-
1
-
-
14944385553
-
Global cancer statistics, 2002
-
Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74-108.
-
(2005)
CA Cancer J Clin.
, vol.55
, pp. 74-108
-
-
Parkin, D.M.1
Bray, F.2
Ferlay, J.3
-
2
-
-
25144500506
-
Hepatocellular carcinoma: A clinical update
-
Pons-Renedo F, Llovet JM. Hepatocellular carcinoma: a clinical update. Med Gen Med. 2003;5:11.
-
(2003)
Med Gen Med.
, vol.5
, pp. 11
-
-
Pons-Renedo, F.1
Llovet, J.M.2
-
3
-
-
80955160714
-
Cancer Facts and Figures 2010
-
American Cancer Society
-
American Cancer Society. Cancer Facts and Figures 2010. Atlanta: American Cancer Society; 2010.
-
(2010)
Atlanta: American Cancer Society
-
-
-
4
-
-
40949109774
-
Epidemiology of hepatocellular carcinoma in USA
-
El-Serag HB. Epidemiology of hepatocellular carcinoma in USA. Hepatol Res. 2007;37:S88-S94.
-
(2007)
Hepatol Res.
, vol.37
-
-
El-Serag, H.B.1
-
5
-
-
0642303165
-
The continuing increase in the incidence of hepatocellular carcinoma in the United States: An update
-
El-Serag HB, Davila JA, Petersen NJ, et al. The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update. Ann Intern Med. 2003;139:817-823.
-
(2003)
Ann Intern Med.
, vol.139
, pp. 817-823
-
-
El-Serag, H.B.1
Davila, J.A.2
Petersen, N.J.3
-
6
-
-
0033545541
-
Rising incidence of hepatocellular carcinoma in the United States
-
El-Serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med. 1999;340: 745-750.
-
(1999)
N Engl J Med.
, vol.340
, pp. 745-750
-
-
El-Serag, H.B.1
Mason, A.C.2
-
7
-
-
84864036544
-
-
NHANES III Data
-
NHANES III Data. http://www.cdc.gov/NCIDOD/Diseases/hepatitis/c/plan/HCV- infection.html; 2008.
-
(2008)
-
-
-
8
-
-
33645976174
-
Ubiquitous activation of Ras and Jak/stat pathways in human HCC
-
Calvisi DF, Ladu S, Gorden A, et al. Ubiquitous activation of Ras and Jak/stat pathways in human HCC. Gastroenterology. 2006; 130:1117-1128.
-
(2006)
Gastroenterology
, vol.130
, pp. 1117-1128
-
-
Calvisi, D.F.1
Ladu, S.2
Gorden, A.3
-
9
-
-
4544312006
-
The pathogenesis of hepatocellular carcinoma is multifactorial event. Novel immunological treatment in prospect
-
Marotta F, Vangieri B, Cecere A, et al. The pathogenesis of hepatocellular carcinoma is multifactorial event. Novel immunological treatment in prospect. Clin Ter. 2004;155:187-199.
-
(2004)
Clin Ter.
, vol.155
, pp. 187-199
-
-
Marotta, F.1
Vangieri, B.2
Cecere, A.3
-
10
-
-
33745547361
-
New therapies for hepatocellular carcinoma
-
Avila MA, Berasain C, Sangro B, et al. New therapies for hepatocellular carcinoma. Oncogene. 2006;25:3866-3884.
-
(2006)
Oncogene.
, vol.25
, pp. 3866-3884
-
-
Avila, M.A.1
Berasain, C.2
Sangro, B.3
-
11
-
-
0033056764
-
The molecular perspective: The Ras oncogene
-
Goodsell DS. The molecular perspective: the Ras oncogene. Oncologist. 1999;4:263-264.
-
(1999)
Oncologist.
, vol.4
, pp. 263-264
-
-
Goodsell, D.S.1
-
12
-
-
0038192317
-
Integrity of c-Raf-1/MEK signal transduction cascade is essential for hepatitis B virus gene expression
-
Stockl L, Berting A, Malkowski B, et al. Integrity of c-Raf-1/MEK signal transduction cascade is essential for hepatitis B virus gene expression. Oncogene. 2003;22:2604-2610.
-
(2003)
Oncogene.
