-
1
-
-
84895129079
-
-
(ed. Bijlsma, J. W.), 206-231 (BMJ Group, London, 2012)
-
Burmester, G. R., Pratt, A. G., Scherer, H. U. & van Laar, J. M. in EULAR Textbook on Rheumatic Diseases 1st edn, Ch. Rheumatoid arthritis: pathogenesis and clinical features (ed. Bijlsma, J. W.), 206-231 (BMJ Group, London, 2012).
-
M. in EULAR Textbook on Rheumatic Diseases 1st Edn Rheumatoid Arthritis: Pathogenesis and Clinical Features
-
-
Burmester, G.R.1
Pratt, A.G.2
Scherer, H.U.3
Van Laar, J.4
-
2
-
-
36549027490
-
The central role of T cells in rheumatoid arthritis
-
Cope, A. P, Schulze-Koops, H. & Aringer, M. The central role of T cells in rheumatoid arthritis. Clin. Exp. Rheumatol. 25 (Suppl. 46), S4-S11 (2007).
-
(2007)
Clin. Exp. Rheumatol.
, vol.25
, Issue.SUPPL. 46
-
-
Cope, A.P.1
Schulze-Koops, H.2
Aringer, M.3
-
3
-
-
84861139699
-
Autoimmune arthritis: The interface between the immune system and joints
-
Komatsu, N. & Takayanagi, H. Autoimmune arthritis: the interface between the immune system and joints. Adv. Immunol. 115, 45-71 (2012).
-
(2012)
Adv. Immunol
, vol.115
, pp. 45-71
-
-
Komatsu, N.1
Takayanagi, H.2
-
4
-
-
0028842007
-
A reexamination of the relationship between active rheumatoid arthritis and the acquired immunodeficiency syndrome
-
Ornstein, M. H., Kerr, L. D. & Spiera H. A reexamination of the relationship between active rheumatoid arthritis and the acquired immunodeficiency syndrome. Arthritis Rheum. 38, 1701-1706 (1995).
-
(1995)
Arthritis Rheum
, vol.38
, pp. 1701-1706
-
-
Ornstein, M.H.1
Kerr, L.D.2
Spiera, H.3
-
5
-
-
54549119268
-
Co-stimulatory modulation in rheumatoid arthritis: The role of (CTLA4-Ig) abatacept
-
Fiocco, U. et al. Co-stimulatory modulation in rheumatoid arthritis: the role of (CTLA4-Ig) abatacept. Autoimmun. Rev. 8, 76-82 (2008).
-
(2008)
Autoimmun. Rev
, vol.8
, pp. 76-82
-
-
Fiocco, U.1
-
6
-
-
33747203086
-
Immunopathologic role of B lymphocytes in rheumatoid arthritis: Rationale of B cell-directed therapy
-
Martinez-Gamboa, L., Brezinschek, H. P., Burmester, G. R. & Dörner, T. Immunopathologic role of B lymphocytes in rheumatoid arthritis: rationale of B cell-directed therapy. Autoimmun. Rev. 5, 437-442 (2006).
-
(2006)
Autoimmun. Rev
, vol.5
, pp. 437-442
-
-
Martinez-Gamboa, L.1
Brezinschek, H.P.2
Burmester, G.R.3
Dörner, T.4
-
7
-
-
0021065248
-
The tissue architecture of synovial membranes in inflammatory and non-inflammatory joint diseases. I. The localization of the major synovial cell populations as detected by monoclonal reagents directed towards Ia and monocyte-macrophage antigens
-
Burmester, G. R. et al. The tissue architecture of synovial membranes in inflammatory and non-inflammatory joint diseases. I. The localization of the major synovial cell populations as detected by monoclonal reagents directed towards Ia and monocyte-macrophage antigens. Rheumatol. Int. 3, 173-181 (1983).
-
(1983)
Rheumatol. Int
, vol.3
, pp. 173-181
-
-
Burmester, G.R.1
-
8
-
-
84855172814
-
The pathogenesis of rheumatoid arthritis
-
McInnes, I. B. & Schett, G. The pathogenesis of rheumatoid arthritis. N. Engl. J. Med. 365, 2205-2219 (2011).
-
(2011)
N. Engl. J. Med
, vol.365
, pp. 2205-2219
-
-
McInnes, I.B.1
Schett, G.2
-
9
-
-
84857737880
-
Inflammatory bone loss: Pathogenesis and therapeutic intervention
-
Redlich, K. & Smolen, J. S. Inflammatory bone loss: pathogenesis and therapeutic intervention. Nat. Rev. Drug Disc. 11, 234-250 (2012).
-
(2012)
Nat. Rev. Drug Disc
, vol.11
, pp. 234-250
-
-
Redlich, K.1
Smolen, J.S.2
-
10
-
-
0035164284
-
Secretion of gelatinases and activation of gelatinase A (MMP2) by human rheumatoid synovial fibroblasts
-
Smolian, H. et al. Secretion of gelatinases and activation of gelatinase A (MMP2) by human rheumatoid synovial fibroblasts. Biol. Chem. 382, 1491-1499 (2001).
-
(2001)
Biol. Chem
, vol.382
, pp. 1491-1499
-
-
Smolian, H.1
-
11
-
-
77957366832
-
Rheumatoid arthritis progression mediated by activated synovial fibroblasts
-
Neumann, E., Lefèvre, S., Zimmermann, B., Gay, S. & Müller-Ladner, U. Rheumatoid arthritis progression mediated by activated synovial fibroblasts. Trends Mol. Med. 16, 458-468 (2010).
-
(2010)
Trends Mol. Med
, vol.16
, pp. 458-468
-
-
Neumann, E.1
Lefèvre, S.2
Zimmermann, B.3
Gay, S.4
Müller-Ladner, U.5
-
12
-
-
34249720998
-
Cytokines in the pathogenesis of rheumatoid arthritis
-
McInnes, I. B. & Schett, G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat. Rev. Immunol. 7, 429-442 (2007).
-
(2007)
Nat. Rev. Immunol
, vol.7
, pp. 429-442
-
-
McInnes, I.B.1
Schett, G.2
-
13
-
-
84859438199
-
The pathogenesis of rheumatoid arthritis: New insights from old clinical data?
-
Smolen, J. S., Aletaha, D. & Redlich, K. The pathogenesis of rheumatoid arthritis: new insights from old clinical data? Nat. Rev. Rheumatol. 8, 235-243 (2012).
-
(2012)
Nat. Rev. Rheumatol
, vol.8
, pp. 235-243
-
-
Smolen, J.S.1
Aletaha, D.2
Redlich, K.3
-
14
-
-
72949116165
-
A network meta-analysis of randomized controlled trials of biologics for rheumatoid arthritis: A Cochrane overview
-
Singh, J. A. et al. A network meta-analysis of randomized controlled trials of biologics for rheumatoid arthritis: a Cochrane overview. CMAJ 181, 787-796 (2009).
