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Volumn 171, Issue 5, 2014, Pages 1129-1141

The GPCR, class C, group 6, subtype A (GPRC6A) receptor: From cloning to physiological function

Author keywords

7TM receptor; amino acid sensing; divalent cation sensing; GPRC6A; knockout mouse

Indexed keywords

ALPHA AMINO ACID; ARGININE; ARGININE DERIVATIVE; CALCIUM ION; G PROTEIN COUPLED RECEPTOR; GPRC6A PROTEIN; INSULIN; LYSINE DERIVATIVE; MESSENGER RNA; ORNITHINE DERIVATIVE; OSTEOCALCIN; TESTOSTERONE; UNCLASSIFIED DRUG;

EID: 84895170979     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12365     Document Type: Review
Times cited : (90)

References (76)
  • 1
    • 34347336424 scopus 로고    scopus 로고
    • Stress, eating and the reward system
    • Adam TC, Epel ES, (2007). Stress, eating and the reward system. Physiol Behav 91: 449-458.
    • (2007) Physiol Behav , vol.91 , pp. 449-458
    • Adam, T.C.1    Epel, E.S.2
  • 3
    • 28244475075 scopus 로고    scopus 로고
    • The gene repertoire and the common evolutionary history of glutamate, pheromone (V2R), taste(1) and other related G protein-coupled receptors
    • Bjarnadõttir TK, Fredriksson R, Schiöth HB, (2005). The gene repertoire and the common evolutionary history of glutamate, pheromone (V2R), taste(1) and other related G protein-coupled receptors. Gene 362: 70-84.
    • (2005) Gene , vol.362 , pp. 70-84
    • Bjarnadõttir, T.K.1    Fredriksson, R.2    Schiöth, H.B.3
  • 4
    • 33845973375 scopus 로고    scopus 로고
    • Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors
    • Bräuner-Osborne H, Wellendorph P, Jensen AA, (2007). Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors. Curr Drug Targets 8: 169-184.
    • (2007) Curr Drug Targets , vol.8 , pp. 169-184
    • Bräuner-Osborne, H.1    Wellendorph, P.2    Jensen, A.A.3
  • 6
    • 36448995359 scopus 로고    scopus 로고
    • High-resolution crystal structure of an engineered human β2-adrenergic G protein-coupled receptor
    • Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, et al. (2007). High-resolution crystal structure of an engineered human β2-adrenergic G protein-coupled receptor. Science 318: 1258-1265.
    • (2007) Science , vol.318 , pp. 1258-1265
    • Cherezov, V.1    Rosenbaum, D.M.2    Hanson, M.A.3    Rasmussen, S.G.4    Thian, F.S.5    Kobilka, T.S.6
  • 7
    • 33645809317 scopus 로고    scopus 로고
    • Activity of L-α-amino acids at the promiscuous goldfish odorant receptor 5.24
    • Christiansen B, Wellendorph P, Bräuner-Osborne H, (2006a). Activity of L-α-amino acids at the promiscuous goldfish odorant receptor 5.24. Eur J Pharmacol 536: 98-101.
    • (2006) Eur J Pharmacol , vol.536 , pp. 98-101
    • Christiansen, B.1    Wellendorph, P.2    Bräuner-Osborne, H.3
  • 8
    • 33646550835 scopus 로고    scopus 로고
    • Known regulators of nitric oxide synthase and arginase are agonists at the human G-protein-coupled receptor GPRC6A
    • Christiansen B, Wellendorph P, Bräuner-Osborne H, (2006b). Known regulators of nitric oxide synthase and arginase are agonists at the human G-protein-coupled receptor GPRC6A. Br J Pharmacol 147: 855-863.
    • (2006) Br J Pharmacol , vol.147 , pp. 855-863
    • Christiansen, B.1    Wellendorph, P.2    Bräuner-Osborne, H.3
  • 9
    • 33947311829 scopus 로고    scopus 로고
    • Pharmacological characterization of mouse GPRC6A, an L-α-amino acid receptor with ability to sense divalent cations
    • Christiansen B, Hansen KB, Wellendorph P, Bräuner-Osborne H, (2007). Pharmacological characterization of mouse GPRC6A, an L-α-amino acid receptor with ability to sense divalent cations. Br J Pharmacol 150: 798-807.
