메뉴 건너뛰기




Volumn 72, Issue 9, 2013, Pages 1549-1558

Foxp3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; CD4 ANTIGEN; CD45RA ANTIGEN; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CXCR3; DISEASE MODIFYING ANTIRHEUMATIC DRUG; GAMMA INTERFERON; HELIOS TRANSCRIPTION FACTOR; IKAROS TRANSCRIPTION FACTOR; INTERLEUKIN 2; KI 67 ANTIGEN; PREDNISOLONE; STAT5A PROTEIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

EID: 84881432074     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2012-202216     Document Type: Article
Times cited : (134)

References (43)
  • 1
    • 82555196095 scopus 로고    scopus 로고
    • Systemic lupus erythematosus
    • Tsokos GC. Systemic lupus erythematosus. N Engl J Med 2011;365:2110-21.
    • (2011) N Engl J Med , vol.365 , pp. 2110-2121
    • Tsokos, G.C.1
  • 2
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: Mechanisms of differentiation and function
    • Josefowicz SZ, Lu LF, Rudensky AY. Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol 2012;30:531-64.
    • (2012) Annu Rev Immunol , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1    Lu, L.F.2    Rudensky, A.Y.3
  • 3
    • 77957801548 scopus 로고    scopus 로고
    • Pathogenetic aspects of systemic lupus erythematosus with an emphasis on regulatory T cells
    • Scheinecker C, Bonelli M, Smolen JS. Pathogenetic aspects of systemic lupus erythematosus with an emphasis on regulatory T cells. J Autoimmun 2010;35:269-75.
    • (2010) J Autoimmun , vol.35 , pp. 269-275
    • Scheinecker, C.1    Bonelli, M.2    Smolen, J.S.3
  • 4
    • 33846900430 scopus 로고    scopus 로고
    • high T regulatory cell function in patients with active systemic lupus erythematosus
    • Valencia X, Yarboro C, Illei G, et al. Deficient CD4+CD25 high T regulatory cell function in patients with active systemic lupus erythematosus. J Immunol 2007;178:2579-88. (Pubitemid 46233461)
    • (2007) Journal of Immunology , vol.178 , Issue.4 , pp. 2579-2588
    • Valencia, X.1    Yarboro, C.2    Illei, G.3    Lipsky, P.E.4
  • 7
    • 0242403301 scopus 로고    scopus 로고
    • Quantification of regulatory T cells in patients with systemic lupus erythematosus
    • DOI 10.1016/S0896-8411(03)00121-5
    • Crispin JC, Martinez A, Alcocer-Varela J. Quantification of regulatory T cells in patients with systemic lupus erythematosus. J Autoimmun 2003;21:273-6. (Pubitemid 37410115)
    • (2003) Journal of Autoimmunity , vol.21 , Issue.3 , pp. 273-276
    • Crispin, J.C.1    Martinez, A.2    Alcocer-Varela, J.3
  • 9
    • 81755184312 scopus 로고    scopus 로고
    • Regulatory T-cells in systemic lupus erythematosus and rheumatoid arthritis
    • Chavele KM, Ehrenstein MR. Regulatory T-cells in systemic lupus erythematosus and rheumatoid arthritis. FEBS Lett 2011;585:3603-10.
