메뉴 건너뛰기




Volumn 7, Issue 5, 2014, Pages 1352-1362

Molecular mechanisms of chemoresistance in osteosarcoma (review)

Author keywords

Chemoresistance; Osteosarcoma

Indexed keywords

APURINIC ACID; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GLUTATHIONE TRANSFERASE P1; HIGH MOBILITY GROUP B1 PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MICRORNA; MULTIDRUG RESISTANCE PROTEIN; REDUCED FOLATE CARRIER; SOMATOMEDIN C RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; VASCULOTROPIN; XERODERMA PIGMENTOSUM GROUP D PROTEIN;

EID: 84896259603     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2014.1935     Document Type: Review
Times cited : (204)

References (156)
  • 1
    • 33746450466 scopus 로고    scopus 로고
    • Chemotherapy resistance in osteosarcoma: Current challenges and future directions
    • Chou AJ and Gorlick R: Chemotherapy resistance in osteosarcoma: current challenges and future directions. Expert Rev Anticancer There 6: 1075-1085, 2006.
    • (2006) Expert Rev Anticancer There , vol.6 , pp. 1075-1085
    • Chou, A.J.1    Gorlick, R.2
  • 3
    • 50649107280 scopus 로고    scopus 로고
    • Therapy for osteosarcoma: Where do we go from here?
    • Chou AJ, Geller DS and Gorlick R: Therapy for osteosarcoma: where do we go from here? Paediatr Drugs 10: 315-327, 2008.
    • (2008) Paediatr Drugs , vol.10 , pp. 315-327
    • Chou, A.J.1    Geller, D.S.2    Gorlick, R.3
  • 4
    • 0024427025 scopus 로고
    • Adjuvant chemotherapy for osteosarcoma
    • Eilber FR and Rosen G: Adjuvant chemotherapy for osteosarcoma. Semin Oncol 16: 312-322, 1989.
    • (1989) Semin Oncol , vol.16 , pp. 312-322
    • Eilber, F.R.1    Rosen, G.2
  • 5
    • 54049089246 scopus 로고    scopus 로고
    • Current status and perspectives regarding the treatment of osteo-sarcoma: Chemotherapy
    • Sakamoto A and Iwamoto Y: Current status and perspectives regarding the treatment of osteo-sarcoma: chemotherapy: Rev Recent Clin Trials 3: 228-231, 2008.
    • (2008) Rev Recent Clin Trials , vol.3 , pp. 228-231
    • Sakamoto, A.1    Iwamoto, Y.2
  • 6
    • 0027351189 scopus 로고
    • Karnofsky memorial lecture. Ode to methotrexate
    • Bertino JR: Karnofsky memorial lecture. Ode to methotrexate. J Clin Oncol 11: 5-14, 1993.
    • (1993) J Clin Oncol , vol.11 , pp. 5-14
    • Bertino, J.R.1
  • 7
    • 12444266802 scopus 로고    scopus 로고
    • Genomic imbalances associated with methotrexate resistance in human osteosarcoma cell lines detected by comparative genomic hybridization-based techniques
    • Hattinger CM, Reverter-Branchat G, Remondini D, et al: Genomic imbalances associated with methotrexate resistance in human osteosarcoma cell lines detected by comparative genomic hybridization-based techniques. Eur J Cell Biol 82: 483-493, 2003.
    • (2003) Eur J Cell Biol , vol.82 , pp. 483-493
    • Hattinger, C.M.1    Reverter-Branchat, G.2    Remondini, D.3
  • 9
    • 64149090965 scopus 로고    scopus 로고
    • Methotrexate in pediatric osteosarcoma: Response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression
    • Patiño-García A, Zalacaín M, Marrodán L, San-Julián M and Sierrasesúmaga L: Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression. J Pediatr 154: 688-693, 2009.
    • (2009) J Pediatr , vol.154 , pp. 688-693
    • Patiño-García, A.1    Zalacaín, M.2    Marrodán, L.3    San-Julián, M.4    Sierrasesúmaga, L.5
  • 10
    • 0142150087 scopus 로고    scopus 로고
    • Reduced folate carrier protein expression in osteosarcoma: Implications for the prediction of tumor chemosensitivity
    • Ifergan I, Meller I, Issakov J and Assaraf YG: Reduced folate carrier protein expression in osteosarcoma: implications for the prediction of tumor chemosensitivity. Cancer 98: 1958-1966, 2003.
    • (2003) Cancer , vol.98 , pp. 1958-1966
    • Ifergan, I.1    Meller, I.2    Issakov, J.3    Assaraf, Y.G.4
  • 11
    • 4644251592 scopus 로고    scopus 로고
    • Functional analysis of altered reduced folate carrier sequence changes identified in osteosarcomas
    • Flintoff WF, Sadlish H, Gorlick R, Yang R and Williams FM: Functional analysis of altered reduced folate carrier sequence changes identified in osteosarcomas. Biochim Biophys Acta 1690: 110-117, 2004.
    • (2004) Biochim Biophys Acta , vol.1690 , pp. 110-117
    • Flintoff, W.F.1    Sadlish, H.2    Gorlick, R.3    Yang, R.4    Williams, F.M.5
  • 12
    • 9144254448 scopus 로고    scopus 로고
    • Analysis of dihydrofolate reductase and reduced folate carrier gene status in relation to methotrexate resistance in osteosarcoma cells
    • Serra M, Reverter-Branchat G, Maurici D, et al: Analysis of dihydrofolate reductase and reduced folate carrier gene status in relation to methotrexate resistance in osteosarcoma cells. Ann Oncol 15: 151-160, 2004.
    • (2004) Ann Oncol , vol.15 , pp. 151-160
    • Serra, M.1    Reverter-Branchat, G.2    Maurici, D.3
  • 13
    • 0037317006 scopus 로고    scopus 로고
    • Sequence alterations in the reduced folate carrier are observed in osteosarcoma tumor samples
    • Yang R, Sowers R, Mazza BA, et al: Sequence alterations in the reduced folate carrier are observed in osteosarcoma tumor samples. Clin Cancer Res 9: 837-844, 2003.
    • (2003) Clin Cancer Res , vol.9 , pp. 837-844
    • Yang, R.1    Sowers, R.2    Mazza, B.A.3
  • 14
    • 84872354932 scopus 로고    scopus 로고
    • High dose trimetrexate with leucovorin protection in recurrent childhood malignancies: A phase II trial
    • Trippett T, Meyers P, Gorlick R, et al: High dose trimetrexate with leucovorin protection in recurrent childhood malignancies: a phase II trial. J Clin Oncol (ASCO Annual Meeting Abstracts): 9: 889, 1999.
    • (1999) J Clin Oncol (ASCO Annual Meeting Abstracts) , vol.9 , pp. 889
    • Trippett, T.1    Meyers, P.2    Gorlick, R.3
  • 15
    • 0025176784 scopus 로고
    • P-glycoproteins in pathology: The multidrug resistance gene family in humans
    • Weinstein RS, Kuszak JR, Kluskens LF and Coon JS: P-glycoproteins in pathology: the multidrug resistance gene family in humans. Hum Pathol 21: 34-48, 1990.
    • (1990) Hum Pathol , vol.21 , pp. 34-48
    • Weinstein, R.S.1    Kuszak, J.R.2    Kluskens, L.F.3    Coon, J.S.4
  • 16
    • 0025051429 scopus 로고
    • Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185 Val-185 substitution in P-glycoprotein
    • Safa AR, Stern RK, Choi K, et al: Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185Val-185 substitution in P-glycoprotein. Proc Natl Acad Sci USA 87: 7225-7229, 1990.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 7225-7229
    • Safa, A.R.1    Stern, R.K.2    Choi, K.3
  • 17
    • 0034509426 scopus 로고    scopus 로고
    • Osteosarcomas and other cancers of bone
    • Bramwell VH: Osteosarcomas and other cancers of bone. Curr Opin Oncol 12: 330-336, 2000.
    • (2000) Curr Opin Oncol , vol.12 , pp. 330-336
    • Bramwell, V.H.1
  • 18
    • 0035110767 scopus 로고    scopus 로고
    • The co-expression of p53 protein and P-glycoprotein is correlated to a poor prognosis in osteosarcoma
    • Park YB, Kim HS, Oh JH and Lee SH: The co-expression of p53 protein and P-glycoprotein is correlated to a poor prognosis in osteosarcoma. Int Orthop 24: 307-310, 2001.
    • (2001) Int Orthop , vol.24 , pp. 307-310
    • Park, Y.B.1    Kim, H.S.2    Oh, J.H.3    Lee, S.H.4
  • 19
    • 33749426881 scopus 로고    scopus 로고
    • Multidrug resistance mediated by ABC transporters in osteosarcoma cell lines: MRNA analysis and functional radiotracer studies
    • Gomes CM, van Paassen H, Romeo S, et al: Multidrug resistance mediated by ABC transporters in osteosarcoma cell lines: mRNA analysis and functional radiotracer studies. Nucl Med Biol 33: 831-840, 2006.
    • (2006) Nucl Med Biol , vol.33 , pp. 831-840
    • Gomes, C.M.1    van Paassen, H.2    Romeo, S.3
  • 20
    • 36049026825 scopus 로고    scopus 로고
    • May P-glycoprotein status be used to stratify high-grade osteosarcoma patients? Results from the Italian/Scandinavian Sarcoma Group 1 treatment protocol
    • Serra M, Pasello M, Manara MC, et al: May P-glycoprotein status be used to stratify high-grade osteosarcoma patients? Results from the Italian/Scandinavian Sarcoma Group 1 treatment protocol. Int J Oncol 29: 1459-1468, 2006.
