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Volumn 8, Issue 9, 2012, Pages 505-514

B-cell depletion in the treatment of lupus nephritis

Author keywords

[No Author keywords available]

Indexed keywords

ATACICEPT; AZATHIOPRINE; BELIMUMAB; CALCINEURIN INHIBITOR; CORTICOSTEROID; CYCLOPHOSPHAMIDE; EPRATUZUMAB; GLUCOCORTICOID; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; OCRELIZUMAB; PLACEBO; RITUXIMAB; STEROID;

EID: 84865479037     PISSN: 17595061     EISSN: 1759507X     Source Type: Journal    
DOI: 10.1038/nrneph.2012.141     Document Type: Review
Times cited : (72)

References (81)
  • 1
    • 40049093765 scopus 로고    scopus 로고
    • Systemic lupus erythematosus
    • Rahman, A. & Isenberg, D. A. Systemic lupus erythematosus. N. Engl. J. Med. 358, 929-939 (2008
    • (2008) N. Engl. J. Med. , vol.358 , pp. 929-939
    • Rahman, A.1    Isenberg, D.A.2
  • 2
    • 69549106587 scopus 로고    scopus 로고
    • Pathogenesis of kidney disease in systemic lupus erythematosus
    • Bagavant, H. & Fu, S. M. Pathogenesis of kidney disease in systemic lupus erythematosus. Curr. Opin. Rheumatol. 21, 489-494 (2009
    • (2009) Curr. Opin. Rheumatol. , vol.21 , pp. 489-494
    • Bagavant, H.1    Fu, S.M.2
  • 3
    • 0031052874 scopus 로고    scopus 로고
    • Age-specific incidence rates of myocardial infarction and angina in women with systemic lupus erythematosus: Comparison with the framingham study
    • Manzi, S. et al. Age-specific incidence rates of myocardial infarction and angina in women with systemic lupus erythematosus: comparison with the Framingham study. Am. J. Epidemiol. 145, 408-415 (1997
    • (1997) Am. J. Epidemiol. , vol.145 , pp. 408-415
    • Manzi, S.1
  • 4
    • 1842530440 scopus 로고    scopus 로고
    • Cardiovascular disease a hazard despite improved prognosis in patients with systemic lupus erythematosus: Results from a swedish population based study 1964-1995
    • Björnådal, L., Yin, L., Granath, F., Klareskog, L. & Ekbom, A. Cardiovascular disease a hazard despite improved prognosis in patients with systemic lupus erythematosus: results from a Swedish population based study 1964-1995. J. Rheumatol. 31, 713-719 (2004
    • (2004) J. Rheumatol. , vol.31 , pp. 713-719
    • Björnådal, L.1    Yin, L.2    Granath, F.3    Klareskog, L.4    Ekbom, A.5
  • 5
    • 0030268581 scopus 로고    scopus 로고
    • Methylprednisolone and cyclophosphamide, alone or in combination, in patients with lupus nephritis. A randomized, controlled trial
    • Gourley, M. F. et al. Methylprednisolone and cyclophosphamide, alone or in combination, in patients with lupus nephritis. A randomized, controlled trial. Ann. Intern. Med. 125, 549-557 (1996
    • (1996) Ann. Intern. Med. , vol.125 , pp. 549-557
    • Gourley, M.F.1
  • 6
    • 0742278571 scopus 로고    scopus 로고
    • Treatment of diffuse proliferative lupus nephritis: A meta-Analysis of randomized controlled trials
    • Flanc, R. S. et al. Treatment of diffuse proliferative lupus nephritis: A meta-Analysis of randomized controlled trials. Am. J. Kidney Dis. 43, 197-208 (2004
    • (2004) Am. J. Kidney Dis. , vol.43 , pp. 197-208
    • Flanc, R.S.1
  • 7
    • 84865517507 scopus 로고    scopus 로고
    • Systematic review and meta-Analysis of the association of systemic lupus erythematosus and malignancy [abstract]
    • (2011) 8 Cameron J S Lupus nephritis an historical perspective 1968-1998 J Nephrol 12
    • Dey, I. D. & Isenberg, D. A. Systematic review and meta-Analysis of the association of systemic lupus erythematosus and malignancy [abstract]. Arthritis Rheum. 63, 2283 (2011). 8. Cameron, J. S. Lupus nephritis: An historical perspective 1968-1998. J. Nephrol. 12, S29-S41 (1999).