    • (2011) FEBS Lett , vol.585 , pp. 3603-3610
    • Chavele, K.M.1    Ehrenstein, M.R.2
  • 11
    • 33947121146 scopus 로고    scopus 로고
    • Transient regulatory T-cells: A state attained by all activated human T-cells
    • DOI 10.1016/j.clim.2006.10.014, PII S1521661606009405
    • Pillai V, Ortega SB, Wang CK, et al. Transient regulatory T-cells: a state attained by all activated human T-cells. Clin Immunol 2007;123:18-29. (Pubitemid 46401504)
    • (2007) Clinical Immunology , vol.123 , Issue.1 , pp. 18-29
    • Pillai, V.1    Ortega, S.B.2    Wang, C.K.3    Karandikar, N.J.4
  • 12
    • 33646240855 scopus 로고    scopus 로고
    • Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development
    • Gavin MA, Torgerson TR, Houston E, et al. Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc Natl Acad Sci USA 2006;103:6659-64.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 6659-6664
    • Gavin, M.A.1    Torgerson, T.R.2    Houston, E.3
  • 13
    • 15244354286 scopus 로고    scopus 로고
    • Regulatory T cell lineage specification by the forkhead transcription factor Foxp3
    • DOI 10.1016/j.immuni.2005.01.016
    • Fontenot JD, Rasmussen JP, Williams LM, et al. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 2005;22:329-41. (Pubitemid 40387475)
    • (2005) Immunity , vol.22 , Issue.3 , pp. 329-341
    • Fontenot, J.D.1    Rasmussen, J.P.2    Williams, L.M.3    Dooley, J.L.4    Farr, A.G.5    Rudensky, A.Y.6
  • 14
    • 36048978911 scopus 로고    scopus 로고
    • Foxp3 Transcription-Factor-Dependent and -Independent Regulation of the Regulatory T Cell Transcriptional Signature
    • DOI 10.1016/j.immuni.2007.09.010, PII S107476130700492X
    • Hill JA, Feuerer M, Tash K, et al. Foxp3 transcription-factor-dependent and-independent regulation of the regulatory T cell transcriptional signature. Immunity 2007;27:786-800. (Pubitemid 350110546)
    • (2007) Immunity , vol.27 , Issue.5 , pp. 786-800
    • Hill, J.A.1    Feuerer, M.2    Tash, K.3    Haxhinasto, S.4    Perez, J.5    Melamed, R.6    Mathis, D.7    Benoist, C.8
  • 15
    • 77951638740 scopus 로고    scopus 로고
    • Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3 + T regulatory cells
    • Thornton AM, Korty PE, Tran DQ, et al. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3 + T regulatory cells. J Immunol 2010;184:3433-41.
    • (2010) J Immunol , vol.184 , pp. 3433-3441
    • Thornton, A.M.1    Korty, P.E.2    Tran, D.Q.3
  • 16
    • 78650636296 scopus 로고    scopus 로고
    • Comment on "expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3 + T regulatory cells"
    • Verhagen J, Wraith DC. Comment on "Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3 + T regulatory cells". J Immunol 2010;185:7129.
    • (2010) J Immunol , vol.185 , pp. 7129
    • Verhagen, J.1    Wraith, D.C.2
  • 17
    • 80052287274 scopus 로고    scopus 로고
    • Helios expression is a marker of T cell activation and proliferation
    • Akimova T, Beier UH, Wang L, et al. Helios expression is a marker of T cell activation and proliferation. PLoS One 2011;6:e24226.
    • (2011) PLoS One , vol.6
    • Akimova, T.1    Beier, U.H.2    Wang, L.3
  • 18
    • 84856567623 scopus 로고    scopus 로고
    • Expression of Helios in peripherally induced Foxp3+ regulatory T cells
    • Gottschalk RA, Corse E, Allison JP. Expression of Helios in peripherally induced Foxp3+ regulatory T cells. J Immunol 2012;188:976-80.
    • (2012) J Immunol , vol.188 , pp. 976-980
    • Gottschalk, R.A.1    Corse, E.2    Allison, J.P.3
  • 19
    • 77950628840 scopus 로고    scopus 로고
    • A role for the transcription factor Helios in human CD4(+)CD25(+) regulatory T cells
    • Getnet D, Grosso JF, Goldberg MV, et al. A role for the transcription factor Helios in human CD4(+)CD25(+) regulatory T cells. Mol Immunol 2010;47:1595-600.
    • (2010) Mol Immunol , vol.47 , pp. 1595-1600
    • Getnet, D.1    Grosso, J.F.2    Goldberg, M.V.3
  • 20
    • 84859123340 scopus 로고    scopus 로고
    • Phenotypic and functional properties of helios(+) regulatory T cells
    • Zabransky DJ, Nirschl CJ, Durham NM, et al. Phenotypic and functional properties of helios(+) regulatory T cells. PLoS One 2012;7:e34547.
