메뉴 건너뛰기




Volumn 8, Issue 2, 2013, Pages

Nuclear Receptor NR4A2 Orchestrates Th17 Cell-Mediated Autoimmune Inflammation via IL-21 Signalling

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 21; INTERLEUKIN 23 RECEPTOR; NUCLEAR RECEPTOR RELATED FACTOR 1; TRANSCRIPTION FACTOR FOXP3;

EID: 84874339517     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0056595     Document Type: Article
Times cited : (70)

References (52)
  • 1
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • Sospedra M, Martin R, (2005) Immunology of multiple sclerosis. Annu Rev Immunol 23: 683-747.
    • (2005) Annu Rev Immunol , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 2
    • 35348960243 scopus 로고    scopus 로고
    • Th17: the third member of the effector T cell trilogy
    • Bettelli E, Korn T, Kuchroo VK, (2007) Th17: the third member of the effector T cell trilogy. Curr Opin Immunol 19: 652-657.
    • (2007) Curr Opin Immunol , vol.19 , pp. 652-657
    • Bettelli, E.1    Korn, T.2    Kuchroo, V.K.3
  • 3
    • 75749097320 scopus 로고    scopus 로고
    • Th1 and Th17 cells: adversaries and collaborators
    • Damsker JM, Hansen AM, Caspi RR, (2010) Th1 and Th17 cells: adversaries and collaborators. Ann N Y Acad Sci 1183: 211-221.
    • (2010) Ann N Y Acad Sci , vol.1183 , pp. 211-221
    • Damsker, J.M.1    Hansen, A.M.2    Caspi, R.R.3
  • 4
    • 39449087338 scopus 로고    scopus 로고
    • Th17 cells: effector T cells with inflammatory properties
    • Korn T, Oukka M, Kuchroo V, Bettelli E, (2007) Th17 cells: effector T cells with inflammatory properties. Semin Immunol 19: 362-371.
    • (2007) Semin Immunol , vol.19 , pp. 362-371
    • Korn, T.1    Oukka, M.2    Kuchroo, V.3    Bettelli, E.4
  • 5
    • 67349216357 scopus 로고    scopus 로고
    • Autoimmune T cell responses in the central nervous system
    • Goverman J, (2009) Autoimmune T cell responses in the central nervous system. Nat Rev Immunol 9: 393-407.
    • (2009) Nat Rev Immunol , vol.9 , pp. 393-407
    • Goverman, J.1
  • 6
    • 73349109145 scopus 로고    scopus 로고
    • Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes
    • Jager A, Dardalhon V, Sobel RA, Bettelli E, Kuchroo VK, (2009) Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J Immunol 183: 7169-7177.
    • (2009) J Immunol , vol.183 , pp. 7169-7177
    • Jager, A.1    Dardalhon, V.2    Sobel, R.A.3    Bettelli, E.4    Kuchroo, V.K.5
  • 7
    • 42249084849 scopus 로고    scopus 로고
    • Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category
    • Luger D, Silver PB, Tang J, Cua D, Chen Z, et al. (2008) Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med 205: 799-810.
    • (2008) J Exp Med , vol.205 , pp. 799-810
    • Luger, D.1    Silver, P.B.2    Tang, J.3    Cua, D.4    Chen, Z.5
  • 8
    • 46949086111 scopus 로고    scopus 로고
    • A rush to judgment on Th17
    • Steinman L, (2008) A rush to judgment on Th17. J Exp Med 205: 1517-1522.
    • (2008) J Exp Med , vol.205 , pp. 1517-1522
    • Steinman, L.1
  • 9
    • 33947543465 scopus 로고    scopus 로고
    • Inflammatory cell migration into the central nervous system: a few new twists on an old tale
    • Man S, Ubogu EE, Ransohoff RM, (2007) Inflammatory cell migration into the central nervous system: a few new twists on an old tale. Brain Pathol 17: 243-250.