    • (2006) Int J Oncol , vol.29 , pp. 1459-1468
    • Serra, M.1    Pasello, M.2    Manara, M.C.3
  • 22
    • 0033606088 scopus 로고    scopus 로고
    • Relationship between P-glycoprotein positivity, doxorubicin binding ability and histologic response to chemotherapy in osteosarcomas
    • Kusuzaki K, Hirata M, Takeshita H, Murata H, Hashiguchi S, Ashihara T and Hirasawa Y: Relationship between P-glycoprotein positivity, doxorubicin binding ability and histologic response to chemotherapy in osteosarcomas. Cancer Lett 138: 203-208, 1999.
    • (1999) Cancer Lett , vol.138 , pp. 203-208
    • Kusuzaki, K.1    Hirata, M.2    Takeshita, H.3    Murata, H.4    Hashiguchi, S.5    Ashihara, T.6    Hirasawa, Y.7
  • 23
    • 0034190396 scopus 로고    scopus 로고
    • Multidrug resistance-1 gene expression does not increase during tumor progression in the MGH-OGS murine osteosarcoma tumor model
    • Trammell RA, Johnson CB, Barker JR, Bell RS and Allan DG: Multidrug resistance-1 gene expression does not increase during tumor progression in the MGH-OGS murine osteosarcoma tumor model. J Orthop Res 18: 449-455, 2000.
    • (2000) J Orthop Res , vol.18 , pp. 449-455
    • Trammell, R.A.1    Johnson, C.B.2    Barker, J.R.3    Bell, R.S.4    Allan, D.G.5
  • 24
    • 18744431612 scopus 로고    scopus 로고
    • MDR1 gene expression and outcome in osteosarcoma: A prospective, multicenter study
    • Wunder JS, Bull SB, Aneliunas V, et al: MDR1 gene expression and outcome in osteosarcoma: a prospective, multicenter study. J Clin Oncol 18: 2685-2694, 2000.
    • (2000) J Clin Oncol , vol.18 , pp. 2685-2694
    • Wunder, J.S.1    Bull, S.B.2    Aneliunas, V.3
  • 25
    • 0038298496 scopus 로고    scopus 로고
    • The association of P-glycoprotein with response to chemotherapy and clinical outcome in patients with osteosarcoma. A meta-analysis
    • Pakos EE and Ioannidis JP: The association of P-glycoprotein with response to chemotherapy and clinical outcome in patients with osteosarcoma. A meta-analysis. Cancer 98: 581-589, 2003.
    • (2003) Cancer , vol.98 , pp. 581-589
    • Pakos, E.E.1    Ioannidis, J.P.2
  • 26
    • 62549110360 scopus 로고    scopus 로고
    • Immunohistochemical estimates of angiogenesis, proliferative activity, p53 expression, and multiple drug resistance have no prognostic impact in osteosarcoma: A comparative clinicopathological investigation
    • Sorensen FB, Jensen K, Vaeth M, et al: Immunohistochemical estimates of angiogenesis, proliferative activity, p53 expression, and multiple drug resistance have no prognostic impact in osteosarcoma: A comparative clinicopathological investigation. Sarcoma 2008: 874075, 2008.
    • (2008) Sarcoma , pp. 874075
    • Sorensen, F.B.1    Jensen, K.2    Vaeth, M.3
  • 27
    • 0034060345 scopus 로고    scopus 로고
    • Osteoblastic differentiation and P-glycoprotein multidrug resistance in a murine osteosarcoma model
    • Takeshita H, Kusuzaki K, Murata H, et al: Osteoblastic differentiation and P-glycoprotein multidrug resistance in a murine osteosarcoma model. Br J Cancer 82: 1327-1331, 2000.
    • (2000) Br J Cancer , vol.82 , pp. 1327-1331
    • Takeshita, H.1    Kusuzaki, K.2    Murata, H.3
  • 28
    • 77956544799 scopus 로고    scopus 로고
    • Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma
    • Susa M, Iyer AK, Ryu K, Choy E, Hornicek FJ, Mankin H, Milane L, Amiji MM and Duan Z: Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma. PLoS One 5: e10764, 2010.
    • (2010) PLoS One , vol.5
    • Susa, M.1    Iyer, A.K.2    Ryu, K.3    Choy, E.4    Hornicek, F.J.5    Mankin, H.6    Milane, L.7    Amiji, M.M.8    Duan, Z.9
  • 29
    • 71949105972 scopus 로고    scopus 로고
    • Doxorubicin loaded polymeric nanoparticulate delivery system to overcome drug resistance in osteosarcoma
    • Susa M, Iyer AK, Ryu K, Hornicek FJ, Mankin H, Amiji MM and Duan Z: Doxorubicin loaded polymeric nanoparticulate delivery system to overcome drug resistance in osteosarcoma. BMC Cancer 9: 399, 2009.
    • (2009) BMC Cancer , vol.9 , pp. 399
    • Susa, M.1    Iyer, A.K.2    Ryu, K.3    Hornicek, F.J.4    Mankin, H.5    Amiji, M.M.6    Duan, Z.7
  • 30
    • 84875772283 scopus 로고    scopus 로고
    • Lipid-functionalized dextran nanosystems to overcome multidrug resistance in cancer: A pilot study
    • Kobayashi E, Iyer AK, Hornicek FJ, Amiji MM and Duan Z: Lipid-functionalized dextran nanosystems to overcome multidrug resistance in cancer: a pilot study. Clin Orthop Relat Res 471: 915-925, 2013.
    • (2013) Clin Orthop Relat Res , vol.471 , pp. 915-925
    • Kobayashi, E.1    Iyer, A.K.2    Hornicek, F.J.3    Amiji, M.M.4    Duan, Z.5
  • 31
    • 0642374221 scopus 로고    scopus 로고
    • The role of glutathione-S-transferase in anti-cancer drug resistance
    • Townsend DM and Tew KD: The role of glutathione-S-transferase in anti-cancer drug resistance. Oncogene 22: 7369-7375, 2003.
    • (2003) Oncogene , vol.22 , pp. 7369-7375
    • Townsend, D.M.1    Tew, K.D.2
  • 32
    • 0028106016 scopus 로고
    • Glutathione-associated enzymes in anticancer drug resistance
    • Tew KD: Glutathione-associated enzymes in anticancer drug resistance. Cancer Res 54: 4313-4320, 1994.
    • (1994) Cancer Res , vol.54 , pp. 4313-4320
    • Tew, K.D.1
  • 33
    • 0030895104 scopus 로고    scopus 로고
    • Detection and significance of glutathione-S-transferase pi in osteogenic tumors of dogs
    • Shoieb A and Hahn K: Detection and significance of glutathione-S-transferase pi in osteogenic tumors of dogs. Int J Oncol 10: 635-639, 1997.
    • (1997) Int J Oncol , vol.10 , pp. 635-639
    • Shoieb, A.1    Hahn, K.2
  • 34
    • 0030902367 scopus 로고    scopus 로고
    • Overexpression of resistance-related proteins (metallothioneins, glutathione-S-transferase pi, heat shock protein 27, and lung resistance-related protein) in osteosarcoma. Relationship with poor prognosis
    • Uozaki H, Horiuchi H, Ishida T, Iijima T, Imamura T and Machinami R: Overexpression of resistance-related proteins (metallothioneins, glutathione-S-transferase pi, heat shock protein 27, and lung resistance-related protein) in osteosarcoma. Relationship with poor prognosis. Cancer 79: 2336-2344, 1997.
    • (1997) Cancer , vol.79 , pp. 2336-2344
    • Uozaki, H.1    Horiuchi, H.2    Ishida, T.3    Iijima, T.4    Imamura, T.5    Machinami, R.6
  • 35
    • 38749131631 scopus 로고    scopus 로고
    • Expression of MDR1 and GST-pi in osteosarcoma and soft tissue sarcoma and their correlation with chemotherapy resistance
    • In Chinese
    • Wei L, Song XR, Wang XW, Li M and Zuo WS: Expression of MDR1 and GST-pi in osteosarcoma and soft tissue sarcoma and their correlation with chemotherapy resistance. Zhonghua Zhong Liu Za Zhi 28: 445-448, 2006 (In Chinese).
    • (2006) Zhonghua Zhong Liu Za Zhi , vol.28 , pp. 445-448
    • Wei, L.1    Song, X.R.2    Wang, X.W.3    Li, M.4    Zuo, W.S.5
  • 37
    • 34250757693 scopus 로고    scopus 로고
    • Expression of human glutathione S-transferase P1 mediates the chemosensitivity of osteosarcoma cells
    • Huang G, Mills L and Worth LL: Expression of human glutathione S-transferase P1 mediates the chemosensitivity of osteosarcoma cells. Mol Cancer Ther 6: 1610-1619, 2007.
    • (2007) Mol Cancer Ther , vol.6 , pp. 1610-1619
    • Huang, G.1    Mills, L.2    Worth, L.L.3
  • 38
    • 84858706750 scopus 로고    scopus 로고
    • Germline genetic polymorphisms may influence chemotherapy response and disease outcome in osteosarcoma: A pilot study
    • Windsor RE, Strauss SJ, Kallis C, Wood NE and Whelan JS: Germline genetic polymorphisms may influence chemotherapy response and disease outcome in osteosarcoma: a pilot study. Cancer 118: 1856-1867, 2012.