    • (2007) Br J Pharmacol , vol.150 , pp. 798-807
    • Christiansen, B.1    Hansen, K.B.2    Wellendorph, P.3    Bräuner-Osborne, H.4
  • 10
    • 14944379046 scopus 로고    scopus 로고
    • An orphan receptor adopted by a family of transmitters
    • Civelli O, (2005). An orphan receptor adopted by a family of transmitters. Mol Pharmacol 67: 583-584.
    • (2005) Mol Pharmacol , vol.67 , pp. 583-584
    • Civelli, O.1
  • 11
    • 84867045005 scopus 로고    scopus 로고
    • L-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances
    • Clemmensen C, Madsen A, Smajilovic S, Holst B, Bräuner-Osborne H, (2012). L-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances. Amino Acids 43: 1265-1275.
    • (2012) Amino Acids , vol.43 , pp. 1265-1275
    • Clemmensen, C.1    Madsen, A.2    Smajilovic, S.3    Holst, B.4    Bräuner-Osborne, H.5
  • 14
    • 23444434108 scopus 로고
    • Homeostatic signals. Marriage of the flytrap and the serpent
    • Conklin BR, Bourne HR, (1994). Homeostatic signals. Marriage of the flytrap and the serpent. Nature 367: 22.
    • (1994) Nature , vol.367 , pp. 22
    • Conklin, B.R.1    Bourne, H.R.2
  • 15
    • 79952069515 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels
    • Dehghan A, Dupuis J, Barbalic M, Bis JC, Eiriksdottir G, Lu C, et al. (2011). Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation 123: 731-738.
    • (2011) Circulation , vol.123 , pp. 731-738
    • Dehghan, A.1    Dupuis, J.2    Barbalic, M.3    Bis, J.C.4    Eiriksdottir, G.5    Lu, C.6
  • 16
    • 79251591614 scopus 로고    scopus 로고
    • A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors
    • Doumazane E, Scholler P, Zwier JM, Trinquet E, Rondard P, Pin J-P, (2011). A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors. FASEB J 25: 66-77.
    • (2011) FASEB J , vol.25 , pp. 66-77
    • Doumazane, E.1    Scholler, P.2    Zwier, J.M.3    Trinquet, E.4    Rondard, P.5    Pin, J.-P.6
  • 17
    • 84865116618 scopus 로고    scopus 로고
    • Antiandrogen gold nanoparticles dual-target and overcome treatment resistance in hormone-insensitive prostate cancer cells
    • Dreaden EC, Gryder BE, Austin LA, Tene Defo BA, Hayden SC, Pi M, et al. (2012). Antiandrogen gold nanoparticles dual-target and overcome treatment resistance in hormone-insensitive prostate cancer cells. Bioconjug Chem 23: 1507-1512.
    • (2012) Bioconjug Chem , vol.23 , pp. 1507-1512
    • Dreaden, E.C.1    Gryder, B.E.2    Austin, L.A.3    Tene Defo, B.A.4    Hayden, S.C.5    Pi, M.6
  • 18
    • 70849106449 scopus 로고    scopus 로고
    • Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor
    • Faure H, Gorojankina T, Rice N, Dauban P, Dodd RH, Bräuner-Osborne H, et al. (2009). Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor. Cell Calcium 46: 323-332.
    • (2009) Cell Calcium , vol.46 , pp. 323-332
    • Faure, H.1    Gorojankina, T.2    Rice, N.3    Dauban, P.4    Dodd, R.H.5    Bräuner-Osborne, H.6
  • 21
    • 0035914405 scopus 로고    scopus 로고
    • Heterodimerization of calcium sensing receptors with metabotropic glutamate receptors in neurons
    • Gama L, Wilt SG, Breitwieser GE, (2001). Heterodimerization of calcium sensing receptors with metabotropic glutamate receptors in neurons. J Biol Chem 276: 39053-39059.