-
(2009)
CMAJ
, vol.181
, pp. 787-796
-
-
Singh, J.A.1
-
15
-
-
78751704593
-
Indirect comparisons of the efficacy of biological antirheumatic agents in rheumatoid arthritis in patients with an inadequate response to conventional disease-modifying antirheumatic drugs or to an anti-tumour necrosis factor agent: A meta-analysis
-
Salliot, C. et al. Indirect comparisons of the efficacy of biological antirheumatic agents in rheumatoid arthritis in patients with an inadequate response to conventional disease-modifying antirheumatic drugs or to an anti-tumour necrosis factor agent: a meta-analysis. Ann. Rheum. Dis. 70, 266-271 (2011).
-
(2011)
Ann. Rheum. Dis
, vol.70
, pp. 266-271
-
-
Salliot, C.1
-
16
-
-
79951716374
-
Ten years with biologics: To whom do data on effectiveness and safety apply?
-
Simard, J. F. et al. Ten years with biologics: to whom do data on effectiveness and safety apply? Rheumatology (Oxford) 50, 204-213 (2011).
-
(2011)
Rheumatology (Oxford)
, vol.50
, pp. 204-213
-
-
Simard, J.F.1
-
17
-
-
84872065897
-
JAKs and STATs in immunity, immunodeficiency, and cancer
-
O'Shea, J. J., Holland, S. M. & Staudt, L. M. JAKs and STATs in immunity, immunodeficiency, and cancer. N. Engl. J. Med. 368, 161-170 (2013).
-
(2013)
N. Engl. J. Med
, vol.368
, pp. 161-170
-
-
O'Shea, J.J.1
Holland, S.M.2
Staudt, L.M.3
-
18
-
-
84879806081
-
Small molecules targeting JAKs-A new approach in the treatment of rheumatoid arthritis
-
Feist, E. & Burmester, G. R. Small molecules targeting JAKs-a new approach in the treatment of rheumatoid arthritis. Rheumatology (Oxford) 52, 1352-1357 (2013).
-
(2013)
Rheumatology (Oxford)
, vol.52
, pp. 1352-1357
-
-
Feist, E.1
Burmester, G.R.2
-
19
-
-
73349111641
-
Is there a feudal hierarchy amongst regulatory immune cells? More than just TREGs
-
Mauri, C. & Carter, N. Is there a feudal hierarchy amongst regulatory immune cells? More than just TREGs. Arthritis Res. Ther. 11, 237 (2009).
-
(2009)
Arthritis Res. Ther
, vol.11
, pp. 237
-
-
Mauri, C.1
Carter, N.2
-
20
-
-
78649526238
-
Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases
-
Buckner, J. H. Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases. Nat. Rev. Immunol. 10, 849-859 (2010).
-
(2010)
Nat. Rev. Immunol
, vol.10
, pp. 849-859
-
-
Buckner, J.H.1
-
21
-
-
35348876040
-
FOXP3 and regulatory Tcells: A model for autoimmunity
-
Ochs, H. D., Gambineri, E. & Torgerson, T. R. IPEX, FOXP3 and regulatory Tcells: a model for autoimmunity. Immunol. Res. 38, 112-121 (2007).
-
(2007)
Immunol. Res
, vol.38
, pp. 112-121
-
-
Ochs, H.D.1
Gambineri, E.2
Ipex, R.T.T.3
-
22
-
-
0038666539
-
CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis
-
Morgan, M. E. et al. CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis. Arthritis Rheum. 48, 1452-1460 (2003).
-
(2003)
Arthritis Rheum
, vol.48
, pp. 1452-1460
-
-
Morgan, M.E.1
-
23
-
-
20144370643
-
The role of regulatory T cells in antigen-induced arthritis: Aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells
-
Frey, O. et al. The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells. Arthritis Res. Ther. 7, R291-R301 (2005).
-
(2005)
Arthritis Res. Ther
, vol.7
-
-
Frey, O.1
-
24
-
-
84864878463
-
Induced T regulatory cells suppress osteoclastogenesis and bone erosion in collagen-induced arthritis better than natural T regulatory cells
-
Kong, N. et al. Induced T regulatory cells suppress osteoclastogenesis and bone erosion in collagen-induced arthritis better than natural T regulatory cells. Ann. Rheum. Dis. 71, 1567-1572 (2012).
-
(2012)
Ann. Rheum. Dis
, vol.71
, pp. 1567-1572
-
-
Kong, N.1
-
25
-
-
84881432074
-
FOXP3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus
-
Alexander, T. et al. FOXP3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus. Ann. Rheum. Dis. 72, 1549-1558 (2013).
-
(2013)
Ann. Rheum. Dis
, vol.72
, pp. 1549-1558
-
-
Alexander, T.1
-
26
-
-
67049168780
-
Plasticity of CD4+ FOXP3+ T cells
-
Zhou, X., Bailey-Bucktrout, S., Jeker, L. T. & Bluestone, J. A. Plasticity of CD4+ FOXP3+ T cells. Curr. Opin. Immunol. 21, 281-285 (2009).
-
(2009)
Curr. Opin. Immunol
, vol.21
, pp. 281-285
-
-
Zhou, X.1
Bailey-Bucktrout, S.2
Jeker, L.T.3
Bluestone, J.A.4
-
27
-
-
70349969840
-
Regulatory T cells as therapeutic targets in rheumatoid arthritis
-
Esensten, J. H., Wofsy, D. & Bluestone, J. A. Regulatory T cells as therapeutic targets in rheumatoid arthritis. Nat. Rev. Rheumatol. 5, 560-565 (2009).
-
(2009)
Nat. Rev. Rheumatol
, vol.5
, pp. 560-565
-
-
Esensten, J.H.1
Wofsy, D.2
Bluestone, J.A.3
-
28
-
-
0037261145
-
Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis
-
Cao, D. et al. Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis. Eur. J. Immunol. 33, 215-223 (2003).
-
(2003)
Eur. J. Immunol
, vol.33
, pp. 215-223
-
-
Cao, D.1
-
29
-
-
17644384896
-
CD4+ CD25+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis
-
Möttönen, M. et al. CD4+ CD25+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis. Clin. Exp. Immunol. 140, 360-367 (2005).
-
(2005)
Clin. Exp. Immunol
, vol.140
, pp. 360-367
-
-
Möttönen, M.1
-
30
-
-
33747605602
-
Early rheumatoid arthritis is associated with a deficit in the CD4+CD25high regulatory T cell population in peripheral blood
-
Lawson, C. A. et al. Early rheumatoid arthritis is associated with a deficit in the CD4+CD25high regulatory T cell population in peripheral blood. Rheumatology (Oxford) 45, 1210-1217 (2006).
-
(2006)
Rheumatology (Oxford)
, vol.45
, pp. 1210-1217
-
-
Lawson, C.A.1
-
31
-
-
51449116424
-
CD4+CD25high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis
-
Han, G. M. O'Neil-Andersen, N. J., Zurier, R. B. & Lawrence, D. A. CD4+CD25high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis. Cell. Immunol. 253, 92-101 (2008).