    • (2007) Brain Pathol , vol.17 , pp. 243-250
    • Man, S.1    Ubogu, E.E.2    Ransohoff, R.M.3
  • 10
    • 0344389016 scopus 로고    scopus 로고
    • Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis
    • Matusevicius D, Kivisakk P, He B, Kostulas N, Ozenci V, et al. (1999) Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult Scler 5: 101-104.
    • (1999) Mult Scler , vol.5 , pp. 101-104
    • Matusevicius, D.1    Kivisakk, P.2    He, B.3    Kostulas, N.4    Ozenci, V.5
  • 11
    • 79951677394 scopus 로고    scopus 로고
    • Fate mapping of IL-17-producing T cells in inflammatory responses
    • Hirota K, Duarte JH, Veldhoen M, Hornsby E, Li Y, et al. (2011) Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol 12: 255-263.
    • (2011) Nat Immunol , vol.12 , pp. 255-263
    • Hirota, K.1    Duarte, J.H.2    Veldhoen, M.3    Hornsby, E.4    Li, Y.5
  • 12
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, et al. (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441: 235-238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5
  • 14
    • 34547232503 scopus 로고    scopus 로고
    • IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
    • Korn T, Bettelli E, Gao W, Awasthi A, Jager A, et al. (2007) IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 448: 484-487.
    • (2007) Nature , vol.448 , pp. 484-487
    • Korn, T.1    Bettelli, E.2    Gao, W.3    Awasthi, A.4    Jager, A.5
  • 15
    • 70449711235 scopus 로고    scopus 로고
    • Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation
    • Das J, Ren G, Zhang L, Roberts AI, Zhao X, et al. (2009) Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation. J Exp Med 206: 2407-2416.
    • (2009) J Exp Med , vol.206 , pp. 2407-2416
    • Das, J.1    Ren, G.2    Zhang, L.3    Roberts, A.I.4    Zhao, X.5
  • 16
    • 77958584113 scopus 로고    scopus 로고
    • Generation of pathogenic T(H)17 cells in the absence of TGF-beta signalling
    • Ghoreschi K, Laurence A, Yang XP, Tato CM, McGeachy MJ, et al. (2011) Generation of pathogenic T(H)17 cells in the absence of TGF-beta signalling. Nature 467: 967-971.
    • (2011) Nature , vol.467 , pp. 967-971
    • Ghoreschi, K.1    Laurence, A.2    Yang, X.P.3    Tato, C.M.4    McGeachy, M.J.5
  • 17
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, et al. (2003) Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421: 744-748.
    • (2003) Nature , vol.421 , pp. 744-748
    • Cua, D.J.1    Sherlock, J.2    Chen, Y.3    Murphy, C.A.4    Joyce, B.5
  • 18
    • 39449110445 scopus 로고    scopus 로고
    • The link between IL-23 and Th17 cell-mediated immune pathologies
    • McGeachy MJ, Cua DJ, (2007) The link between IL-23 and Th17 cell-mediated immune pathologies. Semin Immunol 19: 372-376.
    • (2007) Semin Immunol , vol.19 , pp. 372-376
    • McGeachy, M.J.1    Cua, D.J.2
  • 19
    • 0027074637 scopus 로고
    • Identification of a new brain-specific transcription factor, NURR1
    • Law SW, Conneely OM, DeMayo FJ, O'Malley BW, (1992) Identification of a new brain-specific transcription factor, NURR1. Mol Endocrinol 6: 2129-2135.
    • (1992) Mol Endocrinol , vol.6 , pp. 2129-2135
    • Law, S.W.1    Conneely, O.M.2    DeMayo, F.J.3    O'Malley, B.W.4
  • 20
    • 5544325468 scopus 로고    scopus 로고
    • Nurr1, an orphan nuclear receptor with essential functions in developing dopamine cells
    • Perlmann T, Wallen-Mackenzie A, (2004) Nurr1, an orphan nuclear receptor with essential functions in developing dopamine cells. Cell Tissue Res 318: 45-52.
