Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 Å resolution: Implications for catalysis and AZT activation

Biochemistry

Volumn 37, Issue 11, 1998, Pages 3677-3686

  Lavie, Amon ^a   Konrad, Manfred ^b   Brundiers, Ralf ^b   Goody, Roger S ^b   Schlichting, Ilme ^b   Reinstein, Jochen ^b  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOTRANSFERASE; THYMIDINE PHOSPHATE; ZIDOVUDINE;

ARTICLE; ENZYME CONFORMATION; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; ESCHERICHIA COLI; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SACCHAROMYCES CEREVISIAE;

BIOTRANSFORMATION; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DINUCLEOSIDE PHOSPHATES; ENZYME ACTIVATION; FUNGAL PROTEINS; HERPESVIRUS 1, HUMAN; HUMANS; KINETICS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; NUCLEOSIDE-PHOSPHATE KINASE; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; ZIDOVUDINE;

ESCHERICHIA COLI; SACCHAROMYCES CEREVISIAE;

EID: 0032539978     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9720787     Document Type: Article

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