Overcoming glutathione S-transferase P1-related cisplatin resistance in osteosarcoma

Cancer Research

Volumn 68, Issue 16, 2008, Pages 6661-6668

  Pasello, Michela ^a   Michelacci, Francesca ^a   Scionti, Isabella ^a   Hattinger, Claudia Maria ^a   Zuntini, Monia ^a   Caccuri, Anna Maria ^b   Scotlandi, Katia ^a   Picci, Piero ^a   Serra, Massimo ^a  

^a RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

6 (7 NITRO 2,1,3 BENZOXADIAZOL 4 YL THIO)HEXANOL; ANTINEOPLASTIC AGENT; CISPLATIN; DOXORUBICIN; ENZYME INHIBITOR; GLUTATHIONE TRANSFERASE P1; METHOTREXATE; UNCLASSIFIED DRUG; 6 (7 NITRO 2,1,3 BENZOXADIAZOL 4 YLTHIO)HEXANOL; 6-(7-NITRO-2,1,3-BENZOXADIAZOL-4-YLTHIO)HEXANOL; GSTP1 PROTEIN, HUMAN; OXADIAZOLE DERIVATIVE;

ARTICLE; CANCER CELL CULTURE; CANCER GRADING; CANCER PATIENT; CANCER RELAPSE; DRUG ACTIVITY; ENZYME ACTIVITY; GENETIC ASSOCIATION; HUMAN; IN VITRO STUDY; OSTEOSARCOMA; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; RECURRENCE RISK; APOPTOSIS; BONE TUMOR; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; DRUG INTERACTION; DRUG RESISTANCE; ENZYMOLOGY; METABOLISM; SURVIVAL RATE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BONE NEOPLASMS; CISPLATIN; DOXORUBICIN; DRUG INTERACTIONS; DRUG RESISTANCE, NEOPLASM; GLUTATHIONE S-TRANSFERASE PI; HUMANS; OSTEOSARCOMA; OXADIAZOLES; SURVIVAL RATE; TUMOR CELLS, CULTURED;

EID: 53049088957     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-5840     Document Type: Article

References (29)

