB, Davila JA, Petersen NJ, et al. The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update. Ann Intern Med. 2003;139:817-823.
    • (2003) Ann Intern Med. , vol.139 , pp. 817-823
    • El-Serag, H.B.1    Davila, J.A.2    Petersen, N.J.3
  • 6
    • 0033545541 scopus 로고    scopus 로고
    • Rising incidence of hepatocellular carcinoma in the United States
    • El-Serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med. 1999;340: 745-750.
    • (1999) N Engl J Med. , vol.340 , pp. 745-750
    • El-Serag, H.B.1    Mason, A.C.2
  • 7
    • 84864036544 scopus 로고    scopus 로고
    • NHANES III Data
    • NHANES III Data. http://www.cdc.gov/NCIDOD/Diseases/hepatitis/c/plan/HCV- infection.html; 2008.
    • (2008)
  • 8
    • 33645976174 scopus 로고    scopus 로고
    • Ubiquitous activation of Ras and Jak/stat pathways in human HCC
    • Calvisi DF, Ladu S, Gorden A, et al. Ubiquitous activation of Ras and Jak/stat pathways in human HCC. Gastroenterology. 2006; 130:1117-1128.
    • (2006) Gastroenterology , vol.130 , pp. 1117-1128
    • Calvisi, D.F.1    Ladu, S.2    Gorden, A.3
  • 9
    • 4544312006 scopus 로고    scopus 로고
    • The pathogenesis of hepatocellular carcinoma is multifactorial event. Novel immunological treatment in prospect
    • Marotta F, Vangieri B, Cecere A, et al. The pathogenesis of hepatocellular carcinoma is multifactorial event. Novel immunological treatment in prospect. Clin Ter. 2004;155:187-199.
    • (2004) Clin Ter. , vol.155 , pp. 187-199
    • Marotta, F.1    Vangieri, B.2    Cecere, A.3
  • 10
    • 33745547361 scopus 로고    scopus 로고
    • New therapies for hepatocellular carcinoma
    • Avila MA, Berasain C, Sangro B, et al. New therapies for hepatocellular carcinoma. Oncogene. 2006;25:3866-3884.
    • (2006) Oncogene. , vol.25 , pp. 3866-3884
    • Avila, M.A.1    Berasain, C.2    Sangro, B.3
  • 11
    • 0033056764 scopus 로고    scopus 로고
    • The molecular perspective: The Ras oncogene
    • Goodsell DS. The molecular perspective: the Ras oncogene. Oncologist. 1999;4:263-264.
    • (1999) Oncologist. , vol.4 , pp. 263-264
    • Goodsell, D.S.1
  • 12
    • 0038192317 scopus 로고    scopus 로고
    • Integrity of c-Raf-1/MEK signal transduction cascade is essential for hepatitis B virus gene expression
    • Stockl L, Berting A, Malkowski B, et al. Integrity of c-Raf-1/MEK signal transduction cascade is essential for hepatitis B virus gene expression. Oncogene. 2003;22:2604-2610.
    • (2003) Oncogene. , vol.22 , pp. 2604-2610
    • Stockl, L.1    Berting, A.2    Malkowski, B.3
  • 13
    • 0035799529 scopus 로고    scopus 로고
    • Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the hepatitis C virus (HCV) core protein
    • Giambartolomei S, Covone F, Levrero M, et al. Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the hepatitis C virus (HCV) core protein. Oncogene. 2001;20:2606-2610.
    • (2001) Oncogene. , vol.20 , pp. 2606-2610
    • Giambartolomei, S.1    Covone, F.2    Levrero, M.3
  • 14
    • 0036324927 scopus 로고    scopus 로고
    • Hepatitis C virus and its roles in cell proliferation
    • Shimotohno K, Watashi K, Tsuchihara K, et al. Hepatitis C virus and its roles in cell proliferation. J Gastroenterol. 2002;37:50-54.
    • (2002) J Gastroenterol. , vol.37 , pp. 50-54
    • Shimotohno, K.1    Watashi, K.2    Tsuchihara, K.3
  • 15
    • 33746565515 scopus 로고    scopus 로고
    • Role of Raf kinase in cancer: Therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway
    • Gollob JA, Wilhelm S, Carter C, et al. Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway. Semin Oncol. 2006;33:392-406.