    • (1999) Arthritis Rheum. , vol.63 , Issue.2283
    • Dey, I.D.1    Isenberg, D.A.2
  • 8
    • 33846964112 scopus 로고    scopus 로고
    • Renal biopsy in lupus patients with low levels of proteinuria
    • Christopher-Stine, L. et al. Renal biopsy in lupus patients with low levels of proteinuria. J. Rheumatol. 34, 332-335 (2007
    • (2007) J. Rheumatol. , vol.34 , pp. 332-335
    • Christopher-Stine, L.1
  • 9
    • 0942265440 scopus 로고    scopus 로고
    • The classification of glomerulonephritis in systemic lupus erythematosus revisited
    • Weening, J. J. et al. The classification of glomerulonephritis in systemic lupus erythematosus revisited. J. Am. Soc. Nephrol. 15, 241-250 (2004
    • (2004) J. Am. Soc. Nephrol. , vol.15 , pp. 241-250
    • Weening, J.J.1
  • 10
    • 4444291079 scopus 로고    scopus 로고
    • Surviving the butterfly and the wolf: Mortality trends in systemic lupus erythematosus
    • Borchers, A. T., Keen, C. L., Shoenfeld, Y. & Gershwin, M. E. Surviving the butterfly and the wolf: mortality trends in systemic lupus erythematosus. Autoimmun. Rev. 3, 423-453 (2004
    • (2004) Autoimmun. Rev. , vol.3 , pp. 423-453
    • Borchers, A.T.1    Keen, C.L.2    Shoenfeld, Y.3    Gershwin, M.E.4
  • 11
    • 0141891339 scopus 로고    scopus 로고
    • Morbidity and mortality in systemic lupus erythematosus during a 10-year period: A comparison of early and late manifestations in a cohort of 1,000 patients
    • Cervera, R. et al. Morbidity and mortality in systemic lupus erythematosus during a 10-year period: A comparison of early and late manifestations in a cohort of 1,000 patients. Medicine (Baltimore) 82, 299-308 (2003
    • (2003) Medicine (Baltimore) , vol.82 , pp. 299-308
    • Cervera, R.1
  • 12
    • 79551581442 scopus 로고    scopus 로고
    • Treatment of proliferative lupus nephritis: A slowly changing landscape
    • Tesar, V. & Hruskova, Z. Treatment of proliferative lupus nephritis: A slowly changing landscape. Nat. Rev. Nephrol. 7, 96-109 (2011
    • (2011) Nat. Rev. Nephrol. , vol.7 , pp. 96-109
    • Tesar, V.1    Hruskova, Z.2
  • 13
    • 0036673864 scopus 로고    scopus 로고
    • Immunosuppressive therapy in lupus nephritis: The euro-lupus nephritis trial, a randomized trial of low-dose versus high-dose intravenous cyclophosphamide
    • Houssiau, F. A. et al. Immunosuppressive therapy in lupus nephritis: The Euro-Lupus nephritis trial, a randomized trial of low-dose versus high-dose intravenous cyclophosphamide. Arthritis Rheum. 46, 2121-2131 (2002
    • (2002) Arthritis Rheum , vol.46 , pp. 2121-2131
    • Houssiau, F.A.1
  • 14
    • 28144433147 scopus 로고    scopus 로고
    • Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis
    • Ginzler, E. M. et al. Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis. N. Engl. J. Med. 353, 2219-2228 (2005
    • (2005) N. Engl. J. Med. , vol.353 , pp. 2219-2228
    • Ginzler, E.M.1
  • 15
    • 0034687429 scopus 로고    scopus 로고
    • Efficacy of mycophenolate mofetil in patients with diffuse proliferative lupus nephritis. Hong kong-guangzhou nephrology study group
    • Chan, T. M. et al. Efficacy of mycophenolate mofetil in patients with diffuse proliferative lupus nephritis. Hong Kong-Guangzhou nephrology study group. N. Engl. J. Med. 343, 1156-1162 (2000
    • (2000) N. Engl. J. Med. , vol.343 , pp. 1156-1162
    • Chan, T.M.1
  • 16
    • 65649140169 scopus 로고    scopus 로고
    • Mycophenolate mofetil versus cyclophosphamide for induction treatment of lupus nephritis
    • Appel, G. B. et al. Mycophenolate mofetil versus cyclophosphamide for induction treatment of lupus nephritis. J. Am. Soc. Nephrol. 20, 1103-1112 (2009
    • (2009) J. Am. Soc. Nephrol. , vol.20 , pp. 1103-1112
    • Appel, G.B.1
  • 17
    • 20444466207 scopus 로고    scopus 로고
    • Long-term study of mycophenolate mofetil as continuous induction and maintenance treatment for diffuse proliferative lupus nephritis
    • Chan, T. M., Tse, K. C., Tang, C. S., Mok, M. Y. & Li, F. K. Long-term study of mycophenolate mofetil as continuous induction and maintenance treatment for diffuse proliferative lupus nephritis. J. Am. Soc. Nephrol. 16, 1076-1084 (2005
