Structures of human thymidylate kinase in complex with prodrugs: Implications for the structure-based design of novel compounds

Biochemistry

Volumn 42, Issue 9, 2003, Pages 2568-2577

  Ostermann, Nils ^a,e   Segur Peña, Dario ^b   Meier, Chris ^c   Veit, Thomas ^a,f   Monnerjahn, Christian ^d   Konrad, Manfred ^d   Lavie, Arnon ^a,b  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c UNIVERSITY OF HAMBURG   (Germany)

^d MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^e NOVARTIS PHARMA AG   (Switzerland)

^f EVONIK INDUSTRIES AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; DRUG PRODUCTS; ENZYMES; MOLECULAR STRUCTURE; PHOSPHATES;

NUCLEOSIDE ANALOGUE PRODRUGS;

BIOCHEMISTRY;

NUCLEOSIDE DERIVATIVE; PHOSPHOTRANSFERASE; PRODRUG; PYROPHOSPHORIC ACID DERIVATIVE; THYMIDINE PHOSPHATE; THYMIDYLATE KINASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CATALYSIS; CONFORMATIONAL TRANSITION; CORRELATION ANALYSIS; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; ENZYME CONFORMATION; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; HUMAN; PRIORITY JOURNAL; STEADY STATE;

ANTI-HIV AGENTS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; KINETICS; MACROMOLECULAR SUBSTANCES; NUCLEOSIDE-PHOSPHATE KINASE; PRODRUGS; PROTEIN CONFORMATION; STAVUDINE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THYMIDINE; THYMIDINE MONOPHOSPHATE;

EID: 0242500963     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi027302t     Document Type: Article

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