-
(2008)
Cell. Immunol
, vol.253
, pp. 92-101
-
-
Han O'Neil-Andersen, M.G.N.J.1
Zurier, R.B.2
Lawrence, D.A.3
-
32
-
-
3543140687
-
Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy
-
Ehrenstein, M. R. et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy. J. Exp. Med. 200, 277-285 (2004).
-
(2004)
J. Exp. Med
, vol.200
, pp. 277-285
-
-
Ehrenstein, M.R.1
-
33
-
-
42649092503
-
Immunity to citrullinated proteins in rheumatoid arthritis
-
Klareskog, L., Rönnelid, J., Lundberg, K., Padyukov, L. & Alfredsson, L. Immunity to citrullinated proteins in rheumatoid arthritis. Annu. Rev. Immunol. 26, 651-675 (2008).
-
(2008)
Annu. Rev. Immunol
, vol.26
, pp. 651-675
-
-
Klareskog, L.1
Rönnelid, J.2
Lundberg, K.3
Padyukov, L.4
Alfredsson, L.5
-
34
-
-
0030839970
-
AntiA2/RA33 autoantibodies are directed to the RNA binding region of the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. Differential epitope recognition in rheumatoid arthritis, systemic lupus erythematosus, and mixed connective tissue disease
-
Skriner, K. et al. AntiA2/RA33 autoantibodies are directed to the RNA binding region of the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. Differential epitope recognition in rheumatoid arthritis, systemic lupus erythematosus, and mixed connective tissue disease. J. Clin. Invest. 100, 127-135 (1997).
-
(1997)
J. Clin. Invest
, vol.100
, pp. 127-135
-
-
Skriner, K.1
-
35
-
-
80052894690
-
Therapeutic potential of TREGs to treat rheumatoid arthritis
-
Wright, G. P., Stauss, H. J. & Ehrenstein, M. R. Therapeutic potential of TREGs to treat rheumatoid arthritis. Semin. Immunol. 23, 195-201 (2011).
-
(2011)
Semin. Immunol
, vol.23
, pp. 195-201
-
-
Wright, G.P.1
Stauss, H.J.2
Ehrenstein, M.R.3
-
36
-
-
1042290337
-
Specific autoantibodies precede the symptoms of rheumatoid arthritis: A study of serial measurements in blood donors
-
Nielen, M. M. et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum. 50, 380-386 (2004).
-
(2004)
Arthritis Rheum
, vol.50
, pp. 380-386
-
-
Nielen, M.M.1
-
37
-
-
82555168440
-
Interleukin2 and regulatory T cells in graftversushost disease
-
Koreth, J. et al. Interleukin2 and regulatory T cells in graftversushost disease. N. Engl. J. Med. 365, 2055-2066 (2011).
-
(2011)
N. Engl. J. Med
, vol.365
, pp. 2055-2066
-
-
Koreth, J.1
-
38
-
-
82555196118
-
Regulatory Tcell responses to low-dose interleukin2 in HCV-induced vasculitis
-
Saadoun, D. et al. Regulatory Tcell responses to low-dose interleukin2 in HCV-induced vasculitis. N. Engl. J. Med. 365, 2067-2077 (2011).
-
(2011)
N. Engl. J. Med
, vol.365
, pp. 2067-2077
-
-
Saadoun, D.1
-
39
-
-
78650830420
-
Selective activation of naturally occurring regulatory T cells (TREGs) by the monoclonal antibody BT061 as a novel therapeutic opportunity: Pre-clinical and early clinical results [abstract OP0138]
-
Czeloth, N. et al. Selective activation of naturally occurring regulatory T cells (TREGs) by the monoclonal antibody BT061 as a novel therapeutic opportunity: pre-clinical and early clinical results [abstract OP0138]. Ann. Rheum. Dis. 69 (Suppl. 3), 99 (2010).
-
(2010)
Ann. Rheum. Dis.
, vol.69
, Issue.SUPPL. 3
, pp. 99
-
-
Czeloth, N.1
-
41
-
-
84895084482
-
-
US National Library Of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/ct2/show/NCT01481493?term=bt061&rank=2 (2011).
-
(2011)
-
-
-
42
-
-
84872403415
-
Tregitope update: Mechanism of action parallels IVIg
-
Cousens, L. P. et al. Tregitope update: Mechanism of action parallels IVIg. Autoimmun. Rev. 12, 436-443 (2013).
-
(2013)
Autoimmun. Rev
, vol.12
, pp. 436-443
-
-
Cousens, L.P.1
-
43
-
-
76849086881
-
Targeting B cells in immune-mediated inflammatory disease: A comprehensive review of mechanisms of action and identification of biomarkers
-
Dörner, T., Kinnman, N. & Tak, P. P. Targeting B cells in immune-mediated inflammatory disease: a comprehensive review of mechanisms of action and identification of biomarkers. Pharmacol. Ther. 125, 464-475 (2010).
-
(2010)
Pharmacol. Ther
, vol.125
, pp. 464-475
-
-
Dörner, T.1
Kinnman, N.2
Tak, P.P.3
-
44
-
-
73349131124
-
Directed therapies for autoimmune disease
-
Dörner, T., Radbruch, A. & Burmester, G. R. 2011;celldirected therapies for autoimmune disease. Nat. Rev. Rheumatol. 5, 433-441 (2009).
-
(2009)
Nat. Rev. Rheumatol
, vol.5
, pp. 433-441
-
-
Dörner, T.1
Radbruch, A.2
Burmester, G.R.3
-
45
-
-
41549169663
-
Antibodies to citrullinated proteins in arthritis: Pathology and promise
-
Klareskog, L., Widhe, M., Hermansson, M. & Rönnelid, J. Antibodies to citrullinated proteins in arthritis: pathology and promise. Curr. Opin. Rheumatol. 20, 300-305 (2008).
-
(2008)
Curr. Opin. Rheumatol
, vol.20
, pp. 300-305
-
-
Klareskog, L.1
Widhe, M.2
Hermansson, M.3
Rönnelid, J.4
-
46
-
-
84877587255
-
Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition
-
Amara, K. et al. Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition. J. Exp. Med. 210, 445-455 (2013).
-
(2013)
J. Exp. Med
, vol.210
, pp. 445-455
-
-
Amara, K.1
-
47
-
-
2942537697
-
Efficacy of 2011;celltargeted therapy with rituximab in patients with rheumatoid arthritis
-
Edwards, J. C. et al. Efficacy of 2011;celltargeted therapy with rituximab in patients with rheumatoid arthritis. N. Engl. J. Med. 350, 2572-2581 (2004).
-
(2004)
N. Engl. J. Med
, vol.350
, pp. 2572-2581
-
-
Edwards, J.C.1
-
48
-
-
33646483031
-
The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment: Results of a phase IIB randomized, double-blind, placebo-controlled, dose-ranging trial
-
Emery, P. et al. The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment: results of a phase IIB randomized, double-blind, placebo-controlled, dose-ranging trial. Arthritis Rheum. 54, 1390-1400 (2006).
-
(2006)
Arthritis Rheum
, vol.54
, pp. 1390-1400
-
-
Emery, P.1
-
49
-
-
33746961890
-
Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks
-
Cohen, S. B. et al. Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheum. 54, 2793-2806 (2006).