    • (2005) J. Am. Soc. Nephrol. , vol.16 , pp. 1076-1084
    • Chan, T.M.1    Tse, K.C.2    Tang, C.S.3    Mok, M.Y.4    Li, F.K.5
  • 18
    • 0030477697 scopus 로고    scopus 로고
    • Cumulative rate of relapse of lupus nephritis after successful treatment with cyclophosphamide
    • Ciruelo, E., de la Cruz, J., López, I. & Gómez Reino, J. J. Cumulative rate of relapse of lupus nephritis after successful treatment with cyclophosphamide. Arthritis Rheum. 39, 2028-2034 (1996
    • (1996) Arthritis Rheum. , vol.39 , pp. 2028-2034
    • Ciruelo, E.1    De La Cruz, J.2    López, I.3    Gómez Reino, J.J.4
  • 19
    • 34548434009 scopus 로고    scopus 로고
    • The long-term outcome of 93 patients with proliferative lupus nephritis
    • Moroni, G. et al. The long-term outcome of 93 patients with proliferative lupus nephritis. Nephrol. Dial. Transplant. 22, 2531-2539 (2007
    • (2007) Nephrol. Dial. Transplant. , vol.22 , pp. 2531-2539
    • Moroni, G.1
  • 20
    • 0036226234 scopus 로고    scopus 로고
    • Renal flares in 91 sle patients with diffuse proliferative glomerulonephritis
    • Mosca, M. et al. Renal flares in 91 SLE patients with diffuse proliferative glomerulonephritis. Kidney Int. 61, 1502-1509 (2002
    • (2002) Kidney Int , vol.61 , pp. 1502-1509
    • Mosca, M.1
  • 21
    • 0036222879 scopus 로고    scopus 로고
    • Renal flares are common in patients with severe proliferative lupus nephritis treated with pulse immunosuppressive therapy: Long-term follow-up of a cohort of 145 patients participating in randomized controlled studies
    • Illei, G. G. et al. Renal flares are common in patients with severe proliferative lupus nephritis treated with pulse immunosuppressive therapy: long-term follow-up of a cohort of 145 patients participating in randomized controlled studies. Arthritis Rheum. 46, 995-1002 (2002
    • (2002) Arthritis Rheum , vol.46 , pp. 995-1002
    • Illei, G.G.1
  • 22
    • 73449086703 scopus 로고    scopus 로고
    • The 10-year follow-up data of the euro-lupus nephritis trial comparing low-dose and high-dose intravenous cyclophosphamide
    • Houssiau, F. A. et al. The 10-year follow-up data of the Euro-Lupus nephritis trial comparing low-dose and high-dose intravenous cyclophosphamide. Ann. Rheum. Dis. 69, 61-64 (2010
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 61-64
    • Houssiau, F.A.1
  • 23
    • 35948956955 scopus 로고    scopus 로고
    • B cells in glomerulonephritis: Focus on lupus nephritis
    • Clatworthy, M. R. & Smith, K. G. B cells in glomerulonephritis: focus on lupus nephritis. Semin. Immunopathol. 29, 337-353 (2007
    • (2007) Semin. Immunopathol. , vol.29 , pp. 337-353
    • Clatworthy, M.R.1    Smith, K.G.2
  • 24
  • 26
    • 71049118062 scopus 로고    scopus 로고
    • Rituximab is an effective treatment for lupus nephritis and allows a reduction in maintenance steroids
    • Pepper, R. et al. Rituximab is an effective treatment for lupus nephritis and allows a reduction in maintenance steroids. Nephrol. Dial. Transplant. 24, 3717-3723 (2009
    • (2009) Nephrol. Dial. Transplant. , vol.24 , pp. 3717-3723
    • Pepper, R.1
  • 27
    • 67349230530 scopus 로고    scopus 로고
    • Rituximab and mycophenolate mofetil for relapsing proliferative lupus nephritis: A long-term prospective study
    • Boletis, J. N. et al. Rituximab and mycophenolate mofetil for relapsing proliferative lupus nephritis: A long-term prospective study. Nephrol. Dial. Transplant. 24, 2157-2160 (2009
    • (2009) Nephrol. Dial. Transplant. , vol.24 , pp. 2157-2160
    • Boletis, J.N.1
  • 28
    • 66149099305 scopus 로고    scopus 로고
    • Rituximab in severe lupus nephritis: Early bcell depletion affects long-term renal outcome. Clin
    • Melander, C. et al. Rituximab in severe lupus nephritis: Early Bcell depletion affects long-term renal outcome. Clin. J. Am. Soc. Nephrol. 4, 579-587 (2009
    • (2009) J. Am. Soc. Nephrol. , vol.4 , pp. 579-587
    • Melander, C.1
  • 29
    • 70149093654 scopus 로고    scopus 로고
    • Is combination rituximab with cyclophosphamide better than rituximab alone in the treatment of lupus nephritis?
