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Volumn 100, Issue 1, 1997, Pages 127-135

Anti-A2/RA33 autoantibodies are directed to the RNA binding region of the A2 protein of the heterogeneous nuclear ribonucleoprotein complex: Differential epitope recognition in rheumatoid arthritis, systemic lupus erythematosus, and mixed connective tissue disease

Author keywords

Anti A2 RA33 autoantibody; Epitope recognition; Mixed connective tissue disease; Rheumatoid arthritis; SLE

Indexed keywords

AUTOANTIBODY; RNA;

EID: 0030839970     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119504     Document Type: Article
Times cited : (95)

References (47)
  • 1
    • 0028922074 scopus 로고
    • Autoantibodies in the diagnosis of systemic rheumatic diseases
    • von Mühlen, C.A., and E.M. Tan. 1995. Autoantibodies in the diagnosis of systemic rheumatic diseases. Semin. Arthritis Rheum. 24:323-358.
    • (1995) Semin. Arthritis Rheum. , vol.24 , pp. 323-358
    • Von Mühlen, C.A.1    Tan, E.M.2
  • 2
    • 0002650044 scopus 로고    scopus 로고
    • Antinuclear antibodies
    • W.N. Kelley, E.D. Harris, S. Ruddy, and C.B. Sledge, editors. W.B. Saunders Company, Philadelphia, PA
    • Peng, S.L., J.A. Hardin, and J. Craft. 1997. Antinuclear antibodies. In Textbook of Rheumatology. W.N. Kelley, E.D. Harris, S. Ruddy, and C.B. Sledge, editors. W.B. Saunders Company, Philadelphia, PA. 250-266.
    • (1997) Textbook of Rheumatology , pp. 250-266
    • Peng, S.L.1    Hardin, J.A.2    Craft, J.3
  • 3
    • 0029618990 scopus 로고
    • Ribonucleoprotein complexes as autoantigens
    • van Venrooij, W., and G.J.M. Pruijn. 1995. Ribonucleoprotein complexes as autoantigens. Curr. Opin. Immunol. 7:819-824.
    • (1995) Curr. Opin. Immunol. , vol.7 , pp. 819-824
    • Van Venrooij, W.1    Pruijn, G.J.M.2
  • 4
    • 0002302853 scopus 로고    scopus 로고
    • Rheumatoid factors
    • W.N. Kelley, E.D. Harris, S. Ruddy and C.B. Sledge, editors. W.B. Saunders Company, Philadelphia, PA
    • Tighe, H., and D.A. Carson. 1997. Rheumatoid factors. In Textbook of Rheumatology. W.N. Kelley, E.D. Harris, S. Ruddy and C.B. Sledge, editors. W.B. Saunders Company, Philadelphia, PA. 241-249.
    • (1997) Textbook of Rheumatology , pp. 241-249
    • Tighe, H.1    Carson, D.A.2
  • 7
    • 0029045961 scopus 로고
    • The antiperinuclear factor and antikeratin antibody systems
    • Youinou, P., and G. Serre. 1995. The antiperinuclear factor and antikeratin antibody systems. Int. Arch. Allergy Immunol. 107:508-518.
    • (1995) Int. Arch. Allergy Immunol. , vol.107 , pp. 508-518
    • Youinou, P.1    Serre, G.2
  • 8
    • 0029017016 scopus 로고
    • The antiperinuclear factor and the so-called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodies
    • Sebbag, M., M. Simon, C. Vincent, C. Masson-Bessière, E. Girbal, J.J. Durieux, and G. Serre. 1995. The antiperinuclear factor and the so-called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodies. J. Clin. Invest. 95:2672-2679.
    • (1995) J. Clin. Invest. , vol.95 , pp. 2672-2679
    • Sebbag, M.1    Simon, M.2    Vincent, C.3    Masson-Bessière, C.4    Girbal, E.5    Durieux, J.J.6    Serre, G.7
  • 9
    • 0028275351 scopus 로고
    • The Sa system: A novel antigen-antibody system specific for rheumatoid arthritis
    • Dèspres, N., G. Boire, F.J. Lopez-Longo, and H.A. Menard. 1994. The Sa system: a novel antigen-antibody system specific for rheumatoid arthritis. J. Rheumatol. 21:1027-1033.
