The l-α-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in l-arginine-induced insulin release

Amino Acids

Volumn 44, Issue 2, 2013, Pages 383-390

  Smajilovic, Sanela ^a   Clemmensen, Christoffer ^a   Johansen, Lars Dan ^a   Wellendorph, Petrine ^a   Holst, Jens Juul ^b   Thams, Peter Grevsen ^b   Ogo, Egbuna ^c   Bräuner Osborne, Hans ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Capital Region   (Denmark)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

GPRC6A; Insulin release; l Arginine

Indexed keywords

G PROTEIN COUPLED RECEPTOR; PROTEIN GPRC6A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; CONTROLLED STUDY; GLUCOSE METABOLISM; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION;

ANIMALS; ARGININE; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, G-PROTEIN-COUPLED;

MUS;

EID: 84874062399     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-012-1341-8     Document Type: Article

References (41)

1. Ahren B (2009) Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes. Nat Rev Drug Discov 8(5):369-385
2. Ayala JE, Bracy DP, Hansotia T, Flock G, Seino Y, Wasserman DH, Drucker DJ (2008) Insulin action in the double incretin receptor knockout mouse. Diabetes 57(2):288-297
3. Blachier F, Leclercq-Meyer V, Marchand J, Woussen-Colle MC, Mathias PC, Sener A (1989) Stimulus-secretion coupling of arginine-induced insulin release. Functional response of islets to l-arginine and l-ornithine. Biochim Biophys Acta 1013(2):144-151
4. 2+-sensing receptor in mouse taste cells. J Cell Sci 123(Pt 6):972-982
5. Christiansen B, Hansen KB, Wellendorph P, Bräuner-Osborne H (2007) Pharmacological characterization of mouse GPRC6A, an l-alpha-amino-acid receptor modulated by divalent cations. Br J Pharmacol 150(6):798-807
6. Christoffersen C, Jauhiainen M, Moser M, Porse B, Ehnholm C, Boesl M, Dahlback B, Nielsen LB (2008) Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice. J Biol Chem 283(4):1839-1847
7. Clemmensen C, Madsen AN, Smajilovic S, Holst B, Bräuner-Osborne H (2011) l-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances. Amino Acids (epub ahead of print)
8. Floyd JC Jr, Fajans SS, Conn JW, Knopf RF, Rull J (1966) Stimulation of insulin secretion by amino acids. J Clin Invest 45(9):1487-1502
9. Gordin A, Meyers C, Arimura A, Coy DH, Schally AV (1977) An in vivo model for testing inhibition of arginine-induced insulin and glucagon release by somatostatin analogs. Acta Endocrinol (Copenhagen) 86(4):833-841
10. Guo J, Jou W, Gavrilova O, Hall KD (2009) Persistent diet-induced obesity in male C57BL/6 mice resulting from temporary obesigenic diets. PLoS One 4(4):e5370
11. Haid D, Widmayer P, Breer H (2011) Nutrient sensing receptors in gastric endocrine cells. J Mol Histol 42(4):355-364
12. Hamamoto S, Nomura S, Yasui T, Okada A, Hirose M, Shimizu H, Itoh Y, Tozawa K, Kohri K (2010) Effects of impaired functional domains of osteopontin on renal crystal formation: analyses of OPN transgenic and OPN knockout mice. J Bone Miner Res 25(12):2436-2447
13. + fluxes in pancreatic beta-cells. Am J Physiol 240(3):E245-E252
14. + on arginine stimulation of insulin release in isolated mouse islets. Diabetologia 30(8):659-665
15. Holst JJ (2004) On the physiology of GIP and GLP-1. Horm Metab Res 36(11-12):747-754
16. Jobgen W, Meininger CJ, Jobgen SC, Li P, Lee MJ, Smith SB, Spencer TE, Fried SK, Wu G (2009) Dietary l-arginine supplementation reduces white fat gain and enhances skeletal muscle and brown fat masses in diet-induced obese rats. J Nutr 139(2):230-237
17. Kaul A, Koster M, Neuhaus H, Braun T (2000) Myf-5 revisited: loss of early myotome formation does not lead to a rib phenotype in homozygous Myf-5 mutant mice. Cell 102(1):17-19
18. Kuang D, Yao Y, Lam J, Tsushima RG, Hampson DR (2005) Cloning and characterization of a family C orphan G-protein coupled receptor. J Neurochem 93(2):383-391
19. Lucotti P, Setola E, Monti LD, Galluccio E, Costa S, Sandoli EP, Fermo I, Rabaiotti G, Gatti R, Piatti P (2006) Beneficial effects of a long-term oral l-arginine treatment added to a hypocaloric diet and exercise training program in obese, insulin-resistant type 2 diabetic patients. Am J Physiol Endocrinol Metab 291(5):E906-E912