    • Li, E. K. et al. Is combination rituximab with cyclophosphamide better than rituximab alone in the treatment of lupus nephritis? Rheumatology (Oxford) 48, 892-898 (2009
    • (2009) Rheumatology (Oxford) , vol.48 , pp. 892-898
    • Li, E.K.1
  • 30
    • 34247246405 scopus 로고    scopus 로고
    • Histopathologic and clinical outcome of rituximab treatment in patients with cyclophosphamide-resistant proliferative lupus nephritis
    • Gunnarsson, I. et al. Histopathologic and clinical outcome of rituximab treatment in patients with cyclophosphamide-resistant proliferative lupus nephritis. Arthritis Rheum. 56, 1263-1272 (2007
    • (2007) Arthritis Rheum. , vol.56 , pp. 1263-1272
    • Gunnarsson, I.1
  • 31
    • 70350525210 scopus 로고    scopus 로고
    • Clinical and immunological effects of rituximab in patients with lupus nephritis refractory to conventional therapy: A pilot study
    • Vigna-Perez, M. et al. Clinical and immunological effects of rituximab in patients with lupus nephritis refractory to conventional therapy: A pilot study. Arthritis Res. Ther. 8, R83 (2006
    • (2006) Arthritis Res. Ther. , vol.8
    • Vigna-Perez, M.1
  • 32
    • 13444252282 scopus 로고    scopus 로고
    • Remission of proliferative lupus nephritis following b cell depletion therapy is preceded by down-regulation of the t cell costimulatory molecule cd40 ligand: An open-label trial
    • Sfikakis, P. P. et al. Remission of proliferative lupus nephritis following B cell depletion therapy is preceded by down-regulation of the T cell costimulatory molecule CD40 ligand: An open-label trial. Arthritis Rheum. 52, 501-513 (2005
    • (2005) Arthritis Rheum. , vol.52 , pp. 501-513
    • Sfikakis, P.P.1
  • 33
    • 80053542023 scopus 로고    scopus 로고
    • B cell biomarkers of rituximab responses in systemic lupus erythematosus
    • Vital, E. M. et al. B cell biomarkers of rituximab responses in systemic lupus erythematosus. Arthritis Rheum. 63, 3038-3047 (2011
    • (2011) Arthritis Rheum. , vol.63 , pp. 3038-3047
    • Vital, E.M.1
  • 34
    • 80051863465 scopus 로고    scopus 로고
    • Intensive short-term treatment with rituximab, cyclophosphamide and methylprednisolone pulses induces remission in severe cases of sle with nephritis and avoids further immunosuppressive maintenance therapy
    • Roccatello, D. et al. Intensive short-term treatment with rituximab, cyclophosphamide and methylprednisolone pulses induces remission in severe cases of SLE with nephritis and avoids further immunosuppressive maintenance therapy. Nephrol. Dial. Transplant. 26, 3987-3992 (2011
    • (2011) Nephrol. Dial. Transplant. , vol.26 , pp. 3987-3992
    • Roccatello, D.1
  • 35
    • 77955379986 scopus 로고    scopus 로고
    • Safety and efficacy of rituximab in systemic lupus erythematosus: Results from 136 patients from the french autoimmunity and rituximab registry
    • Terrier, B. et al. Safety and efficacy of rituximab in systemic lupus erythematosus: results from 136 patients from the French autoimmunity and rituximab registry. Arthritis Rheum. 62, 2458-2466 (2010
    • (2010) Arthritis Rheum. , vol.62 , pp. 2458-2466
    • Terrier, B.1
  • 36
    • 79952196706 scopus 로고    scopus 로고
    • Long-term efficacy and safety of rituximab in refractory and relapsing systemic lupus erythematosus
    • Catapano, F., Chaudhry, A. N., Jones, R. B., Smith, K. G. & Jayne, D. W. Long-term efficacy and safety of rituximab in refractory and relapsing systemic lupus erythematosus. Nephrol. Dial. Transplant. 25, 3586-3592 (2010
    • (2010) Nephrol. Dial. Transplant. , vol.25 , pp. 3586-3592
    • Catapano, F.1    Chaudhry, A.N.2    Jones, R.B.3    Smith, K.G.4    Jayne, D.W.5
  • 37
    • 76049094173 scopus 로고    scopus 로고
    • Anti-cd20 therapy in patients with refractory systemic lupus erythematosus: A longitudinal analysis of 52 hispanic patients
    • Garcia-Carrasco, M. et al. Anti-CD20 therapy in patients with refractory systemic lupus erythematosus: A longitudinal analysis of 52 Hispanic patients. Lupus 19, 213-219 (2010
    • (2010) Lupus , vol.19 , pp. 213-219
    • Garcia-Carrasco, M.1
  • 38
    • 77951237518 scopus 로고    scopus 로고
    • Use of rituximab in the treatment of refractory systemic lupus erythematosus: Singapore experience
    • Lateef, A., Lahiri, M., Teng, G. G. & Vasoo, S. Use of rituximab in the treatment of refractory systemic lupus erythematosus: Singapore experience. Lupus 19, 765-770 (2010
    • (2010) Lupus , vol.19 , pp. 765-770
    • Lateef, A.1    Lahiri, M.2    Teng, G.G.3    Vasoo, S.4
  • 39
    • 65249187242 scopus 로고    scopus 로고
    • A retrospective seven-year analysis of the use of b cell depletion therapy in systemic lupus erythematosus at university college london hospital: The first fifty patients
    • Lu, T. Y. et al. A retrospective seven-year analysis of the use of B cell depletion therapy in systemic lupus erythematosus at University College London Hospital: The first fifty patients. Arthritis Rheum. 61, 482-487 (2009
    • (2009) Arthritis Rheum. , vol.61 , pp. 482-487
    • Lu, T.Y.1
  • 40
    • 44349131653 scopus 로고    scopus 로고
    • Longterm clinical and immunological effects of anti-cd20 treatment in patients with refractory systemic lupus erythematosus
