Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population

Nature Genetics

Volumn 42, Issue 9, 2010, Pages 751-755

  Takata, Ryo ^a,b   Akamatsu, Shusuke ^a,c   Kubo, Michiaki ^d   Takahashi, Atsushi ^a   Hosono, Naoya ^d   Kawaguchi, Takahisa ^d   Tsunoda, Tatsuhiko ^d   Inazawa, Johji ^e   Kamatani, Naoyuki ^a   Ogawa, Osamu ^c   Fujioka, Tomoaki ^b   Nakamura, Yusuke ^f   Nakagawa, Hidewaki ^a  

^a RIKEN   (Japan)

^b IWATE MEDICAL UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d RIKEN   (United States)

^e TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^f UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ASIAN; CARCINOMA; CASE CONTROL STUDY; CHROMOSOME 13; CHROMOSOME 2; CHROMOSOME 5; CHROMOSOME 6; ETHNOLOGY; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; HUMAN; MALE; POPULATION GENETICS; PROSTATE TUMOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ASIAN CONTINENTAL ANCESTRY GROUP; CARCINOMA; CASE-CONTROL STUDIES; CHROMOSOMES, HUMAN, PAIR 13; CHROMOSOMES, HUMAN, PAIR 2; CHROMOSOMES, HUMAN, PAIR 5; CHROMOSOMES, HUMAN, PAIR 6; GENE FREQUENCY; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENETICS, POPULATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSTATIC NEOPLASMS;

EID: 77956637724     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.635     Document Type: Letter

References (29)

1. Parkin, D.M., Bray, F., Ferlay, J. & Pisani, P. Global cancer statistics, 2002. CA Cancer J. Clin. 55, 74-108 (2005).
2. Matsuda, T. & Saika, K. Comparison of time trends in prostate cancer incidence (1973-2002) in Asia, from cancer incidence in five continents, Vols IV-IX. Jpn. J. Clin. Oncol. 39, 468-469 (2009).
3. Kurahashi, N. et al. Dairy product, saturated fatty acid, and calcium intake and prostate cancer in a prospective cohort of Japanese men. Cancer Epidemiol. Biomarkers Prev. 17, 930-937 (2008).
4. Schaid, D.J. The complex genetic epidemiology of prostate cancer. Hum. Mol. Genet. 13, R103-R121 (2004).
5. Lichtenstein, P. et al. Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland. N. Engl. J. Med. 343, 78-85 (2000).
6. Gudmundsson, J. et al. Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat. Genet. 39, 631-637 (2007).
7. Yeager, M. et al. Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat. Genet. 39, 645-649 (2007).
8. Gudmundsson, J. et al. Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat. Genet. 39, 977-983 (2007).
9. Gudmundsson, J. et al. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Nat. Genet. 40, 281-283 (2008).
10. Eeles, R.A. et al. Multiple newly identified loci associated with prostate cancer susceptibility. Nat. Genet. 40, 316-321 (2008).
11. Thomas, G. et al. Multiple loci identified in a genome-wide association study of prostate cancer. Nat. Genet. 40, 310-315 (2008).
12. Gudmundsson, J. et al. Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. Nat. Genet. 41, 1022-1026 (2009).
13. Eeles, R.A. et al. Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat. Genet. 41, 1116-1121 (2009).
14. Yeager, M. et al. Identification of a new prostate cancer susceptibility locus on chromosome 8q24. Nat. Genet. 41, 1055-1057 (2009).
15. Al Olama, A.A. et al. Multiple loci on 8q24 associated with prostate cancer susceptibility. Nat. Genet. 41, 1058-1060 (2009).
16. Witte, J.S. Prostate cancer genomics: Towards a new understanding. Nat. Rev. Genet. 10, 77-82 (2009).
17. Freedman, M.L. et al. Assessing the impact of population stratification on genetic association studies. Nat. Genet. 36, 388-393 (2004).
18. Yamaguchi-Kabata, Y. et al. Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups: Effects on population-based association studies. Am. J. Hum. Genet. 83, 445-456 (2008).
19. Devlin, B. & Roeder, K. Genomic control for association studies. Biometrics 55, 997-1004 (1999).
20. Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661-678 (2007).
21. Barrett, J., Fry, B., Maller, J. & Daly, M. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263-265 (2005).
22. Aftab, S., Semenec, L., Chu, J.S. & Chen, N. Identification and characterization of novel human tissue-specific RFX transcriptional factors. BMC Evol. Biol. 8, 226 (2008).
23. Pi, M. et al. GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome. PLoS One 3, e3858 (2008).
24. Teufel, A., Wong, E.A., Mukhopadhyay, M., Malik, N. & Westphal, H. FoxP4, a novel forkhead transcription factor. Biochim. Biophys. Acta 1627, 147-152 (2003).
25. Croucher, P.J. et al. Haplotype structure and association to Crohn’s disease of CARD15 mutations in two ethnically divergent populations. Eur. J. Hum. Genet. 11, 6-16 (2003).
26. Nakamura, Y. The BioBank Japan project. Clin. Adv. Hematol. Oncol. 5, 696-697 (2007).
27. Ohnishi, Y. et al. A high-throughput SNP typing system for genome-wide association studies. J. Hum. Genet. 46, 471-477 (2001).
28. Gabriel, S.B. et al. The structure of haplotype blocks in the human genome. Science 296, 2225-2229 (2002).
29. Purcell, S. et al. PLINK: A tool set for whole-genome association and population- based linkage analyses. Am. J. Hum. Genet. 81, 559-575 (2007).