    • (2012) PLoS One , vol.7
    • Zabransky, D.J.1    Nirschl, C.J.2    Durham, N.M.3
  • 21
    • 84863360489 scopus 로고    scopus 로고
    • Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in vitro expansion
    • Published Online First: 31 Jan. doi: 10.1182/blood-2011-09-377895
    • Kim YC, Bhairavabhotla R, Yoon J, et al. Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in vitro expansion. Blood Published Online First: 31 Jan 2012. doi: 10.1182/blood-2011-09-377895
    • (2012) Blood
    • Kim, Y.C.1    Bhairavabhotla, R.2    Yoon, J.3
  • 22
    • 59449092041 scopus 로고    scopus 로고
    • Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system
    • Alexander T, Thiel A, Rosen O, et al. Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system. Blood 2009;113:214-23.
    • (2009) Blood , vol.113 , pp. 214-223
    • Alexander, T.1    Thiel, A.2    Rosen, O.3
  • 24
    • 46249105330 scopus 로고    scopus 로고
    • Single-cell phospho-protein analysis by flow cytometry
    • doi: 10.1002/0471142735. im0817s96
    • Schulz KR, Danna EA, Krutzik PO, et al. Single-cell phospho-protein analysis by flow cytometry. Curr Protoc Immunol 2012;96:8.17.1-8.17.20. doi: 10.1002/0471142735. im0817s96
    • (2012) Curr Protoc Immunol , vol.96 , pp. 1-20
    • Schulz, K.R.1    Danna, E.A.2    Krutzik, P.O.3
  • 25
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995;155:1151-64.
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3
  • 27
    • 66949171924 scopus 로고    scopus 로고
    • Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor
    • Miyara M, Yoshioka Y, Kitoh A, et al. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 2009;30:899-911.
    • (2009) Immunity , vol.30 , pp. 899-911
    • Miyara, M.1    Yoshioka, Y.2    Kitoh, A.3
  • 28
    • 69949133380 scopus 로고    scopus 로고
    • CXCR3, inflammation, and autoimmune diseases
    • Lacotte S, Brun S, Muller S, et al. CXCR3, inflammation, and autoimmune diseases. Ann NY Acad Sci 2009;1173:310-17.
    • (2009) Ann NY Acad Sci , vol.1173 , pp. 310-317
    • Lacotte, S.1    Brun, S.2    Muller, S.3
  • 29
    • 33947254437 scopus 로고    scopus 로고
    • Cutting edge: Chemokine receptor CCR4 is necessary for antigen-driven cutaneous accumulation of CD4 T cells under physiological conditions
    • Campbell JJ, O'Connell DJ, Wurbel MA. Cutting Edge: chemokine receptor CCR4 is necessary for antigen-driven cutaneous accumulation of CD4T cells under physiological conditions. J Immunol 2007;178:3358-62. (Pubitemid 46417598)
    • (2007) Journal of Immunology , vol.178 , Issue.6 , pp. 3358-3362
    • Campbell, J.J.1    O'Connell, D.J.2    Wurbel, M.-A.3
  • 30
    • 33846980131 scopus 로고    scopus 로고
    • Epigenetic control of the foxp3 locus in regulatory T cells
    • Floess S, Freyer J, Siewert C, et al. Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol 2007;5:e38.
    • (2007) PLoS Biol , vol.5
    • Floess, S.1    Freyer, J.2    Siewert, C.3
  • 32
    • 77952754636 scopus 로고    scopus 로고
    • Different proliferative potential and migratory characteristics of human CD4+ regulatory T cells that express either CD45RA or CD45RO
    • Booth NJ, McQuaid AJ, Sobande T, et al. Different proliferative potential and migratory characteristics of human CD4+ regulatory T cells that express either CD45RA or CD45RO. J Immunol 2010;184:4317-26.
    • (2010) J Immunol , vol.184 , pp. 4317-4326
    • Booth, N.J.1    McQuaid, A.J.2    Sobande, T.3
  • 33
    • 67649876115 scopus 로고    scopus 로고
    • New insights into the regulation of T cells by gamma(c) family cytokines
    • Rochman Y, Spolski R, Leonard WJ. New insights into the regulation of T cells by gamma(c) family cytokines. Nat Rev Immunol 2009;9:480-90.
    • (2009) Nat Rev Immunol , vol.9 , pp. 480-490
    • Rochman, Y.1    Spolski, R.2    Leonard, W.J.3
  • 34
    • 79960657991 scopus 로고    scopus 로고
    • Multidimensional single cell based STAT phosphorylation profiling identifies a novel biosignature for evaluation of systemic lupus erythematosus activity
    • Huang X, Guo Y, Bao C, et al. Multidimensional single cell based STAT phosphorylation profiling identifies a novel biosignature for evaluation of systemic lupus erythematosus activity. PLoS One 2011;6:e21671.