    • Lindholm, C. et al. Longterm clinical and immunological effects of anti-CD20 treatment in patients with refractory systemic lupus erythematosus. J. Rheumatol. 35, 826-833 (2008
    • (2008) J. Rheumatol. , vol.35 , pp. 826-833
    • Lindholm, C.1
  • 41
    • 39549108298 scopus 로고    scopus 로고
    • Treatment of refractory sle with rituximab plus cyclophosphamide: Clinical effects, serological changes, and predictors of response
    • Jónsdóttir, T. et al. Treatment of refractory SLE with rituximab plus cyclophosphamide: clinical effects, serological changes, and predictors of response. Ann. Rheum. Dis. 67, 330-334 (2008
    • (2008) Ann. Rheum. Dis. , vol.67 , pp. 330-334
    • Jónsdóttir, T.1
  • 42
    • 34250631349 scopus 로고    scopus 로고
    • A multicenter phase i/ii trial of rituximab for refractory systemic lupus erythematosus
    • Tanaka, Y. et al. A multicenter phase I/II trial of rituximab for refractory systemic lupus erythematosus. Mod. Rheumatol. 17, 191-197 (2007
    • (2007) Mod. Rheumatol. , vol.17 , pp. 191-197
    • Tanaka, Y.1
  • 43
    • 28544449032 scopus 로고    scopus 로고
    • Bcell depletion in the treatment of patients with systemic lupus erythematosus: A longitudinal analysis of 24 patients
    • Leandro, M. J., Cambridge, G., Edwards, J. C., Ehrenstein, M. R. & Isenberg, D. A. Bcell depletion in the treatment of patients with systemic lupus erythematosus: A longitudinal analysis of 24 patients. Rheumatology (Oxford) 44, 1542-1545 (2005
    • (2005) Rheumatology (Oxford) , vol.44 , pp. 1542-1545
    • Leandro, M.J.1    Cambridge, G.2    Edwards, J.C.3    Ehrenstein, M.R.4    Isenberg, D.A.5
  • 44
    • 4043179907 scopus 로고    scopus 로고
    • B cell depletion as a novel treatment for systemic lupus erythematosus: A phase i/ii dose-escalation trial of rituximab
    • Looney, R. J. et al. B cell depletion as a novel treatment for systemic lupus erythematosus: A phase I/II dose-escalation trial of rituximab. Arthritis Rheum. 50, 2580-2589 (2004
    • (2004) Arthritis Rheum. , vol.50 , pp. 2580-2589
    • Looney, R.J.1
  • 45
    • 84866184129 scopus 로고    scopus 로고
    • Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: The lupus nephritis assessment with rituximab (lunar) study
    • Rovin, B. H. et al. Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: The lupus nephritis assessment with rituximab (LUNAR) study. Arthritis Rheum. 64, 1215-1226 (2012
    • (2012) Arthritis Rheum. , vol.64 , pp. 1215-1226
    • Rovin, B.H.1
  • 46
    • 84872673188 scopus 로고    scopus 로고
    • Efficacy and safety of ocrelizumab, a humanized anticd20 antibody, in patients with active proliferative lupus nephritis (ln): Results from the randomized, double-blind phase iii belong study [abstract]
    • Mysler, E. F. et al. Efficacy and safety of ocrelizumab, a humanized antiCD20 antibody, in patients with active proliferative lupus nephritis (LN): results from the randomized, double-blind phase III BELONG study [abstract]. Arthritis Rheum. 62, 1455 (2010
    • (2010) Arthritis Rheum. , vol.62 , Issue.1455
    • Mysler, E.F.1
  • 47
    • 78649873438 scopus 로고    scopus 로고
    • Updates on the treatment of lupus nephritis
    • Bomback, A. S. & Appel, G. B. Updates on the treatment of lupus nephritis. J. Am. Soc. Nephrol. 21, 2028-2035 (2010
    • (2010) J. Am. Soc. Nephrol. , vol.21 , pp. 2028-2035
    • Bomback, A.S.1    Appel, G.B.2
  • 49
    • 51849148443 scopus 로고    scopus 로고
    • Ocrelizumab, a humanized anti-cd20 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase i/ii randomized, blinded, placebo-controlled, dose-ranging study
    • Genovese, M. C. et al. Ocrelizumab, a humanized anti-CD20 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I/II randomized, blinded, placebo-controlled, dose-ranging study. Arthritis Rheum. 58, 2652-2661 (2008
    • (2008) Arthritis Rheum. , vol.58 , pp. 2652-2661
    • Genovese, M.C.1
  • 50
    • 77955175014 scopus 로고    scopus 로고
    • Results of a phase i/ii study of ocrelizumab, a fully humanized anti-cd20 mab, in patients with relapsed/refractory follicular lymphoma
    • Morschhauser, F. et al. Results of a phase I/II study of ocrelizumab, a fully humanized anti-CD20 mAb, in patients with relapsed/refractory follicular lymphoma. Ann. Oncol. 21, 1870-1876 (2010
    • (2010) Ann. Oncol. , vol.21 , pp. 1870-1876
    • Morschhauser, F.1
  • 51
    • 84856388514 scopus 로고    scopus 로고
    • Safety and efficacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to methotrexate: Results of a fortyeightweek randomized, double-blind, placebo-controlled, parallel-group phase iii trial
    • Rigby, W. et al. Safety and efficacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a fortyeightweek randomized, double-blind, placebo-controlled, parallel-group phase III trial. Arthritis Rheum. 64, 350-359 (2012
    • (2012) Arthritis Rheum. , vol.64 , pp. 350-359
    • Rigby, W.1
  • 52
    • 84873070286 scopus 로고    scopus 로고
    • Study of the safety of mdx1342 in combination with methotrexate in patients with rheumatoid arthritis (MDX1342-1301)
    • US National Library Of Medicine, [online]
    • US National library of Medicine. Study of the safety of MDX1342 in combination with methotrexate in patients with rheumatoid arthritis (MDX1342-1301). Clinicaltrials.gov [online], http://clinicaltrials.gov/ct2/show/ NCT00639834.
