The plant alkaloid voacamine induces apoptosis-independent autophagic cell death on both sensitive and multidrug resistant human osteosarcoma cells

Autophagy

Volumn 4, Issue 8, 2008, Pages 1020-1033

  Meschini, Stefania ^a   Condello, Maria ^a   Calcabrini, Annarica ^a   Marra, Manuela ^a   Formisano, Giuseppe ^a   Lista, Pasquale ^a   De Milito, Angelo ^a   Federici, Elena ^a   Arancia, Giuseppe ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Autophagy; Cell death; Multidrug resistance; Osteosarcoma cells; Voacamine

Indexed keywords

ALKALOID; ANTINEOPLASTIC AGENT; DANSYLCADAVERINE; DOXORUBICIN; FLUORESCEIN ISOTHIOCYANATE; GLYCOPROTEIN P; MICROTUBULE ASSOCIATED PROTEIN 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SMALL INTERFERING RNA; STAUROSPORINE; UNCLASSIFIED DRUG; VOACAMINE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL DEATH; CHEMOSENSITIZATION; CONTROLLED STUDY; ELECTRON MICROSCOPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIGHT CHAIN; MULTIDRUG RESISTANCE; OSTEOSARCOMA CELL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RNA INTERFERENCE; WILD TYPE;

PESCHIERA FUCHSIAEFOLIA;

EID: 58149104056     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.6952     Document Type: Article

References (39)