    • (2006) Semin Oncol. , vol.33 , pp. 392-406
    • Gollob, J.A.1    Wilhelm, S.2    Carter, C.3
  • 16
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004;64:7099-7109.
    • (2004) Cancer Res. , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 17
    • 55749088393 scopus 로고    scopus 로고
    • Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
    • Wilhelm SM, Adnane L, Newell P, et al. Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther. 2008;7:3129-3140.
    • (2008) Mol Cancer Ther. , vol.7 , pp. 3129-3140
    • Wilhelm, S.M.1    Adnane, L.2    Newell, P.3
  • 18
    • 27444436166 scopus 로고    scopus 로고
    • Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation
    • Rahmani M, Davis EM, Bauer C, et al. Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation. J Biol Chem. 2005;280:35217-35227.
    • (2005) J Biol Chem. , vol.280 , pp. 35217-35227
    • Rahmani, M.1    Davis, E.M.2    Bauer, C.3
  • 19
    • 27144502652 scopus 로고    scopus 로고
    • The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006
    • Yu C, Bruzek LM, Meng XW, et al. The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006. Oncogene. 2005;24:6861-6869.
    • (2005) Oncogene. , vol.24 , pp. 6861-6869
    • Yu, C.1    Bruzek, L.M.2    Meng, X.W.3
  • 20
    • 49249137986 scopus 로고    scopus 로고
    • Human melanoma cytolysis by combined inhibition of mammalian target of rapamycin and vascular endothelial growth factor/vascular endothelial growth factor receptor-2
    • Molhoek KR, Griesemann H, Shu J, et al. Human melanoma cytolysis by combined inhibition of mammalian target of rapamycin and vascular endothelial growth factor/vascular endothelial growth factor receptor-2. Cancer Res. 2008;68:4392-4397.
    • (2008) Cancer Res. , vol.68 , pp. 4392-4397
    • Molhoek, K.R.1    Griesemann, H.2    Shu, J.3
  • 21
    • 38049019119 scopus 로고    scopus 로고
    • Safety and anti-tumor activity of sorafenib (Nexavar) in combination with other anti-cancer agents: A review of clinical trials
    • Takimoto CH, Awada A. Safety and anti-tumor activity of sorafenib (Nexavar) in combination with other anti-cancer agents: a review of clinical trials. Cancer Chemother Pharmacol. 2008;61:535-548.
    • (2008) Cancer Chemother Pharmacol. , vol.61 , pp. 535-548
    • Takimoto, C.H.1    Awada, A.2
  • 22
    • 68049122102 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
    • Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6:e1000097.
    • (2009) PLoS Med. , vol.6
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3
  • 23
    • 84864037551 scopus 로고    scopus 로고
    • http://www.ncbi.nlm.nih.gov/pubmed.
  • 24
    • 84864036545 scopus 로고    scopus 로고
    • http://www.isiknowledge.com.
  • 25
    • 84864037125 scopus 로고    scopus 로고
    • https://register.clinicaltrials.gov/.
  • 26
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008;359:378-390.
    • (2008) N Engl J Med. , vol.359 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 27
    • 57749189578 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial
    • Cheng AL, Kang YK, Chen Z, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 2009;10:25-34.
    • (2009) Lancet Oncol. , vol.10 , pp. 25-34
    • Cheng, A.L.1    Kang, Y.K.2    Chen, Z.3
  • 28
    • 33749017926 scopus 로고    scopus 로고
    • Phase II study of sorafenib in patients with advanced hepatocellular carcinoma
    • Abou-Alfa GK, Schwartz L, Ricci S, et al. Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J Clin Oncol. 2006;24:4293-4300.
    • (2006) J Clin Oncol. , vol.24 , pp. 4293-4300
    • Abou-Alfa, G.K.1    Schwartz, L.2    Ricci, S.3
  • 29
    • 84864035175 scopus 로고    scopus 로고
    • Efficacy, safety and impact on quality of life of a treatment with sorafenib in elderly cancer patients with advanced hepatocellular carcinoma. Result of a phase II study
    • Massa E, Stadier C, et al. Efficacy, safety and impact on quality of life of a treatment with sorafenib in elderly cancer patients with advanced hepatocellular carcinoma. Result of a phase II study. Ann Oncol. 2009;20:s65.