    • (2001) J Biol Chem , vol.276 , pp. 39053-39059
    • Gama, L.1    Wilt, S.G.2    Breitwieser, G.E.3
  • 22
    • 78651276763 scopus 로고    scopus 로고
    • The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: Human and rodent perspectives
    • Garland T, Jr, Schutz H, Chappell MA, Keeney BK, Meek TH, Copes LE, et al. (2011). The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectives. J Exp Med 214: 206-229.
    • (2011) J Exp Med , vol.214 , pp. 206-229
    • Garland Jr., T.1    Schutz, H.2    Chappell, M.A.3    Keeney, B.K.4    Meek, T.H.5    Copes, L.E.6
  • 24
    • 84864221004 scopus 로고    scopus 로고
    • A new era of GPCR structural and chemical biology
    • Granier S, Kobilka B, (2012). A new era of GPCR structural and chemical biology. Nat Chem Biol 8: 670-673.
    • (2012) Nat Chem Biol , vol.8 , pp. 670-673
    • Granier, S.1    Kobilka, B.2
  • 25
    • 80052571011 scopus 로고    scopus 로고
    • Nutrient sensing receptors in gastric endocrine cells
    • Haid D, Widmayer P, Breer H, (2011). Nutrient sensing receptors in gastric endocrine cells. J Mol Histol 42: 355-364.
    • (2011) J Mol Histol , vol.42 , pp. 355-364
    • Haid, D.1    Widmayer, P.2    Breer, H.3
  • 26
    • 84865137463 scopus 로고    scopus 로고
    • Receptors responsive to protein breakdown products in G-cells and d-cells of mouse, swine and human
    • Haid DC, Jordan-Biegger C, Widmayer P, Breer H, (2012). Receptors responsive to protein breakdown products in G-cells and d-cells of mouse, swine and human. Front Physiol 3: 65.
    • (2012) Front Physiol , vol.3 , pp. 65
    • Haid, D.C.1    Jordan-Biegger, C.2    Widmayer, P.3    Breer, H.4
  • 29
    • 84873138013 scopus 로고    scopus 로고
    • Nutrient sensing in the gut: New roads to therapeutics?
    • Janssen S, Depoortere I, (2013). Nutrient sensing in the gut: new roads to therapeutics? Trends Endocrinol Metab 24: 92-100.
    • (2013) Trends Endocrinol Metab , vol.24 , pp. 92-100
    • Janssen, S.1    Depoortere, I.2
  • 30
    • 0036843081 scopus 로고    scopus 로고
    • The dance of the clams: Twists and turns in the family C GPCR homodimer
    • Jensen AA, Greenwood JR, Bräuner-Osborne H, (2002). The dance of the clams: twists and turns in the family C GPCR homodimer. Trends Pharmacol Sci 23: 491-493.
    • (2002) Trends Pharmacol Sci , vol.23 , pp. 491-493
    • Jensen, A.A.1    Greenwood, J.R.2    Bräuner-Osborne, H.3
  • 32
    • 0032030262 scopus 로고    scopus 로고
    • Effect of septic shock on nitrate, free amino acids, and urea in murine plasma and urine
    • Komarov AM, Reddy MN, (1998). Effect of septic shock on nitrate, free amino acids, and urea in murine plasma and urine. Clin Biochem 31: 107-111.
    • (1998) Clin Biochem , vol.31 , pp. 107-111
    • Komarov, A.M.1    Reddy, M.N.2
  • 33
    • 17444394482 scopus 로고    scopus 로고
    • Cloning and characterization of a family C orphan G-protein coupled receptor
    • Kuang D, Yao Y, Lam J, Tsushima RG, Hampson DR, (2005). Cloning and characterization of a family C orphan G-protein coupled receptor. J Neurochem 93: 383-391.