-
(2006)
Arthritis Rheum
, vol.54
, pp. 2793-2806
-
-
Cohen, S.B.1
-
50
-
-
77954632414
-
Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis
-
Jones, R. B. et al. Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis. N. Engl. J. Med. 363, 211-220 (2010).
-
(2010)
N. Engl. J. Med
, vol.363
, pp. 211-220
-
-
Jones, R.B.1
-
51
-
-
34548221347
-
Mechanisms of killing by anti-CD20 monoclonal antibodies
-
Glennie, M. J., French, R. R., Cragg, M. S. & Taylor, R. P. Mechanisms of killing by anti-CD20 monoclonal antibodies. Mol. Immunol. 44, 3823-3837 (2007).
-
(2007)
Mol. Immunol
, vol.44
, pp. 3823-3837
-
-
Glennie, M.J.1
French, R.R.2
Cragg, M.S.3
Taylor, R.P.4
-
52
-
-
79955979273
-
Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in 2011;cell malignancies
-
Alduaij, W. et al. Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in 2011;cell malignancies. Blood 117, 4519-4529 (2011).
-
(2011)
Blood
, vol.117
, pp. 4519-4529
-
-
Alduaij, W.1
-
53
-
-
1642306050
-
Antibody specificity controls in vivo effector mechanisms of anti-CD20 reagents
-
Cragg, M. S. & Glennie, M. J. Antibody specificity controls in vivo effector mechanisms of anti-CD20 reagents. Blood 103, 2738-2743 (2004).
-
(2004)
Blood
, vol.103
, pp. 2738-2743
-
-
Cragg, M.S.1
Glennie, M.J.2
-
54
-
-
84868675342
-
Rationale of anti-CD19 immunotherapy: An option to target autoreactive plasma cells in autoimmunity
-
Mei, H. E., Schmidt, S. & Dörner T. Rationale of anti-CD19 immunotherapy: an option to target autoreactive plasma cells in autoimmunity. Arthritis Res. Ther. 14 (Suppl. 5), S1 (2012).
-
(2012)
Arthritis Res. Ther.
, vol.14
, Issue.SUPPL. 5
-
-
Mei, H.E.1
Schmidt, S.2
Dörner, T.3
-
55
-
-
0037108490
-
BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases
-
Roschke, V. et al. BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases. J. Immunol. 169, 4314-4321 (2002).
-
(2002)
J. Immunol
, vol.169
, pp. 4314-4321
-
-
Roschke, V.1
-
56
-
-
0018949401
-
Characterization of a human B lymphocyte-specific antigen
-
Stashenko, P., Nadler, L. M., Hardy, R. & Schlossman, S. F. Characterization of a human B lymphocyte-specific antigen. J. Immunol. 125, 1678-1685 (1980).
-
(1980)
J. Immunol
, vol.125
, pp. 1678-1685
-
-
Stashenko, P.1
Nadler, L.M.2
Hardy, R.3
Schlossman, S.F.4
-
57
-
-
0345362815
-
Expression of cell surface markers after human B lymphocyte activation
-
Stashenko, P., Nadler, L. M., Hardy, R. & Schlossman, S. F. Expression of cell surface markers after human B lymphocyte activation. Proc. Natl Acad. Sci. USA 78, 3848-3852 (1981).
-
(1981)
Proc. Natl Acad. Sci. USA
, vol.78
, pp. 3848-3852
-
-
Stashenko, P.1
Nadler, L.M.2
Hardy, R.3
Schlossman, S.F.4
-
58
-
-
54249100952
-
Potent in vitro and in vivo activity of an Fc-engineered anti-CD19 monoclonal antibody against lymphoma and leukemia
-
Horton, H. M. et al. Potent in vitro and in vivo activity of an Fc-engineered anti-CD19 monoclonal antibody against lymphoma and leukemia. Cancer Res. 68, 8049-8057 (2008).
-
(2008)
Cancer Res
, vol.68
, pp. 8049-8057
-
-
Horton, H.M.1
-
59
-
-
49649120397
-
Tumor regression in cancer patients by very low doses of a T cell-engaging antibody
-
Bargou, R. et al. Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science 321, 974-977 (2008).
-
(2008)
Science
, vol.321
, pp. 974-977
-
-
Bargou, R.1
-
60
-
-
0030588569
-
CD19 regulates B lymphocyte signaling thresholds critical for the development of 2011;1 lineage cells and autoimmunity
-
Sato, S., Ono, N., Steeber, D. A., Pisetsky, D. S. & Tedder, T. F. CD19 regulates B lymphocyte signaling thresholds critical for the development of 2011;1 lineage cells and autoimmunity. J. Immunol. 157, 4371-4378 (1996).
-
(1996)
J. Immunol
, vol.157
, pp. 4371-4378
-
-
Sato, S.1
Ono, N.2
Steeber, D.A.3
Pisetsky, D.S.4
Tedder, T.F.5
-
61
-
-
78049372729
-
Epratuzumab targeting of CD22 affects adhesion molecule expression and migration of 2011;cells in systemic lupus erythematosus
-
Daridon, C. et al. Epratuzumab targeting of CD22 affects adhesion molecule expression and migration of 2011;cells in systemic lupus erythematosus. Arthritis Res. Ther. 12, R204 (2010).
-
(2010)
Arthritis Res. Ther.
, vol.12
-
-
Daridon, C.1
-
62
-
-
26644450721
-
CD22: A multifunctional receptor that regulates B lymphocyte survival and signal transduction
-
Tedder, T. F., Poe, J. C. & Haas, K. M. CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction. Adv. Immunol. 88, 1-50 (2005).
-
(2005)
Adv. Immunol
, vol.88
, pp. 1-50
-
-
Tedder, T.F.1
Poe, J.C.2
Haas, K.M.3
-
63
-
-
41849121941
-
Differential effects of epratuzumab on peripheral blood B cells of patients with systemic lupus erythematosus versus normal controls
-
Jacobi, A. M. et al. Differential effects of epratuzumab on peripheral blood B cells of patients with systemic lupus erythematosus versus normal controls. Ann. Rheum. Dis. 67, 450-457 (2008).
-
(2008)
Ann. Rheum. Dis
, vol.67
, pp. 450-457
-
-
Jacobi, A.M.1
-
64
-
-
84874429605
-
CD22 ligation inhibits downstream 2011;cell receptor signaling and Ca2+ flux upon activation
-
Sieger, N. et al. CD22 ligation inhibits downstream 2011;cell receptor signaling and Ca2+ flux upon activation. Arthritis Rheum. 65, 770-779 (2013).
-
(2013)
Arthritis Rheum
, vol.65
, pp. 770-779
-
-
Sieger, N.1
-
65
-
-
0037732689
-
The role of B cells in rheumatoid arthritis: Mechanisms and therapeutic targets
-
Dörner, T. & Burmester, G. R. The role of B cells in rheumatoid arthritis: mechanisms and therapeutic targets. Curr. Opin. Rheumatol. 15, 246-252 (2003).