, vol.22
, pp. 2604-2610
-
-
Stockl, L.1
Berting, A.2
Malkowski, B.3
-
13
-
-
0035799529
-
Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the hepatitis C virus (HCV) core protein
-
Giambartolomei S, Covone F, Levrero M, et al. Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the hepatitis C virus (HCV) core protein. Oncogene. 2001;20:2606-2610.
-
(2001)
Oncogene.
, vol.20
, pp. 2606-2610
-
-
Giambartolomei, S.1
Covone, F.2
Levrero, M.3
-
15
-
-
33746565515
-
Role of Raf kinase in cancer: Therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway
-
Gollob JA, Wilhelm S, Carter C, et al. Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway. Semin Oncol. 2006;33:392-406.
-
(2006)
Semin Oncol.
, vol.33
, pp. 392-406
-
-
Gollob, J.A.1
Wilhelm, S.2
Carter, C.3
-
16
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004;64:7099-7109.
-
(2004)
Cancer Res.
, vol.64
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
-
17
-
-
55749088393
-
Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
-
Wilhelm SM, Adnane L, Newell P, et al. Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther. 2008;7:3129-3140.
-
(2008)
Mol Cancer Ther.
, vol.7
, pp. 3129-3140
-
-
Wilhelm, S.M.1
Adnane, L.2
Newell, P.3
-
18
-
-
27444436166
-
Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation
-
Rahmani M, Davis EM, Bauer C, et al. Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation. J Biol Chem. 2005;280:35217-35227.
-
(2005)
J Biol Chem.
, vol.280
, pp. 35217-35227
-
-
Rahmani, M.1
Davis, E.M.2
Bauer, C.3
-
19
-
-
27144502652
-
The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006
-
Yu C, Bruzek LM, Meng XW, et al. The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006. Oncogene. 2005;24:6861-6869.
-
(2005)
Oncogene.
, vol.24
, pp. 6861-6869
-
-
Yu, C.1
Bruzek, L.M.2
Meng, X.W.3
-
20
-
-
49249137986
-
Human melanoma cytolysis by combined inhibition of mammalian target of rapamycin and vascular endothelial growth factor/vascular endothelial growth factor receptor-2
-
Molhoek KR, Griesemann H, Shu J, et al. Human melanoma cytolysis by combined inhibition of mammalian target of rapamycin and vascular endothelial growth factor/vascular endothelial growth factor receptor-2. Cancer Res. 2008;68:4392-4397.
-
(2008)
Cancer Res.
, vol.68
, pp. 4392-4397
-
-
Molhoek, K.R.1
Griesemann, H.2
Shu, J.3
-
21
-
-
38049019119
-
Safety and anti-tumor activity of sorafenib (Nexavar) in combination with other anti-cancer agents: A review of clinical trials
-
Takimoto CH, Awada A. Safety and anti-tumor activity of sorafenib (Nexavar) in combination with other anti-cancer agents: a review of clinical trials. Cancer Chemother Pharmacol. 2008;61:535-548.
-
(2008)
Cancer Chemother Pharmacol.
, vol.61
, pp. 535-548
-
-
Takimoto, C.H.1
Awada, A.2
-
22
-
-
68049122102
-
Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
-
Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6:e1000097.
-
(2009)
PLoS Med.
, vol.6
-
-
Moher, D.1
Liberati, A.2
Tetzlaff, J.3
-
23
-
-
84864037551
-
-
http://www.ncbi.nlm.nih.gov/pubmed.
-
-
-
-
24
-
-
84864036545
-
-
http://www.isiknowledge.com.
-
-
-
-
25
-
-
84864037125
-
-
https://register.clinicaltrials.gov/.
-
-
-
-
26
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008;359:378-390.
-
(2008)
N Engl J Med.
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
-
27
-
-
57749189578
-
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial
-
Cheng AL, Kang YK, Chen Z, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 2009;10:25-34.
-
(2009)
Lancet Oncol.
, vol.10
, pp. 25-34
-
-
Cheng, A.L.1
Kang, Y.K.2
Chen, Z.3
-
28
-
-
33749017926
-
Phase II study of sorafenib in patients with advanced hepatocellular carcinoma
-
Abou-Alfa GK, Schwartz L, Ricci S, et al. Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J Clin Oncol. 2006;24:4293-4300.
-
(2006)
J Clin Oncol.
