Enhanced voluntary wheel running in GPRC6A receptor knockout mice

Physiology and Behavior

Volumn 118, Issue , 2013, Pages 144-151

  Clemmensen, Christoffer ^a   Pehmøller, Christian ^b   Klein, Anders B ^c   Ratner, Cecilia ^c   Wojtaszewski, Jørgen F P ^b   Bräuner Osborne, Hans ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c Mental Health Services CPH   (Denmark)

Author keywords

Energy balance; Exercise; GPRC6A; Reward; Wheel running

Indexed keywords

BIOLOGICAL MARKER; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 6A; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BODY COMPOSITION; CONTROLLED STUDY; ENERGY BALANCE; ENERGY EXPENDITURE; ENERGY METABOLISM; FOOD INTAKE; GENOTYPE; MALE; MOUSE; NONHUMAN; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RUNNING; TREADMILL EXERCISE; WHEEL RUNNING;

EID: 84878800736     PISSN: 00319384     EISSN: 1873507X     Source Type: Journal    
DOI: 10.1016/j.physbeh.2013.05.015     Document Type: Article

References (38)

1. Maclean P.S., Bergouignan A., Cornier M.A., Jackman M.R. Biology's response to dieting: the impetus for weight regain. Am J Physiol Regul Integr Comp Physiol 2011, 301:R581-R600.
2. Speakman J.R., Levitsky D.A., Allison D.B., Bray M.S., de Castro J.M., Clegg D.J., et al. Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity. Dis Model Mech 2011, 4:733-745.
3. Tschöp M.H., Speakman J.R., Arch J.R., Auwerx J., Bruning J.C., Chan L., et al. A guide to analysis of mouse energy metabolism. Nat Methods 2012, 9:57-63.
4. Ellacott K.L., Morton G.J., Woods S.C., Tso P., Schwartz M.W. Assessment of feeding behavior in laboratory mice. Cell Metab 2010, 12:10-17.
5. Smajilovic S., Clemmensen C., Johansen L.D., Wellendorph P., Holst J.J., Thams P.G., et al. The l-α-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in l-arginine-induced insulin release. Amino Acids 2013, 44:383-390.
6. Pi M., Chen L., Huang M.Z., Zhu W., Ringhofer B., Luo J., et al. GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome. PLoS One 2008, 3:e3858.
7. Wellendorph P., Johansen L.D., Jensen A.A., Casanova E., Gassmann M., Deprez P., et al. No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions. J Mol Endocrinol 2009, 42:215-223.
8. Pi M., Zhang L., Lei S.F., Huang M.Z., Zhu W., Zhang J., et al. Impaired osteoblast function in GPRC6A null mice. J Bone Miner Res 2010, 25:1092-1102.
9. Oury F., Sumara G., Sumara O., Ferron M., Chang H., Smith C.E., et al. Endocrine regulation of male fertility by the skeleton. Cell 2011, 144:796-809.
10. Pi M., Quarles L.D. Multiligand specificity and wide tissue expression of GPRC6A reveals new endocrine networks. Endocrinology 2012, 153:2062-2069.
11. Wellendorph P., Hansen K.B., Balsgaard A., Greenwood J.R., Egebjerg J., Bräuner-Osborne H. Deorphanization of GPRC6A: a promiscuous l-α-amino acid receptor with preference for basic amino acids. Mol Pharmacol 2005, 67:589-597.
12. Wellendorph P., Johansen L.D., Bräuner-Osborne H. Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients. Mol Pharmacol 2009, 76:453-465.
13. Wellendorph P., Bräuner-Osborne H. Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor. Gene 2004, 335:37-46.
14. Castaneda T.R., Jurgens H., Wiedmer P., Pfluger P., Diano S., Horvath T.L., et al. Obesity and the neuroendocrine control of energy homeostasis: the role of spontaneous locomotor activity. J Nutr 2005, 135:1314-1319.
15. Calvo J.A., Daniels T.G., Wang X., Paul A., Lin J., Spiegelman B.M., et al. Muscle-specific expression of PPARγ coactivator-1α improves exercise performance and increases peak oxygen uptake. J Appl Physiol 2008, 104:1304-1312.
16. Werme M., Messer C., Olson L., Gilden L., Thoren P., Nestler E.J., et al. Delta FosB regulates wheel running. J Neurosci 2002, 22:8133-8138.
17. Morton G.J., Kaiyala K.J., Fisher J.D., Ogimoto K., Schwartz M.W., Wisse B.E. Identification of a physiological role for leptin in the regulation of ambulatory activity and wheel running in mice. Am J Physiol Endocrinol Metab 2011, 300:E392-E401.