    • (2011) PLoS One , vol.6
    • Huang, X.1    Guo, Y.2    Bao, C.3
  • 36
    • 33747099523 scopus 로고    scopus 로고
    • Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells
    • Pacholczyk R, Ignatowicz H, Kraj P, et al. Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells. Immunity 2006;25:249-59.
    • (2006) Immunity , vol.25 , pp. 249-259
    • Pacholczyk, R.1    Ignatowicz, H.2    Kraj, P.3
  • 37
    • 74049164847 scopus 로고    scopus 로고
    • Regulatory T cells exert checks and balances on self tolerance and autoimmunity
    • Wing K, Sakaguchi S. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol 2010;11:7-13.
    • (2010) Nat Immunol , vol.11 , pp. 7-13
    • Wing, K.1    Sakaguchi, S.2
  • 38
    • 58249117641 scopus 로고    scopus 로고
    • CXCR3+CD4+ T cells are enriched in inflamed kidneys and urine and provide a new biomarker for acute nephritis flares in systemic lupus erythematosus patients
    • Enghard P, Humrich JY, Rudolph B, et al. CXCR3+CD4+ T cells are enriched in inflamed kidneys and urine and provide a new biomarker for acute nephritis flares in systemic lupus erythematosus patients. Arthritis Rheum 2009;60:199-206.
    • (2009) Arthritis Rheum , vol.60 , pp. 199-206
    • Enghard, P.1    Humrich, J.Y.2    Rudolph, B.3
  • 39
    • 84865352053 scopus 로고    scopus 로고
    • Peripherally Circulating CD4(+) FOXP3(+) CXCR3(+) T regulatory cells correlate with renal allograft function
    • Hoerning A, Kohler S, Jun C, et al. Peripherally Circulating CD4(+) FOXP3(+) CXCR3(+) T regulatory cells correlate with renal allograft function. Scand J Immunol 2012;76:320-8.
    • (2012) Scand J Immunol , vol.76 , pp. 320-328
    • Hoerning, A.1    Kohler, S.2    Jun, C.3
  • 40
    • 80051801789 scopus 로고    scopus 로고
    • Expanded subpopulation of FoxP3+ T regulatory cells in renal cell carcinoma co-express Helios, indicating they could be derived from natural but not induced Tregs
    • Elkord E, Sharma S, Burt DJ, et al. Expanded subpopulation of FoxP3+ T regulatory cells in renal cell carcinoma co-express Helios, indicating they could be derived from natural but not induced Tregs. Clin Immunol 2011;140:218-22.
    • (2011) Clin Immunol , vol.140 , pp. 218-222
    • Elkord, E.1    Sharma, S.2    Burt, D.J.3
  • 41
    • 76249100290 scopus 로고    scopus 로고
    • Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus
    • Humrich JY, Morbach H, Undeutsch R, et al. Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus. Proc Natl Acad Sci USA 2010;107:204-9.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 204-209
    • Humrich, J.Y.1    Morbach, H.2    Undeutsch, R.3
  • 42
    • 78149360607 scopus 로고    scopus 로고
    • Autoimmunity and chronic inflammation-two clearance-related steps in the etiopathogenesis of SLE
    • Munoz LE, Janko C, Schulze C, et al. Autoimmunity and chronic inflammation-two clearance-related steps in the etiopathogenesis of SLE. Autoimmun Rev 2010;10:38-42.
    • (2010) Autoimmun Rev , vol.10 , pp. 38-42
    • Munoz, L.E.1    Janko, C.2    Schulze, C.3
  • 43
    • 63149094153 scopus 로고    scopus 로고
    • Phenotypic and functional analysis of CD4+
    • Bonelli M, Savitskaya A, Steiner CW, et al. Phenotypic and functional analysis of CD4+. J Immunol 2009;182:1689-95.
    • (2009) J Immunol , vol.182 , pp. 1689-1695
    • Bonelli, M.1    Savitskaya, A.2    Steiner, C.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.