    • (2005) J Neurochem , vol.93 , pp. 383-391
    • Kuang, D.1    Yao, Y.2    Lam, J.3    Tsushima, R.G.4    Hampson, D.R.5
  • 34
    • 33749017040 scopus 로고    scopus 로고
    • Ancestral reconstruction of the ligand-binding pocket of Family C G protein-coupled receptors
    • Kuang D, Yao Y, Maclean D, Wang M, Hampson DR, Chang BS, (2006). Ancestral reconstruction of the ligand-binding pocket of Family C G protein-coupled receptors. Proc Natl Acad Sci U S A 103: 14050-14055.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 14050-14055
    • Kuang, D.1    Yao, Y.2    Maclean, D.3    Wang, M.4    Hampson, D.R.5    Chang, B.S.6
  • 35
    • 0032512921 scopus 로고    scopus 로고
    • 2+-sensing function of the metabotropic glutamate receptors
    • 2+-sensing function of the metabotropic glutamate receptors. Science 279: 1722-1725.
    • (1998) Science , vol.279 , pp. 1722-1725
    • Kubo, Y.1    Miyashita, T.2    Murata, Y.3
  • 36
    • 33645474088 scopus 로고    scopus 로고
    • Differential effects of exercise on body weight gain and adiposity in obesity-prone and -resistant rats
    • Levin BE, Dunn-Meynell AA, (2006). Differential effects of exercise on body weight gain and adiposity in obesity-prone and -resistant rats. Int J Obes 30: 722-727.
    • (2006) Int J Obes , vol.30 , pp. 722-727
    • Levin, B.E.1    Dunn-Meynell, A.A.2
  • 37
    • 84861469775 scopus 로고    scopus 로고
    • Replication and fine mapping for association of the C2orf43, FOXP4, GPRC6A and RFX6 genes with prostate cancer in the Chinese population
    • Long QZ, Du YF, Ding XY, Li X, Song WB, Yang Y, et al. (2012). Replication and fine mapping for association of the C2orf43, FOXP4, GPRC6A and RFX6 genes with prostate cancer in the Chinese population. PLoS ONE 7: e37866.
    • (2012) PLoS ONE , vol.7
    • Long, Q.Z.1    Du, Y.F.2    Ding, X.Y.3    Li, X.4    Song, W.B.5    Yang, Y.6
  • 38
    • 77349102726 scopus 로고    scopus 로고
    • Distribution pattern of GPRC6A mRNA in mouse tissue by in situ hybridization
    • Luo J, Liu Z, Liu J, Eugene CY, (2010). Distribution pattern of GPRC6A mRNA in mouse tissue by in situ hybridization. Zhong Nan Da Xue Xue Bao Yi Xue Ban 35: 1-10.
    • (2010) Zhong Nan da Xue Xue Bao Yi Xue Ban , vol.35 , pp. 1-10
    • Luo, J.1    Liu, Z.2    Liu, J.3    Eugene, C.Y.4
  • 39
    • 8544260348 scopus 로고    scopus 로고
    • Molecular determinants of ligand selectivity in a vertebrate odorant receptor
    • Luu P, Acher F, Bertrand HO, Fan J, Ngai J, (2004). Molecular determinants of ligand selectivity in a vertebrate odorant receptor. J Neurosci 24: 10128-10137.
    • (2004) J Neurosci , vol.24 , pp. 10128-10137
    • Luu, P.1    Acher, F.2    Bertrand, H.O.3    Fan, J.4    Ngai, J.5
  • 40
    • 84862560443 scopus 로고    scopus 로고
    • The regulation of K- and L-cell activity by GLUT2 and the calcium-sensing receptor CasR in rat small intestine
    • Mace OJ, Schindler M, Patel S, (2012). The regulation of K- and L-cell activity by GLUT2 and the calcium-sensing receptor CasR in rat small intestine. J Physiol 590: 2917-2936.
    • (2012) J Physiol , vol.590 , pp. 2917-2936
    • Mace, O.J.1    Schindler, M.2    Patel, S.3
  • 41
    • 34247210665 scopus 로고    scopus 로고
    • Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
    • Muto T, Tsuchiya D, Morikawa K, Jingami H, (2007). Structures of the extracellular regions of the group II/III metabotropic glutamate receptors. Proc Natl Acad Sci U S A 104: 3759-3764.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 3759-3764
    • Muto, T.1    Tsuchiya, D.2    Morikawa, K.3    Jingami, H.4
  • 44
    • 0027295942 scopus 로고
    • The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins
    • O'Hara PJ, Sheppard PO, Thøgersen H, Venezia D, Haldeman BA, McGrane V, et al. (1993). The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins. Neuron 11: 41-52.
