Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase: New insights into the phosphoryl transfer mechanism

Journal of Biological Chemistry

Volumn 278, Issue 7, 2003, Pages 4963-4971

  Haouz, Ahmed ^a   Vanheusden, Veerle ^b   Munier Lehmann, Hélène ^a   Froeyen, Mattheus ^c   Herdewijn, Piet ^c   Van Calenbergh, Serge ^b   Delarue, Marc ^a  

^a INSTITUT PASTEUR   (France)

^b GHENT UNIVERSITY   (Belgium)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CATALYSIS; CONFORMATIONS; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; SYNTHESIS (CHEMICAL); YEAST;

BINDING PROPERTIES;

ENZYME INHIBITION;

ENZYME INHIBITOR; MAGNESIUM ION; PHOSPHOTRANSFERASE; THYMIDYLATE KINASE; THYMIDYLATE KINASE INHIBITOR; UNCLASSIFIED DRUG; NUCLEOSIDE MONOPHOSPHATE KINASE;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; ENZYME INHIBITOR INTERACTION; INHIBITION KINETICS; MOLECULAR DYNAMICS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; X RAY DIFFRACTION; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYMOLOGY; METABOLISM; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

ESCHERICHIA COLI; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

CATALYTIC DOMAIN; DRUG DESIGN; ENZYME INHIBITORS; MYCOBACTERIUM TUBERCULOSIS; NUCLEOSIDE-PHOSPHATE KINASE; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0038136960     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209630200     Document Type: Article

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