-
(2003)
Curr. Opin. Rheumatol
, vol.15
, pp. 246-252
-
-
Dörner, T.1
Burmester, G.R.2
-
66
-
-
79955806071
-
Updated consensus statement on the use of rituximab in patients with rheumatoid arthritis
-
Buch, M. H. et al. Updated consensus statement on the use of rituximab in patients with rheumatoid arthritis. Ann. Rheum. Dis. 70, 909-920 (2011).
-
(2011)
Ann. Rheum. Dis
, vol.70
, pp. 909-920
-
-
Buch, M.H.1
-
67
-
-
84863841745
-
Safety and efficacy of ocrelizumab in combination with methotrexate in MTX-naive subjects with rheumatoid arthritis: The phase III FILM trial
-
Stohl, W. et al. Safety and efficacy of ocrelizumab in combination with methotrexate in MTX-naive subjects with rheumatoid arthritis: the phase III FILM trial. Ann. Rheum. Dis. 71, 1289-1296 (2012).
-
(2012)
Ann. Rheum. Dis
, vol.71
, pp. 1289-1296
-
-
Stohl, W.1
-
68
-
-
84863012323
-
Safety and efficacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to at least one tumor necrosis factor inhibitor: Results of a fortyeightweek randomized, double-blind, placebo-controlled, parallel-group phase III trial
-
Tak, P. P. et al. Safety and efficacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to at least one tumor necrosis factor inhibitor: results of a fortyeightweek randomized, double-blind, placebo-controlled, parallel-group phase III trial. Arthritis Rheum. 64, 360-370 (2012).
-
(2012)
Arthritis Rheum
, vol.64
, pp. 360-370
-
-
Tak, P.P.1
-
69
-
-
77955386129
-
Ofatumumab, a human anti-CD20 monoclonal antibody, for treatment of rheumatoid arthritis with an inadequate response to one or more disease-modifying antirheumatic drugs: Results of a randomized, double-blind, placebo-controlled, phase I/II study
-
Østergaard, M. et al. Ofatumumab, a human anti-CD20 monoclonal antibody, for treatment of rheumatoid arthritis with an inadequate response to one or more disease-modifying antirheumatic drugs: results of a randomized, double-blind, placebo-controlled, phase I/II study. Arthritis Rheum. 62, 2227-2238 (2010).
-
(2010)
Arthritis Rheum.
, vol.62
, pp. 2227-2238
-
-
Østergaard, M.1
-
70
-
-
84860390375
-
Ofatumumab, a fully human anti-CD20 monoclonal antibody, in biological-naive, rheumatoid arthritis patients with an inadequate response to methotrexate: A randomised, double-blind, placebo-controlled clinical trial
-
Taylor, P. C. et al. Ofatumumab, a fully human anti-CD20 monoclonal antibody, in biological-naive, rheumatoid arthritis patients with an inadequate response to methotrexate: a randomised, double-blind, placebo-controlled clinical trial. Ann. Rheum. Dis. 70, 2119-2125 (2011).
-
(2011)
Ann. Rheum. Dis
, vol.70
, pp. 2119-2125
-
-
Taylor, P.C.1
-
71
-
-
84895134885
-
-
US National Library Of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/show/NCT01008852 (2013).
-
(2013)
-
-
-
72
-
-
0029875268
-
CAMPATH-1H in rheumatoid arthritis-an intravenous dose-ranging study
-
Isaacs, J. D. et al. CAMPATH-1H in rheumatoid arthritis-an intravenous dose-ranging study. Br. J. Rheumatol. 35, 231-240 (1996).
-
(1996)
Br. J. Rheumatol
, vol.35
, pp. 231-240
-
-
Isaacs, J.D.1
-
73
-
-
39749114393
-
Morbidity and mortality in rheumatoid arthritis patients with prolonged therapy-induced lymphopenia: Twelve-year outcomes
-
Lorenzi, A. R. et al. Morbidity and mortality in rheumatoid arthritis patients with prolonged therapy-induced lymphopenia: twelve-year outcomes. Arthritis Rheum. 58, 370-375 (2008).
-
(2008)
Arthritis Rheum
, vol.58
, pp. 370-375
-
-
Lorenzi, A.R.1
-
74
-
-
84874920634
-
Alemtuzumab: Evidence for its potential in relapsing-remitting multiple sclerosis
-
Brown, J. & Coles, A. J. Alemtuzumab: evidence for its potential in relapsing-remitting multiple sclerosis. Drug Des. Devel. Ther. 7, 131-118 (2013).
-
(2013)
Drug Des. Devel. Ther
, vol.7
, pp. 131-118
-
-
Brown, J.1
Coles, A.J.2
-
75
-
-
0036144353
-
Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome
-
Groom, J. et al. Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome. J. Clin. Invest. 109, 59-68 (2002).
-
(2002)
J. Clin. Invest
, vol.109
, pp. 59-68
-
-
Groom, J.1
-
76
-
-
11844301640
-
Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines
-
Ohata, J. et al. Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines. J. Immunol. 174, 864-870 (2005).
-
(2005)
J. Immunol
, vol.174
, pp. 864-870
-
-
Ohata, J.1
-
77
-
-
17344380531
-
TACI and BCMA are receptors for a TNF homologue implicated in 2011;cell autoimmune disease
-
Gross, J. A. et al. TACI and BCMA are receptors for a TNF homologue implicated in 2011;cell autoimmune disease. Nature 404, 995-999 (2000).
-
(2000)
Nature
, vol.404
, pp. 995-999
-
-
Gross, J.A.1
-
78
-
-
44449118619
-
Spleen tyrosine kinase: A novel target for therapeutic intervention of rheumatoid arthritis
-
Bajpai, M., Chopra, P., Dastidar, S. G. & Ray, A. Spleen tyrosine kinase: a novel target for therapeutic intervention of rheumatoid arthritis. Expert Opin. Investig. Drugs. 17, 641-659 (2008).
-
(2008)
Expert Opin. Investig. Drugs
, vol.17
, pp. 641-659
-
-
Bajpai, M.1
Chopra, P.2
Dastidar, S.G.3
Ray, A.4
-
79
-
-
77953245981
-
A multitude of kinases-which are the best targets in treating rheumatoid arthritis?
-
Lindstrom, T. M & Robinson, W. H. A multitude of kinases - which are the best targets in treating rheumatoid arthritis? Rheum. Dis. Clin. North Am. 36, 367-383 (2010).
-
(2010)
Rheum. Dis. Clin. North Am
, vol.36
, pp. 367-383
-
-
Lindstrom, T.M.1
Robinson, W.H.2
-
80
-
-
78049527643
-
Regulatory B cells in autoimmunity: Developments and controversies
-
Mauri, C. & Blair, P. A. Regulatory B cells in autoimmunity: developments and controversies. Nat. Rev. Rheumatol. 6, 636-643 (2010).
-
(2010)
Nat. Rev. Rheumatol
, vol.6
, pp. 636-643
-
-
Mauri, C.1
Blair, P.A.2
-
81
-
-
78751469622
-
Characterization of a rare IL10competent 2011;cell subset in humans that parallels mouse regulatory B10 cells
-
Iwata, Y. Characterization of a rare IL10competent 2011;cell subset in humans that parallels mouse regulatory B10 cells. Blood 117, 530-541 (2011).