    • (1993) Neuron , vol.11 , pp. 41-52
    • O'Hara, P.J.1    Sheppard, P.O.2    Thøgersen, H.3    Venezia, D.4    Haldeman, B.A.5    McGrane, V.6
  • 45
    • 84863995921 scopus 로고    scopus 로고
    • GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes
    • Orlandi C, Posokhova E, Masuho I, Ray TA, Hasan N, Gregg RG, et al. (2012). GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes. J Cell Biol 197: 711-719.
    • (2012) J Cell Biol , vol.197 , pp. 711-719
    • Orlandi, C.1    Posokhova, E.2    Masuho, I.3    Ray, T.A.4    Hasan, N.5    Gregg, R.G.6
  • 46
    • 79952289069 scopus 로고    scopus 로고
    • Endocrine regulation of male fertility by the skeleton
    • Oury F, Sumara G, Sumara O, Ferron M, Chang H, Smith CE, et al. (2011). Endocrine regulation of male fertility by the skeleton. Cell 144: 796-809.
    • (2011) Cell , vol.144 , pp. 796-809
    • Oury, F.1    Sumara, G.2    Sumara, O.3    Ferron, M.4    Chang, H.5    Smith, C.E.6
  • 47
    • 84874040640 scopus 로고    scopus 로고
    • The G protein-coupled receptor family C group 6 subtype A (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells
    • Oya M, Kitaguchi T, Pais R, Reimann F, Gribble F, Tsuboi T, (2013). The G protein-coupled receptor family C group 6 subtype A (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells. J Biol Chem 288: 4513-4521.
    • (2013) J Biol Chem , vol.288 , pp. 4513-4521
    • Oya, M.1    Kitaguchi, T.2    Pais, R.3    Reimann, F.4    Gribble, F.5    Tsuboi, T.6
  • 48
    • 0016683392 scopus 로고
    • Arginine-stimulated acute phase of insulin and glucagon secretion. I. in normal man
    • Palmer JP, Walter RM, Ensinck JW, (1975). Arginine-stimulated acute phase of insulin and glucagon secretion. I. in normal man. Diabetes 24: 735-740.
    • (1975) Diabetes , vol.24 , pp. 735-740
    • Palmer, J.P.1    Walter, R.M.2    Ensinck, J.W.3
  • 49
    • 82255184385 scopus 로고    scopus 로고
    • GPRC6A regulates prostate cancer progression
    • Pi M, Quarles LD, (2012a). GPRC6A regulates prostate cancer progression. Prostate 72: 399-409.
    • (2012) Prostate , vol.72 , pp. 399-409
    • Pi, M.1    Quarles, L.D.2
  • 50
    • 28844442189 scopus 로고    scopus 로고
    • Identification of a novel extracellular cation-sensing G-protein-coupled receptor
    • Pi M, Faber P, Ekema G, Jackson PD, Ting A, Wang N, et al. (2005). Identification of a novel extracellular cation-sensing G-protein-coupled receptor. J Biol Chem 280: 40201-40209.
    • (2005) J Biol Chem , vol.280 , pp. 40201-40209
    • Pi, M.1    Faber, P.2    Ekema, G.3    Jackson, P.D.4    Ting, A.5    Wang, N.6
  • 51
    • 57349197966 scopus 로고    scopus 로고
    • GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome
    • Pi M, Chen L, Huang MZ, Zhu W, Ringhofer B, Luo J, et al. (2008). GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome. Plos ONE 3: e3858.
    • (2008) Plos ONE , vol.3
    • Pi, M.1    Chen, L.2    Huang, M.Z.3    Zhu, W.4    Ringhofer, B.5    Luo, J.6
  • 52
    • 78650038629 scopus 로고    scopus 로고
    • GPRC6A mediates the non-genomic effects of steroids
    • Pi M, Parrill AL, Quarles LD, (2010a). GPRC6A mediates the non-genomic effects of steroids. J Biol Chem 285: 39953-39964.