20. Luo J, Liu Z, Liu J, Eugene CY (2010) Distribution pattern of GPRC6A mRNA in mouse tissue by in situ hybridization. Zhong Nan Da Xue Xue Bao Yi Xue Ban 35(1):1-10
21. Mitsuma T, Rhue N, Kayama M, Mori Y, Adachi K, Yokoi Y, Ping J, Nogimori T, Hirooka Y (1999) Distribution of calcium sensing receptor in rats: an immunohistochemical study. Endocr Regul 33(2):55-59
22. Nilsson M, Holst JJ, Bjorck IM (2007) Metabolic effects of amino acid mixtures and whey protein in healthy subjects: studies using glucose-equivalent drinks. Am J Clin Nutr 85(4):996-1004
23. Oury F, Sumara G, Sumara O, Ferron M, Chang H, Smith CE, Hermo L, Suarez S, Roth BL, Ducy P, Karsenty G (2011) Endocrine regulation of male fertility by the skeleton. Cell 144(5):796-809
24. Palmer JP, Ensinck JW (1975) Acute-phase insulin secretion and glucose tolerance in young and aged normal men and diabetic patients. J Clin Endocrinol Metab 41(3):498-503
25. Persy VP, Verhulst A, Ysebaert DK, De Greef KE, De Broe ME (2003) Reduced postischemic macrophage infiltration and interstitial fibrosis in osteopontin knockout mice. Kidney Int 63(2):543-553
26. Pi M, Faber P, Ekema G, Jackson PD, Ting A, Wang N, Fontilla-Poole M, Mays RW, Brunden KR, Harrington JJ, Quarles LD (2005) Identification of a novel extracellular cation-sensing G-protein-coupled receptor. J Biol Chem 280(48):40201-40209
27. Pi M, Chen L, Huang MZ, Zhu W, Ringhofer B, Luo J, Christenson L, Li B, Zhang J, Jackson PD, Faber P, Brunden KR, Harrington JJ, Quarles LD (2008) GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome. PLoS One 3(12):e3858
28. Pi M, Parrill AL, Quarles LD (2010) GPRC6A mediates the non-genomic effects of steroids. J Biol Chem 285(51):39953-39964
29. Pi M, Wu Y, Quarles LD (2011) GPRC6A mediates responses to osteocalcin in beta-cells in vitro and pancreas in vivo. J Bone Miner Res 26(7):1680-1683
30. Piatti PM, Monti LD, Valsecchi G, Magni F, Setola E, Marchesi F, Galli-Kienle M, Pozza G, Alberti KG (2001) Long-term oral l-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients. Diabetes Care 24(5):875-880
31. Regard JB, Kataoka H, Cano DA, Camerer E, Yin L, Zheng YW, Scanlan TS, Hebrok M, Coughlin SR (2007) Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. J Clin Invest 117(12):4034-4043
32. Smith PA, Sakura H, Coles B, Gummerson N, Proks P, Ashcroft FM (1997) Electrogenic arginine transport mediates stimulus-secretion coupling in mouse pancreatic beta-cells. J Physiol 499(Pt 3):625-635
33. Tfelt-Hansen J, Brown EM (2005) The calcium-sensing receptor in normal physiology and pathophysiology: a review. Crit Rev Clin Lab Sci 42(1):35-70
34. Thams P, Capito K (1999) l-arginine stimulation of glucose-induced insulin secretion through membrane depolarization and independent of nitric oxide. Eur J Endocrinol 140(1):87-93
35. Tolhurst G, Reimann F, Gribble FM (2009) Nutritional regulation of glucagon-like peptide-1 secretion. J Physiol 587(Pt 1):27-32
36. Weinhaus AJ, Poronnik P, Tuch BE, Cook DI (1997) Mechanisms of arginine-induced increase in cytosolic calcium concentration in the beta-cell line NIT-1. Diabetologia 40(4):374-382
37. Wellendorph P, Bräuner-Osborne H (2004) Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor. Gene 335:37-46
38. Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H (2005) Deorphanization of GPRC6A: a promiscuous l-alpha-amino acid receptor with preference for basic amino acids. Mol Pharmacol 67(3):589-597
39. Wellendorph P, Burhenne N, Christiansen B, Walter B, Schmale H, Bräuner-Osborne H (2007) The rat GPRC6A: cloning and characterization. Gene 396(2):257-267
40. Wellendorph P, Johansen LD, Jensen AA, Casanova E, Gassmann M, Deprez P, Clement-Lacroix P, Bettler B, Bräuner-Osborne H (2009) No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions. J Mol Endocrinol 42(3):215-223
41. Wolfrum C, Poy MN, Stoffel M (2005) Apolipoprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis. Nat Med 11(4):418-422