-
(2011)
Blood
, vol.117
, pp. 530-541
-
-
Iwata, Y.1
-
82
-
-
84874720574
-
CD19+CD24hiCD38hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiation
-
Flores-Borja, F. et al. CD19+CD24hiCD38hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiation. Sci. Transl. Med. 5, 173ra23 (2013).
-
(2013)
Sci. Transl. Med.
, vol.5
, pp. 173-223
-
-
Flores-Borja, F.1
-
83
-
-
46249090513
-
Colony-stimulating factors in inflammation and autoimmunity
-
Hamilton, J. A. Colony-stimulating factors in inflammation and autoimmunity. Nat. Rev. Immunol. 8, 533-544 (2008).
-
(2008)
Nat. Rev. Immunol
, vol.8
, pp. 533-544
-
-
Hamilton, J.A.1
-
84
-
-
0028328236
-
Evidence for GMCSF receptor expression in synovial tissue. An analysis by semi-quantitative polymerase chain reaction on rheumatoid arthritis and osteoarthritis synovial biopsies
-
Berenbaum, F., Rajzbaum, G., Amor, B. & Toubert, A. Evidence for GMCSF receptor expression in synovial tissue. An analysis by semi-quantitative polymerase chain reaction on rheumatoid arthritis and osteoarthritis synovial biopsies. Eur. Cytokine Netw. 5, 43-46 (1994).
-
(1994)
Eur. Cytokine Netw
, vol.5
, pp. 43-46
-
-
Berenbaum, F.1
Rajzbaum, G.2
Amor, B.3
Toubert, A.4
-
85
-
-
84866490334
-
Pulmonary alveolar proteinosis
-
Wang, T., Lazar, C. A., Fishbein, M. C. & Lynch, J. P. 3rd. Pulmonary alveolar proteinosis. Semin. Respir. Crit. Care Med. 33, 498-508 (2012).
-
(2012)
Semin. Respir. Crit. Care Med
, vol.33
, pp. 498-508
-
-
Wang, T.1
Lazar, C.A.2
Fishbein, M.C.3
-
86
-
-
79960712114
-
Pulmonary alveolar proteinosis
-
Khan, A. & Agarwal, R. Pulmonary alveolar proteinosis. Respir. Care 56, 1016-1028 (2011).
-
(2011)
Respir. Care
, vol.56
, pp. 1016-1028
-
-
Khan, A.1
Agarwal, R.2
-
87
-
-
48449102092
-
The structure of the GMCSF receptor complex reveals a distinct mode of cytokine receptor activation
-
Hansen, G. et al. The structure of the GMCSF receptor complex reveals a distinct mode of cytokine receptor activation. Cell 134, 496-507 (2008).
-
(2008)
Cell
, vol.134
, pp. 496-507
-
-
Hansen, G.1
-
88
-
-
80955177524
-
Mavrilimumab, a human monoclonal antibody targeting GMCSF receptorα, in subjects with rheumatoid arthritis: A randomised, double-blind, placebo-controlled, phase I, firstinhuman study
-
Burmester, G. R. et al. Mavrilimumab, a human monoclonal antibody targeting GMCSF receptorα, in subjects with rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase I, firstinhuman study. Ann. Rheum. Dis. 70, 1542-1549 (2011).
-
(2011)
Ann. Rheum. Dis
, vol.70
, pp. 1542-1549
-
-
Burmester, G.R.1
-
89
-
-
84881479459
-
Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis
-
Burmester, G. R. et al. Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis. Ann. Rheum. Dis. 72, 1445-1452 (2013).
-
(2013)
Ann. Rheum. Dis
, vol.72
, pp. 1445-1452
-
-
Burmester, G.R.1
-
90
-
-
84895156384
-
-
US National Library Of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], http://www.clinicaltrials.gov/ct2/show/NCT01023256?term=nct01023256&rank=1 (2012).
-
(2012)
-
-
-
91
-
-
51349111163
-
An overview of IL17 function and signaling
-
Gaffen, S. L. An overview of IL17 function and signaling. Cytokine 43, 402-407 (2008).
-
(2008)
Cytokine
, vol.43
, pp. 402-407
-
-
Gaffen, S.L.1
-
92
-
-
69349093225
-
Interleukin17 and type 17 helper T cells
-
Miossec, P., Korn, T. & Kuchroo, V. K. Interleukin17 and type 17 helper T cells. N. Engl. J. Med. 361, 888-898 (2009).
-
(2009)
N. Engl. J. Med
, vol.361
, pp. 888-898
-
-
Miossec, P.1
Korn, T.2
Kuchroo, V.K.3
-
93
-
-
66049151440
-
TH17 and natural TREG cell population dynamics in systemic lupus erythematosus
-
Yang, J. et al. TH17 and natural TREG cell population dynamics in systemic lupus erythematosus. Arthritis Rheum. 60, 1472-1483 (2009).
-
(2009)
Arthritis Rheum
, vol.60
, pp. 1472-1483
-
-
Yang, J.1
-
94
-
-
75649142843
-
The gene expression of type 17 Thelper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosus
-
Kwan, B. C. et al. The gene expression of type 17 Thelper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosus. Rheumatology (Oxford) 48, 1491-1497 (2009).
-
(2009)
Rheumatology (Oxford)
, vol.48
, pp. 1491-1497
-
-
Kwan, B.C.1
-
95
-
-
70749113527
-
Laser microdissection-based analysis of cytokine balance in the kidneys of patients with lupus nephritis
-
Wang, Y. et al. Laser microdissection-based analysis of cytokine balance in the kidneys of patients with lupus nephritis. Clin. Exp. Immunol. 159, 1-10 (2010).
-
(2010)
Clin. Exp. Immunol
, vol.159
, pp. 1-10
-
-
Wang, Y.1
-
96
-
-
77957032994
-
TH17 plasticity in human autoimmune arthritis is driven by the inflammatory environment
-
Nistala, K. et al. TH17 plasticity in human autoimmune arthritis is driven by the inflammatory environment. Proc. Natl Acad. Sci. USA 107, 14751-14756 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 14751-14756
-
-
Nistala, K.1
-
97
-
-
84857737880
-
Inflammatory bone loss: Pathogenesis and therapeutic intervention
-
Redlich, K. & Smolen, J. S. Inflammatory bone loss: pathogenesis and therapeutic intervention. Nat. Rev. Drug Discov. 11, 234-250 (2012).
-
(2012)
Nat. Rev. Drug Discov
, vol.11
, pp. 234-250
-
-
Redlich, K.1
Smolen, J.S.2
-
98
-
-
77958072084
-
Effects of AIN457, a fully human antibody to interleukin17A, on psoriasis, rheumatoid arthritis, and uveitis
-
Hueber, W. et al. Effects of AIN457, a fully human antibody to interleukin17A, on psoriasis, rheumatoid arthritis, and uveitis. Sci. Transl. Med. 2, 52ra72 (2010).