    • (2010) J Biol Chem , vol.285 , pp. 39953-39964
    • Pi, M.1    Parrill, A.L.2    Quarles, L.D.3
  • 54
    • 79959507054 scopus 로고    scopus 로고
    • GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo
    • Pi M, Wu Y, Quarles LD, (2011). GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo. J Bone Miner Res 26: 1680-1683.
    • (2011) J Bone Miner Res , vol.26 , pp. 1680-1683
    • Pi, M.1    Wu, Y.2    Quarles, L.D.3
  • 55
    • 84866763104 scopus 로고    scopus 로고
    • GPRC6A mediates the effects of L-arginine on insulin secretion in mouse pancreatic islets
    • Pi M, Wu Y, Lenchik NI, Gerling I, Quarles LD, (2012b). GPRC6A mediates the effects of L-arginine on insulin secretion in mouse pancreatic islets. Endocrinology 153: 4608-4615.
    • (2012) Endocrinology , vol.153 , pp. 4608-4615
    • Pi, M.1    Wu, Y.2    Lenchik, N.I.3    Gerling, I.4    Quarles, L.D.5
  • 56
    • 0034602293 scopus 로고    scopus 로고
    • Cys-140 is critical for metabotropic glutamate receptor-1 dimerization
    • Ray K, Hauschild BC, (2000). Cys-140 is critical for metabotropic glutamate receptor-1 dimerization. J Biol Chem 275: 34245-34251.
    • (2000) J Biol Chem , vol.275 , pp. 34245-34251
    • Ray, K.1    Hauschild, B.C.2
  • 59
    • 0029903640 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor 5 is a disulfide-linked dimer
    • Romano C, Yang WL, Omalley KL, (1996). Metabotropic glutamate receptor 5 is a disulfide-linked dimer. J Biol Chem 271: 28612-28616.
    • (1996) J Biol Chem , vol.271 , pp. 28612-28616
    • Romano, C.1    Yang, W.L.2    Omalley, K.L.3
  • 61
    • 33747739191 scopus 로고    scopus 로고
    • Coupling of agonist binding to effector domain activation in metabotropic glutamate-like receptors
    • Rondard P, Liu J, Huang S, Malhaire F, Vol C, Pinault A, et al. (2006). Coupling of agonist binding to effector domain activation in metabotropic glutamate-like receptors. J Biol Chem 281: 24653-24661.
    • (2006) J Biol Chem , vol.281 , pp. 24653-24661
    • Rondard, P.1    Liu, J.2    Huang, S.3    Malhaire, F.4    Vol, C.5    Pinault, A.6
  • 63
    • 84871797522 scopus 로고    scopus 로고
    • 2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors
    • 2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors. Nat Commun 3: 1329.
    • (2012) Nat Commun , vol.3 , pp. 1329
    • Rossol, M.1    Pierer, M.2    Raulien, N.3    Quandt, D.4    Meusch, U.5    Rothe, K.6
  • 64
    • 84874062399 scopus 로고    scopus 로고
    • The L-alpha-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in L-arginine-induced insulin release
    • Smajilovic S, Clemmensen C, Johansen LD, Wellendorph P, Holst JJ, Thams PG, et al. (2013). The L-alpha-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in L-arginine-induced insulin release. Amino Acids 44: 383-390.
    • (2013) Amino Acids , vol.44 , pp. 383-390
    • Smajilovic, S.1    Clemmensen, C.2    Johansen, L.D.3    Wellendorph, P.4    Holst, J.J.5    Thams, P.G.6
  • 66
    • 77956637724 scopus 로고    scopus 로고
    • Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population
    • Takata R, Akamatsu S, Kubo M, Takahashi A, Hosono N, Kawaguchi T, et al. (2010). Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. Nat Genet 42: 751-754.