    • (2004) Cell Tissue Res , vol.318 , pp. 45-52
    • Perlmann, T.1    Wallen-Mackenzie, A.2
  • 21
    • 0037226797 scopus 로고    scopus 로고
    • Mutations in NR4A2 associated with familial Parkinson disease
    • Le WD, Xu P, Jankovic J, Jiang H, Appel SH, et al. (2003) Mutations in NR4A2 associated with familial Parkinson disease. Nat Genet 33: 85-89.
    • (2003) Nat Genet , vol.33 , pp. 85-89
    • Le, W.D.1    Xu, P.2    Jankovic, J.3    Jiang, H.4    Appel, S.H.5
  • 22
    • 77957329141 scopus 로고    scopus 로고
    • Minireview: Nuclear Hormone Receptor 4A Signaling: Implications for Metabolic Disease
    • Pearen MA, Muscat GE, (2010) Minireview: Nuclear Hormone Receptor 4A Signaling: Implications for Metabolic Disease. Mol Endocrinol 24: 1-13.
    • (2010) Mol Endocrinol , vol.24 , pp. 1-13
    • Pearen, M.A.1    Muscat, G.E.2
  • 23
    • 70349443394 scopus 로고    scopus 로고
    • Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis
    • Aherne CM, McMorrow J, Kane D, FitzGerald O, Mix KS, et al. (2009) Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis. Mol Immunol 46: 3345-3357.
    • (2009) Mol Immunol , vol.46 , pp. 3345-3357
    • Aherne, C.M.1    McMorrow, J.2    Kane, D.3    FitzGerald, O.4    Mix, K.S.5
  • 24
    • 38149108222 scopus 로고    scopus 로고
    • Increased expression of the orphan nuclear receptor NURR1 in psoriasis and modulation following TNF-alpha inhibition
    • O'Kane M, Markham T, McEvoy AN, Fearon U, Veale DJ, et al. (2008) Increased expression of the orphan nuclear receptor NURR1 in psoriasis and modulation following TNF-alpha inhibition. J Invest Dermatol 128: 300-310.
    • (2008) J Invest Dermatol , vol.128 , pp. 300-310
    • O'Kane, M.1    Markham, T.2    McEvoy, A.N.3    Fearon, U.4    Veale, D.J.5
  • 25
    • 63049083734 scopus 로고    scopus 로고
    • A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death
    • Saijo K, Winner B, Carson CT, Collier JG, Boyer L, et al. (2009) A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell 137: 47-59.
    • (2009) Cell , vol.137 , pp. 47-59
    • Saijo, K.1    Winner, B.2    Carson, C.T.3    Collier, J.G.4    Boyer, L.5
  • 26
    • 20044383560 scopus 로고    scopus 로고
    • Microarray analysis identifies an aberrant expression of apoptosis and DNA damage-regulatory genes in multiple sclerosis
    • Satoh J, Nakanishi M, Koike F, Miyake S, Yamamoto T, et al. (2005) Microarray analysis identifies an aberrant expression of apoptosis and DNA damage-regulatory genes in multiple sclerosis. Neurobiol Dis 18: 537-550.
    • (2005) Neurobiol Dis , vol.18 , pp. 537-550
    • Satoh, J.1    Nakanishi, M.2    Koike, F.3    Miyake, S.4    Yamamoto, T.5
  • 27
    • 46149104979 scopus 로고    scopus 로고
    • Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines
    • Doi Y, Oki S, Ozawa T, Hohjoh H, Miyake S, et al. (2008) Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines. Proc Natl Acad Sci U S A 105: 8381-8386.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 8381-8386
    • Doi, Y.1    Oki, S.2    Ozawa, T.3    Hohjoh, H.4    Miyake, S.5
  • 28
    • 67049137416 scopus 로고    scopus 로고
    • Synthetic retinoid AM80 inhibits Th17 cells and ameliorates experimental autoimmune encephalomyelitis
    • Klemann C, Raveney BJ, Klemann AK, Ozawa T, von Horsten S, et al. (2009) Synthetic retinoid AM80 inhibits Th17 cells and ameliorates experimental autoimmune encephalomyelitis. Am J Pathol 174: 2234-2245.