-
(2010)
Sci. Transl. Med.
, vol.2
, pp. 52-72
-
-
Hueber, W.1
-
99
-
-
84877603562
-
Efficacy and safety of secukinumab in patients with rheumatoid arthritis: A phase II, dose-finding, double-blind, randomised, placebo controlled study
-
Genovese, M. C. et al. Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study. Ann. Rheum. Dis. 72, 863-869 (2013).
-
(2013)
Ann. Rheum. Dis
, vol.72
, pp. 863-869
-
-
Genovese, M.C.1
-
100
-
-
84873168729
-
Secukinumab induction and maintenance therapy in moderatetosevere plaque psoriasis: A randomized, double-blind, placebo-controlled, phase II regimen-finding study
-
Rich, P. et al. Secukinumab induction and maintenance therapy in moderatetosevere plaque psoriasis: a randomized, double-blind, placebo-controlled, phase II regimen-finding study. Br. J. Dermatol. 168, 402-411 (2013).
-
(2013)
Br. J. Dermatol
, vol.168
, pp. 402-411
-
-
Rich, P.1
-
101
-
-
84868680312
-
Secukinumab, a human antiIL17A monoclonal antibody, for moderate to severe Crohn's disease: Unexpected results of a randomised, double-blind placebo-controlled trial
-
Hueber, W. et al. Secukinumab, a human antiIL17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut 61, 1693-1700 (2012).
-
(2012)
Gut
, vol.61
, pp. 1693-1700
-
-
Hueber, W.1
-
102
-
-
84859073115
-
Antiinterleukin17 monoclonal antibody ixekizumab in chronic plaque psoriasis
-
Leonardi, C. et al. Antiinterleukin17 monoclonal antibody ixekizumab in chronic plaque psoriasis. N. Engl. J. Med. 366, 1190-1199 (2012).
-
(2012)
N. Engl. J. Med
, vol.366
, pp. 1190-1199
-
-
Leonardi, C.1
-
103
-
-
77950535421
-
LY2439821, a humanized antiinterleukin17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase i randomized, double-blind, placebo-controlled, proofofconcept study
-
Genovese, M. C. et al. LY2439821, a humanized antiinterleukin17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase I randomized, double-blind, placebo-controlled, proofofconcept study. Arthritis Rheum. 62, 929-939 (2010).
-
(2010)
Arthritis Rheum
, vol.62
, pp. 929-939
-
-
Genovese, M.C.1
-
104
-
-
84874552498
-
A phase 2 study of multiple subcutaneous doses of LY2439821, an antiIL17 monoclonal antibody, in patients with rheumatoid arthritis in two populations: Naïve to biologic therapy or inadequate responders to tumor necrosis factor α inhibitors [abstract]
-
Genovese, M. et al. A phase 2 study of multiple subcutaneous doses of LY2439821, an antiIL17 monoclonal antibody, in patients with rheumatoid arthritis in two populations: naïve to biologic therapy or inadequate responders to tumor necrosis factor α inhibitors [abstract]. Arthritis Rheum. 63 (Suppl. 10) 2591 (2011).
-
(2011)
Arthritis Rheum.
, vol.63
, Issue.SUPPL. 10
, pp. 2591
-
-
Genovese, M.1
-
105
-
-
33749320939
-
Function of interleukin20 as a proinflammatory molecule in rheumatoid and experimental arthritis
-
Hsu, Y. H. et al. Function of interleukin20 as a proinflammatory molecule in rheumatoid and experimental arthritis. Arthritis Rheum. 54, 2722-2733 (2006).
-
(2006)
Arthritis Rheum
, vol.54
, pp. 2722-2733
-
-
Hsu, Y.H.1
-
107
-
-
80053929207
-
20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss
-
2011
-
Hsu, Y. H. AntiIL20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss. J. Exp. Med. 208, 1849-1861 (2011).
-
(2011)
J. Exp. Med
, vol.208
, pp. 1849-1861
-
-
Hsu, Y.H.1
-
108
-
-
80053929207
-
20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss
-
Hsu, Y. H. et al. AntiIL20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss. J. Exp. Med. 208, 1849-1861 (2011).
-
(2011)
J. Exp. Med
, vol.208
, pp. 1849-1861
-
-
Hsu, Y.H.1
-
109
-
-
84895181962
-
NNC0109-0012 (antiIL20 mAb), well tolerated in healthy subjects and patients with rheumatoid arthritis [abstract FRI0196]
-
Al Kotbi, N., Jensen, L. & Graff, L. B. NNC0109-0012 (antiIL20 mAb), well tolerated in healthy subjects and patients with rheumatoid arthritis [abstract FRI0196]. Ann. Rheum. Dis. 71 (Suppl. 3), 379 (2012).
-
(2012)
Ann. Rheum. Dis.
, vol.71
, Issue.SUPPL. 3
, pp. 379
-
-
Al Kotbi, N.1
Jensen, L.2
Graff, L.B.3
-
110
-
-
84895181962
-
NNC0109-0012 (antiIL20 mAb), well tolerated in patients with rheumatoid arthritis [abstract FRI0197]
-
Leszczynski, P., Eshof, M. K., Stegmann, H. V. B., Hundahl Møller, N. P. & Graff, L. B. NNC0109-0012 (antiIL20 mAb), well tolerated in patients with rheumatoid arthritis [abstract FRI0197]. Ann. Rheum. Dis. 71 (Suppl. 3), 379 (2012).
-
(2012)
Ann. Rheum. Dis.
, vol.71
, Issue.SUPPL. 3
, pp. 379
-
-
Leszczynski, P.1
Eshof, M.K.2
Stegmann, H.V.B.3
Hundahl Møller, N.P.4
Graff, L.B.5
-
111
-
-
84895166843
-
Efficacy and safety of NNC0109-0012 (antiIL20 mAb) in patients with rheumatoid arthritis: Results from a phase 2a trial [abstract LB0004]
-
Šenolt, L., Göthberg, M., Valencia, X. & Dokoupilová, E. Efficacy and safety of NNC0109-0012 (antiIL20 mAb) in patients with rheumatoid arthritis: results from a phase 2a trial [abstract LB0004]. Ann. Rheum. Dis. 71 (Suppl. 3), 152 (2012).
-
(2012)
Ann. Rheum. Dis.
, vol.71
, Issue.SUPPL. 3
, pp. 152
-
-
Šenolt, L.1
Göthberg, M.2
Valencia, X.3
Dokoupilová, E.4
-
112
-
-
84863229614
-
Interleukin21 promotes osteoclastogenesis in humans with rheumatoid arthritis and in mice with collagen-induced arthritis
-
Kwok, S. K. et al. Interleukin21 promotes osteoclastogenesis in humans with rheumatoid arthritis and in mice with collagen-induced arthritis. Arthritis Rheum. 64, 740-751 (2012).
