Thymidylate kinase of Mycobacterium tuberculosis: A chimera sharing properties common to eukaryotic and bacterial enzymes

Protein Science

Volumn 10, Issue 6, 2001, Pages 1195-1205

  Munier Lehmann, Hélène ^a   Chaffotte, Alain ^a   Pochet, Sylvie ^a   Labesse, Gilles ^b  

^a INSTITUT PASTEUR   (France)

^b CENTRE DE BIOCHIMIE STRUCTURALE   (France)

Author keywords

Circular dichroism; Fluorescence spectroscopy; Molecular modeling; Structure function relationship; Tuberculosis

Indexed keywords

BACTERIAL ENZYME; THYMIDINE KINASE;

ARTICLE; CHIMERA; CIRCULAR DICHROISM; COMPETITIVE INHIBITION; ENZYME METABOLISM; FLUORESCENCE SPECTROSCOPY; MOLECULAR MODEL; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PHOSPHORYLATION;

AMINO ACID SEQUENCE; CATALYSIS; CIRCULAR DICHROISM; ELECTROPHORESIS, POLYACRYLAMIDE GEL; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM TUBERCULOSIS; NUCLEOSIDE-PHOSPHATE KINASE; PHOSPHORYLATION; PLASMIDS; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROMETRY, FLUORESCENCE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TEMPERATURE; THERMODYNAMICS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; EUKARYOTA; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 0035000378     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.45701     Document Type: Article

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