Regulation of neuronal autophagy in axon: Implication of autophagy in axonal function and dysfunction/degeneration

Autophagy

Volumn 3, Issue 2, 2007, Pages 139-141

  Yue, Zhenyu ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Autophagosome; Axon; Axonal dystrophy; Axonal transport; LC3; MAP1B; Neurodegeneration; Neuronal autophagy; p62 SQSTM1

Indexed keywords

GLUTAMATE RECEPTOR; GREEN FLUORESCENT PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 5; PROTEIN P62;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BIOGENESIS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EXCITOTOXICITY; MOUSE; NERVE DEGENERATION; NONHUMAN; PHAGOSOME; PROTEIN PHOSPHORYLATION; PURKINJE CELL; REGULATORY MECHANISM; SMOOTH ENDOPLASMIC RETICULUM;

MUS;

EID: 33947372556     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.3602     Document Type: Article

References (19)

1. Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 2004; 15:1101-11.
2. Wang QJ, Ding Y, Kohtz S, Mizushima N, Cristea IM, Rout MP, Chait BT, Zhong Y, Heintz N and Yue Z. Induction of autophagy in axonal dystrophy and degeneration. J Neurosci 2006; 26:8057-68.
3. Rubinszstein DC, DiFiglia M, Heintz N, Nixon RA, Qin ZH Ravikumar B, Stefanis L, Tolkovsky A. Autophagy and its possible roles in nervous system diseases, damage and repair. Autophagy 2005; 1:11-22.
4. Li H, Li SH, Yu ZX, Shelbourne P, Li XJ. Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice. J Neurosci 2001; 21:8473-81.
5. Yue Z, Horton A, Bravin M, DeJager PL, Selimi F, Heintz N. A novel protein complex linking the delta 2 glutamate receptor and autophagy. Implications for neurodegeneration in lurcher mice. Neuron 2002; 35:921-33.
6. Zuo J, De Jager PL, Takahashi KA, Jiang W, Linden DJ, Heintz N. Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene. Nature 1997; 388:769-73.
7. Koike M, Shibata M, Waguri S, Yoshimura K, Tanida I, Kominami E, Gotow T, Peters C, von Figura K, Mizushima N, Saftig P, Uchiyama Y. Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Barten disease). Am J Pathol 2005; 167:1713-28.
8. Broadwell RD, Caraldo AM. The neuronal endoplasmic reticulum: Its cytochemistry and contribution to the endomembrane system. II. Axons and terminals. J Comp Neurol 1984; 230:231-48.
9. Novikoff PM, Novikoff AB, Quintana N, Hauw JJ. Golgi apparatus, GERL, and lysosomes of neurons in rat dorsal root ganglia, studied by thick section and thin section cytochemistry. J Cell Biol 1971; 50:859-86.
10. Matthews MR, Raisman G. A light and electron microscopic study of the cellular response to axonal injury in the superior cervical ganglion of the rat. Proc R Soc Lond B Biol Sci 1972; 181:43-79.
11. Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Yokoyama M, Mishima K, Saito I, Okano H, Mizushima N. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006; 441:885-9.
12. Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, Ueno T, Koike M, Uchiyama Y, Kominami E, Tanaka K. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006; 441:880-4.
13. Chu CT. Autophagic stress in neuronal injury and disease. J Neuropathol Exp Neurol 2006; 65:423-32.
14. Gordon-Weeks PR, Fischer I. MAP1B expression and microtubule stability in growing and regenerating axons. Microsc Res Tech 2000; 48:63-74.
15. Kochl R, Hu XW, Chan EY, Tooze SA. Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes. Traffic 2006; 7:129-45.
16. Fass E, Shvets E, Degani I, Hirschberg K, Elazar Z. Microtubules support production of starvation-induced autophagosomes but not their targeting and fusion with lysosomes. J Biol Chem 2006.
17. Gonzalez-Billault C, Jiminez-Mareos EM, Caceres A, Diaz-Nido J, Wandosell F, Avila J. Microtubule-associated protein 1B function during normal development, regeneration, and pathological conditions in the nervous system. J Neurobiol 2004; 58:48-59.
18. Hollenbeck PJ. Products of endocytosis and autophagy are retrieved from axons by regulated retrograde organelle transport. J Cell Biol 1993; 121:305-15.
19. Bjorkoy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, Srenmark H, Johansen T. p62/SQSTM1 forms protein aggregares degraded by autophagy and has a protective effect on hunringtin-induced cell death. J Cell Biol 2005; 171:603-14.