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Volumn 1690, Issue 2, 2004, Pages 110-117

Functional analysis of altered reduced folate carrier sequence changes identified in osteosarcomas

Author keywords

(E) GFP; (enhanced) green fluorescent protein; Biotin succinimide, sulfo NHS SS biotin; Biotinylation; Fusion protein; HRP; Methotrexate; Osteosarcomas; Reduced folate carrier; sulfosuccinimidyl 2 (biotinamido) ethyl 1,3 dithiopropionate

Indexed keywords

ALANINE; ASPARAGINE; GLUTAMIC ACID; GLYCINE; GREEN FLUORESCENT PROTEIN; ISOLEUCINE; LEUCINE; LYSINE; METHIONINE; METHOTREXATE; PROLINE; REDUCED FOLATE CARRIER; SERINE; THREONINE; TRYPTOPHAN; VALINE;

EID: 4644251592     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2004.05.008     Document Type: Article
Times cited : (25)

References (31)
  • 3
    • 0031861214 scopus 로고    scopus 로고
    • Intensification of preoperative chemotherapy for osteogenic sarcoma: The results of the Memorial Sloan-Kettering (T12) protocol
    • Meyers P.A., Gorlick R., Heller G., Casper E., Lane J., Huvos A.G., Healy J.H. Intensification of preoperative chemotherapy for osteogenic sarcoma: the results of the Memorial Sloan-Kettering (T12) protocol. J. Clin. Oncol. 16:1998;2452-2458
    • (1998) J. Clin. Oncol. , vol.16 , pp. 2452-2458
    • Meyers, P.A.1    Gorlick, R.2    Heller, G.3    Casper, E.4    Lane, J.5    Huvos, A.G.6    Healy, J.H.7
  • 4
    • 0018091466 scopus 로고
    • High-dose methotrexate in osteogenic sarcoma: A 5-year experience
    • Jaffe N., Frei E., Watts H., Traggis D. High-dose methotrexate in osteogenic sarcoma: a 5-year experience. Cancer Treat. Rep. 62:1978;259-264
    • (1978) Cancer Treat. Rep. , vol.62 , pp. 259-264
    • Jaffe, N.1    Frei, E.2    Watts, H.3    Traggis, D.4
  • 5
    • 0026002081 scopus 로고
    • Treatment of osteosarcoma of the extremities with the T-10 protocol, with emphasis on the effects of preoperative chemotherapy with single-agent high-dose methotrexate: A Scandinavian Sarcoma group study
    • Seater G., Alvegard T.A., Elomaa I., Stenwig A.E., Holmstrom T., Solheim O.P. Treatment of osteosarcoma of the extremities with the T-10 protocol, with emphasis on the effects of preoperative chemotherapy with single-agent high-dose methotrexate: a Scandinavian Sarcoma group study. J. Clin. Oncol. 9:1991;1766-1775
    • (1991) J. Clin. Oncol. , vol.9 , pp. 1766-1775
    • Seater, G.1    Alvegard, T.A.2    Elomaa, I.3    Stenwig, A.E.4    Holmstrom, T.5    Solheim, O.P.6
  • 6
    • 0031943038 scopus 로고    scopus 로고
    • Predictive factors of histologic response to primary chemotherapy in osteosarcoma of the extremity: Study of 272 patients preoperatively treated with high-dose methotrexate, doxorubicin, and cisplatin
    • Bacci G., Ferrari S., Delepine N., Bertoni F., Picci P., Mercuri M., Bacchini P., Brach del Prever A., Tienghi A., Comandone A., Campanacci M. Predictive factors of histologic response to primary chemotherapy in osteosarcoma of the extremity: study of 272 patients preoperatively treated with high-dose methotrexate, doxorubicin, and cisplatin. J. Clin. Oncol. 16:1998;658-663
    • (1998) J. Clin. Oncol. , vol.16 , pp. 658-663
    • Bacci, G.1    Ferrari, S.2    Delepine, N.3    Bertoni, F.4    Picci, P.5    Mercuri, M.6    Bacchini, P.7    Brach Del Prever, A.8    Tienghi, A.9    Comandone, A.10    Campanacci, M.11
  • 7
    • 0029009264 scopus 로고
    • Dose escalation with pharmacokinetics monitoring in methotrexate chemotherapy of osteosarcoma
    • Delepine N., Delepine G., Cornille H., Brion F., Arnaud P., Desbois J.C. Dose escalation with pharmacokinetics monitoring in methotrexate chemotherapy of osteosarcoma. Anticancer Res. 15:1995;489-494
    • (1995) Anticancer Res. , vol.15 , pp. 489-494
    • Delepine, N.1    Delepine, G.2    Cornille, H.3    Brion, F.4    Arnaud, P.5    Desbois, J.C.6
  • 9
    • 0142150087 scopus 로고    scopus 로고
    • Reduced folate carrier protein expression in osteosarcoma
    • Ifergan I., Meller I., Issakov I., Assaraf Y.G. Reduced folate carrier protein expression in osteosarcoma. Cancer. 98:2003;1958-1966
    • (2003) Cancer , vol.98 , pp. 1958-1966
    • Ifergan, I.1    Meller, I.2    Issakov, I.3    Assaraf, Y.G.4