    • (2009) Ann Oncol. , vol.20
    • Massa, E.1    Stadier, C.2
  • 30
    • 59449089100 scopus 로고    scopus 로고
    • Phase 2 open-label study of singleagent sorafenib in treating advanced hepatocellular carcinoma in a hepatitis B-endemic Asian population: Presence of lung metastasis predicts poor response
    • Yau T, Chan P, Ng KK, et al. Phase 2 open-label study of singleagent sorafenib in treating advanced hepatocellular carcinoma in a hepatitis B-endemic Asian population: presence of lung metastasis predicts poor response. Cancer. 2009;115:428-436.
    • (2009) Cancer. , vol.115 , pp. 428-436
    • Yau, T.1    Chan, P.2    Ng, K.K.3
  • 31
    • 36949033865 scopus 로고    scopus 로고
    • Phase i study of sorafenib in Japanese patients with hepatocellular carcinoma
    • Furuse J, Ishii H, Nakachi K, et al. Phase I study of sorafenib in Japanese patients with hepatocellular carcinoma. Cancer Sci. 2008;99:159-165.
    • (2008) Cancer Sci. , vol.99 , pp. 159-165
    • Furuse, J.1    Ishii, H.2    Nakachi, K.3
  • 32
    • 84864046690 scopus 로고    scopus 로고
    • Short-term efficacy and safety of treatment of advanced hepatocellular carcinoma with sorafenib
    • Castroagudin JF, Molina E, et al. Short-term efficacy and safety of treatment of advanced hepatocellular carcinoma with sorafenib. J Hepatol. 2008;48:s141-s142.
    • (2008) J Hepatol. , vol.48
    • Castroagudin, J.F.1    Molina, E.2
  • 33
    • 77956228586 scopus 로고    scopus 로고
    • Sorafenib plus octreotide is an effective and safe treatment in advanced hepatocellular carcinoma: Multicenter phase II so LAR. study
    • Prete SD, Montella L, Caraglia M, et al. Sorafenib plus octreotide is an effective and safe treatment in advanced hepatocellular carcinoma: multicenter phase II So LAR.study. Cancer Chemother Pharmacol. 2010;66:837-844.
    • (2010) Cancer Chemother Pharmacol. , vol.66 , pp. 837-844
    • Prete, S.D.1    Montella, L.2    Caraglia, M.3
  • 34
    • 77955796298 scopus 로고    scopus 로고
    • A phase II trial of sorafenib in combination with 5-fluorouracil continuous infusion in patients with advanced hepatocellular carcinoma: Preliminary data
    • Petrini I, Muul LM, et al. A phase II trial of sorafenib in combination with 5-fluorouracil continuous infusion in patients with advanced hepatocellular carcinoma: preliminary data. J Clin Oncol. 2009;27:4592.
    • (2009) J Clin Oncol. , vol.27 , pp. 4592
    • Petrini, I.1    Muul, L.M.2
  • 35
    • 84864026743 scopus 로고    scopus 로고
    • Prospective phase II study of combination sorafenib plus mitomycin-c in the treatment of advanced hepatocellular carcinoma
    • Gianluca D, Muul LM, et al. Prospective phase II study of combination sorafenib plus mitomycin-c in the treatment of advanced hepatocellular carcinoma. Ann Oncol. 2009;20:8.
    • (2009) Ann Oncol. , vol.20 , pp. 8
    • Gianluca, D.1    Muul, L.M.2
  • 36
    • 78549283549 scopus 로고    scopus 로고
    • Phase II trial of sorafenib with capecitabine and oxaliplatin (SECOX) in patients with locally advanced or metastatic hepatocellular carcinoma
    • Yau T, Chan P, et al. Phase II trial of sorafenib with capecitabine and oxaliplatin (SECOX) in patients with locally advanced or metastatic hepatocellular carcinoma. EJC Suppl. 2009;7:20-21.
    • (2009) EJC Suppl. , vol.7 , pp. 20-21
    • Yau, T.1    Chan, P.2
  • 37
    • 78349298645 scopus 로고    scopus 로고
    • Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: A randomized trial
    • Abou-Alfa GK, Johnson P, Knox JJ, et al. Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: a randomized trial. JAMA. 2010;304:2154- 2160.