    • (2012) Cancer , vol.118 , pp. 1856-1867
    • Windsor, R.E.1    Strauss, S.J.2    Kallis, C.3    Wood, N.E.4    Whelan, J.S.5
  • 39
    • 84874061870 scopus 로고    scopus 로고
    • Predictive potential of glutathione S-transferase polymorphisms for prognosis of osteosarcoma patients on chemotherapy
    • Zhang SL, Mao NF, Sun JY, Shi ZC, Wang B and Sun YJ: Predictive potential of glutathione S-transferase polymorphisms for prognosis of osteosarcoma patients on chemotherapy. Asian Pac J Cancer Prev 13: 2705-2709, 2012.
    • (2012) Asian Pac J Cancer Prev , vol.13 , pp. 2705-2709
    • Zhang, S.L.1    Mao, N.F.2    Sun, J.Y.3    Shi, Z.C.4    Wang, B.5    Sun, Y.J.6
  • 40
    • 84874024558 scopus 로고    scopus 로고
    • Glutathione S-transferase P1 and DNA polymorphisms influence response to chemotherapy and prognosis of bone tumors
    • Yang LM, Li XH and Bao CF: Glutathione S-transferase P1 and DNA polymorphisms influence response to chemotherapy and prognosis of bone tumors. Asian Pac J Cancer Prev 13: 5883-5886, 2012.
    • (2012) Asian Pac J Cancer Prev , vol.13 , pp. 5883-5886
    • Yang, L.M.1    Li, X.H.2    Bao, C.F.3
  • 42
    • 79960809400 scopus 로고    scopus 로고
    • Targeting glutathione-S transferase enzymes in musculoskeletal sarcomas: A promising therapeutic strategy
    • Pasello M, Manara MC, Michelacci F, et al: Targeting glutathione-S transferase enzymes in musculoskeletal sarcomas: a promising therapeutic strategy. Anal Cell Pathol (Amst) 34: 131-145, 2011.
    • (2011) Anal Cell Pathol (Amst) , vol.34 , pp. 131-145
    • Pasello, M.1    Manara, M.C.2    Michelacci, F.3
  • 43
    • 84858011803 scopus 로고    scopus 로고
    • Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines
    • Sau A, Filomeni G, Pezzola S, et al: Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines. Mol Biosyst 8: 994-1006, 2012.
    • (2012) Mol Biosyst , vol.8 , pp. 994-1006
    • Sau, A.1    Filomeni, G.2    Pezzola, S.3
  • 44
    • 24344451212 scopus 로고    scopus 로고
    • APE1 and XRCC1 protein expression levels predict cancer-specific survival following radical radiotherapy in bladder cancer
    • Sak SC, Harnden P, Johnston CF, Paul AB and Kiltie AE: APE1 and XRCC1 protein expression levels predict cancer-specific survival following radical radiotherapy in bladder cancer. Clin Cancer Res 11: 6205-6211, 2005.
    • (2005) Clin Cancer Res , vol.11 , pp. 6205-6211
    • Sak, S.C.1    Harnden, P.2    Johnston, C.F.3    Paul, A.B.4    Kiltie, A.E.5
  • 46
    • 0036718792 scopus 로고    scopus 로고
    • The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress
    • Silber JR, Bobola MS, Blank A, Schoeler KD, Haroldson PD, Huynh MB and Kolstoe DD: The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress. Clin Cancer Res 8: 3008-3018, 2002.
    • (2002) Clin Cancer Res , vol.8 , pp. 3008-3018
    • Silber, J.R.1    Bobola, M.S.2    Blank, A.3    Schoeler, K.D.4    Haroldson, P.D.5    Huynh, M.B.6    Kolstoe, D.D.7
  • 47
    • 30344434348 scopus 로고    scopus 로고
    • Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (Ape/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an Ape1/Ref-1 inhibitor
    • Yang S, Irani K, Heffron SE, Jurnak F and Meyskens FL Jr: Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (Ape/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an Ape1/Ref-1 inhibitor. Mol Cancer Ther 4: 1923-1935, 2005.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1923-1935
    • Yang, S.1    Irani, K.2    Heffron, S.E.3    Jurnak, F.4    Meyskens Jr., F.L.5
  • 48
    • 4444327784 scopus 로고    scopus 로고
    • Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: Enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition
    • Wang D, Luo M and Kelley MR: Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition. Mol Cancer Ther 3: 679-686, 2004.
    • (2004) Mol Cancer Ther , vol.3 , pp. 679-686
    • Wang, D.1    Luo, M.2    Kelley, M.R.3
  • 49
    • 35548948785 scopus 로고    scopus 로고
    • Vector-based Ape1 small interfering RNA enhances the sensitivity of human osteosarcoma cells to endostatin in vivo
    • Wang D, Zhong ZY, Li MX, Xiang DB and Li ZP: Vector-based Ape1 small interfering RNA enhances the sensitivity of human osteosarcoma cells to endostatin in vivo. Cancer Sci 98: 1993-2001, 2007.
    • (2007) Cancer Sci , vol.98 , pp. 1993-2001
    • Wang, D.1    Zhong, Z.Y.2    Li, M.X.3    Xiang, D.B.4    Li, Z.P.5
  • 50
    • 77952062040 scopus 로고    scopus 로고
    • APEX1 gene amplification and its protein overexpression in osteosarcoma: Correlation with recurrence, metastasis, and survival
    • Yang JL, Yang D, Cogdell D, et al: APEX1 gene amplification and its protein overexpression in osteosarcoma: correlation with recurrence, metastasis, and survival. Technol Cancer Res Treat 9: 161-169, 2010.
    • (2010) Technol Cancer Res Treat , vol.9 , pp. 161-169
    • Yang, J.L.1    Yang, D.2    Cogdell, D.3
  • 51
    • 4444336712 scopus 로고    scopus 로고
    • Inhibition of the human apurinic/apyrimidinic endonuclease (APE1) repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone
    • Luo M and Kelley MR: Inhibition of the human apurinic/apyrimidinic endonuclease (APE1) repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone. Anticancer Res 24: 2127-2134, 2004.
    • (2004) Anticancer Res , vol.24 , pp. 2127-2134
    • Luo, M.1    Kelley, M.R.2
  • 52
    • 24044516224 scopus 로고    scopus 로고
    • Isolation of a small molecule inhibitor of base excision repair
    • Madhusudan S, Smart F, Shrimpton P, et al: Isolation of a small molecule inhibitor of base excision repair. Nucleic Acids Res 33: 4711-4724, 2005.
    • (2005) Nucleic Acids Res , vol.33 , pp. 4711-4724
    • Madhusudan, S.1    Smart, F.2    Shrimpton, P.3
  • 53
    • 40849135868 scopus 로고    scopus 로고
    • Potent inhibition of human apurinic/apyrimidinic endonuclease 1 by arylstibonic acids
    • Seiple LA, Cardellina JH II, Akee R and Stivers JT: Potent inhibition of human apurinic/apyrimidinic endonuclease 1 by arylstibonic acids. Mol Pharmacol 73: 669-677, 2008.
    • (2008) Mol Pharmacol , vol.73 , pp. 669-677
    • Seiple, L.A.1    Cardellina, J.H.I.I.2    Akee, R.3    Stivers, J.T.4
  • 54
    • 34548276529 scopus 로고    scopus 로고
    • The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target
    • Fishel ML and Kelley MR: The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target. Mol Aspects Med 28: 375-395, 2007.
    • (2007) Mol Aspects Med , vol.28 , pp. 375-395
    • Fishel, M.L.1    Kelley, M.R.2
  • 55
    • 2242484585 scopus 로고    scopus 로고
    • Expression of genes of potential importance in the response to chemotherapy in osteosarcoma patients
    • In German
    • Nathrath M, Kremer M, Letzel H, Remberger K, Höfler H and Ulle T: Expression of genes of potential importance in the response to chemotherapy in osteosarcoma patients. Klin Padiatr 214: 230-235, 2002 (In German).
    • (2002) Klin Padiatr , vol.214 , pp. 230-235
    • Nathrath, M.1    Kremer, M.2    Letzel, H.3    Remberger, K.4    Höfler, H.5    Ulle, T.6
  • 56
    • 77955661262 scopus 로고    scopus 로고
    • Expressions of ERCC2 and ERCC4 genes in osteosarcoma and peripheral blood lymphocytes and their clinical significance
    • In Chinese
    • Li X, Guo W, Shen DH, Yang RL, Liu J and Zhao H: Expressions of ERCC2 and ERCC4 genes in osteosarcoma and peripheral blood lymphocytes and their clinical significance. Beijing Da Xue Xue Bao 39: 467-471, 2007 (In Chinese).
    • (2007) Beijing Da Xue Xue Bao , vol.39 , pp. 467-471
    • Li, X.1    Guo, W.2    Shen, D.H.3    Yang, R.L.4    Liu, J.5    Zhao, H.6
  • 57
    • 70349678400 scopus 로고    scopus 로고
    • Common variations in ERCC2 are associated with response to cisplatin chemotherapy and clinical outcome in osteosarcoma patients
    • Caronia D, Patiño-García A, Milne RL, Zalacain-Díez M, Pita G, Alonso MR, Moreno LT, et al: Common variations in ERCC2 are associated with response to cisplatin chemotherapy and clinical outcome in osteosarcoma patients. Pharmacogenomics J 9: 347-353, 2009.
    • (2009) Pharmacogenomics J , vol.9 , pp. 347-353
    • Caronia, D.1    Patiño-García, A.2    Milne, R.L.3    Zalacain-Díez, M.4    Pita, G.5    Alonso, M.R.6    Moreno, L.T.7
  • 59
    • 84873614801 scopus 로고    scopus 로고
    • Association of four ERCC1 and ERCC2 SNPs with survival of bone tumour patients
    • Hao T, Feng W, Zhang J, Sun YJ and Wang G: Association of four ERCC1 and ERCC2 SNPs with survival of bone tumour patients. Asian Pac J Cancer Prev 13: 3821-3824, 2012.