  • 11
    • 0032807982 scopus 로고    scopus 로고
    • Carrier-mediated membrane transport of folates in mammalian cells
    • Sirotnak F.M., Tolner B. Carrier-mediated membrane transport of folates in mammalian cells. Annu. Rev. Nutr. 19:1999;91-122
    • (1999) Annu. Rev. Nutr. , vol.19 , pp. 91-122
    • Sirotnak, F.M.1    Tolner, B.2
  • 13
    • 0020598269 scopus 로고
    • Transport of methotrexate in Chinese hamster ovary cells: A mutant defective in methotrexate uptake and binding
    • Flintoff W.F., Nagainis C.R. Transport of methotrexate in Chinese hamster ovary cells: a mutant defective in methotrexate uptake and binding. Arch. Biochem. Biophys. 233:1983;433-440
    • (1983) Arch. Biochem. Biophys. , vol.233 , pp. 433-440
    • Flintoff, W.F.1    Nagainis, C.R.2
  • 14
    • 0033523092 scopus 로고    scopus 로고
    • Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion
    • Ferguson P.L., Flintoff W.F. Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion. J. Biol. Chem. 274:1999;16269-16278
    • (1999) J. Biol. Chem. , vol.274 , pp. 16269-16278
    • Ferguson, P.L.1    Flintoff, W.F.2
  • 15
    • 0034163511 scopus 로고    scopus 로고
    • Mutations in the reduced folate carrier affect protein localization and stability
    • Sadlish H., Murray R.C., Williams F.M.R., Flintoff W.F. Mutations in the reduced folate carrier affect protein localization and stability. Biochem. J. 346:2000;509-516
    • (2000) Biochem. J. , vol.346 , pp. 509-516
    • Sadlish, H.1    Murray, R.C.2    Williams, F.M.R.3    Flintoff, W.F.4
  • 16
    • 0027963626 scopus 로고
    • Isolation of a hamster cDNA clone coding for a function involved in methotrexate uptake
    • Williams F.M.R., Murray R.C., Underhill T.M., Flintoff W.F. Isolation of a hamster cDNA clone coding for a function involved in methotrexate uptake. J. Biol. Chem. 269:1994;5810-5816
    • (1994) J. Biol. Chem. , vol.269 , pp. 5810-5816
    • Williams, F.M.R.1    Murray, R.C.2    Underhill, T.M.3    Flintoff, W.F.4
  • 17
    • 0024586477 scopus 로고
    • Mutant Chinese hamster ovary cells with defective methotrexate uptake are distinguishable by reversion analysis
    • Underhill T.M., Flintoff W.F. Mutant Chinese hamster ovary cells with defective methotrexate uptake are distinguishable by reversion analysis. Somat. Cell Mol. Genet. 15:1989;49-59
    • (1989) Somat. Cell Mol. Genet. , vol.15 , pp. 49-59
    • Underhill, T.M.1    Flintoff, W.F.2
  • 18
    • 0036828910 scopus 로고    scopus 로고
    • Functional role of Arginine 373 in substrate translocation by the reduced folate carrier
    • Sadlish H., Williams F.M.R., Flintoff W.F. Functional role of Arginine 373 in substrate translocation by the reduced folate carrier. J. Biol. Chem. 277:2002;42105-42112
    • (2002) J. Biol. Chem. , vol.277 , pp. 42105-42112
    • Sadlish, H.1    Williams, F.M.R.2    Flintoff, W.F.3
  • 20
    • 0032478826 scopus 로고    scopus 로고
    • A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate
    • Zhao R., Assaraf Y.G., Goldman I.D. A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate. J. Biol. Chem. 273:1998;7873-7879
    • (1998) J. Biol. Chem. , vol.273 , pp. 7873-7879
    • Zhao, R.1    Assaraf, Y.G.2    Goldman, I.D.3
  • 21
    • 0142135129 scopus 로고    scopus 로고
    • The region between transmembrane domains 1 and 2 of the reduced folate carrier forms part of the substrate binding pocket
    • Flintoff W.F., Williams F.M.R., Sadlish H. The region between transmembrane domains 1 and 2 of the reduced folate carrier forms part of the substrate binding pocket. J. Biol. Chem. 278:2003;40861-40876
    • (2003) J. Biol. Chem. , vol.278 , pp. 40861-40876
    • Flintoff, W.F.1    Williams, F.M.R.2    Sadlish, H.3
  • 22
    • 0042828873 scopus 로고    scopus 로고
    • Characterization of a cysteine-less human reduced folate carrier: Localization of a substrate binding domain by cysteine-scanning mutagenesis and cysteine accessibility methods
    • Cao W., Matherly L.H. Characterization of a cysteine-less human reduced folate carrier: localization of a substrate binding domain by cysteine-scanning mutagenesis and cysteine accessibility methods. Biochem. J. 374:2003;27-36
    • (2003) Biochem. J. , vol.374 , pp. 27-36