, vol.24
, pp. 4293-4300
-
-
Abou-Alfa, G.K.1
Schwartz, L.2
Ricci, S.3
-
29
-
-
84864035175
-
Efficacy, safety and impact on quality of life of a treatment with sorafenib in elderly cancer patients with advanced hepatocellular carcinoma. Result of a phase II study
-
Massa E, Stadier C, et al. Efficacy, safety and impact on quality of life of a treatment with sorafenib in elderly cancer patients with advanced hepatocellular carcinoma. Result of a phase II study. Ann Oncol. 2009;20:s65.
-
(2009)
Ann Oncol.
, vol.20
-
-
Massa, E.1
Stadier, C.2
-
30
-
-
59449089100
-
Phase 2 open-label study of singleagent sorafenib in treating advanced hepatocellular carcinoma in a hepatitis B-endemic Asian population: Presence of lung metastasis predicts poor response
-
Yau T, Chan P, Ng KK, et al. Phase 2 open-label study of singleagent sorafenib in treating advanced hepatocellular carcinoma in a hepatitis B-endemic Asian population: presence of lung metastasis predicts poor response. Cancer. 2009;115:428-436.
-
(2009)
Cancer.
, vol.115
, pp. 428-436
-
-
Yau, T.1
Chan, P.2
Ng, K.K.3
-
31
-
-
36949033865
-
Phase i study of sorafenib in Japanese patients with hepatocellular carcinoma
-
Furuse J, Ishii H, Nakachi K, et al. Phase I study of sorafenib in Japanese patients with hepatocellular carcinoma. Cancer Sci. 2008;99:159-165.
-
(2008)
Cancer Sci.
, vol.99
, pp. 159-165
-
-
Furuse, J.1
Ishii, H.2
Nakachi, K.3
-
32
-
-
84864046690
-
Short-term efficacy and safety of treatment of advanced hepatocellular carcinoma with sorafenib
-
Castroagudin JF, Molina E, et al. Short-term efficacy and safety of treatment of advanced hepatocellular carcinoma with sorafenib. J Hepatol. 2008;48:s141-s142.
-
(2008)
J Hepatol.
, vol.48
-
-
Castroagudin, J.F.1
Molina, E.2
-
33
-
-
77956228586
-
Sorafenib plus octreotide is an effective and safe treatment in advanced hepatocellular carcinoma: Multicenter phase II so LAR. study
-
Prete SD, Montella L, Caraglia M, et al. Sorafenib plus octreotide is an effective and safe treatment in advanced hepatocellular carcinoma: multicenter phase II So LAR.study. Cancer Chemother Pharmacol. 2010;66:837-844.
-
(2010)
Cancer Chemother Pharmacol.
, vol.66
, pp. 837-844
-
-
Prete, S.D.1
Montella, L.2
Caraglia, M.3
-
34
-
-
77955796298
-
A phase II trial of sorafenib in combination with 5-fluorouracil continuous infusion in patients with advanced hepatocellular carcinoma: Preliminary data
-
Petrini I, Muul LM, et al. A phase II trial of sorafenib in combination with 5-fluorouracil continuous infusion in patients with advanced hepatocellular carcinoma: preliminary data. J Clin Oncol. 2009;27:4592.
-
(2009)
J Clin Oncol.
, vol.27
, pp. 4592
-
-
Petrini, I.1
Muul, L.M.2
-
35
-
-
84864026743
-
Prospective phase II study of combination sorafenib plus mitomycin-c in the treatment of advanced hepatocellular carcinoma
-
Gianluca D, Muul LM, et al. Prospective phase II study of combination sorafenib plus mitomycin-c in the treatment of advanced hepatocellular carcinoma. Ann Oncol. 2009;20:8.
-
(2009)
Ann Oncol.
, vol.20
, pp. 8
-
-
Gianluca, D.1
Muul, L.M.2
-
36
-
-
78549283549
-
Phase II trial of sorafenib with capecitabine and oxaliplatin (SECOX) in patients with locally advanced or metastatic hepatocellular carcinoma
-
Yau T, Chan P, et al. Phase II trial of sorafenib with capecitabine and oxaliplatin (SECOX) in patients with locally advanced or metastatic hepatocellular carcinoma. EJC Suppl. 2009;7:20-21.
-
(2009)
EJC Suppl.