    • Clinicaltrials. Gov
  • 53
    • 78650997402 scopus 로고    scopus 로고
    • Treatment of systemic lupus erythematosus with epratuzumab
    • Traczewski, P. & Rudnicka, L. Treatment of systemic lupus erythematosus with epratuzumab. Br. J. Clin. Pharmacol. 71, 175-182 (2011).
    • (2011) Br. J. Clin. Pharmacol. , vol.71 , pp. 175-182
    • Traczewski, P.1    Rudnicka, L.2
  • 54
    • 53749095799 scopus 로고    scopus 로고
    • Initial clinical trial of epratuzumab (humanized anti-cd22 antibody) for immunotherapy of systemic lupus erythematosus
    • Dörner, T. et al. Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus. Arthritis Res. Ther. 8, R74 (2006
    • (2006) Arthritis Res. Ther. , vol.8
    • Dörner, T.1
  • 55
    • 41849121941 scopus 로고    scopus 로고
    • Differential effects of epratuzumab on peripheral blood b cells of patients with systemic lupus erythematosus versus normal controls
    • Jacobi, A. M. et al. Differential effects of epratuzumab on peripheral blood B cells of patients with systemic lupus erythematosus versus normal controls. Ann. Rheum. Dis. 67, 450-457 (2008
    • (2008) Ann. Rheum. Dis. , vol.67 , pp. 450-457
    • Jacobi, A.M.1
  • 56
    • 55849128896 scopus 로고    scopus 로고
    • Durable complete responses from therapy with combined epratuzumab and rituximab: Final results from an international multicenter, phase 2 study in recurrent, indolent, non-hodgkin lymphoma
    • Leonard, J. P. et al. Durable complete responses from therapy with combined epratuzumab and rituximab: final results from an international multicenter, phase 2 study in recurrent, indolent, non-Hodgkin lymphoma. Cancer 113, 2714-2723 (2008
    • (2008) Cancer , vol.113 , pp. 2714-2723
    • Leonard, J.P.1
  • 57
    • 70349658717 scopus 로고    scopus 로고
    • Baff: A local and systemic target in autoimmune diseases
    • Moisini, I. & Davidson, A. BAFF: A local and systemic target in autoimmune diseases. Clin. Exp. Immunol. 158, 155-163 (2009
    • (2009) Clin. Exp. Immunol. , vol.158 , pp. 155-163
    • Moisini, I.1    Davidson, A.2
  • 58
    • 79952070370 scopus 로고    scopus 로고
    • Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: A randomised, placebo-controlled, phase 3 trial
    • Navarra, S. V. et al. Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: A randomised, placebo-controlled, phase 3 trial. Lancet 377, 721-731 (2011
    • (2011) Lancet , vol.377 , pp. 721-731
    • Navarra, S.V.1
  • 59
    • 84863907923 scopus 로고    scopus 로고
    • Effect of belimumab treatment on renal outcomes: Results from phase 3 belimumab clinical trials in patients with systemic lupus erythematosus [abstract]
    • Dooley, M. A. et al. Effect of belimumab treatment on renal outcomes: results from phase 3 belimumab clinical trials in patients with systemic lupus erythematosus [abstract]. Arthritis Rheum. 63, 2472 (2011)
    • (2011) Arthritis Rheum. , vol.63 , Issue.2472
    • Dooley, M.A.1
  • 60
    • 65149106325 scopus 로고    scopus 로고
    • An exploratory dose-escalating study investigating the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenous atacicept in patients with systemic lupus erythematosus
    • Pena-Rossi, C. et al. An exploratory dose-escalating study investigating the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenous atacicept in patients with systemic lupus erythematosus. Lupus 18, 547-555 (2009
    • (2009) Lupus , vol.18 , pp. 547-555
    • Pena-Rossi, C.1
  • 61
    • 84873061401 scopus 로고    scopus 로고
    • Atacicept Phase IIIII In Generalized Systemic Lupus Erythematosus (April SLE)
    • US National Library Of Medicine, [online]
    • US National library of Medicine. Atacicept phase II/III in generalized systemic lupus erythematosus (April SLE). Clinicaltrials.gov [online], http://clinicaltrials.gov/ct2/show/NCT00624338?term=1.