    • Cao, W.1    Matherly, L.H.2
  • 23
    • 0033975105 scopus 로고    scopus 로고
    • Role of the amino acid 45 residue in reduced folate carrier function and ion-transport as characterized by site-directed mutagenesis
    • Zhao R., Gao F., Wang P.J., Goldman I.D. Role of the amino acid 45 residue in reduced folate carrier function and ion-transport as characterized by site-directed mutagenesis. Mol. Pharmacol. 57:2000;317-323
    • (2000) Mol. Pharmacol. , vol.57 , pp. 317-323
    • Zhao, R.1    Gao, F.2    Wang, P.J.3    Goldman, I.D.4
  • 24
    • 0034613382 scopus 로고    scopus 로고
    • Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake
    • Drori S., Jansen G., Mauritz R., Peters G.J., Assaraf Y.G. Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake. J. Biol. Chem. 275:2000;30855-30863
    • (2000) J. Biol. Chem. , vol.275 , pp. 30855-30863
    • Drori, S.1    Jansen, G.2    Mauritz, R.3    Peters, G.J.4    Assaraf, Y.G.5
  • 25
    • 0036936617 scopus 로고    scopus 로고
    • Role of the E45K-reduced folate carrier gene mutation in methotrexate resistance in human leukemia cells
    • Gifford A.J., Haber M., Witt T.L., Whetsine J.R., Taub J.W., Matherly L.H., Norris M.D. Role of the E45K-reduced folate carrier gene mutation in methotrexate resistance in human leukemia cells. Leukemia. 16:2002;2379-2387
    • (2002) Leukemia , vol.16 , pp. 2379-2387
    • Gifford, A.J.1    Haber, M.2    Witt, T.L.3    Whetsine, J.R.4    Taub, J.W.5    Matherly, L.H.6    Norris, M.D.7
  • 26
    • 0020059356 scopus 로고
    • Preoperative chemotherapy for osteogenic sarcoma: Selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy
    • Rosen G., Caparros B., Huvos A.G., Kosloff C., Nirenberg A., Cacavio A., Marcove R.C., Lane J.M., Mehta B., Urban C. Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy. Cancer. 49:1982;1221-1230
    • (1982) Cancer , vol.49 , pp. 1221-1230
    • Rosen, G.1    Caparros, B.2    Huvos, A.G.3    Kosloff, C.4    Nirenberg, A.5    Cacavio, A.6    Marcove, R.C.7    Lane, J.M.8    Mehta, B.9    Urban, C.10
  • 27
    • 0028887425 scopus 로고
    • Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake
    • Williams F.M.R., Flintoff W.F. Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake. J. Biol. Chem. 270:1995;2987-2992
    • (1995) J. Biol. Chem. , vol.270 , pp. 2987-2992
    • Williams, F.M.R.1    Flintoff, W.F.2
  • 28
    • 0029084385 scopus 로고
    • Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells
    • Wong S.C., Proefke S.A., Bhushan A., Matherly L.H. Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells. J. Biol. Chem. 270:1995;17468-17475
    • (1995) J. Biol. Chem. , vol.270 , pp. 17468-17475
    • Wong, S.C.1    Proefke, S.A.2    Bhushan, A.3    Matherly, L.H.4
  • 29
    • 0035204297 scopus 로고    scopus 로고
    • Expression of the reduced folate carrier SLC19A1 in IEC-6 cells results in two distinct transport activities
    • Rajgopal A., Sierra E.E., Zhao R., Goldman I.D. Expression of the reduced folate carrier SLC19A1 in IEC-6 cells results in two distinct transport activities. Am. J. Physiol., Cell Physiol. 281:2001;C1579-C1586
    • (2001) Am. J. Physiol., Cell Physiol. , vol.281
    • Rajgopal, A.1    Sierra, E.E.2    Zhao, R.3    Goldman, I.D.4
  • 30
    • 0017031624 scopus 로고
    • Genetic characteristics of methotrexate resistant Chinese hamster ovary cells
    • Flintoff W.F., Spindler S.M., Siminovitch L. Genetic characteristics of methotrexate resistant Chinese hamster ovary cells. In Vitro. 12:1976;749-757
    • (1976) In Vitro , vol.12 , pp. 749-757
    • Flintoff, W.F.1    Spindler, S.M.2    Siminovitch, L.3
  • 31
    • 0035955602 scopus 로고    scopus 로고
    • Methylation-dependent silencing of the reduced folate carrier gene in inherently methotrexate-resistant human breast cancer cells
    • Worm J., Kirkin A.F., Dzhandhugazyan K.N., Guldberg P. Methylation-dependent silencing of the reduced folate carrier gene in inherently methotrexate-resistant human breast cancer cells. J. Biol. Chem. 276:2001;39990-40000
    • (2001) J. Biol. Chem. , vol.276 , pp. 39990-40000
    • Worm, J.1    Kirkin, A.F.2    Dzhandhugazyan, K.N.3    Guldberg, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.