    • (1994) J. Rheumatol. , vol.21 , pp. 1027-1033
    • Dèspres, N.1    Boire, G.2    Lopez-Longo, F.J.3    Menard, H.A.4
  • 10
    • 0026669341 scopus 로고
    • Purification and partial sequencing of the nuclear autoantigen RA33 shows that it is indistinguishable from the A2 protein of the heterogeneous nuclear ribonucleoprotein complex
    • Steiner, G., K. Hartmuth, K. Skriner, I. Maurer-Fogy, A. Sinski, E. Thalmann, W. Hassfeld, A. Barta, and J.S. Smolen. 1992. Purification and partial sequencing of the nuclear autoantigen RA33 shows that it is indistinguishable from the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. J. Clin. Invest. 90:1061-1066.
    • (1992) J. Clin. Invest. , vol.90 , pp. 1061-1066
    • Steiner, G.1    Hartmuth, K.2    Skriner, K.3    Maurer-Fogy, I.4    Sinski, A.5    Thalmann, E.6    Hassfeld, W.7    Barta, A.8    Smolen, J.S.9
  • 13
    • 0029011046 scopus 로고
    • Autoimmune response to the spliceosome. An immunologic link between rheumatoid arthritis, mixed connective tissue disease, and systemic lupus erythematosus
    • Hassfeld, W., G. Steiner, A. Studnicka-Benke, K. Skriner, W. Graninger, I. Fischer, and J.S. Smolen. 1995. Autoimmune response to the spliceosome. An immunologic link between rheumatoid arthritis, mixed connective tissue disease, and systemic lupus erythematosus. Arthritis Rheum. 38:777-785.
    • (1995) Arthritis Rheum. , vol.38 , pp. 777-785
    • Hassfeld, W.1    Steiner, G.2    Studnicka-Benke, A.3    Skriner, K.4    Graninger, W.5    Fischer, I.6    Smolen, J.S.7
  • 14
    • 0027375989 scopus 로고
    • Anti-RA33 antinuclear autoantibody in rheumatoid arthritis and mixed connective tissue disease: Comparison with antikeratin and antiperinuclear antibodies
    • Meyer, O., F. Tauxe, D. Fabregas, C. Gabay, M. Goycochea, T. Haim, A. Elias, and M.F. Kahn. 1993. Anti-RA33 antinuclear autoantibody in rheumatoid arthritis and mixed connective tissue disease: comparison with antikeratin and antiperinuclear antibodies. Clin. Exp. Rheumatol. 11:473-478.
    • (1993) Clin. Exp. Rheumatol. , vol.11 , pp. 473-478
    • Meyer, O.1    Tauxe, F.2    Fabregas, D.3    Gabay, C.4    Goycochea, M.5    Haim, T.6    Elias, A.7    Kahn, M.F.8
  • 15
    • 0023955859 scopus 로고
    • Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins
    • Piñol-Roma, S., Y.D. Choi, M.J. Matunis, and G. Dreyfuss. 1988. Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins. Genes Dev. 2:215-227.
    • (1988) Genes Dev. , vol.2 , pp. 215-227
    • Piñol-Roma, S.1    Choi, Y.D.2    Matunis, M.J.3    Dreyfuss, G.4
  • 16
    • 0026527447 scopus 로고
    • Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm
    • Piñol-Roma, S., and G. Dreyfuss. 1992. Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm. Nature (Lond.). 355:730-732.
    • (1992) Nature (Lond.) , vol.355 , pp. 730-732
    • Piñol-Roma, S.1    Dreyfuss, G.2
  • 18
    • 0024807032 scopus 로고
    • Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: A diversity of RNA binding proteins is generated by small peptide inserts
    • Burd, C.G., M.S. Swanson, M. Görlach, and G. Dreyfuss. 1989. Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts. Proc. Natl. Acad. Sci. USA. 86:9788-9792.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 9788-9792
    • Burd, C.G.1    Swanson, M.S.2    Görlach, M.3    Dreyfuss, G.4
  • 21
    • 0002427352 scopus 로고
    • Classification and diagnostic criteria for mixed connective tissue diseases
    • R. Kasukawa and G.C. Sharp, editors. Elsevier, Amsterdam
    • Alarcón-Segovia, D., and M. Villareal. 1987. Classification and diagnostic criteria for mixed connective tissue diseases. In Mixed Connective Tissue Diseases and Anti-nuclear Antibodies. R. Kasukawa and G.C. Sharp, editors. Elsevier, Amsterdam. 33-40.
