Molecular cloning and characterization of Brugia malayi thymidylate kinase

Acta Tropica

Volumn 133, Issue 1, 2014, Pages 83-92

  Doharey, Pawan Kumar ^a   Suthar, Manish Kumar ^a   Verma, Anita ^a   Kumar, Vikash ^a   Yadav, Sunita ^a   Balaramnavar, Vishal M ^a   Rathaur, Sushma ^b   Saxena, Anil Kumar ^a   Siddiqi, Mohammad Imran ^a   Saxena, Jitendra Kumar ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b BANARAS HINDU UNIVERSITY   (India)

Author keywords

Brugia malayi; Drug target; Enzyme inhibition; Homology modelling and docking; Substrate specificity; Thymidylate kinase

Indexed keywords

ADENOSINE TRIPHOSPHATE; BROXURIDINE; CLOXURIDINE; COMPLEMENTARY DNA; DIVALENT CATION; DNA; MAGNESIUM; NUCLEOSIDE ANALOG; THYMIDINE PHOSPHATE; THYMIDINE TRIPHOSPHATE; ZIDOVUDINE;

CHEMOTHERAPY; COLIFORM BACTERIUM; DRUG; ENZYME ACTIVITY; GENE; HOMOLOGY; INHIBITION; SUBSTRATE;

ARTICLE; BINDING SITE; BONE TURNOVER; BRUGIA MALAYI; CATALYSIS; CIRCULAR DICHROISM; DNA SYNTHESIS; ENZYME ACTIVITY; ESCHERICHIA COLI; FILARIA; GEL FILTRATION CHROMATOGRAPHY; GENETIC CODE; LYMPHATIC FILARIASIS; MOLECULAR CLONING; MOLECULAR MODEL; MOLECULAR WEIGHT; NONHUMAN; PH; PHYLOGENY; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; TEMPERATURE; WESTERN BLOTTING;

BRUGIA MALAYI; DRUG TARGET; ENZYME INHIBITION; HOMOLOGY MODELLING AND DOCKING; SUBSTRATE SPECIFICITY; THYMIDYLATE KINASE;

ANIMALS; BRUGIA MALAYI; CATALYTIC DOMAIN; CATIONS, DIVALENT; CHROMATOGRAPHY, GEL; CLONING, MOLECULAR; ENZYME ACTIVATORS; ENZYME INHIBITORS; ENZYME STABILITY; ESCHERICHIA COLI; GENE EXPRESSION; HYDROGEN-ION CONCENTRATION; MAGNESIUM; MODELS, MOLECULAR; MOLECULAR WEIGHT; NUCLEOSIDE-PHOSPHATE KINASE; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; TEMPERATURE;

EID: 84896053835     PISSN: 0001706X     EISSN: 18736254     Source Type: Journal    
DOI: 10.1016/j.actatropica.2014.02.003     Document Type: Article

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