-
1
-
-
78650362917
-
Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection
-
Flanagan ME, Blumenkopf TA, Brissette WH et al. Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection. J Med Chem 2010;53:8468-84.
-
(2010)
J Med Chem
, vol.53
, pp. 8468-8484
-
-
Flanagan, M.E.1
Blumenkopf, T.A.2
Brissette, W.H.3
-
2
-
-
84864662570
-
Kinase inhibition-a new approach to the treatment of rheumatoid arthritis
-
Fox DA. Kinase inhibition-a new approach to the treatment of rheumatoid arthritis. N Engl J Med 2012;367:565-7.
-
(2012)
N Engl J Med
, vol.367
, pp. 565-567
-
-
Fox, D.A.1
-
3
-
-
0242332186
-
Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor
-
Changelian PS, Flanagan ME, Ball DJ et al. Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor. Science 2003;302:875-8.
-
(2003)
Science
, vol.302
, pp. 875-878
-
-
Changelian, P.S.1
Flanagan, M.E.2
Ball, D.J.3
-
4
-
-
67650093218
-
The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo
-
Kremer JM, Bloom BJ, Breedveld FC et al. The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo. Arthritis Rheum 2009;60:1895-905.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 1895-1905
-
-
Kremer, J.M.1
Bloom, B.J.2
Breedveld, F.C.3
-
5
-
-
84860388892
-
Phase II study of tofacitinib (CP-690,550) combined with methotrexate in patients with rheumatoid arthritis and an inadequate response to methotrexate
-
Tanaka Y, Suzuki M, Nakamura H et al. Phase II study of tofacitinib (CP-690,550) combined with methotrexate in patients with rheumatoid arthritis and an inadequate response to methotrexate. Arthritis Care Res (Hoboken) 2011;63:1150-8.
-
(2011)
Arthritis Care Res (Hoboken)
, vol.63
, pp. 1150-1158
-
-
Tanaka, Y.1
Suzuki, M.2
Nakamura, H.3
-
6
-
-
38049018155
-
A quantitative analysis of kinase inhibitor selectivity
-
Karaman MW, Herrgard S, Treiber DK et al. A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol 2008;26:127-32.
-
(2008)
Nat Biotechnol
, vol.26
, pp. 127-132
-
-
Karaman, M.W.1
Herrgard, S.2
Treiber, D.K.3
-
7
-
-
77955375143
-
Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis
-
Meyer DM, Jesson MI, Li X et al. Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis. J Inflamm (Lond) 2010;7:41.
-
(2010)
J Inflamm (Lond)
, vol.7
, pp. 41
-
-
Meyer, D.M.1
Jesson, M.I.2
Li, X.3
-
9
-
-
84864716411
-
Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis
-
Fleischmann R, Kremer J, Cush J et al. Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis. N Engl J Med 2012;367:495-507.
-
(2012)
N Engl J Med
, vol.367
, pp. 495-507
-
-
Fleischmann, R.1
Kremer, J.2
Cush, J.3
-
10
-
-
84864703156
-
Tofacitinib or adalimumab versus placebo in rheumatoid arthritis
-
van Vollenhoven RF, Fleischmann R, Cohen S et al. Tofacitinib or adalimumab versus placebo in rheumatoid arthritis. N Engl J Med 2012;367:508-19.
-
(2012)
N Engl J Med
, vol.367
, pp. 508-519
-
-
van Vollenhoven, R.F.1
Fleischmann, R.2
Cohen, S.3
-
11
-
-
84880629763
-
-
Poster EULAR , Berlin. Abstract THU0151
-
van Vollenhoven RF, Fleischmann RM, Cohen SB et al. Effects of tofacitinib (cp-690,550), an oral Janus kinase inhibitor, or adalimumab on patient-reported outcomes in a Phase 3 study of active rheumatoid arthritis. Poster EULAR 2012, Berlin. Abstract THU0151.
-
(2012)
Effects of tofacitinib (cp-690,550), an oral Janus kinase inhibitor, or adalimumab on patient-reported outcomes in a Phase 3 study of active rheumatoid arthritis
-
-
van Vollenhoven, R.F.1
Fleischmann, R.M.2
Cohen, S.B.3
-
12
-
-
84873707288
-
and on behalf of the ORAL Step investigators. Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial
-
pii: S0140- 6736(12)61424-X
-
Burmester GR, Blanco R, Charles-Schoeman C et al. and on behalf of the ORAL Step investigators. Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial. Lancet. 2013. pii: S0140- 6736(12)61424-X.
-
(2013)
Lancet.
-
-
Burmester, G.R.1
Blanco, R.2
Charles-Schoeman, C.3
-
14
-
-
84880588314
-
12-Week results of a phase 2B dose-ranging study of LY3009104 (INCB028050), an oral JAK1/JAK2 inhibitor, in combination with traditional DMARDS in patients with rheumatoid arthritis, EULAR
-
Berlin. Abstract LB0005
-
Keystone E, Taylor P, Genovese M et al. 12-Week results of a phase 2B dose-ranging study of LY3009104 (INCB028050), an oral JAK1/JAK2 inhibitor, in combination with traditional DMARDS in patients with rheumatoid arthritis, EULAR 2012, Berlin. Abstract LB0005.
-
(2012)
-
-
Keystone, E.1
Taylor, P.2
Genovese, M.3
-
15
-
-
84880585734
-
-
EULAR. Berlin. Abstract OP0263
-
Vanhoutte FP, Mazur M, Namour F. et al. Efficacy and safety of GLPG0634, a selective JAK1 inhibitor, after short-term treatment of rheumatoid arthritis; results of a phase IIA trial. EULAR 2012, Berlin. Abstract OP0263.
-
(2012)
Efficacy and safety of GLPG0634, a selective JAK1 inhibitor, after short-term treatment of rheumatoid arthritis; results of a phase IIA trial.
-
-
Vanhoutte, F.P.1
Mazur, M.2
Namour, F.3
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