    • (2012) Asian Pac J Cancer Prev , vol.13 , pp. 3821-3824
    • Hao, T.1    Feng, W.2    Zhang, J.3    Sun, Y.J.4    Wang, G.5
  • 60
    • 65549167833 scopus 로고    scopus 로고
    • Targeting the mTOR signaling network for cancer therapy
    • Meric-Bernstam F and Gonzalez-Angulo AM: Targeting the mTOR signaling network for cancer therapy. J Clin Oncol 27: 2278-2287, 2009.
    • (2009) J Clin Oncol , vol.27 , pp. 2278-2287
    • Meric-Bernstam, F.1    Gonzalez-Angulo, A.M.2
  • 61
    • 49749093760 scopus 로고    scopus 로고
    • Evaluation of the mammalian target of rapamycin pathway and the effect of rapamycin on target expression and cellular proliferation in osteosarcoma cells from dogs
    • Gordon IK, Ye F and Kent MS: Evaluation of the mammalian target of rapamycin pathway and the effect of rapamycin on target expression and cellular proliferation in osteosarcoma cells from dogs. Am J Vet Res 69: 1079-1084, 2008.
    • (2008) Am J Vet Res , vol.69 , pp. 1079-1084
    • Gordon, I.K.1    Ye, F.2    Kent, M.S.3
  • 62
    • 64549109015 scopus 로고    scopus 로고
    • Targeted therapy of human osteosarcoma with 17AAG or rapamycin: Characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways
    • Gazitt Y, Kolapathi V, Moncada K, Thomas C and Freeman J: Targeted therapy of human osteosarcoma with 17AAG or rapamycin: characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways. Int J Oncol 34: 551-561, 2009.
    • (2009) Int J Oncol , vol.34 , pp. 551-561
    • Gazitt, Y.1    Kolapathi, V.2    Moncada, K.3    Thomas, C.4    Freeman, J.5
  • 63
    • 78650322560 scopus 로고    scopus 로고
    • mTOR/p70S6K signal transduction pathway contributes to osteosarcoma progression and patients' prognosis
    • Zhou Q, Deng Z, Zhu Y, Long H, Zhang S and Zhao J: mTOR/p70S6K signal transduction pathway contributes to osteosarcoma progression and patients' prognosis. Med Oncol 27: 1239-1245, 2010.
    • (2010) Med Oncol , vol.27 , pp. 1239-1245
    • Zhou, Q.1    Deng, Z.2    Zhu, Y.3    Long, H.4    Zhang, S.5    Zhao, J.6
  • 64
    • 40449091406 scopus 로고    scopus 로고
    • Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program
    • Houghton PJ, Morton CL, Kolb EA, et al: Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program. Pediatr Blood Cancer 50: 799-805, 2008.
    • (2008) Pediatr Blood Cancer , vol.50 , pp. 799-805
    • Houghton, P.J.1    Morton, C.L.2    Kolb, E.A.3
  • 65
    • 16844366544 scopus 로고    scopus 로고
    • Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma
    • Wan X, Mendoza A, Khanna C and Helman LJ: Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma. Cancer Res 65: 2406-2411, 2005.
    • (2005) Cancer Res , vol.65 , pp. 2406-2411
    • Wan, X.1    Mendoza, A.2    Khanna, C.3    Helman, L.J.4
  • 66
    • 84890039721 scopus 로고    scopus 로고
    • Rapamycin inhibits ALDH activity, resistance to oxidative stress, and metastatic potential in murine osteosarcoma cells
    • Mu X, Isaac C, Schott T, Huard J and Weiss K: Rapamycin inhibits ALDH activity, resistance to oxidative stress, and metastatic potential in murine osteosarcoma cells. Sarcoma 2013: 480713, 2013.
    • (2013) Sarcoma 2013 , pp. 480713
    • Mu, X.1    Isaac, C.2    Schott, T.3    Huard, J.4    Weiss, K.5
  • 67
    • 0038398622 scopus 로고    scopus 로고
    • The insulin-like growth factor system and cancer
    • LeRoith D and Roberts CT Jr: The insulin-like growth factor system and cancer. Cancer Lett 195: 127-137, 2003.
    • (2003) Cancer Lett , vol.195 , pp. 127-137
    • Leroith, D.1    Roberts Jr., C.T.2
  • 69
    • 84896272413 scopus 로고    scopus 로고
    • Analysis of aberrant signal transduction pathways in osteosarcoma cell lines
    • Chou AJ, Merola PR, Sowers R, et al: Analysis of aberrant signal transduction pathways in osteosarcoma cell lines. Proc Amer Assoc Cancer Res 46: 4551, 2005.
    • (2005) Proc Amer Assoc Cancer Res , vol.46 , pp. 4551
    • Chou, A.J.1    Merola, P.R.2    Sowers, R.3
  • 70
    • 20944447905 scopus 로고    scopus 로고
    • Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors
    • Scotlandi K, Manara MC, Nicoletti G, et al: Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors. Cancer Res 65: 3868-3876, 2005.
    • (2005) Cancer Res , vol.65 , pp. 3868-3876
    • Scotlandi, K.1    Manara, M.C.2    Nicoletti, G.3
  • 71
    • 33845313289 scopus 로고    scopus 로고
    • Down-regulation of insulin-like growth factor I receptor activity by NVP-AEW541 has an antitumor effect on neuroblastoma cells in vitro and in vivo
    • Tanno B, Mancini C, Vitali R, et al: Down-regulation of insulin-like growth factor I receptor activity by NVP-AEW541 has an antitumor effect on neuroblastoma cells in vitro and in vivo. Clin Cancer Res 12: 6772-6780, 2006.
    • (2006) Clin Cancer Res , vol.12 , pp. 6772-6780
    • Tanno, B.1    Mancini, C.2    Vitali, R.3
  • 73
    • 80052702630 scopus 로고    scopus 로고
    • IGF1R-targeted therapy and its enhancement of doxorubicin chemosensitivity in human osteosarcoma cell lines
    • Luk F, Yu Y, Walsh WR and Yang JL: IGF1R-targeted therapy and its enhancement of doxorubicin chemosensitivity in human osteosarcoma cell lines. Cancer Invest 29: 521-532, 2011.
    • (2011) Cancer Invest , vol.29 , pp. 521-532
    • Luk, F.1    Yu, Y.2    Walsh, W.R.3    Yang, J.L.4
  • 74
    • 77955013854 scopus 로고    scopus 로고
    • Lentivirus-mediated shRNA targeting insulin-like growth factor-1 receptor (IGF-1R) enhances chemosensitivity of osteosarcoma cells in vitro and in vivo
    • Wang YH, Xiong J, Wang SF, Yu Y, Wang B, Chen YX, Shi HF and Qiu Y: Lentivirus-mediated shRNA targeting insulin-like growth factor-1 receptor (IGF-1R) enhances chemosensitivity of osteosarcoma cells in vitro and in vivo. Mol Cell Biochem 341: 225-233, 2010.
    • (2010) Mol Cell Biochem , vol.341 , pp. 225-233
    • Wang, Y.H.1    Xiong, J.2    Wang, S.F.3    Yu, Y.4    Wang, B.5    Chen, Y.X.6    Shi, H.F.7    Qiu, Y.8
  • 76
    • 84860389568 scopus 로고    scopus 로고
    • Increased expression of insulin-like growth factor-1 receptor is correlated with tumor metastasis and prognosis in patients with osteosarcoma
    • Wang YH, Han XD, Qiu Y, et al: Increased expression of insulin-like growth factor-1 receptor is correlated with tumor metastasis and prognosis in patients with osteosarcoma. J Surg Oncol 105: 235-243, 2012.
    • (2012) J Surg Oncol , vol.105 , pp. 235-243
    • Wang, Y.H.1    Han, X.D.2    Qiu, Y.3
  • 77
    • 84875543855 scopus 로고    scopus 로고
    • Clinical development of insulin-like growth factor receptor-1 (IGF-1R) inhibitors: At the crossroad?
    • Gombos A, Metzger-Filho O, Dal Lago L and Awada-Hussein A: Clinical development of insulin-like growth factor receptor-1 (IGF-1R) inhibitors: at the crossroad? Invest New Drugs 30: 2433-2442, 2012.
    • (2012) Invest New Drugs , vol.30 , pp. 2433-2442
    • Gombos, A.1    Metzger-Filho, O.2    Dal Lago, L.3    Awada-Hussein, A.4
  • 78
    • 78650750911 scopus 로고    scopus 로고
    • AMG 479 in relapsed or refractory Ewing's family tumors (EFT) or desmoplastic small round cell tumors (DSRCT): Phase II results
    • Tap WD, Demetri GD, Barnette P, et al: AMG 479 in relapsed or refractory Ewing's family tumors (EFT) or desmoplastic small round cell tumors (DSRCT): Phase II results. J Clin Oncol 28: (15 Suppl), 10001, 2010.
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL. , pp. 10001
    • Tap, W.D.1    Demetri, G.D.2    Barnette, P.3
  • 79
    • 84896306368 scopus 로고    scopus 로고
    • Natinoal Institutes of Health: A Study to Determine the Activity of SCH 717454 in Subjects with Relapsed Osteosarcoma or Ewing's Sarcoma (Study P04720AM3), Accessed April 6, 2011
    • Natinoal Institutes of Health: A Study to Determine the Activity of SCH 717454 in Subjects with Relapsed Osteosarcoma or Ewing's Sarcoma (Study P04720AM3). http://clinicaltrials.gov/ct2/show/NCT00617890?term=sch-717454&rank=2. Accessed April 6, 2011.