    • (2010) Nat Genet , vol.42 , pp. 751-754
    • Takata, R.1    Akamatsu, S.2    Kubo, M.3    Takahashi, A.4    Hosono, N.5    Kawaguchi, T.6
  • 67
    • 84866530941 scopus 로고    scopus 로고
    • Novel strategies in drug discovery of the calcium-sensing receptor based on biased signaling
    • Thomsen AR, Smajilovic S, Bräuner-Osborne H, (2012). Novel strategies in drug discovery of the calcium-sensing receptor based on biased signaling. Curr Drug Targets 13: 1324-1335.
    • (2012) Curr Drug Targets , vol.13 , pp. 1324-1335
    • Thomsen, A.R.1    Smajilovic, S.2    Bräuner-Osborne, H.3
  • 68
    • 0028076043 scopus 로고
    • L-glutamate uptake inhibitors may stimulate phosphoinositide hydrolysis in baby hamster kidney cells expressing mGluR1a via heteroexchange with L-glutamate without direct activation of mGluR1a
    • Thomsen C, Hansen L, Suzdak PD, (1994). L-glutamate uptake inhibitors may stimulate phosphoinositide hydrolysis in baby hamster kidney cells expressing mGluR1a via heteroexchange with L-glutamate without direct activation of mGluR1a. J Neurochem 63: 2038-2047.
    • (1994) J Neurochem , vol.63 , pp. 2038-2047
    • Thomsen, C.1    Hansen, L.2    Suzdak, P.D.3
  • 69
    • 0033537013 scopus 로고    scopus 로고
    • Elevated C-reactive protein levels in overweight and obese adults
    • Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB, (1999). Elevated C-reactive protein levels in overweight and obese adults. JAMA 282: 2131-2135.
    • (1999) JAMA , vol.282 , pp. 2131-2135
    • Visser, M.1    Bouter, L.M.2    McQuillan, G.M.3    Wener, M.H.4    Harris, T.B.5
  • 70
    • 84863011395 scopus 로고    scopus 로고
    • Replication and cumulative effects of GWAS-identified genetic variations for prostate cancer in Asians: A case-control study in the ChinaPCa consortium
    • Wang M, Liu F, Hsing AW, Wang X, Shao Q, Qi J, et al. (2012). Replication and cumulative effects of GWAS-identified genetic variations for prostate cancer in Asians: a case-control study in the ChinaPCa consortium. Carcinogenesis 33: 356-360.
    • (2012) Carcinogenesis , vol.33 , pp. 356-360
    • Wang, M.1    Liu, F.2    Hsing, A.W.3    Wang, X.4    Shao, Q.5    Qi, J.6
  • 71
    • 2942519523 scopus 로고    scopus 로고
    • Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor
    • Wellendorph P, Bräuner-Osborne H, (2004). Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor. Gene 335: 37-46.
    • (2004) Gene , vol.335 , pp. 37-46
    • Wellendorph, P.1    Bräuner-Osborne, H.2
  • 72
    • 67650628028 scopus 로고    scopus 로고
    • Molecular basis for amino acid sensing by family C G protein-coupled receptors
    • Wellendorph P, Bräuner-Osborne H, (2009a). Molecular basis for amino acid sensing by family C G protein-coupled receptors. Br J Pharmacol 156: 869-884.
    • (2009) Br J Pharmacol , vol.156 , pp. 869-884
    • Wellendorph, P.1    Bräuner-Osborne, H.2
  • 75
    • 64549116402 scopus 로고    scopus 로고
    • No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions
    • Wellendorph P, Johansen L, Jensen A, Casanova E, Gassmann M, Deprez P, et al. (2009b). No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions. J Mol Endocrinol 42: 215-223.
    • (2009) J Mol Endocrinol , vol.42 , pp. 215-223
    • Wellendorph, P.1    Johansen, L.2    Jensen, A.3    Casanova, E.4    Gassmann, M.5    Deprez, P.6
  • 76
    • 69549111756 scopus 로고    scopus 로고
    • Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients
    • Wellendorph P, Johansen LD, Bräuner-Osborne H, (2009c). Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients. Mol Pharmacol 76: 453-465.
    • (2009) Mol Pharmacol , vol.76 , pp. 453-465
    • Wellendorph, P.1    Johansen, L.D.2    Bräuner-Osborne, H.3


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