Carbocyclic thymidine derivatives efficiently inhibit Plasmodium falciparum thymidylate kinase (PfTMK)

Parasitology International

Volumn 61, Issue 3, 2012, Pages 501-503

  Kato, Aya ^a   Yasuda, Yuri ^a   Kitamura, Yoshiaki ^a   Kandeel, Mahmoud ^a,b   Kitade, Yukio ^a  

^a GIFU UNIVERSITY   (Japan)

^b Kafrelsheikh University   (Egypt)

Author keywords

Anti malaria drug; Carbocyclic nucleoside; Carbocyclic thymidine analog; Enzyme inhibitor; Plasmodium falciparum; Thymidylate kinase

Indexed keywords

1 [2',3' DIHYDROXY 4' (HYDROXYMETHYL)CYCLOPENTYL] 1H THYMINE; 1 [2',3' EPOXY 4' (HYDROXYMETHYL)CYCLOPENTYL] 1H THYMINE; 2 DEOXYGUANOSINE MONOPHOSPHATE; ANTIMALARIAL AGENT; CARBOXYLIC ACID DERIVATIVE; ENZYME INHIBITOR; PURINE; THYMIDINE; THYMIDINE KINASE; THYMIDINE PHOSPHATE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; DRUG POTENCY; DRUG TARGETING; ENZYME INHIBITION; ENZYME SPECIFICITY; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANTIMALARIALS; DEOXYGUANINE NUCLEOTIDES; ENZYME INHIBITORS; NUCLEOSIDE-PHOSPHATE KINASE; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THYMIDINE; THYMIDINE MONOPHOSPHATE;

PLASMODIUM FALCIPARUM;

EID: 84861481451     PISSN: 13835769     EISSN: 18730329     Source Type: Journal    
DOI: 10.1016/j.parint.2012.03.001     Document Type: Article

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