  • 80
    • 0036500022 scopus 로고    scopus 로고
    • ErbB2 expression is correlated with increased survival of patients with osteosarcoma
    • Akatsuka T, Wada T, Kokai Y, et al: ErbB2 expression is correlated with increased survival of patients with osteosarcoma. Cancer 94: 1397-1404, 2002.
    • (2002) Cancer , vol.94 , pp. 1397-1404
    • Akatsuka, T.1    Wada, T.2    Kokai, Y.3
  • 81
    • 78650847136 scopus 로고    scopus 로고
    • VEGF and EMMPRIN expression correlates with survival of patients with osteosarcoma
    • Zhou Q, Zhu Y, Deng Z, Long H, Zhang S and Chen X: VEGF and EMMPRIN expression correlates with survival of patients with osteosarcoma. Surg Oncol 20: 13-19, 2011.
    • (2011) Surg Oncol , vol.20 , pp. 13-19
    • Zhou, Q.1    Zhu, Y.2    Deng, Z.3    Long, H.4    Zhang, S.5    Chen, X.6
  • 82
    • 38549164180 scopus 로고    scopus 로고
    • Initial testing of the VEGFR inhibitor AZD2171 by the pediatric preclinical testing program
    • Maris JM, Courtright J, Houghton PJ, et al: Initial testing of the VEGFR inhibitor AZD2171 by the pediatric preclinical testing program. Pediatr Blood Cancer 50: 581-587, 2008.
    • (2008) Pediatr Blood Cancer , vol.50 , pp. 581-587
    • Maris, J.M.1    Courtright, J.2    Houghton, P.J.3
  • 83
    • 84864044404 scopus 로고    scopus 로고
    • Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: A report from the children's oncology group
    • Ebb D, Meyers P, Grier H, et al: Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: a report from the children's oncology group. J Clin Oncol 30: 2545-2551, 2012.
    • (2012) J Clin Oncol , vol.30 , pp. 2545-2551
    • Ebb, D.1    Meyers, P.2    Grier, H.3
  • 84
    • 0029097316 scopus 로고
    • Molecular controls of growth arrest and apoptosis: P53-dependent and independent pathways
    • Liebermann DA, Hoffman B and Steinman RA: Molecular controls of growth arrest and apoptosis: p53-dependent and independent pathways. Oncogene 11: 199-210, 1995.
    • (1995) Oncogene , vol.11 , pp. 199-210
    • Liebermann, D.A.1    Hoffman, B.2    Steinman, R.A.3
  • 85
    • 0033368192 scopus 로고    scopus 로고
    • De novo deletions of p53 gene and wild-type p53 correlate with acquired cisplatin-resistance in human osteosarcoma OST cell line
    • Asada N, Tsuchiya H and Tomita K: De novo deletions of p53 gene and wild-type p53 correlate with acquired cisplatin-resistance in human osteosarcoma OST cell line. Anticancer Res 19: 5131-5137, 1999.
    • (1999) Anticancer Res , vol.19 , pp. 5131-5137
    • Asada, N.1    Tsuchiya, H.2    Tomita, K.3
  • 86
    • 34147172345 scopus 로고    scopus 로고
    • p53-R273H gains new function in induction of drug resistance through down-regulation of procaspase-3
    • Wong RP, Tsang WP, Chau PY, Co NN, Tsang TY and Kwok TT: p53-R273H gains new function in induction of drug resistance through down-regulation of procaspase-3. Mol Cancer Ther 6: 1054-1061, 2007.
    • (2007) Mol Cancer Ther , vol.6 , pp. 1054-1061
    • Wong, R.P.1    Tsang, W.P.2    Chau, P.Y.3    Co, N.N.4    Tsang, T.Y.5    Kwok, T.T.6
  • 87
    • 0032749714 scopus 로고    scopus 로고
    • Modulation of cisplatinum cytotoxicity by p53: Effect of p53-mediated apoptosis and DNA repair
    • Fan J and Bertino JR: Modulation of cisplatinum cytotoxicity by p53: effect of p53-mediated apoptosis and DNA repair. Mol Pharmacol 56: 966-972, 1999.
    • (1999) Mol Pharmacol , vol.56 , pp. 966-972
    • Fan, J.1    Bertino, J.R.2
  • 88
    • 0034073148 scopus 로고    scopus 로고
    • Sensitization and caffeine potentiation of cisplatin cytotoxicity resulting from introduction of wild-type p53 gene in human osteosarcoma
    • Tsuchiya H, Mori Y, Ueda Y, Okada G and Tomita K: Sensitization and caffeine potentiation of cisplatin cytotoxicity resulting from introduction of wild-type p53 gene in human osteosarcoma. Anticancer Res 20: 235-242, 2000.
    • (2000) Anticancer Res , vol.20 , pp. 235-242
    • Tsuchiya, H.1    Mori, Y.2    Ueda, Y.3    Okada, G.4    Tomita, K.5
  • 89
    • 0034097572 scopus 로고    scopus 로고
    • Enhancement of drug-induced apoptosis by antisense oligodeoxynucleotides targeted against Mdm2 and p21WAF1/CIP1
    • Sato N, Mizumoto K, Maehara N, Kusumoto M, Nishio S, Urashima T, Ogawa T and Tanaka M: Enhancement of drug-induced apoptosis by antisense oligodeoxynucleotides targeted against Mdm2 and p21WAF1/CIP1. Anticancer Res 20: 837-842, 2000.
    • (2000) Anticancer Res , vol.20 , pp. 837-842
    • Sato, N.1    Mizumoto, K.2    Maehara, N.3    Kusumoto, M.4    Nishio, S.5    Urashima, T.6    Ogawa, T.7    Tanaka, M.8
  • 90
    • 1942469420 scopus 로고    scopus 로고
    • A modified p53 enhances apoptosis in sarcoma cell lines mediated by doxorubicin
    • Tang HJ, Qian D, Sondak VK, Stachura S and Lin J: A modified p53 enhances apoptosis in sarcoma cell lines mediated by doxorubicin. Br J Cancer 90: 1285-1292, 2004.
    • (2004) Br J Cancer , vol.90 , pp. 1285-1292
    • Tang, H.J.1    Qian, D.2    Sondak, V.K.3    Stachura, S.4    Lin, J.5
  • 91
    • 0031839485 scopus 로고    scopus 로고
    • Association of loss of heterozygosity at the p53 locus with chemoresistance in osteosarcomas
    • Goto A, Kanda H, Ishikawa Y, et al: Association of loss of heterozygosity at the p53 locus with chemoresistance in osteosarcomas. Jpn J Cancer Res 89: 539-547, 1998.
    • (1998) Jpn J Cancer Res , vol.89 , pp. 539-547
    • Goto, A.1    Kanda, H.2    Ishikawa, Y.3
  • 92
    • 0006988841 scopus 로고    scopus 로고
    • P53 overexpression as an indicator of overall survival and response to treatment in osteosarcomas
    • Pápai Z, Féja CN, Hanna EN, Sztán M, Oláh E and Szendrôi M: P53 overexpression as an indicator of overall survival and response to treatment in osteosarcomas. Pathol Oncol Res 3: 15-19, 1997.
    • (1997) Pathol Oncol Res , vol.3 , pp. 15-19
    • Pápai, Z.1    Féja, C.N.2    Hanna, E.N.3    Sztán, M.4    Oláh, E.5    Szendrôi, M.6
  • 93
    • 67650137057 scopus 로고    scopus 로고
    • The effect of resistance-related proteins on the prognosis and survival of patients with osteosarcoma: An immunohistochemical analysis
    • In Turkish
    • Ozger H, Eralp L, Atalar AC, et al: The effect of resistance-related proteins on the prognosis and survival of patients with osteosarcoma: an immunohistochemical analysis. Acta Orthop Traumatol Turc 43: 28-34, 2009 (In Turkish).
    • (2009) Acta Orthop Traumatol Turc , vol.43 , pp. 28-34
    • Ozger, H.1    Eralp, L.2    Atalar, A.C.3
  • 94
    • 20144381477 scopus 로고    scopus 로고
    • TP53 mutations and outcome in osteosarcoma: A prospective, multicenter study
    • Wunder JS, Gokgoz N, Parkes R, et al: TP53 mutations and outcome in osteosarcoma: a prospective, multicenter study. J Clin Oncol 23: 1483-1490, 2005.
    • (2005) J Clin Oncol , vol.23 , pp. 1483-1490
    • Wunder, J.S.1    Gokgoz, N.2    Parkes, R.3
  • 95
    • 0031918223 scopus 로고    scopus 로고
    • BCL-2 family: Regulators of cell death
    • Chao DT and Korsmeyer SJ: BCL-2 family: regulators of cell death. Ann Rev Immunol 16: 395-419, 1998.
    • (1998) Ann Rev Immunol , vol.16 , pp. 395-419
    • Chao, D.T.1    Korsmeyer, S.J.2
  • 96
    • 0030979773 scopus 로고    scopus 로고
    • Double identity for proteins of the Bcl-2 family
    • Reed JC: Double identity for proteins of the Bcl-2 family. Nature 387: 773-776, 1997.