1. Asada N, Tsuchiya H, Ueda Y, Tomita K. Establisliment and characterization of an acquired cisplatin-resistant subline in a human osteosarcoma cell line. Anticancer Res 1998;18:1765-8.
2. Komiya S, Gebhardt MC, Mangham DC, Inoue A. Role of glutathione in cisplatin resistance in osteosarcoma cell lines. J Orthop Res 1998;16:15-22.
3. Perego P, Caserini C, Gatti L, et al. A novel trinuclear platinum complex overcomes cisplatin resistance in an osteosarcoma cell system. Mol Pharmacol 1999;55:528-34.
4. Martelli L, Di Mario F, Botti P, Ragazzi E, Martelli M, Kelland L. Accumulation, platinum-DNA adduct formation and cytotoxicity of cisplatin, oxaliplatin and satraplatin in sensitive and resistant human osteosarcoma cell lines, characterized by p53 wild-type status. Biochem Pharmacol 2007;74:20-7.
5. Siddik ZH. Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 2003;22:7265-79.
6. Kelland LR. Preclinical perspectives on platinum resistance. Drugs 2000;59:1-8.
7. Tew KD, Monks A, Barone L, et al. Glutathioneassociated enzymes in the human cell lines of the National Cancer Institute Drug Screening Program. Mol Pharmacol 1996;50:149-59.
8. Goto S, lida T, Cho S, Oka M, Kohno S, Kondo T. Overexpression of glutathione S-transferase π enhances the adduct formation of cisplatin with glutathione in human cancer cells. Free Radic Res 1999;31:549-58.
9. Ricci G, De Maria F, Antonini G, et al. 7-Nitro-2,1,3-benzoxadiazole derivatives, a new class of suicide inhibitors for glutathione S-transferases. Mechanism of action of potential anticancer drugs. J Biol Chem 2005; 280:26397-405.
10. Turella P, Cerella C, Filomeni G, et al. Proapoptotic activity of new glutathione S-transferase inhibitors. Cancer Res 2005;65:3751-61.
11. Turella P, Filomeni G, Dupuis ML, et al. A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells. 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells. J Biol Chem 2006;281:23725-32.
12. Benini S, Baldini N, Manara MC, et al. Redundancy of autocrine loops in human osteosarcoma cells. Int J Cancer 1999;581-8.
13. Serra M, Scotlandi K, Manara MC, et al. Establishment and characterization of multidrug-resistant human osteosarcoma cell lines. Anticancer Res 1993;13:323-9.
14. Serra M, Reverter-Branchat G, Maurici D, et al. Analysis of dihydrofolate reductase and reduced folate carrier gene status in relation to methotrexate resistance in osteosarcoma cells. Ann Oncol 2004;15:151-60.
15. Pasello M, Hattinger CM, Stoico G, et al. 4-Demethoxy-3-deamino-3'- aziridinyl-4'-methylsulphonyl-daunorubicin (PNU-159548): a promising new candidate for chemotherapeutic treatment of osteosarcoma patients. Eur J Cancer 2005;41:2184-95.
16. Chou TC, Motzer RJ, Tong Y, Bosl GJ. Computerized quantitation of synergism and antagonism of Taxol, topotecan and cisplatin against teratocarcinoma cell growth: a rational approach to clinical protocol design. J Natl Cancer Inst 1994;86:1517-24.
17. Molenaar C, Teuben J-M, Heetebrij RJ, Tanke HJ, Reedijk J. New insights in the cellular processing of platinum antitumor compounds, using fluorophorelabeled platinum complexes and digital fluorescence microscopy. J Biol Inorg Chem 2000;5:655-65.
18. Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974;249:7130-9.
19. Mannervik B, Alin P, Guthenberg C, et al. Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties. Proc Natl Acad Sci U S A 1985;82:7202-6.
20. Chou AJ, Gorlick R. Chemotherapy resistance in osteosarcoma: current challenges and future directions. Expert Rev Anticancer Ther 2006;6:1075-85.
21. Ferrari S, Palmerini E. Adjuvant and neoadjuvant combination chemotherapy for osteogenic osteosarcoma. Curr Opin Oncol 2007; 19:341-6.
22. Giaccone G. Clinical perspectives on platinum resistance. Drugs 2000;59:9-17.
23. Townsend DM, Tew KD. The role of glutathione-S-transferase in anti-cancer drug resistance. Oncogene 2003;22:7369-75.
24. Huang G, Mills L, Worth LL. Expression of human glutathione S-transferase P1 mediates the chemosensitivity of osteosarcoma cells. Mol Cancer Ther 2007;6:1610-9.
25. MacCorkle RA, Tan TH. Mitogen-activated protein kinases in cell cycle control. Cell Biochem Biophys 2005; 43:451-61.
26. Goto S, Ihara Y, Urata Y, et al. Doxorubicininduced DNA intercalation and scavenging by nuclear glutathione S-transferase π. FASEB J 2001;15:2702-14.
27. Cullen KJ, Newkirk KA, Schumaker LM, Aldosari N, Rone JD, Haddad BR. Glutathione S-transferase amplification is associated with cisplatin resistance in head and neck squamos cell carcinoma cell lines and primary tumors. Cancer Res 2003;63:8097-102.
28. Ali-Osman F, Brunner JM, Kutluk TM, Hess K. Prognostic significance of glutathione S-transferase π expression and subcellular localization in human gliomas. Clin Cancer Res 1997;3:2253-61.
29. Uozaki H, Horiuchi H, Ishida T, Iijima T, Imamura T, Machinami R. Overexpression of resistance-related proteins (metallothioneins, glutathione-S-transferase pi, heat shock protein 27, and lung resistance-related protein) in osteosarcoma. Relationship with poor prognosis. Cancer 1997;12:2336-44.