    • (2010) JAMA. , vol.304 , pp. 2154-2160
    • Abou-Alfa, G.K.1    Johnson, P.2    Knox, J.J.3
  • 38
    • 77953124105 scopus 로고    scopus 로고
    • Phase II study of combining sorafenib with metronomic tegafur/uracil for advanced hepatocellular carcinoma
    • Hsu CH, Shen YC, Lin ZZ, et al. Phase II study of combining sorafenib with metronomic tegafur/uracil for advanced hepatocellular carcinoma. J Hepatol. 2010;53:126-131.
    • (2010) J Hepatol. , vol.53 , pp. 126-131
    • Hsu, C.H.1    Shen, Y.C.2    Lin, Z.Z.3
  • 39
    • 84864036542 scopus 로고    scopus 로고
    • Sorafenib plus cisplatin and gemcitabine in the treatment of advanced hepatocellular carcinoma: A phase II study by the Grupo Oncologico Dell'Italia Meridonale (PROT GOIM 2705)
    • Giuliana F, Rosenberg A, et al. Sorafenib plus cisplatin and gemcitabine in the treatment of advanced hepatocellular carcinoma: a phase II study by the Grupo Oncologico Dell'Italia Meridonale (PROT. GOIM 2705). Cancer Treat Rev. 2010;36:S96.
    • (2010) Cancer Treat Rev. , vol.36
    • Giuliana, F.1    Rosenberg, A.2
  • 40
    • 79961225011 scopus 로고    scopus 로고
    • First-in-men demonstration of sorafenib plus TACE for the treatment of advanced hepatocellular carcinoma (SOCRATES trial)
    • Erhardt A, Kollings F, et al. First-in-men demonstration of sorafenib plus TACE for the treatment of advanced hepatocellular carcinoma (SOCRATES trial). Hepatology. 2009;50:1080A.
    • (2009) Hepatology. , vol.50
    • Erhardt, A.1    Kollings, F.2
  • 41
    • 77949903292 scopus 로고    scopus 로고
    • Phase II trial of sorafenib wit doxirubicin eluting bead-transarterial chemoembolization (DEB-TACE) for patients with hepatocellular carcinoma: Interim safety and efficacy analysis
    • Reyes DK, Azad N, et al. Phase II trial of sorafenib wit doxirubicin eluting bead-transarterial chemoembolization (DEB-TACE) for patients with hepatocellular carcinoma: interim safety and efficacy analysis. Hepatology. 2009;50:6A-7A.
    • (2009) Hepatology. , vol.50
    • Reyes, D.K.1    Azad, N.2
  • 42
    • 60449093312 scopus 로고    scopus 로고
    • Combination of sorafenib and doxorubicin in patients with advanced hepatocellular carcinoma: Results from a phase i extension trial
    • Richly H, Schultheis B, Adamietz IA, et al. Combination of sorafenib and doxorubicin in patients with advanced hepatocellular carcinoma: results from a phase I extension trial. Eur J Cancer. 2009;45:579-587.
    • (2009) Eur J Cancer. , vol.45 , pp. 579-587
    • Richly, H.1    Schultheis, B.2    Adamietz, I.A.3
  • 43
    • 84864026336 scopus 로고    scopus 로고
    • Phase i safety, pharmacokinetic, and pharmacodynamic study of AVE 1642, a human monoclonal antibody inhibiting the insulin-like grouth factor-1 receptor (IGF- 1R/CD221), administered as single agent and in combination with sorafinib as first line therapy in patients with advanced hepatocellular carcinoma
    • Faivre S, Feng L, et al. Phase I safety, pharmacokinetic, and pharmacodynamic study of AVE 1642, a human monoclonal antibody inhibiting the insulin-like grouth factor-1 receptor (IGF- 1R/CD221), administered as single agent and in combination with sorafinib as first line therapy in patients with advanced hepatocellular carcinoma. Hepatology. 2010;52:S 466A-288.
    • (2010) Hepatology. , vol.52
    • Faivre, S.1    Feng, L.2
  • 44
    • 78649972858 scopus 로고    scopus 로고
    • Continuous administration of sorafenib in combination with transarterial chemoembolization in patients with hepatocellular carcinoma: Results of a phase i study
    • Dufour JF, Hoppe H, Heim MH, et al. Continuous administration of sorafenib in combination with transarterial chemoembolization in patients with hepatocellular carcinoma: results of a phase I study. Oncologist. 2010;15:1198-1204.