    • (1997) Nature , vol.387 , pp. 773-776
    • Reed, J.C.1
  • 97
    • 0033119372 scopus 로고    scopus 로고
    • BCL-2 gene family and the regulation of programmed cell death
    • Korsmeyer SJ: BCL-2 gene family and the regulation of programmed cell death. Cancer Res 59 (7 Suppl): 1693s-1700s, 1999.
    • (1999) Cancer Res , vol.59 , Issue.7 SUPPL.
    • Korsmeyer, S.J.1
  • 98
    • 27844455674 scopus 로고    scopus 로고
    • bcl-2/bax expression and p53 gene status in human bladder cancer: Relationship to early recurrence with intravesical chemotherapy after resection
    • Ye D, Li H, Qian S, Sun Y, Zheng J and Ma Y: bcl-2/bax expression and p53 gene status in human bladder cancer: relationship to early recurrence with intravesical chemotherapy after resection. J Urol 160: 2025-2029, 1998.
    • (1998) J Urol , vol.160 , pp. 2025-2029
    • Ye, D.1    Li, H.2    Qian, S.3    Sun, Y.4    Zheng, J.5    Ma, Y.6
  • 99
    • 0032610195 scopus 로고    scopus 로고
    • The relationship between cisplatin-induced apoptosis and p53, bcl-2 and bax expression in human lung cancer cells
    • Han JY, Chung YJ, Park SW, Kim JS, Rhyu MG, Kim HK and Lee KS: The relationship between cisplatin-induced apoptosis and p53, bcl-2 and bax expression in human lung cancer cells. Korean J Intern Med 14: 42-52, 1999.
    • (1999) Korean J Intern Med , vol.14 , pp. 42-52
    • Han, J.Y.1    Chung, Y.J.2    Park, S.W.3    Kim, J.S.4    Rhyu, M.G.5    Kim, H.K.6    Lee, K.S.7
  • 100
    • 0032743892 scopus 로고    scopus 로고
    • Chemosensitivity of human hepatocellular carcinoma cell line QGY-7703 is related to bcl-2 protein levels
    • Luo D, Cheng SC, Xie H and Xie Y: Chemosensitivity of human hepatocellular carcinoma cell line QGY-7703 is related to bcl-2 protein levels. Tumour Biol 20: 331-340, 1999.
    • (1999) Tumour Biol , vol.20 , pp. 331-340
    • Luo, D.1    Cheng, S.C.2    Xie, H.3    Xie, Y.4
  • 101
    • 4544263294 scopus 로고    scopus 로고
    • Molecular mechanism of chemoresistance to cisplatin in ovarian cancer cell lines
    • Murata T, Haisa M, Uetsuka H, et al: Molecular mechanism of chemoresistance to cisplatin in ovarian cancer cell lines. Int J Mol Med 13: 865-868, 2004.
    • (2004) Int J Mol Med , vol.13 , pp. 865-868
    • Murata, T.1    Haisa, M.2    Uetsuka, H.3
  • 102
    • 0002336719 scopus 로고    scopus 로고
    • Role of apoptosis and apoptosis-related proteins in the cisplatin-resistant phenotype of human tumor cell lines
    • Perego P, Righetti SC, Supino R, et al: Role of apoptosis and apoptosis-related proteins in the cisplatin-resistant phenotype of human tumor cell lines. Apoptosis 2: 540-548, 1997.
    • (1997) Apoptosis , vol.2 , pp. 540-548
    • Perego, P.1    Righetti, S.C.2    Supino, R.3
  • 103
    • 70449715116 scopus 로고    scopus 로고
    • Enhanced chemosensitivity of drug-resistant osteosarcoma cells by lentivirus-mediated Bcl-2 silencing
    • Zhao Y, Zhang CL, Zeng BF, Wu XS, Gao TT and Oda Y: Enhanced chemosensitivity of drug-resistant osteosarcoma cells by lentivirus-mediated Bcl-2 silencing. Biochem Biophys Res Commun 390: 642-647, 2009.
    • (2009) Biochem Biophys Res Commun , vol.390 , pp. 642-647
    • Zhao, Y.1    Zhang, C.L.2    Zeng, B.F.3    Wu, X.S.4    Gao, T.T.5    Oda, Y.6
  • 104
    • 84876270484 scopus 로고    scopus 로고
    • Enhanced chemosensitivity by simultaneously inhibiting cell cycle progression and promoting apoptosis of drug-resistant osteosarcoma MG63/DXR cells by targeting Cyclin D1 and Bcl-2
    • Zhang C, Zhao Y and Zeng B: Enhanced chemosensitivity by simultaneously inhibiting cell cycle progression and promoting apoptosis of drug-resistant osteosarcoma MG63/DXR cells by targeting Cyclin D1 and Bcl-2. Cancer Biomark 12: 155-167, 2012.
    • (2012) Cancer Biomark , vol.12 , pp. 155-167
    • Zhang, C.1    Zhao, Y.2    Zeng, B.3
  • 105
    • 0034629336 scopus 로고    scopus 로고
    • Lack of oxidative phosphorylation and low mitochondrial membrane potential decrease susceptibility to apoptosis and do not modulate the protective effect of Bcl-x(L) in osteosarcoma cells
    • Dey R and Moraes CT: Lack of oxidative phosphorylation and low mitochondrial membrane potential decrease susceptibility to apoptosis and do not modulate the protective effect of Bcl-x(L) in osteosarcoma cells. J Biol Chem 275: 7087-7094, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 7087-7094
    • Dey, R.1    Moraes, C.T.2
  • 106
    • 1342332363 scopus 로고    scopus 로고
    • Antisense to apoptosis inhibitors facilitates chemotherapy and TRAIL-induced death signaling
    • Zangemeister-Wittke U: Antisense to apoptosis inhibitors facilitates chemotherapy and TRAIL-induced death signaling. Ann NY Acad Sci 1002: 90-94, 2003.
    • (2003) Ann NY Acad Sci , vol.1002 , pp. 90-94
    • Zangemeister-Wittke, U.1
  • 107
    • 0034602188 scopus 로고    scopus 로고
    • Role of BAX in the apoptotic response to anticancer agents
    • Zhang L, Yu J, Park BH, et al: Role of BAX in the apoptotic response to anticancer agents. Science 290: 989-992, 2000.
    • (2000) Science , vol.290 , pp. 989-992
    • Zhang, L.1    Yu, J.2    Park, B.H.3
  • 108
    • 44849116896 scopus 로고    scopus 로고
    • Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis
    • Eliseev RA, Dong YF Sampson E, et al: Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis. Oncogene 27: 3605-3614, 2008.
    • (2008) Oncogene , vol.27 , pp. 3605-3614
    • Eliseev, R.A.1    Dong, Y.F.2    Sampson, E.3
  • 109
    • 47249134609 scopus 로고    scopus 로고
    • c-Myc and caspase-2 are involved in activating Bax during cytotoxic drug-induced apoptosis
    • Cao X, Bennett RL and May WS: c-Myc and caspase-2 are involved in activating Bax during cytotoxic drug-induced apoptosis. J Biol Chem 283: 14490-14496, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 14490-14496
    • Cao, X.1    Bennett, R.L.2    May, W.S.3
  • 110
    • 1942498999 scopus 로고    scopus 로고
    • Evaluation of P-glycoprotein, HER-2/ErbB-2, p53, and Bcl-2 in primary tumor and metachronous lung metastases in patients with high-grade osteosarcoma
    • Ferrari S, Bertoni F, Zanella L, et al: Evaluation of P-glycoprotein, HER-2/ErbB-2, p53, and Bcl-2 in primary tumor and metachronous lung metastases in patients with high-grade osteosarcoma. Cancer 100: 1936-1942, 2004.
    • (2004) Cancer , vol.100 , pp. 1936-1942
    • Ferrari, S.1    Bertoni, F.2    Zanella, L.3
  • 111
    • 84858797071 scopus 로고    scopus 로고
    • Expressions of p53, c-MYC, BCL-2 and apoptotic index in human osteosarcoma and their correlations with prognosis of patients
    • Wu X, Cai ZD, Lou LM and Zhu YB: Expressions of p53, c-MYC, BCL-2 and apoptotic index in human osteosarcoma and their correlations with prognosis of patients. Cancer Epidemiol 36: 212-216, 2012.
    • (2012) Cancer Epidemiol , vol.36 , pp. 212-216
    • Wu, X.1    Cai, Z.D.2    Lou, L.M.3    Zhu, Y.B.4
  • 112
    • 77955983894 scopus 로고    scopus 로고
    • Functional and biological analysis of Bcl-xL expression in human osteosarcoma
    • Wang ZX, Yang JS, Pan X, Wang JR, Li J, Yin YM and De W: Functional and biological analysis of Bcl-xL expression in human osteosarcoma. Bone 47: 445-454, 2010.
    • (2010) Bone , vol.47 , pp. 445-454
    • Wang, Z.X.1    Yang, J.S.2    Pan, X.3    Wang, J.R.4    Li, J.5    Yin, Y.M.6    De, W.7
  • 113
    • 36849017898 scopus 로고    scopus 로고
    • Livin and Bcl-2 expression in high-grade osteosarcoma
    • Nedelcu T, Kubista B, Koller A, et al: Livin and Bcl-2 expression in high-grade osteosarcoma. J Cancer Res Clin Oncol 134: 237-244, 2008.
    • (2008) J Cancer Res Clin Oncol , vol.134 , pp. 237-244
    • Nedelcu, T.1    Kubista, B.2    Koller, A.3
  • 114
    • 39749134998 scopus 로고    scopus 로고
    • Prognostic value of bax, bcl-2, and p53 staining in primary osteosarcoma
    • Kaseta MK, Khaldi L, Gomatos IP, et al: Prognostic value of bax, bcl-2, and p53 staining in primary osteosarcoma. J Surg Oncol 97: 259-266, 2008.