    • (2009) Am J Pathol , vol.174 , pp. 2234-2245
    • Klemann, C.1    Raveney, B.J.2    Klemann, A.K.3    Ozawa, T.4    von Horsten, S.5
  • 29
    • 54049134808 scopus 로고    scopus 로고
    • Fingolimod (FTY720) as an acute rescue therapy for intraocular inflammatory disease
    • Raveney BJ, Copland DA, Nicholson LB, Dick AD, (2008) Fingolimod (FTY720) as an acute rescue therapy for intraocular inflammatory disease. Arch Ophthalmol 126: 1390-1395.
    • (2008) Arch Ophthalmol , vol.126 , pp. 1390-1395
    • Raveney, B.J.1    Copland, D.A.2    Nicholson, L.B.3    Dick, A.D.4
  • 30
    • 58149261815 scopus 로고    scopus 로고
    • The clinical time-course of experimental autoimmune uveoretinitis using topical endoscopic fundal imaging with histologic and cellular infiltrate correlation
    • Copland DA, Wertheim MS, Armitage WJ, Nicholson LB, Raveney BJ, et al. (2008) The clinical time-course of experimental autoimmune uveoretinitis using topical endoscopic fundal imaging with histologic and cellular infiltrate correlation. Invest Ophthalmol Vis Sci 49: 5458-5465.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 5458-5465
    • Copland, D.A.1    Wertheim, M.S.2    Armitage, W.J.3    Nicholson, L.B.4    Raveney, B.J.5
  • 31
    • 30944455075 scopus 로고    scopus 로고
    • IL-23 leads to diabetes induction after subdiabetogenic treatment with multiple low doses of streptozotocin
    • Mensah-Brown EP, Shahin A, Al-Shamisi M, Wei X, Lukic ML, (2006) IL-23 leads to diabetes induction after subdiabetogenic treatment with multiple low doses of streptozotocin. Eur J Immunol 36: 216-223.
    • (2006) Eur J Immunol , vol.36 , pp. 216-223
    • Mensah-Brown, E.P.1    Shahin, A.2    Al-Shamisi, M.3    Wei, X.4    Lukic, M.L.5
  • 32
    • 33746916045 scopus 로고    scopus 로고
    • Abortive activation precedes functional deletion of CD8+ T cells following encounter with self-antigens expressed by resting B cells in vivo
    • Fraser JM, Janicki CN, Raveney BJ, Morgan DJ, (2006) Abortive activation precedes functional deletion of CD8+ T cells following encounter with self-antigens expressed by resting B cells in vivo. Immunology 119: 126-133.
    • (2006) Immunology , vol.119 , pp. 126-133
    • Fraser, J.M.1    Janicki, C.N.2    Raveney, B.J.3    Morgan, D.J.4
  • 33
    • 70149093033 scopus 로고    scopus 로고
    • TNFR1-dependent regulation of myeloid cell function in experimental autoimmune uveoretinitis
    • Raveney BJ, Copland DA, Dick AD, Nicholson LB, (2009) TNFR1-dependent regulation of myeloid cell function in experimental autoimmune uveoretinitis. J Immunol 183: 2321-2329.
    • (2009) J Immunol , vol.183 , pp. 2321-2329
    • Raveney, B.J.1    Copland, D.A.2    Dick, A.D.3    Nicholson, L.B.4
  • 34
    • 31044434001 scopus 로고    scopus 로고
    • Severe chronic experimental autoimmune uveitis (EAU) of the C57BL/6 mouse induced by adoptive transfer of IRBP1-20-specific T cells
    • Shao H, Liao T, Ke Y, Shi H, Kaplan HJ, et al. (2006) Severe chronic experimental autoimmune uveitis (EAU) of the C57BL/6 mouse induced by adoptive transfer of IRBP1-20-specific T cells. Exp Eye Res 82: 323-331.