    • (1987) Mixed Connective Tissue Diseases and Anti-nuclear Antibodies , pp. 33-40
    • Alarcón-Segovia, D.1    Villareal, M.2
  • 22
    • 0022648673 scopus 로고
    • Characterization of foot-and mouth disease gene products with antisera against bacterially synthesised fusion proteins
    • Strebel, K., E. Beck, K. Strohmaier, and H. Schaller. 1986. Characterization of foot-and mouth disease gene products with antisera against bacterially synthesised fusion proteins. J. Virol. 57:983-991.
    • (1986) J. Virol. , vol.57 , pp. 983-991
    • Strebel, K.1    Beck, E.2    Strohmaier, K.3    Schaller, H.4
  • 23
    • 1842296128 scopus 로고
    • The A2 protein of the heterogeneous nuclear ribonucleoprotein (hnRNP-A2)/RA33
    • W.J. van Venrooij and R.N. Maini, editors. Kluwer Academic Publishers, Dordrecht/Boston/London
    • Steiner, G. 1994. The A2 protein of the heterogeneous nuclear ribonucleoprotein (hnRNP-A2)/RA33. In Manual of Biological Markers of Disease. Vol. B. W.J. van Venrooij and R.N. Maini, editors. Kluwer Academic Publishers, Dordrecht/Boston/London. 1.3/1-9.
    • (1994) Manual of Biological Markers of Disease , vol.B , pp. 13
    • Steiner, G.1
  • 25
    • 0027263365 scopus 로고
    • Nuclear proteins that bind the pre-mRNA 3′ splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n
    • Ishikawa, F., M.J. Matunis, G. Dreyfuss, and T.R. Cech. 1993. Nuclear proteins that bind the pre-mRNA 3′ splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n. Mol. Cell. Biol. 13:4301-4310.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 4301-4310
    • Ishikawa, F.1    Matunis, M.J.2    Dreyfuss, G.3    Cech, T.R.4
  • 26
    • 0028215301 scopus 로고
    • RNA binding specificity of hnRNP A1: Significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing
    • Burd, C.G., and G. Dreyfuss. 1994. RNA binding specificity of hnRNP A1: significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing. EMBO (Eur. Mol. Biol. Organ.) J. 13:1197-1204.
    • (1994) EMBO (Eur. Mol. Biol. Organ.) J. , vol.13 , pp. 1197-1204
    • Burd, C.G.1    Dreyfuss, G.2
  • 28
    • 0025937937 scopus 로고
    • Mapping of epitopes on U1 snRNP polypeptide A with synthetic peptides and autoimmune sera
    • Barakat, S., J.P. Briand, N. Abuaf, M.H. van Regenmortel, and S. Muller. 1991. Mapping of epitopes on U1 snRNP polypeptide A with synthetic peptides and autoimmune sera. Clin. Exp. Immunol. 86:71-78.
    • (1991) Clin. Exp. Immunol. , vol.86 , pp. 71-78
    • Barakat, S.1    Briand, J.P.2    Abuaf, N.3    Van Regenmortel, M.H.4    Muller, S.5
  • 29
    • 0015289868 scopus 로고
    • Mixed connective tissue disease: An apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen
    • Sharp, G.C, W.S. Irvin, E.M. Tan, G.R. Gould, and H.R. Holman. 1972. Mixed connective tissue disease: an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen. Am. J. Med. 52:148-159.
    • (1972) Am. J. Med. , vol.52 , pp. 148-159
    • Sharp, G.C.1    Irvin, W.S.2    Tan, E.M.3    Gould, G.R.4    Holman, H.R.5
  • 30
    • 0025129996 scopus 로고
    • Clinical significance of antibodies to a 68 kDa U1RNP polypeptide in connective tissue disease
    • McHugh, N., I. James, and P. Maddison. 1990. Clinical significance of antibodies to a 68 kDa U1RNP polypeptide in connective tissue disease. J. Rheumatol. 17:1320-1328.
    • (1990) J. Rheumatol. , vol.17 , pp. 1320-1328
    • McHugh, N.1    James, I.2    Maddison, P.3
  • 31
    • 0028809602 scopus 로고
    • Overlapping syndromes, undifferentiated connective tissue disease, and other fibrosing conditions
    • Kallenberg, C.G. 1995. Overlapping syndromes, undifferentiated connective tissue disease, and other fibrosing conditions. Curr. Opin. Rheumatol. 7: 568-573.