    • (2008) J Surg Oncol , vol.97 , pp. 259-266
    • Kaseta, M.K.1    Khaldi, L.2    Gomatos, I.P.3
  • 115
    • 37549031248 scopus 로고    scopus 로고
    • Prognostic value of bax, cytochrome C, and caspase-8 protein expression in primary osteosarcoma
    • Kaseta MK, Gomatos IP, Khaldi L, et al: Prognostic value of bax, cytochrome C, and caspase-8 protein expression in primary osteosarcoma. Hybridoma (Larchmt) 26: 355-362, 2007.
    • (2007) Hybridoma (Larchmt) , vol.26 , pp. 355-362
    • Kaseta, M.K.1    Gomatos, I.P.2    Khaldi, L.3
  • 116
    • 33745713171 scopus 로고    scopus 로고
    • Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
    • Degenhardt K, Mathew R, Beaudoin B, et al: Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 10: 51-64, 2006.
    • (2006) Cancer Cell , vol.10 , pp. 51-64
    • Degenhardt, K.1    Mathew, R.2    Beaudoin, B.3
  • 117
    • 0034537290 scopus 로고    scopus 로고
    • Autophagy as a regulated pathway of cellular degradation
    • Klionsky DJ and Emr SD: Autophagy as a regulated pathway of cellular degradation. Science 290: 1717-1721, 2000.
    • (2000) Science , vol.290 , pp. 1717-1721
    • Klionsky, D.J.1    Emr, S.D.2
  • 118
    • 34548188741 scopus 로고    scopus 로고
    • Self-eating and self-killing: Crosstalk between autophagy and apoptosis
    • Maiuri MC, Zalckvar E, Kimchi A and Kroemer G: Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 8: 741-752, 2007.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 741-752
    • Maiuri, M.C.1    Zalckvar, E.2    Kimchi, A.3    Kroemer, G.4
  • 119
    • 56749170677 scopus 로고    scopus 로고
    • Autophagic cell death: The story of a misnomer
    • Kroemer G and Levine B: Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol 9: 1004-1010, 2008.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 1004-1010
    • Kroemer, G.1    Levine, B.2
  • 120
    • 50349098812 scopus 로고    scopus 로고
    • Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells
    • Han J, Hou W, Goldstein LA, et al: Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells. J Biol Chem 283: 19665-19677, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 19665-19677
    • Han, J.1    Hou, W.2    Goldstein, L.A.3
  • 121
    • 33846794896 scopus 로고    scopus 로고
    • Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma
    • Amaravadi RK, Yu D, Lum JJ, et al: Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest 117: 326-336, 2007.
    • (2007) J Clin Invest , vol.117 , pp. 326-336
    • Amaravadi, R.K.1    Yu, D.2    Lum, J.J.3
  • 122
    • 77958575758 scopus 로고    scopus 로고
    • Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation
    • Carew JS, Medina EC, Esquivel JA II, et al: Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation. J Cell Mol Med 14: 2448-2459, 2010.
    • (2010) J Cell Mol Med , vol.14 , pp. 2448-2459
    • Carew, J.S.1    Medina, E.C.2    Esquivel, J.A.I.I.3
  • 123
    • 77953383616 scopus 로고    scopus 로고
    • Autophagy blockade sensitizes prostate cancer cells towards Src family kinase inhibitors
    • Wu Z, Chang PC, Yang JC, et al: Autophagy blockade sensitizes prostate cancer cells towards Src family kinase inhibitors. Genes Cancer 1: 40-49, 2010.
    • (2010) Genes Cancer , vol.1 , pp. 40-49
    • Wu, Z.1    Chang, P.C.2    Yang, J.C.3
  • 124
    • 77953289524 scopus 로고    scopus 로고
    • Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model
    • Li J, Hou N, Faried A, Tsutsumi S and Kuwano H: Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model. Eur J Cancer 46: 1900-1909, 2010.
    • (2010) Eur J Cancer , vol.46 , pp. 1900-1909
    • Li, J.1    Hou, N.2    Faried, A.3    Tsutsumi, S.4    Kuwano, H.5
  • 125
    • 69949106925 scopus 로고    scopus 로고
    • The double-edged sword of autophagy modulation in cancer
    • White E and DiPaola RS: The double-edged sword of autophagy modulation in cancer. Clin Cancer Res 15: 5308-5316, 2009.
    • (2009) Clin Cancer Res , vol.15 , pp. 5308-5316
    • White, E.1    Dipaola, R.S.2
  • 126
    • 33847008972 scopus 로고    scopus 로고
    • DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells
    • Katayama M, Kawaguchi T, Berger MS and Pieper RO: DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells. Cell Death Differ 14: 548-558, 2007.
    • (2007) Cell Death Differ , vol.14 , pp. 548-558
    • Katayama, M.1    Kawaguchi, T.2    Berger, M.S.3    Pieper, R.O.4
  • 127
    • 34347394714 scopus 로고    scopus 로고
    • Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance
    • Carew JS, Nawrocki ST, Kahue CN, et al: Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance. Blood 110: 313-322, 2007.
    • (2007) Blood , vol.110 , pp. 313-322
    • Carew, J.S.1    Nawrocki, S.T.2    Kahue, C.N.3
  • 128
    • 54249104991 scopus 로고    scopus 로고
    • Autophagy: A novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model
    • Lambert LA, Qiao N, Hunt KK, Lambert DH, Mills GB, Meijer L and Keyomarsi K: Autophagy: a novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model. Cancer Res 68: 7966-7974, 2008.
    • (2008) Cancer Res , vol.68 , pp. 7966-7974
    • Lambert, L.A.1    Qiao, N.2    Hunt, K.K.3    Lambert, D.H.4    Mills, G.B.5    Meijer, L.6    Keyomarsi, K.7
  • 129
    • 58149104056 scopus 로고    scopus 로고
    • The plant alkaloid voacamine induces apoptosis-independent autophagic cell death on both sensitive and multidrug resistant human osteosarcoma cells
    • Meschini S, Condello M, Calcabrini A, et al: The plant alkaloid voacamine induces apoptosis-independent autophagic cell death on both sensitive and multidrug resistant human osteosarcoma cells. Autophagy 4: 1020-1033, 2008.
    • (2008) Autophagy , vol.4 , pp. 1020-1033
    • Meschini, S.1    Condello, M.2    Calcabrini, A.3
  • 130
    • 84876576952 scopus 로고    scopus 로고
    • Cytoprotective role of autophagy during paclitaxel-induced apoptosis in Saos-2 osteosarcoma cells
    • Kim HJ, Lee SG, Kim YJ, Park JE, Lee KY, Yoo YH and Kim JM: Cytoprotective role of autophagy during paclitaxel-induced apoptosis in Saos-2 osteosarcoma cells. Int J Oncol 42: 1985-1992, 2013.
    • (2013) Int J Oncol , vol.42 , pp. 1985-1992
    • Kim, H.J.1    Lee, S.G.2    Kim, Y.J.3    Park, J.E.4    Lee, K.Y.5    Yoo, Y.H.6    Kim, J.M.7
  • 131
    • 77149172547 scopus 로고    scopus 로고
    • Expression of Beclin1 in osteosarcoma and the effects of down-regulation of autophagy on the chemotherapeutic sensitivity
    • Zhang Z, Shao Z, Xiong L, Che B, Deng C and Xu W: Expression of Beclin1 in osteosarcoma and the effects of down-regulation of autophagy on the chemotherapeutic sensitivity. J Huazhong Univ Sci Technolog Med Sci 29: 737-740, 2009.
    • (2009) J Huazhong Univ Sci Technolog Med Sci , vol.29 , pp. 737-740
    • Zhang, Z.1    Shao, Z.2    Xiong, L.3    Che, B.4    Deng, C.5    Xu, W.6
  • 132
    • 80052060417 scopus 로고    scopus 로고
    • RIP3 expression induces a death profile change in U2OS osteosarcoma cells after 5-ALA-PDT
    • Coupienne I, Fettweis G and Piette J: RIP3 expression induces a death profile change in U2OS osteosarcoma cells after 5-ALA-PDT. Lasers Surg Med 43: 557-564, 2011.
    • (2011) Lasers Surg Med , vol.43 , pp. 557-564
    • Coupienne, I.1    Fettweis, G.2    Piette, J.3
  • 133
    • 84855406005 scopus 로고    scopus 로고
    • HMGB1 promotes drug resistance in osteosarcoma
    • Huang J, Ni J, Liu K, et al: HMGB1 promotes drug resistance in osteosarcoma. Cancer Res 72: 230-238, 2012.
    • (2012) Cancer Res , vol.72 , pp. 230-238
    • Huang, J.1    Ni, J.2    Liu, K.3
  • 134
    • 85046981421 scopus 로고    scopus 로고
    • Targeting HMGB1-mediated autophagy as a novel therapeutic strategy for osteosarcoma
    • Huang J, Liu K, Yu Y, et al: Targeting HMGB1-mediated autophagy as a novel therapeutic strategy for osteosarcoma. Autophagy 8: 275-277, 2012.
    • (2012) Autophagy , vol.8 , pp. 275-277
    • Huang, J.1    Liu, K.2    Yu, Y.3
  • 135
    • 33846277696 scopus 로고    scopus 로고
    • Repression of protein synthesis by miRNAs: How many mechanisms?
    • Pillai RS, Bhattacharyya SN and Fillipowicz W: Repression of protein synthesis by miRNAs: how many mechanisms? Trends Cell Biol 17: 118-126, 2007.
