A new family of inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

Nucleosides, Nucleotides and Nucleic Acids

Volumn 26, Issue 8-9, 2007, Pages 1057-1061

  Gasse, C ^a   Huteau, V ^a   Douguet, D ^b   Munier Lehmann, H ^a   Pochet, S ^a  

^a INSTITUT PASTEUR   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 THYMIDYLMETHYL PHENYL) PROPIONAMIDE; AMIDE; BACTERIAL ENZYME; CARBOXYLIC ACID DERIVATIVE; PROPIONAMIDE DERIVATIVE; THYMIDINE KINASE; THYMIDINE KINASE INHIBITOR; THYMIDINE PHOSPHATE; THYMIDYLATE KINASE; UNCLASSIFIED DRUG;

ALKYLATION; ANTIBACTERIAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG TARGETING; ENZYME INHIBITION; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE ANALYSIS; TUBERCULOSIS;

ALGORITHMS; ANTITUBERCULAR AGENTS; CATALYTIC DOMAIN; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NUCLEOSIDE-PHOSPHATE KINASE;

MYCOBACTERIUM TUBERCULOSIS;

EID: 36849051189     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770701513349     Document Type: Article

References (8)

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2. Li de la Sierra, I.; et al. X-ray structure of TMP kinase from Mycobacterium tuberculosis complexed with TMP at 1.95 A resolution. J. Mol. Biol. 2001, 311, 87-100.
3. Fioravanti, E.; et al. Mycobacterium tuberculosis thymidylate kinase: structural studies of intermediates along the reaction pathway. J. Mol. Biol. 2003, 327, 1077-1092.
4. Pochet, S.; Dugúe, L.; Douguet, D.; Labesse, G.; Munier-Lehmann, H. Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications. ChemBioChem 2002, 3, 108-110.
5. Pochet, S.; Dugúe, L.; Labesse, G.; Delepierre, M.; Munier-Lehmann, H. Comparative study of purine and pyrimidine nucleoside analogues acting on thymidylate kinases of Mycobacterium tuberculosis and of humans. ChemBioChem 2003, 4, 742-747.
6. Vanheusden, V.; et al. 3′-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase. J. Med. Chem. 2003, 46, 3811-3821.
7. Vanheusden, V.; et al. Synthesis and biological evaluation of thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase. Bioorg. Med. Chem. Lett. 2002, 12, 2695-2698.
8. Douguet, D.; Munier-Lehmann, H.; Labesse, G.; Pochet, S. LEA3D: A computer-aided ligand design for structure-based drug design. J. Med. Chem. 2005, 48, 2457-2468.