18. Guyenet S.J., Schwartz M.W. Clinical review: Regulation of food intake, energy balance, and body fat mass: implications for the pathogenesis and treatment of obesity. J Clin Endocrinol Metab 2012, 97:745-755.
19. Clemmensen C., Aznar S., Knudsen G.M., Klein A.B. The microtubule-associated protein 1A (MAP1A) is an early molecular target of soluble Abeta-peptide. Cell Mol Neurobiol 2012, 32:561-566.
20. Pehmoller C., Treebak J.T., Birk J.B., Chen S., Mackintosh C., Hardie D.G., et al. Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle. Am J Physiol Endocrinol Metab 2009, 297:E665-E675.
21. Woods A., Salt I., Scott J., Hardie D.G., Carling D. The α1 and α2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro. FEBS Lett 1996, 397:347-351.
22. Pilegaard H., Birk J.B., Sacchetti M., Mourtzakis M., Hardie D.G., Stewart G., et al. PDH-E1α dephosphorylation and activation in human skeletal muscle during exercise: effect of intralipid infusion. Diabetes 2006, 55:3020-3027.
23. Nagao K., Bannai M., Seki S., Kawai N., Mori M., Takahashi M. Voluntary wheel running is beneficial to the amino acid profile of lysine-deficient rats. Am J Physiol Endocrinol Metab 2010, 298:E1170-E1178.
24. Lorentzon M., Lorentzon R., Lerner U.H., Nordstrom P. Calcium sensing receptor gene polymorphism, circulating calcium concentrations and bone mineral density in healthy adolescent girls. Eur J Endocrinol 2001, 144:257-261.
25. Leasure J.L., Jones M. Forced and voluntary exercise differentially affect brain and behavior. Neuroscience 2008, 156:456-465.
26. Swallow J.G., Koteja P., Carter P.A., Garland T. Food consumption and body composition in mice selected for high wheel-running activity. J Comp Physiol B 2001, 171:651-659.
27. Blundell J.E., Stubbs R.J., Hughes D.A., Whybrow S., King N.A. Cross talk between physical activity and appetite control: does physical activity stimulate appetite?. Proc Nutr Soc 2003, 62:651-661.
28. Novak C.M., Burghardt P.R., Levine J.A. The use of a running wheel to measure activity in rodents: relationship to energy balance, general activity, and reward. Neurosci Biobehav Rev 2012, 36:1001-1014.
29. Adam T.C., Epel E.S. Stress, eating and the reward system. Physiol Behav 2007, 91:449-458.
30. Adlard P.A., Cotman C.W. Voluntary exercise protects against stress-induced decreases in brain-derived neurotrophic factor protein expression. Neuroscience 2004, 124:985-992.
31. Greenwood B.N., Foley T.E., Le T.V., Strong P.V., Loughridge A.B., Day H.E., et al. Long-term voluntary wheel running is rewarding and produces plasticity in the mesolimbic reward pathway. Behav Brain Res 2011, 217:354-362.
32. Krawczewski Carhuatanta K.A., Demuro G., Tschop M.H., Pfluger P.T., Benoit S.C., Obici S. Voluntary exercise improves high-fat diet-induced leptin resistance independent of adiposity. Endocrinology 2011, 152:2655-2664.
33. Yin Y., Edelman G.M., Vanderklish P.W. The brain-derived neurotrophic factor enhances synthesis of Arc in synaptoneurosomes. Proc Natl Acad Sci U S A 2002, 99:2368-2373.
34. Berton O., McClung C.A., Dileone R.J., Krishnan V., Renthal W., Russo S.J., et al. Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 2006, 311:864-868.
35. Krishnan V., Han M.H., Graham D.L., Berton O., Renthal W., Russo S.J., et al. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 2007, 131:391-404.
36. Teegarden S.L., Nestler E.J., Bale T.L. Delta FosB-mediated alterations in dopamine signaling are normalized by a palatable high-fat diet. Biol Psychiatry 2008, 64:941-950.
37. Fediuc S., Campbell J.E., Riddell M.C. Effect of voluntary wheel running on circadian corticosterone release and on HPA axis responsiveness to restraint stress in Sprague-Dawley rats. J Appl Physiol 2006, 100:1867-1875.
38. Rhodes J.S., van Praag H., Jeffrey S., Girard I., Mitchell G.S., Garland T., et al. Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running. Behav Neurosci 2003, 117:1006-1016.