    • Clinicaltrials. Gov
  • 62
    • 77954707963 scopus 로고    scopus 로고
    • Clinical improvements in proliferative vs membranous lupus nephritis following bcell depletion: Pooled data from two cohorts
    • Jónsdóttir, T. et al. Clinical improvements in proliferative vs membranous lupus nephritis following Bcell depletion: pooled data from two cohorts. Rheumatology (Oxford) 49, 1502-1504 (2010
    • (2010) Rheumatology (Oxford) , vol.49 , pp. 1502-1504
    • Jónsdóttir, T.1
  • 63
    • 84857502425 scopus 로고    scopus 로고
    • The ukbiogeas registry. Efficacy of rituximab in 164 patients with biopsy-proven lupus nephritis: Pooled data from european cohorts
    • Díaz-Lagares, C. et al. The UKBIOGEAS Registry. Efficacy of rituximab in 164 patients with biopsy-proven lupus nephritis: pooled data from European cohorts. Autoimmun. Rev. 11, 357-364 (2012
    • (2012) Autoimmun. Rev. , vol.11 , pp. 357-364
    • Díaz-Lagares, C.1
  • 64
    • 81455135753 scopus 로고    scopus 로고
    • Mycophenolate versus azathioprine as maintenance therapy for lupus nephritis
    • Dooley, M. A. et al. Mycophenolate versus azathioprine as maintenance therapy for lupus nephritis. N. Engl. J. Med. 365, 1886-1895 (2011
    • (2011) N. Engl. J. Med. , vol.365 , pp. 1886-1895
    • Dooley, M.A.1
  • 65
    • 78649751475 scopus 로고    scopus 로고
    • Azathioprine versus mycophenolate mofetil for long-term immunosuppression in lupus nephritis: Results from the maintain nephritis trial
    • Houssiau, F. A. et al. Azathioprine versus mycophenolate mofetil for long-term immunosuppression in lupus nephritis: results from the MAINTAIN nephritis trial. Ann. Rheum. Dis. 69, 2083-2089 (2010
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 2083-2089
    • Houssiau, F.A.1
  • 66
    • 1442355581 scopus 로고    scopus 로고
    • Sequential therapies for proliferative lupus nephritis
    • Contreras, G. et al. Sequential therapies for proliferative lupus nephritis. N. Engl. J. Med. 350, 971-980 (2004
    • (2004) N. Engl. J. Med. , vol.350 , pp. 971-980
    • Contreras, G.1
  • 67
    • 78049507460 scopus 로고    scopus 로고
    • Mycophenolate mofetil as maintenance therapy for proliferative lupus nephritis: A long-term observational prospective study
    • Laskari, K., Mavragani, C. P., Tzioufas, A. G. & Moutsopoulos, H. M. Mycophenolate mofetil as maintenance therapy for proliferative lupus nephritis: A long-term observational prospective study. Arthritis Res. Ther. 12, R208 (2010
    • (2010) Arthritis Res. Ther. , vol.12
    • Laskari, K.1    Mavragani, C.P.2    Tzioufas, A.G.3    Moutsopoulos, H.M.4
  • 68
    • 77951610700 scopus 로고    scopus 로고
    • Fcgammariib in autoimmunity and infection: Evolutionary and therapeutic implications
    • Smith, K. G. & Clatworthy, M. R. FcgammaRIIB in autoimmunity and infection: Evolutionary and therapeutic implications. Nat. Rev. Immunol. 10, 328-343 (2010
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 328-343
    • Smith, K.G.1    Clatworthy, M.R.2
  • 70
    • 80052533015 scopus 로고    scopus 로고
    • Fc gamma receptor iib on target b cells promotes rituximab internalization and reduces clinical efficacy
    • Lim, S. H. et al. Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy. Blood 118, 2530-2540 (2011
    • (2011) Blood , vol.118 , pp. 2530-2540
    • Lim, S.H.1
  • 71
    • 80052184545 scopus 로고    scopus 로고
    • The efficacy of repeated treatment with bcell depletion therapy in systemic lupus erythematosus: An evaluation
    • Turner-Stokes, T. et al. The efficacy of repeated treatment with Bcell depletion therapy in systemic lupus erythematosus: An evaluation. Rheumatology (Oxford) 50, 1401-1408 (2011
    • (2011) Rheumatology (Oxford) , vol.50 , pp. 1401-1408
    • Turner-Stokes, T.1
  • 72
    • 34547488545 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy in rheumatic diseases: Evolving clinical and pathologic patterns of disease
    • Calabrese, L. H., Molloy, E. S., Huang, D. & Ransohoff, R. M. Progressive multifocal leukoencephalopathy in rheumatic diseases: Evolving clinical and pathologic patterns of disease. Arthritis Rheum. 56, 2116-2128 (2007
    • (2007) Arthritis Rheum , vol.56 , pp. 2116-2128
    • Calabrese, L.H.1    Molloy, E.S.2    Huang, D.3    Ransohoff, R.M.4
  • 73
    • 84863012323 scopus 로고    scopus 로고
    • Safety and efficacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to at least one tumor necrosis factor inhibitor: Results of a fortyeightweek randomized, double-blind, placebo-controlled, parallel-group phase iii trial
    • Tak, P. P. et al. Safety and efficacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to at least one tumor necrosis factor inhibitor: results of a fortyeightweek randomized, double-blind, placebo-controlled, parallel-group phase III trial. Arthritis Rheum. 64, 360-370 (2012
    • (2012) Arthritis Rheum. , vol.64 , pp. 360-370
    • Tak, P.P.1
  • 74
    • 84863841745 scopus 로고    scopus 로고
    • Safety and efficacy of ocrelizumab in combination with methotrexate in mtx-naive subjects with rheumatoid arthritis: The phase iii film trial
    • doi:10.1136/annrheumdis-2011-200706
    • Stohl, W. et al. Safety and efficacy of ocrelizumab in combination with methotrexate in MTX-naive subjects with rheumatoid arthritis: The phase III FILM trial. Ann. Rheum. Dis. doi:10.1136/annrheumdis-2011-200706.