, vol.7
, pp. 20-21
-
-
Yau, T.1
Chan, P.2
-
37
-
-
78349298645
-
Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: A randomized trial
-
Abou-Alfa GK, Johnson P, Knox JJ, et al. Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: a randomized trial. JAMA. 2010;304:2154- 2160.
-
(2010)
JAMA.
, vol.304
, pp. 2154-2160
-
-
Abou-Alfa, G.K.1
Johnson, P.2
Knox, J.J.3
-
38
-
-
77953124105
-
Phase II study of combining sorafenib with metronomic tegafur/uracil for advanced hepatocellular carcinoma
-
Hsu CH, Shen YC, Lin ZZ, et al. Phase II study of combining sorafenib with metronomic tegafur/uracil for advanced hepatocellular carcinoma. J Hepatol. 2010;53:126-131.
-
(2010)
J Hepatol.
, vol.53
, pp. 126-131
-
-
Hsu, C.H.1
Shen, Y.C.2
Lin, Z.Z.3
-
39
-
-
84864036542
-
Sorafenib plus cisplatin and gemcitabine in the treatment of advanced hepatocellular carcinoma: A phase II study by the Grupo Oncologico Dell'Italia Meridonale (PROT GOIM 2705)
-
Giuliana F, Rosenberg A, et al. Sorafenib plus cisplatin and gemcitabine in the treatment of advanced hepatocellular carcinoma: a phase II study by the Grupo Oncologico Dell'Italia Meridonale (PROT. GOIM 2705). Cancer Treat Rev. 2010;36:S96.
-
(2010)
Cancer Treat Rev.
, vol.36
-
-
Giuliana, F.1
Rosenberg, A.2
-
40
-
-
79961225011
-
First-in-men demonstration of sorafenib plus TACE for the treatment of advanced hepatocellular carcinoma (SOCRATES trial)
-
Erhardt A, Kollings F, et al. First-in-men demonstration of sorafenib plus TACE for the treatment of advanced hepatocellular carcinoma (SOCRATES trial). Hepatology. 2009;50:1080A.
-
(2009)
Hepatology.
, vol.50
-
-
Erhardt, A.1
Kollings, F.2
-
41
-
-
77949903292
-
Phase II trial of sorafenib wit doxirubicin eluting bead-transarterial chemoembolization (DEB-TACE) for patients with hepatocellular carcinoma: Interim safety and efficacy analysis
-
Reyes DK, Azad N, et al. Phase II trial of sorafenib wit doxirubicin eluting bead-transarterial chemoembolization (DEB-TACE) for patients with hepatocellular carcinoma: interim safety and efficacy analysis. Hepatology. 2009;50:6A-7A.
-
(2009)
Hepatology.
, vol.50
-
-
Reyes, D.K.1
Azad, N.2
-
42
-
-
60449093312
-
Combination of sorafenib and doxorubicin in patients with advanced hepatocellular carcinoma: Results from a phase i extension trial
-
Richly H, Schultheis B, Adamietz IA, et al. Combination of sorafenib and doxorubicin in patients with advanced hepatocellular carcinoma: results from a phase I extension trial. Eur J Cancer. 2009;45:579-587.
-
(2009)
Eur J Cancer.
, vol.45
, pp. 579-587
-
-
Richly, H.1
Schultheis, B.2
Adamietz, I.A.3
-
43
-
-
84864026336
-
Phase i safety, pharmacokinetic, and pharmacodynamic study of AVE 1642, a human monoclonal antibody inhibiting the insulin-like grouth factor-1 receptor (IGF- 1R/CD221), administered as single agent and in combination with sorafinib as first line therapy in patients with advanced hepatocellular carcinoma
-
Faivre S, Feng L, et al. Phase I safety, pharmacokinetic, and pharmacodynamic study of AVE 1642, a human monoclonal antibody inhibiting the insulin-like grouth factor-1 receptor (IGF- 1R/CD221), administered as single agent and in combination with sorafinib as first line therapy in patients with advanced hepatocellular carcinoma. Hepatology. 2010;52:S 466A-288.
-
(2010)
Hepatology.
, vol.52
-
-
Faivre, S.1
Feng, L.2
-
44
-
-
78649972858
-
Continuous administration of sorafenib in combination with transarterial chemoembolization in patients with hepatocellular carcinoma: Results of a phase i study
-
Dufour JF, Hoppe H, Heim MH, et al. Continuous administration of sorafenib in combination with transarterial chemoembolization in patients with hepatocellular carcinoma: results of a phase I study. Oncologist. 2010;15:1198-1204.