    • (1995) Curr. Opin. Rheumatol. , vol.7 , pp. 568-573
    • Kallenberg, C.G.1
  • 32
    • 0029064879 scopus 로고
    • Mixed connective tissue disease: Fact or fiction?
    • Citera, G., M.A. Lazaro, and J.A. Maldonado Cocco. 1995. Mixed connective tissue disease: fact or fiction? Lupus. 4:255-257.
    • (1995) Lupus , vol.4 , pp. 255-257
    • Citera, G.1    Lazaro, M.A.2    Maldonado Cocco, J.A.3
  • 33
    • 0029796522 scopus 로고    scopus 로고
    • Autoantibodics to the A/B proteins of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex - Novel tools for the diagnosis of rheumatic diseases
    • Steiner, G., K. Skriner, and J.S. Smolen. 1996. Autoantibodics to the A/B proteins of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex - novel tools for the diagnosis of rheumatic diseases. Int. Arch. Allergy Immunol. 111:314-319.
    • (1996) Int. Arch. Allergy Immunol. , vol.111 , pp. 314-319
    • Steiner, G.1    Skriner, K.2    Smolen, J.S.3
  • 34
    • 0025266662 scopus 로고
    • Antibodies from patients with rheumatoid arthritis and systemic lupus erythematosus recognize different epitopes of a single heterogeneous nuclear RNP core protein. Possible role of cross-reacting antikeratin antibodies
    • Montecucco, C., R. Caporali, C. Negri, F. de Gennaro, A. Cerino, M. Bestagno, F. Cobianchi, and G.C. Astaldi-Ricotti. 1990. Antibodies from patients with rheumatoid arthritis and systemic lupus erythematosus recognize different epitopes of a single heterogeneous nuclear RNP core protein. Possible role of cross-reacting antikeratin antibodies. Arthritis Rheum. 33:180-186.
    • (1990) Arthritis Rheum. , vol.33 , pp. 180-186
    • Montecucco, C.1    Caporali, R.2    Negri, C.3    De Gennaro, F.4    Cerino, A.5    Bestagno, M.6    Cobianchi, F.7    Astaldi-Ricotti, G.C.8
  • 35
    • 0029896047 scopus 로고    scopus 로고
    • hnRNP A1 selectively interacts through its gly-rich domain with different RNA-binding proteins
    • Cartegni, L., M. Maconi, E. Morandi, F. Cobianchi, S. Riva, and G. Biamonti. 1996. hnRNP A1 selectively interacts through its gly-rich domain with different RNA-binding proteins. J. Mol. Biol. 259:337-348.
    • (1996) J. Mol. Biol. , vol.259 , pp. 337-348
    • Cartegni, L.1    Maconi, M.2    Morandi, E.3    Cobianchi, F.4    Riva, S.5    Biamonti, G.6
  • 36
    • 0028176929 scopus 로고
    • Determination of the secondary structure and folding topology of an RNA binding domain of mammalian hnRNP A1 protein using three-dimensional heteronuclear magnetic resonance spectroscopy
    • Garrett, D.S., P.J. Lodi, Y. Shamoo, K.R. Williams, G.M. Clore, and A.M. Gronenborn. 1994. Determination of the secondary structure and folding topology of an RNA binding domain of mammalian hnRNP A1 protein using three-dimensional heteronuclear magnetic resonance spectroscopy. Biochemistry. 33:2852-2858.
    • (1994) Biochemistry , vol.33 , pp. 2852-2858
    • Garrett, D.S.1    Lodi, P.J.2    Shamoo, Y.3    Williams, K.R.4    Clore, G.M.5    Gronenborn, A.M.6
  • 37
    • 0028129989 scopus 로고
    • Conserved structures and diversity of functions of RNA-binding proteins
    • Burd, C.G., and G. Dreyfuss. 1994. Conserved structures and diversity of functions of RNA-binding proteins. Science (Wash. DC). 265:615-621.