    • Ann. Rheum. Dis
    • Stohl, W.1
  • 75
    • 67651084006 scopus 로고    scopus 로고
    • Randomized controlled trials of epratuzumab (anti-cd22 mab targeting b cells) reveal clinically meaningful improvements in patients with moderate/severe sle flares [abstract]
    • Petri, M. et al. Randomized controlled trials of epratuzumab (anti-CD22 mAb targeting B cells) reveal clinically meaningful improvements in patients with moderate/severe SLE flares [abstract]. Ann. Rheum. Dis. 67, 53 (2008
    • (2008) Ann. Rheum. Dis. , vol.67 , pp. 53
    • Petri, M.1
  • 76
    • 67651110504 scopus 로고    scopus 로고
    • Randomized controlled trials of epratuzumab (anti-cd22 mab targeting b cells) reveal clinically meaningful reductions in corticosteroid use with favorable safety profile in moderate and severe flaring sle patients [abstract]
    • Wallace, D. et al. Randomized controlled trials of epratuzumab (anti-CD22 mAb targeting B cells) reveal clinically meaningful reductions in corticosteroid use with favorable safety profile in moderate and severe flaring SLE patients [abstract]. Ann. Rheum. Dis. 67, 212 (2008
    • (2008) Ann. Rheum. Dis. , vol.67 , pp. 212
    • Wallace, D.1
  • 77
    • 67651125355 scopus 로고    scopus 로고
    • Randomized controlled trials of epratuzumab (anti-cd22 mab targeting b cells) reveal clinically meaningful improvements in health related quality of life in sle patients with high disease activity and low baseline self-report measures [abstract]
    • Strand, V. et al. Randomized controlled trials of epratuzumab (anti-CD22 mAb targeting B cells) reveal clinically meaningful improvements in health related quality of life in SLE patients with high disease activity and low baseline self-report measures [abstract]. Ann. Rheum. Dis. 67, 212 (2008
    • (2008) Ann. Rheum. Dis. , vol.67 , pp. 212
    • Strand, V.1
  • 78
    • 79960606104 scopus 로고    scopus 로고
    • Epratuzumab demonstrates clinically meaningful improvements in patients with moderate to severe systemic lupus erythematosus (sle): Results from emblem, a phase iib study [abstract]
    • Wallace, D. J. et al. Epratuzumab demonstrates clinically meaningful improvements in patients with moderate to severe systemic lupus erythematosus (SLE): results from EMBLEM, a phase IIb study [abstract]. Arthritis Rheum. 62, 1452 (2010
    • (2010) Arthritis Rheum. , vol.62 , Issue.1452
    • Wallace, D.J.1
  • 79
    • 83455202976 scopus 로고    scopus 로고
    • Bilag-measured improvement in moderately and severely affected body systems in patients with systemic lupus erythematosus (sle) by epratuzumab: Results from emblem, a phase iib study [abstract]
    • Kalunian, K. C. et al. BILAG-measured improvement in moderately and severely affected body systems in patients with systemic lupus erythematosus (SLE) by epratuzumab: results from EMBLEM, a phase IIb study [abstract]. Arthritis Rheum. 62, 453 (2010
    • (2010) Arthritis Rheum. , vol.62 , Issue.453
    • Kalunian, K.C.1
  • 80
    • 84873061974 scopus 로고    scopus 로고
    • Study of epratuzumab in systemic lupus erythematosus
    • US National library of Medicine [online]
    • US National library of Medicine. Study of epratuzumab in systemic lupus erythematosus. Clinicaltrials.gov [online], http://clinicaltrials.gov/ct2/show/ NCT00383513?term=NCT00383513&rank1.
    • Clinicaltrials. Gov
  • 81
    • 77955767712 scopus 로고    scopus 로고
    • Rituximab as maintenance therapy for anti-neutrophil cytoplasmic antibody-Associated vasculitis
    • Rhee, E. P., Laliberte, K. A. & Niles, J. L. Rituximab as maintenance therapy for anti-neutrophil cytoplasmic antibody-Associated vasculitis. Clin. J. Am. Soc. Nephrol. 5, 1394-1400 (2010).
    • (2010) Clin J. Am. Soc. Nephrol. , vol.5 , pp. 1394-1400
    • Rhee, E.P.1    Laliberte, K.A.2    Niles, J.L.3


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