-
(2010)
Oncologist.
, vol.15
, pp. 1198-1204
-
-
Dufour, J.F.1
Hoppe, H.2
Heim, M.H.3
-
45
-
-
84864053287
-
An interim safety analysis of sorafenib plus transarterial chemoembolization in hepatocellular carcinoma- A phase I/II pilot study (SORATACE-1 trial)
-
Pinter M, Smith W, et al. An interim safety analysis of sorafenib plus transarterial chemoembolization in hepatocellular carcinoma- a phase I/II pilot study (SORATACE-1 trial). Hepatology. 2010;52:1157A-1759.
-
(2010)
Hepatology.
, vol.52
-
-
Pinter, M.1
Smith, W.2
-
46
-
-
80054722090
-
Phase II trial of sorafenib combined with concurrent transarterial chemoembolization with drug-eluting beads for hepatocellular carcinoma
-
Pawlik TM, Reyes DK, Cosgrove D, et al. Phase II trial of sorafenib combined with concurrent transarterial chemoembolization with drug-eluting beads for hepatocellular carcinoma. J Clin Oncol. 2011;29:3960-3967.
-
(2011)
J Clin Oncol.
, vol.29
, pp. 3960-3967
-
-
Pawlik, T.M.1
Reyes, D.K.2
Cosgrove, D.3
-
47
-
-
39049121694
-
Hand-foot skin reaction in patients treated with sorafenib: A clinicopathological study of cutaneous manifestations due to multitargeted kinase inhibitor therapy
-
Yang CH, Lin WC, Chuang CK, et al. Hand-foot skin reaction in patients treated with sorafenib: a clinicopathological study of cutaneous manifestations due to multitargeted kinase inhibitor therapy. Br J Dermatol. 2008;158:592-596.
-
(2008)
Br J Dermatol.
, vol.158
, pp. 592-596
-
-
Yang, C.H.1
Lin, W.C.2
Chuang, C.K.3
-
48
-
-
0037086539
-
A prospective study regarding the complications of transcatheter intraarterial lipiodol chemoembolization in patients with hepatocellular carcinoma
-
Chan AO, Yuen MF, Hui CK, et al. A prospective study regarding the complications of transcatheter intraarterial lipiodol chemoembolization in patients with hepatocellular carcinoma. Cancer. 2002;94:1747-1752.
-
(2002)
Cancer.
, vol.94
, pp. 1747-1752
-
-
Chan, A.O.1
Yuen, M.F.2
Hui, C.K.3
-
49
-
-
0026485002
-
Vascular endothelial growth factor induced by hypoxic may mediate hypoxic-initiated angiogenesis
-
Shweiki D, Itin A, Soffer D, et al. Vascular endothelial growth factor induced by hypoxic may mediate hypoxic-initiated angiogenesis. Nature. 1992;359:843-845.
-
(1992)
Nature.
, vol.359
, pp. 843-845
-
-
Shweiki, D.1
Itin, A.2
Soffer, D.3
-
50
-
-
0344036283
-
Influence of transarterial chemoembolization on angiogenesis and expression of vascular endothelial growth factor and basic fibroblast growth factor in rat with Walker-256 transplanted hepatoma: An experimental study
-
Li X, Feng GS, Zheng CS, et al. Influence of transarterial chemoembolization on angiogenesis and expression of vascular endothelial growth factor and basic fibroblast growth factor in rat with Walker-256 transplanted hepatoma: an experimental study. World J Gastroenterol. 2003;9:2445-2449.
-
(2003)
World J Gastroenterol.
, vol.9
, pp. 2445-2449
-
-
Li, X.1
Feng, G.S.2
Zheng, C.S.3
-
51
-
-
0036223603
-
Recurrences of hepatocellular carcinoma following initial remission by transcatheter arterial chemoembolization
-
Lee JK, Chung YH, et al. Recurrences of hepatocellular carcinoma following initial remission by transcatheter arterial chemoembolization. J Gastroenterol Hepatol. 2002;17:52-58.
-
(2002)
J Gastroenterol Hepatol.
, vol.17
, pp. 52-58
-
-
Lee, J.K.1
Chung, Y.H.2
|