    • (2006) Exp Eye Res , vol.82 , pp. 323-331
    • Shao, H.1    Liao, T.2    Ke, Y.3    Shi, H.4    Kaplan, H.J.5
  • 35
    • 0027953701 scopus 로고
    • Autoimmune diabetes induced by the beta-cell toxin STZ. Immunity to the 60-kDa heat shock protein and to insulin
    • Elias D, Prigozin H, Polak N, Rapoport M, Lohse AW, et al. (1994) Autoimmune diabetes induced by the beta-cell toxin STZ. Immunity to the 60-kDa heat shock protein and to insulin. Diabetes 43: 992-998.
    • (1994) Diabetes , vol.43 , pp. 992-998
    • Elias, D.1    Prigozin, H.2    Polak, N.3    Rapoport, M.4    Lohse, A.W.5
  • 36
    • 43449135305 scopus 로고    scopus 로고
    • TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
    • Zhou L, Lopes JE, Chong MM, Ivanov, II, Min R, et al. (2008) TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 453: 236-240.
    • (2008) Nature , vol.453 , pp. 236-240
    • Zhou, L.1    Lopes, J.E.2    Chong, M.M.3    Ivanov, I.I.4    Min, R.5
  • 37
    • 79953769170 scopus 로고    scopus 로고
    • The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells
    • Sekiya T, Kashiwagi I, Inoue N, Morita R, Hori S, et al. (2011) The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells. Nat Commun 2: 269.
    • (2011) Nat Commun , vol.2 , pp. 269
    • Sekiya, T.1    Kashiwagi, I.2    Inoue, N.3    Morita, R.4    Hori, S.5
  • 38
    • 34547188748 scopus 로고    scopus 로고
    • IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    • Zhou L, Ivanov, II, Spolski R, Min R, Shenderov K, et al. (2007) IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 8: 967-974.
    • (2007) Nat Immunol , vol.8 , pp. 967-974
    • Zhou, L.1    Ivanov, I.I.2    Spolski, R.3    Min, R.4    Shenderov, K.5
  • 39
    • 34547204946 scopus 로고    scopus 로고
    • Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
    • Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, et al. (2007) Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448: 480-483.
    • (2007) Nature , vol.448 , pp. 480-483
    • Nurieva, R.1    Yang, X.O.2    Martinez, G.3    Zhang, Y.4    Panopoulos, A.D.5
  • 40
    • 39449101603 scopus 로고    scopus 로고
    • Transcriptional regulation of Th17 cell differentiation
    • Ivanov, II, Zhou L, Littman DR, (2007) Transcriptional regulation of Th17 cell differentiation. Semin Immunol 19: 409-417.
    • (2007) Semin Immunol , vol.19 , pp. 409-417
    • Ivanov, I.I.1    Zhou, L.2    Littman, D.R.3
  • 41
    • 58449124804 scopus 로고    scopus 로고
    • The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
    • Bauquet AT, Jin H, Paterson AM, Mitsdoerffer M, Ho IC, et al. (2009) The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol 10: 167-175.
    • (2009) Nat Immunol , vol.10 , pp. 167-175
    • Bauquet, A.T.1    Jin, H.2    Paterson, A.M.3    Mitsdoerffer, M.4    Ho, I.C.5
  • 42
    • 42649106556 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
    • Veldhoen M, Hirota K, Westendorf AM, Buer J, Dumoutier L, et al. (2008) The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature 453: 106-109.
    • (2008) Nature , vol.453 , pp. 106-109
    • Veldhoen, M.1    Hirota, K.2    Westendorf, A.M.3    Buer, J.4    Dumoutier, L.5
  • 43
    • 24744464786 scopus 로고    scopus 로고
    • Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo
    • Takeshita F, Minakuchi Y, Nagahara S, Honma K, Sasaki H, et al. (2005) Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo. Proc Natl Acad Sci U S A 102: 12177-12182.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 12177-12182
    • Takeshita, F.1    Minakuchi, Y.2    Nagahara, S.3    Honma, K.4    Sasaki, H.5
  • 44
    • 77958072084 scopus 로고    scopus 로고
    • Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis
    • Hueber W, Patel DD, Dryja T, Wright AM, Koroleva I, et al. (2011) Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis. Sci Transl Med 2: 52ra72.