-
(2012)
Arthritis Rheum
, vol.64
, pp. 740-751
-
-
Kwok, S.K.1
-
113
-
-
77957879962
-
Increased interleukin 21 (IL21) and IL23 are associated with increased disease activity and with radiographic status in patients with early rheumatoid arthritis
-
Rasmussen, T. K. et al. Increased interleukin 21 (IL21) and IL23 are associated with increased disease activity and with radiographic status in patients with early rheumatoid arthritis. J. Rheumatol. 37, 2014-2020 (2010).
-
(2010)
J. Rheumatol
, vol.37
, pp. 2014-2020
-
-
Rasmussen, T.K.1
-
114
-
-
84874339517
-
Nuclear receptor NR4A2 orchestrates TH17 cell-mediated autoimmune inflammation via IL21 signalling
-
Raveney, B. J., Oki, S. & Yamamura, T. Nuclear receptor NR4A2 orchestrates TH17 cell-mediated autoimmune inflammation via IL21 signalling. PLoS ONE 8, e56595 (2013).
-
(2013)
PLoS ONE
, vol.8
-
-
Raveney, B.J.1
Oki, S.2
Yamamura, T.3
-
115
-
-
77950538932
-
21 regulates TH17 cells in rheumatoid arthritis
-
Niu, X. et al. IL21 regulates TH17 cells in rheumatoid arthritis. Hum. Immunol. 71, 334-341 (2010).
-
(2010)
Hum. Immunol
, vol.71
, pp. 334-341
-
-
Niu, X.1
-
116
-
-
84862575218
-
Serum IL, 6 and IL, 21 are associated with markers of B cell activation and structural progression in early rheumatoid arthritis: Results from the ESPOIR cohort
-
Gottenberg, J. E. et al. Serum IL6 and IL21 are associated with markers of B cell activation and structural progression in early rheumatoid arthritis: results from the ESPOIR cohort. Ann. Rheum. Dis. 71, 1243-1248 (2012).
-
(2012)
Ann. Rheum. Dis
, vol.71
, pp. 1243-1248
-
-
Gottenberg, J.E.1
-
117
-
-
84895117856
-
-
US National Library Of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], http://www.clinicaltrials.gov/ct2/show/NCT01208506?term=NCT01208506&rank=1 (2012).
-
(2012)
-
-
-
118
-
-
85028106569
-
Chemokine receptor CCR1 antagonist CCX354C treatment for rheumatoid arthritis: CARAT, 2, a randomised, placebo controlled clinical trial
-
Tak, P. P. et al. Chemokine receptor CCR1 antagonist CCX354C treatment for rheumatoid arthritis: CARAT2, a randomised, placebo controlled clinical trial. Ann. Rheum. Dis. 72, 337-344 (2013).
-
(2013)
Ann. Rheum. Dis.
, vol.72
, pp. 337-344
-
-
Tak, P.P.1
-
119
-
-
84860649140
-
MicroRNAs in rheumatoid arthritis: Potential role in diagnosis and therapy
-
Filková, M., Jüngel, A., Gay, R. E. & Gay, S. MicroRNAs in rheumatoid arthritis: potential role in diagnosis and therapy. BioDrugs 26, 131-141 (2012).
-
(2012)
BioDrugs
, vol.26
, pp. 131-141
-
-
Filková, M.1
Jüngel, A.2
Gay, R.E.3
Gay, S.4
-
120
-
-
84865479037
-
Cell depletion in the treatment of lupus nephritis
-
Gregersen, J. W. & Jayne, D. R. 2011;cell depletion in the treatment of lupus nephritis Nat. Rev. Nephrol. 8, 505-514 (2012).
-
(2011)
Nat. Rev. Nephrol
, vol.8
, pp. 505-514
-
-
Gregersen, J.W.1
Jayne, D.R.2
-
121
-
-
84895189993
-
-
US National Library Of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], http://www.clinicaltrials.gov/ct2/show/study/NCT00639834?term= CD19+rheumatoid&rank=1 (2013).
-
(2013)
-
-
-
122
-
-
84895169233
-
-
US National Library Of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], http://www.clinicaltrials.gov/ct2/show/NCT01390545?term=Veltuzumab&rank=5 (2012).
-
(2012)
-
-
-
123
-
-
84895113655
-
-
US National Library Of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], http://www.clinicaltrials.gov/ct2/show/study/NCT00655824?term= Ofatumumab&rank=9 (2012).
-
(2012)
-
-
-
124
-
-
84895191360
-
-
US National Library Of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], http://www.clinicaltrials.gov/ct2/show/NCT01408576?term=Epratuzumab&rank=5 (2013).
-
(2013)
-
-
-
125
-
-
84895174838
-
-
US National Library Of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], http://www.clinicaltrials.gov/ct2/show/NCT01261793?term=Epratuzumab&rank=8 (2013).
-
(2013)
-
-
-
126
-
-
84889657510
-
Efficacy and safety of epratuzumab in patients with moderate/severe active systemic lupus erythematosus: Results from EMBLEM, a phase IIb, randomised, double-blind, placebo-controlled, multicentre study
-
doi: /annrheumdis-2012-202
-
Wallace, D.J. et al. Efficacy and safety of epratuzumab in patients with moderate/severe active systemic lupus erythematosus: results from EMBLEM, a phase IIb, randomised, double-blind, placebo-controlled, multicentre study. Ann. Rheum. Dis. doi: /annrheumdis-2012-202
-
Ann. Rheum. Dis.
-
-
Wallace, D.J.1
-
127
-
-
84895097476
-
-
US National Library Of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], http://www.clinicaltrials.gov/ct2/show/NCT01706926?term= mavrilimumab+AND+arthritis&rank=2 (2013).
-
(2013)
-
-
-
128
-
-
84895120829
-
-
US National Library Of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], http://www.clinicaltrials.gov/ct2/show/NCT01712399?term= mavrilimumab+AND+arthritis&rank=3 (2013).
-
(2013)
-
-
-
129
-
-
84895124848
-
-
US National Library Of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], http://www.clinicaltrials.gov/ct2/show/NCT01715896?term= mavrilimumab+AND+arthritis&rank=1 (2013).
-
(2013)
-
-
-
130
-
-
84895110997
-
-
US National Library Of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], http://www.clinicaltrials.gov/ct2/show/NCT01640938?term= Secukinumab+AND+rheumatoid&rank=1 (2013).
-
(2013)
-
-
-
131
-
-
84895172315
-
-
US National Library Of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], http://www.clinicaltrials.gov/ct2/show/NCT01770379?term= Secukinumab+AND+rheumatoid&rank=2 (2013).
-
(2013)
-
-
-
132
-
-
84895191579
-
-
US National Library Of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], http://www.clinicaltrials.gov/ct2/show/NCT00966875?term=ixekizumab&rank=8 (2012).
-
(2012)
-
-
-
133
-
-
84895164006
-
-
US National Library Of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], http://www.clinicaltrials.gov/ct2/show/NCT01636843?term=NNC0109+0012&rank=1 (2013).
-
(2013)
-
-
-
134
-
-
84895175907
-
-
US National Library Of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], http://www.clinicaltrials.gov/ct2/show/NCT01636817?term=NNC0109+0012&rank=2 (2013).
-
(2013)
-
-
|