    • (1994) Science (Wash. DC) , vol.265 , pp. 615-621
    • Burd, C.G.1    Dreyfuss, G.2
  • 39
    • 0027753933 scopus 로고
    • Analysis of the RNA-recognition motif and RS and RGG domains: Conservation in metazoan premRNA splicing factors
    • Birney, E., S. Kumar, and A.R. Krainer. 1993. Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan premRNA splicing factors. Nucleic Acids Res. 21:5803-5816.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 5803-5816
    • Birney, E.1    Kumar, S.2    Krainer, A.R.3
  • 40
    • 0030005013 scopus 로고    scopus 로고
    • Human lupus anti-spliceosome A protein autoantibodies bind contiguous surface structures and segregate into two sequential epitope binding patterns
    • James, J.A., and J.B. Harley. 1996. Human lupus anti-spliceosome A protein autoantibodies bind contiguous surface structures and segregate into two sequential epitope binding patterns. J. Immunol. 156:4018-4026.
    • (1996) J. Immunol. , vol.156 , pp. 4018-4026
    • James, J.A.1    Harley, J.B.2
  • 41
    • 0028605257 scopus 로고
    • Autoantibody-defined epitopes on nuclear antigens are conserved, conformation-dependent and active site regions
    • Tan, E.M., Y. Muro, and K.M. Pollard. 1994. Autoantibody-defined epitopes on nuclear antigens are conserved, conformation-dependent and active site regions. Clin. Exp. Rheumatol. 12(Suppl. 11):27-31.
    • (1994) Clin. Exp. Rheumatol. , vol.12 , Issue.11 SUPPL. , pp. 27-31
    • Tan, E.M.1    Muro, Y.2    Pollard, K.M.3
  • 42
    • 0027142993 scopus 로고
    • Role of intermolecular/ intrastructural B and T-cell determinants in the diversification of autoantibodies to ribonucleoprotein particles
    • Fatenejad, S., M.J. Mamula, and J. Craft. 1993. Role of intermolecular/ intrastructural B and T-cell determinants in the diversification of autoantibodies to ribonucleoprotein particles. Proc. Natl. Acad. Sci. USA. 90:12010-12014.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 12010-12014
    • Fatenejad, S.1    Mamula, M.J.2    Craft, J.3
  • 43
    • 0028204119 scopus 로고
    • B cells process and present lupus autoantigens that initiate autoimmune T cell responses
    • Mamula, M.J., S. Fatenejad, and J. Craft. 1994. B cells process and present lupus autoantigens that initiate autoimmune T cell responses. J. Immunol. 152:1453-1461.
    • (1994) J. Immunol. , vol.152 , pp. 1453-1461
    • Mamula, M.J.1    Fatenejad, S.2    Craft, J.3
  • 44
    • 0028912625 scopus 로고
    • Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B′-derived PPPGMRPP and PPPGIRGP induce spliceosome autoimmunity
    • James, J.A., T. Gross, R.H. Scofield, and J.B. Harley. 1995. Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B′-derived PPPGMRPP and PPPGIRGP induce spliceosome autoimmunity. J. Exp. Med. 181:453-461.
    • (1995) J. Exp. Med. , vol.181 , pp. 453-461
    • James, J.A.1    Gross, T.2    Scofield, R.H.3    Harley, J.B.4
  • 45
    • 1842414071 scopus 로고
    • Autoantibodies to hnRNP-A2 (RA33) in sera of MRL/lpr mice
    • Abstr.
    • Steiner, G., J.S. Smolen, and H.M. Smith. 1995. Autoantibodies to hnRNP-A2 (RA33) in sera of MRL/lpr mice. Arthritis Rheum. 39:(Suppl.): S297. (Abstr.)
    • (1995) Arthritis Rheum. , vol.39 , Issue.SUPPL.
    • Steiner, G.1    Smolen, J.S.2    Smith, H.M.3
  • 46
    • 0028268323 scopus 로고
    • B cell epitopes on nuclear autoantigens. What can they tell us?
    • van Venrooij, W.J., and C.W. van Gelder. 1994. B cell epitopes on nuclear autoantigens. What can they tell us? Arthritis Rheum. 37:608-616.
    • (1994) Arthritis Rheum. , vol.37 , pp. 608-616
    • Van Venrooij, W.J.1    Van Gelder, C.W.2
  • 47
    • 0025786163 scopus 로고
    • Autoantibodies in pathology and cell biology
    • Tan, E.M. 1991. Autoantibodies in pathology and cell biology. Cell. 67: 841-842.
    • (1991) Cell , vol.67 , pp. 841-842
    • Tan, E.M.1


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