    • (2011) Sci Transl Med , vol.2
    • Hueber, W.1    Patel, D.D.2    Dryja, T.3    Wright, A.M.4    Koroleva, I.5
  • 45
    • 30944452780 scopus 로고    scopus 로고
    • Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis
    • Hofstetter HH, Ibrahim SM, Koczan D, Kruse N, Weishaupt A, et al. (2005) Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis. Cell Immunol 237: 123-130.
    • (2005) Cell Immunol , vol.237 , pp. 123-130
    • Hofstetter, H.H.1    Ibrahim, S.M.2    Koczan, D.3    Kruse, N.4    Weishaupt, A.5
  • 46
    • 33745321276 scopus 로고    scopus 로고
    • IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
    • Komiyama Y, Nakae S, Matsuki T, Nambu A, Ishigame H, et al. (2006) IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J Immunol 177: 566-573.
    • (2006) J Immunol , vol.177 , pp. 566-573
    • Komiyama, Y.1    Nakae, S.2    Matsuki, T.3    Nambu, A.4    Ishigame, H.5
  • 47
    • 15744390341 scopus 로고    scopus 로고
    • Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease
    • Monteleone G, Monteleone I, Fina D, Vavassori P, Del Vecchio Blanco G, et al. (2005) Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease. Gastroenterology 128: 687-694.
    • (2005) Gastroenterology , vol.128 , pp. 687-694
    • Monteleone, G.1    Monteleone, I.2    Fina, D.3    Vavassori, P.4    Del Vecchio Blanco, G.5
  • 48
    • 13244283212 scopus 로고    scopus 로고
    • IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
    • Langrish CL, Chen Y, Blumenschein WM, Mattson J, Basham B, et al. (2005) IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 201: 233-240.
    • (2005) J Exp Med , vol.201 , pp. 233-240
    • Langrish, C.L.1    Chen, Y.2    Blumenschein, W.M.3    Mattson, J.4    Basham, B.5
  • 49
    • 25444434157 scopus 로고    scopus 로고
    • Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation
    • Leonard WJ, Spolski R, (2005) Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. Nat Rev Immunol 5: 688-698.
    • (2005) Nat Rev Immunol , vol.5 , pp. 688-698
    • Leonard, W.J.1    Spolski, R.2
  • 50
    • 14044262247 scopus 로고    scopus 로고
    • Differential effects of IL-21 during initiation and progression of autoimmunity against neuroantigen
    • Vollmer TL, Liu R, Price M, Rhodes S, La Cava A, et al. (2005) Differential effects of IL-21 during initiation and progression of autoimmunity against neuroantigen. J Immunol 174: 2696-2701.
    • (2005) J Immunol , vol.174 , pp. 2696-2701
    • Vollmer, T.L.1    Liu, R.2    Price, M.3    Rhodes, S.4    La Cava, A.5
  • 51
    • 46749156754 scopus 로고    scopus 로고
    • Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis
    • Coquet JM, Chakravarti S, Smyth MJ, Godfrey DI, (2008) Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis. J Immunol 180: 7097-7101.
    • (2008) J Immunol , vol.180 , pp. 7097-7101
    • Coquet, J.M.1    Chakravarti, S.2    Smyth, M.J.3    Godfrey, D.I.4
  • 52
    • 46749133961 scopus 로고    scopus 로고
    • IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo
    • Sonderegger I, Kisielow J, Meier R, King C, Kopf M, (2008) IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo. Eur J Immunol 38: 1833-1838.
    • (2008) Eur J Immunol , vol.38 , pp. 1833-1838
    • Sonderegger, I.1    Kisielow, J.2    Meier, R.3    King, C.4    Kopf, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.