1. Dunn WA. Autophagy and related mechanisms of lysosome-mediated protein degradation. Trends Cell Biol 1994; 4:139-43.
2. Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science 2000; 290:1717-21.
3. Wang CW, Klionsky DJ. The molecular mechanism of autophagy. Mol Med 2003; 9:65-76.
4. Meijer AJ, Codogno P. Regulation and role of autophagy in mammalian cells. Int J Biochem Cell Biol 2004; 36:2445-62.
5. Eskelinen EL. Maturation of autophagic vacuoles in mammalian cells. Autophagy 2005; 1:1-10.
6. Kondo Y, Kanzawa T, Sawaya R, Kondo S. The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 2005; 5:726-34.
7. Kroemer G, Jäättelä M. Lysosomes and autophagy in cell death control. Nat Rev Cancer 2005; 5:886-97.
8. Jin S, White E. Role of autophagy in cancer. Autophagy 2007; 3:28-31.
9. Codogno P, Meijer AJ. Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ 2005; 12:1509-18.
10. Gonzales-Polo RA, Boya P, Pauleau AL, Jalil A, Larochette N, Souquere S, Eskelinen EL, Pierron G, Saftig P, Kroemer G. The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death. J Cell Science 2005; 118:3091-102.
11. Kondo Y, Kondo S. Autophagy and Cancer Therapy. Autophagy 2006; 2:85-90.
12. Ricci MS, Zong WX. Chemotherapeutic approaches for targeting cell death pathways. Oncologist 2006; 11:342-57.
13. Meschini S, Marra M, Calcabrini A, Federici E, Galeffi C, Arancia G. Voacamine, a bisindolic alkaloid from Peschiera fuchsiaefolia, enhances the cytotoxic effect of doxorubicin on multidrug resistant tumor cells. Int J Oncol 2003; 23:1505-13.
14. Federici E, Palazzino G, Nicoletti M, Galeffi C. Antiplasmodial activity of the alkaloids of Peschiera fuchsiaefolia. Planta Med 2000; 66:93-5.
15. Meschini S, Marra M, Condello M, Calcabrini A, Federici E, Dupuis ML, Cianfriglia M, Arancia G. Voacamine, an alkaloid extracted from Peschiera fuchsiaefolia, inhibits P-glycoprotein action in multidrug resistant tumor cells. Int J Oncol 2005; 27:1597-603.
16. Meschini S, Condello M, Marra M, Formisano G, Federici E, Arancia G. Autophagymediated chemosensitizing effect of the plant alkaloid voacamine on multidrug resistant cells. Toxicol In Vitro 2007; 21:197-203.
17. Serra M, Scotlandi K, Manara MC, Maurici D, Lollini P, De Giovanni C, Toffoli G, Baldini N. Establishment and characterization of multidrug resistant human osteosarcoma cell lines. Anticancer Res 1993; 13:323-30.
18. Patel T, Gores GJ, Kaufmann SH. The role of proteases during apoptosis. FASEB J 1996; 10:587-97.
19. Khalah A, Khosravi-Far R. The mitochondrial death patway. Adv Exp Med Biol 2008; 615:25-45.
20. Biederbick A, Kern HF, Elsasser HP. Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles. Eur J Cell Biol 1995; 66:3-14.
21. Seglen PO, Gordon PB. 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci USA 1982; 79:1889-92.
22. Blommaart EF, Krause U, Schellens JP, Vreeling-Sindelárová H, Meijer AJ. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur J Biochem 1997; 243:240-6.
23. Yamamoto A, Tagawa Y, Yoshimori T, Moriyama Y, Masaki R, Tashiro Y. Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cells, H-4-II-E cells. Cell Struct Funct 1998; 23:33-42.
24. Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. LC3, a mammalian homologue of yeast Apg8p is localized in autophagosomes membranes after processing. EMBO J 2000; 19:5720-8.
25. Kabeya Y, Mizushima N, Yamamoto A, Oshitani-Okamoto S, Ohsumi Y, Yoshimori T. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form II formation. J Cell Sci 2004; 117:2805-12.
26. Tanida I, Ueno T, Kominami E. LC3 conjugation system in mammalian autophagy. Int J Biochem Cell Biol 2004; 36:2503-18.
27. Tanida I, Minematsu-Ikeguchi N, Ueno T, Kominami E. Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy. Autophagy 2005; 1:84-91.
28. Klionsky DJ. The molecular machinery of autophagy: unanswered questions. J Cell Sci 2005; 118:7-18.
29. Fengsrud M, Seglen PQ. Ultrastructural and immunocytochemical characterization of autophagic vacuoles in isolated hepatocytes: effects of vinblastine and asparagines on vacuole distributions. Exp Cell Res 1995; 221:504-19.
30. Rez G, Kovacs J. Time course of vinblastine-induced autophagocytosis and changes in the endoplasmic reticulum in murine pancreatic acinar cells: a morphometric and biochemical study. Eur J Cell Biol 1996; 71:341-50.
31. Johnstone RW, Smyth MJ. P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death. Blood 1999; 93:1075-85.
32. Rueflii AA, Johnstone RW. HMBA induces activation of a caspase-independent cell death pathway to overcome P-glycoprotein-mediated multidrug resistance. Blood 2000; 95:2378-85.
33. Longley DB, Johnston PG. Molecular mechanisms of drug resistance. J Pathol 2005; 205:275-92.
34. Prommier Y, Kohn KW. Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks. Oncogene 2004; 23:2934-49.
35. Lecoeur H, Gougeon ML. Oncosis is associated with exposure of phosphatidylserine residues on the outside layer of the plasma membrane: a reconsideration of the specificity of the annexinV/propidium iodide assay. Cytometry 2001; 44:65-72.
36. May GL, Wright LC, Dyne M, Mackinnon WB, Fox RM, Mountford CE. Plasma membrane lipid composition of vinblastine sensitive and resistant human leukaemic lymphoblasts. Int J Cancer 1988; 42:728-33.
37. Klionsky DJ. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 2007; 8:931-7.
38. Paglin S, Hollister T, Delohery T, Hackett N, McMahill M, Sphicas E, Domingo D, Yahalom J. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 2001; 61:439-44.
39. Kanzawa T, Germano IM, Komata T, Ito H, Kondo Y, Kondo S. Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ 2004; 11:448-57.