    • (2007) Trends Cell Biol , vol.17 , pp. 118-126
    • Pillai, R.S.1    Bhattacharyya, S.N.2    Fillipowicz, W.3
  • 136
    • 20444460289 scopus 로고    scopus 로고
    • MicroRNA expression profiles classify human cancers
    • Lu J, Getz G, Miska EA, et al: MicroRNA expression profiles classify human cancers. Nature 435: 834-838, 2005.
    • (2005) Nature , vol.435 , pp. 834-838
    • Lu, J.1    Getz, G.2    Miska, E.A.3
  • 137
    • 33144490646 scopus 로고    scopus 로고
    • A microRNA expression signature of human solid tumors defines cancer gene targets
    • Volinia S, Calin GA, Liu CG, et al: A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 103: 2257-2261, 2006.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 2257-2261
    • Volinia, S.1    Calin, G.A.2    Liu, C.G.3
  • 138
    • 84856732824 scopus 로고    scopus 로고
    • miR-34a predicts survival of Ewing's sarcoma patients and directly influences cell chemo-sensitivity and malignancy
    • Nakatani F, Ferracin M, Manara MC, et al: miR-34a predicts survival of Ewing's sarcoma patients and directly influences cell chemo-sensitivity and malignancy. J Pathol 226: 796-805, 2012.
    • (2012) J Pathol , vol.226 , pp. 796-805
    • Nakatani, F.1    Ferracin, M.2    Manara, M.C.3
  • 139
    • 79958048319 scopus 로고    scopus 로고
    • Micro-RNA profiles in osteosarcoma as a predictive tool for ifosfamide response
    • Gougelet A, Pissaloux D, Besse A, et al: Micro-RNA profiles in osteosarcoma as a predictive tool for ifosfamide response. Int J Cancer 129: 680-690, 2011.
    • (2011) Int J Cancer , vol.129 , pp. 680-690
    • Gougelet, A.1    Pissaloux, D.2    Besse, A.3
  • 140
    • 70450237022 scopus 로고    scopus 로고
    • Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells
    • Song B, Wang Y, Xi Y, et al: Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells. Oncogene 28: 4065-4074, 2009.
    • (2009) Oncogene , vol.28 , pp. 4065-4074
    • Song, B.1    Wang, Y.2    Xi, Y.3
  • 142
    • 84866436241 scopus 로고    scopus 로고
    • miR-15a and miR-16-1 downregulate CCND1 and induce apoptosis and cell cycle arrest in osteosarcoma
    • Cai CK, Zhao GY, Tian LY, et al: miR-15a and miR-16-1 downregulate CCND1 and induce apoptosis and cell cycle arrest in osteosarcoma. Oncol Rep 28: 1764-1770, 2012.
    • (2012) Oncol Rep , vol.28 , pp. 1764-1770
    • Cai, C.K.1    Zhao, G.Y.2    Tian, L.Y.3
  • 143
    • 78651140052 scopus 로고
    • The role of tumor stem-cells in regrowth of the tumor following drastic applications
    • Makino S: The role of tumor stem-cells in regrowth of the tumor following drastic applications. Acta Unio Int Contra Cancrum 15 (Suppl 1): 196-198, 1959.
    • (1959) Acta Unio Int Contra Cancrum , vol.15 , Issue.SUPPL. 1 , pp. 196-198
    • Makino, S.1
  • 144
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D and Dick JE: Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3: 730-737, 1997.
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 145
    • 0036737914 scopus 로고    scopus 로고
    • Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro
    • Ignatova TN, Kukekov VG, Laywell ED, Suslov ON, Vrionis FD and Steindler DA: Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia 39: 193-206, 2002.
    • (2002) Glia , vol.39 , pp. 193-206
    • Ignatova, T.N.1    Kukekov, V.G.2    Laywell, E.D.3    Suslov, O.N.4    Vrionis, F.D.5    Steindler, D.A.6
  • 146
    • 0141842674 scopus 로고    scopus 로고
    • Identification of a cancer stem cell in human brain tumors
    • Singh SK, Clarke ID, Terasaki M, et al: Identification of a cancer stem cell in human brain tumors. Cancer Res 63: 5821-5828, 2003.
    • (2003) Cancer Res , vol.63 , pp. 5821-5828
    • Singh, S.K.1    Clarke, I.D.2    Terasaki, M.3
  • 147
    • 80155187103 scopus 로고    scopus 로고
    • Cancer stem cells in osteosarcoma: Recent progress and perspective
    • Liu B, Ma W, Jha RK and Gurung K: Cancer stem cells in osteosarcoma: recent progress and perspective. Acta Oncol 50: 1142-1150, 2011.
    • (2011) Acta Oncol , vol.50 , pp. 1142-1150
    • Liu, B.1    Ma, W.2    Jha, R.K.3    Gurung, K.4
  • 148
    • 47949086256 scopus 로고    scopus 로고
    • Cancer stem cells: Markers or biomarkers?
    • Woodward WA and Sulman EP: Cancer stem cells: markers or biomarkers? Cancer Metastasis Rev 27: 459-470, 2008.
    • (2008) Cancer Metastasis Rev , vol.27 , pp. 459-470
    • Woodward, W.A.1    Sulman, E.P.2
  • 149
    • 76749122743 scopus 로고    scopus 로고
    • Resistance of stem-like cells from neuroblastoma cell lines to commonly used chemotherapeutic agents
    • Vangipuram SD, Wang ZJ and Lyman WD: Resistance of stem-like cells from neuroblastoma cell lines to commonly used chemotherapeutic agents. Pediatr Blood Cancer 54: 361-368, 2010.
    • (2010) Pediatr Blood Cancer , vol.54 , pp. 361-368
    • Vangipuram, S.D.1    Wang, Z.J.2    Lyman, W.D.3
  • 150
    • 62149151311 scopus 로고    scopus 로고
    • Identification and expansion of human osteosarcoma-cancer-stem cells by long-term 3-aminobenzamide treatment
    • Di Fiore R, Santulli A, Ferrante RD, et al: Identification and expansion of human osteosarcoma-cancer-stem cells by long-term 3-aminobenzamide treatment. J Cell Physiol 219: 301-313, 2009.
    • (2009) J Cell Physiol , vol.219 , pp. 301-313
    • Di Fiore, R.1    Santulli, A.2    Ferrante, R.D.3
  • 151
    • 67649424217 scopus 로고    scopus 로고
    • Sphere-forming stem-like cell populations with drug resistance in human sarcoma cell lines
    • Fujii H, Honoki K, Tsujiuchi T, Kido A, Yoshitani K and Takakura Y: Sphere-forming stem-like cell populations with drug resistance in human sarcoma cell lines. Int J Oncol 34: 1381-1386, 2009.
    • (2009) Int J Oncol , vol.34 , pp. 1381-1386
    • Fujii, H.1    Honoki, K.2    Tsujiuchi, T.3    Kido, A.4    Yoshitani, K.5    Takakura, Y.6
  • 152
    • 77954351665 scopus 로고    scopus 로고
    • Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance
    • Honoki K, Fujii H, Kubo A, Kido A, Mori T, Tanaka Y and Tsujiuchi T: Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance. Oncol Rep 24: 501-505, 2010.
    • (2010) Oncol Rep , vol.24 , pp. 501-505
    • Honoki, K.1    Fujii, H.2    Kubo, A.3    Kido, A.4    Mori, T.5    Tanaka, Y.6    Tsujiuchi, T.7
  • 153
    • 84859187031 scopus 로고    scopus 로고
    • Therapeutic implications of an enriched cancer stem-like cell population in a human osteosarcoma cell line
    • Martins-Neves SR, Lopes ÁO, do Carmo A, et al: Therapeutic implications of an enriched cancer stem-like cell population in a human osteosarcoma cell line. BMC Cancer 12: 139, 2012.
    • (2012) BMC Cancer , vol.12 , pp. 139
    • Martins-Neves, S.R.1    Lopes, A.O.2    do Carmo, A.3
  • 154
    • 27644497180 scopus 로고    scopus 로고
    • Treatment of osteosarcoma at first recurrence after contemporary therapy: The Memorial Sloan-Kettering Cancer Center experience
    • Chou AJ, Merola PR, Wexler LH, et al: Treatment of osteosarcoma at first recurrence after contemporary therapy: the Memorial Sloan-Kettering Cancer Center experience. Cancer 104: 2214-2221, 2005.
    • (2005) Cancer , vol.104 , pp. 2214-2221
    • Chou, A.J.1    Merola, P.R.2    Wexler, L.H.3
  • 155
    • 19944411434 scopus 로고    scopus 로고
    • Efficacy and safety of liposomal anthracyclines in phase I/II clinical trials
    • Alberts DS, Muggia FM, Carmichael J, et al: Efficacy and safety of liposomal anthracyclines in phase I/II clinical trials. Semin Oncol 31 (Suppl 13): S53-S90, 2004.
    • (2004) Semin Oncol , vol.31 , Issue.SUPPL. 13
    • Alberts, D.S.1    Muggia, F.M.2    Carmichael, J.3
  • 156
    • 84879780600 scopus 로고    scopus 로고
    • Autophagy: Shaping the tumor microenvironment and therapeutic response
    • Maes H, Rubio N, Garg AD and Agostinis P: Autophagy: shaping the tumor microenvironment and therapeutic response. Trends Mol Med 19: 428-446, 2013.
    • (2013) Trends Mol Med , vol.19 , pp. 428-446
    • Maes, H.1    Rubio, N.2    Garg, A.D.3    Agostinis, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.