    • (2010) Oncologist. , vol.15 , pp. 1198-1204
    • Dufour, J.F.1    Hoppe, H.2    Heim, M.H.3
  • 45
    • 84864053287 scopus 로고    scopus 로고
    • An interim safety analysis of sorafenib plus transarterial chemoembolization in hepatocellular carcinoma- A phase I/II pilot study (SORATACE-1 trial)
    • Pinter M, Smith W, et al. An interim safety analysis of sorafenib plus transarterial chemoembolization in hepatocellular carcinoma- a phase I/II pilot study (SORATACE-1 trial). Hepatology. 2010;52:1157A-1759.
    • (2010) Hepatology. , vol.52
    • Pinter, M.1    Smith, W.2
  • 46
    • 80054722090 scopus 로고    scopus 로고
    • Phase II trial of sorafenib combined with concurrent transarterial chemoembolization with drug-eluting beads for hepatocellular carcinoma
    • Pawlik TM, Reyes DK, Cosgrove D, et al. Phase II trial of sorafenib combined with concurrent transarterial chemoembolization with drug-eluting beads for hepatocellular carcinoma. J Clin Oncol. 2011;29:3960-3967.
    • (2011) J Clin Oncol. , vol.29 , pp. 3960-3967
    • Pawlik, T.M.1    Reyes, D.K.2    Cosgrove, D.3
  • 47
    • 39049121694 scopus 로고    scopus 로고
    • Hand-foot skin reaction in patients treated with sorafenib: A clinicopathological study of cutaneous manifestations due to multitargeted kinase inhibitor therapy
    • Yang CH, Lin WC, Chuang CK, et al. Hand-foot skin reaction in patients treated with sorafenib: a clinicopathological study of cutaneous manifestations due to multitargeted kinase inhibitor therapy. Br J Dermatol. 2008;158:592-596.
    • (2008) Br J Dermatol. , vol.158 , pp. 592-596
    • Yang, C.H.1    Lin, W.C.2    Chuang, C.K.3
  • 48
    • 0037086539 scopus 로고    scopus 로고
    • A prospective study regarding the complications of transcatheter intraarterial lipiodol chemoembolization in patients with hepatocellular carcinoma
    • Chan AO, Yuen MF, Hui CK, et al. A prospective study regarding the complications of transcatheter intraarterial lipiodol chemoembolization in patients with hepatocellular carcinoma. Cancer. 2002;94:1747-1752.
    • (2002) Cancer. , vol.94 , pp. 1747-1752
    • Chan, A.O.1    Yuen, M.F.2    Hui, C.K.3
  • 49
    • 0026485002 scopus 로고
    • Vascular endothelial growth factor induced by hypoxic may mediate hypoxic-initiated angiogenesis
    • Shweiki D, Itin A, Soffer D, et al. Vascular endothelial growth factor induced by hypoxic may mediate hypoxic-initiated angiogenesis. Nature. 1992;359:843-845.
    • (1992) Nature. , vol.359 , pp. 843-845
    • Shweiki, D.1    Itin, A.2    Soffer, D.3
  • 50
    • 0344036283 scopus 로고    scopus 로고
    • Influence of transarterial chemoembolization on angiogenesis and expression of vascular endothelial growth factor and basic fibroblast growth factor in rat with Walker-256 transplanted hepatoma: An experimental study
    • Li X, Feng GS, Zheng CS, et al. Influence of transarterial chemoembolization on angiogenesis and expression of vascular endothelial growth factor and basic fibroblast growth factor in rat with Walker-256 transplanted hepatoma: an experimental study. World J Gastroenterol. 2003;9:2445-2449.
    • (2003) World J Gastroenterol. , vol.9 , pp. 2445-2449
    • Li, X.1    Feng, G.S.2    Zheng, C.S.3
  • 51
    • 0036223603 scopus 로고    scopus 로고
    • Recurrences of hepatocellular carcinoma following initial remission by transcatheter arterial chemoembolization
    • Lee JK, Chung YH, et al. Recurrences of hepatocellular carcinoma following initial remission by transcatheter arterial chemoembolization. J Gastroenterol Hepatol. 2002;17:52-58.
    • (2002) J Gastroenterol Hepatol. , vol.17 , pp. 52-58
    • Lee, J.K.1    Chung, Y.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.