Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: From hit to lead generation

Journal of Medicinal Chemistry

Volumn 55, Issue 2, 2012, Pages 852-870

  Choi, Jun Yong ^a   Plummer, Mark S ^b   Starr, Jeremy ^b   Desbonnet, Charlene R ^b   Soutter, Holly ^b   Chang, Jeanne ^b   Miller, J Richard ^b   Dillman, Keith ^b   Miller, Alita A ^b   Roush, William R ^a  

^a Scripps Florida ^*  (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 6 (PYRIDIN 3 YL) 1H IMIDAZO[4,5 B]PYRIDIN 2 (3H) ONE; 1 METHYL 6 (PYRIDIN 4 YL) 1H IMIDAZO[4,5 B]PYRIDIN 2 (3H) ONE; 1 METHYL 6 (PYRIMIDIN 5 YL) 1H IMIDAZO[4,5 B]PYRIDIN 2 (3H) ONE; 1 METHYL 6 PHENYL 1H IMIDAZO[4,5 B]PYRIDIN 2 (3H) ONE; 1 METHYL 6 PHENYL 3 TRITYL 1H IMIDAZO[4,5 B]PYRIDIN 2 (3H) ONE; 2 [3 (1 METHYL 2 OXO 2,3 DIHYDRO 1H IMIDAZO[4,5 B]PYRIDIN 6 YL)BENZAMIDO]ACETIC ACID; 2 [3 (1 METHYL 2 OXO 2,3 DIHYDRO 1H IMIDAZO[4,5 B]PYRIDIN 6 YL)BENZAMIDO]ETHANESULFONIC ACID; 3 (1 METHYL 2 OXO 2,3 DIHYDRO 1H IMIDAZO[4,5 B]PYRIDIN 6 YL)BENZAMIDE; 3 (1 METHYL 2 OXO 2,3 DIHYDRO 1H IMIDAZO[4,5 B]PYRIDIN 6 YL)BENZENESULFONAMIDE; 3 (1 METHYL 2 OXO 2,3 DIHYDRO 1H IMIDAZO[4,5 B]PYRIDIN 6 YL)BENZONITRILE; 3 (1 METHYL 2 OXO 3 TRITYL 2,3 DIHYDRO 1H IMIDAZO[4,5 B]PYRIDIN 6 YL)BENZOIC ACID; 4 (1 METHYL 2 OXO 2,3 DIHYDRO 1H IMIDAZO[4,5 B]PYRIDIN 6 YL)BENZAMIDE; 6 (3 ACETYLPHENYL) 1 METHYL 1H IMIDAZO[4,5 B]PYRIDIN 2 (3H) ONE; 6 (3 AMINOPHENYL) 1 METHYL 1H IMIDAZO[4,5 B]PYRIDIN 2 (3H) ONE; 6 (3 FLUOROPHENYL) 1 METHYL 1H IMIDAZO[4,5 B]PYRIDIN 2 (3H) ONE; 6 (3 HYDROXYPHENYL) 1 METHYL 1H IMIDAZO[4,5 B]PYRIDIN 2 (3H) ONE; 6 (4 HYDROXYPHENYL) 1 METHYL 1H IMIDAZO[4,5 B]PYRIDIN 2 (3H) ONE; 6 [3 (AMINOMETHYL)PHENYL] 1 METHYL 1H IMIDAZO[4,5 B]PYRIDIN 2 (3H) ONE; 6 [3 (HYDROXYMETHYL)PHENYL] 1 METHYL 1H IMIDAZO[4,5 B]PYRIDIN 2 (3H) ONE; 6 [4 (AMINOMETHYL)PHENYL] 1 METHYL 1H IMIDAZO[4,5 B]PYRIDIN 2 (3H) ONE; 6 BROMO 1 METHYL 3 TRITYL 1H IMIDAZO[4,5 B]PYRIDIN 2 (3H) ONE; N (2 AMINO 2 OXOETHYL) 3 (1 METHYL 2 OXO 2,3 DIHYDRO 1H IMIDAZO[4,5 B]PYRIDIN 6 YL)BENZAMIDE; N (3 (1 METHYL 2 OXO 2,3 DIHYDRO 1H IMIDAZO[4,5 B]PYRIDIN 6 YL)PHENYL)ACETAMIDE; N METHYL 3 (1 METHYL 2 OXO 2,3 DIHYDRO 1H IMIDAZO[4,5 B] PYRIDIN 6 YL)BENZAMIDE; N,N DIMETHYL 3 (1 METHYL 2 OXO 2,3 DIHYDRO 1H IMIDAZO[4,5 B] PYRIDIN 6 YL)BENZAMIDE; PENTAFLUOROPHENYL 3 (1 METHYL 2 OXO 3 TRITYL 2,3 DIHYDRO 1H IMIDAZO[4,5 B]PYRIDIN 6 YL)BENZOATE; THYMIDINE KINASE; THYMIDINE KINASE INHIBITOR; THYMIDINE TRIPHOSPHATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL MEMBRANE PERMEABILITY; COMPUTER AIDED DESIGN; CROSS COUPLING REACTION; CRYSTAL STRUCTURE; DNA REPLICATION; DRUG BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; HYDROGEN BOND; IC 50; PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; CRYSTALLOGRAPHY, X-RAY; HUMANS; IMIDAZOLES; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; NUCLEOSIDE-PHOSPHATE KINASE; PROTEIN BINDING; PSEUDOMONAS AERUGINOSA; PYRIDINES; PYRIMIDINES; SEQUENCE ALIGNMENT; THYMIDINE;

EID: 84863052844     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201349f     Document Type: Article

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