-
1
-
-
2942618768
-
A renaissance for Src
-
T.J. Yeatman A renaissance for Src Nat Rev Cancer 4 2004 470 480
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 470-480
-
-
Yeatman, T.J.1
-
2
-
-
84979948588
-
A sarcoma of the fowl transmissible by an agent separable from the tumor cells
-
P. Rous A sarcoma of the fowl transmissible by an agent separable from the tumor cells J Exp Med 13 1911 397 411
-
(1911)
J Exp Med
, vol.13
, pp. 397-411
-
-
Rous, P.1
-
3
-
-
0018461031
-
Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (Src)
-
H. Oppermann, A.D. Levinson, and H.E. Varmus et al. Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (Src) Proc Natl Acad Sci USA 76 1979 1804 1808
-
(1979)
Proc Natl Acad Sci USA
, vol.76
, pp. 1804-1808
-
-
Oppermann, H.1
Levinson, A.D.2
Varmus, H.E.3
-
4
-
-
67449111138
-
Expression patterns of Src-family tyrosine kinases during Xenopus laevis development
-
Z. Ferjentsik, R. Sindelka, and J. Jonak Expression patterns of Src-family tyrosine kinases during Xenopus laevis development Int J Dev Biol 53 2009 163 168
-
(2009)
Int J Dev Biol
, vol.53
, pp. 163-168
-
-
Ferjentsik, Z.1
Sindelka, R.2
Jonak, J.3
-
7
-
-
0027469402
-
Increase in activity and level of pp60c-Src in progressive stages of human colorectal cancer
-
M.S. Talamonti, M.S. Roh, and S.A. Curley et al. Increase in activity and level of pp60c-Src in progressive stages of human colorectal cancer J Clin Invest 91 1993 53 60
-
(1993)
J Clin Invest
, vol.91
, pp. 53-60
-
-
Talamonti, M.S.1
Roh, M.S.2
Curley, S.A.3
-
8
-
-
0034693877
-
Role of Src expression and activation in human cancer
-
R.B. Irby, and T.J. Yeatman Role of Src expression and activation in human cancer Oncogene 19 2000 5636 5642
-
(2000)
Oncogene
, vol.19
, pp. 5636-5642
-
-
Irby, R.B.1
Yeatman, T.J.2
-
9
-
-
0032932248
-
Activating Src mutation in a subset of advanced human colon cancers
-
R.B. Irby, W. Mao, and D. Coppola et al. Activating Src mutation in a subset of advanced human colon cancers Nat Genet 21 1999 187 190
-
(1999)
Nat Genet
, vol.21
, pp. 187-190
-
-
Irby, R.B.1
Mao, W.2
Coppola, D.3
-
10
-
-
0033199696
-
Absence of genetic alteration at codon 531 of the human c-Src gene in 479 advanced colorectal cancers from Japanese and Caucasian patients
-
Y. Daigo, Y. Furukawa, and T. Kawasoe et al. Absence of genetic alteration at codon 531 of the human c-Src gene in 479 advanced colorectal cancers from Japanese and Caucasian patients Cancer Res 59 1999 4222 4224
-
(1999)
Cancer Res
, vol.59
, pp. 4222-4224
-
-
Daigo, Y.1
Furukawa, Y.2
Kawasoe, T.3
-
11
-
-
0025739596
-
C-Src structure in human cancers with elevated pp60c-Src activity
-
P. Wang, F. Fromowitz, and M. Koslow et al. C-Src structure in human cancers with elevated pp60c-Src activity Br J Cancer 64 1991 531 533
-
(1991)
Br J Cancer
, vol.64
, pp. 531-533
-
-
Wang, P.1
Fromowitz, F.2
Koslow, M.3
-
12
-
-
0035147393
-
Lack of mutation at codon 531 of Src in advanced colorectal cancers from Italian patients
-
L. Laghi, P. Bianchi, and O. Orbetegli et al. Lack of mutation at codon 531 of Src in advanced colorectal cancers from Italian patients Br J Cancer 84 2001 196 198
-
(2001)
Br J Cancer
, vol.84
, pp. 196-198
-
-
Laghi, L.1
Bianchi, P.2
Orbetegli, O.3
-
13
-
-
4544235743
-
C-Src and cooperating partners in human cancer
-
R. Ishizawar, and S.J. Parsons C-Src and cooperating partners in human cancer Cancer Cell 6 2004 209 214
-
(2004)
Cancer Cell
, vol.6
, pp. 209-214
-
-
Ishizawar, R.1
Parsons, S.J.2
-
14
-
-
77953704990
-
Building a better understanding of the intracellular tyrosine kinase ptk6-brk by brk
-
P.M. Brauer, and A.L. Tyner Building a better understanding of the intracellular tyrosine kinase ptk6-brk by brk Biochim Biophys Acta 1806 2010 66 73
-
(2010)
Biochim Biophys Acta
, vol.1806
, pp. 66-73
-
-
Brauer, P.M.1
Tyner, A.L.2
-
15
-
-
33745437746
-
Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine
-
A. Haegebarth, W. Bie, and R. Yang et al. Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine Mol Cell Biol 26 2006 4949 4957
-
(2006)
Mol Cell Biol
, vol.26
, pp. 4949-4957
-
-
Haegebarth, A.1
Bie, W.2
Yang, R.3
-
16
-
-
0025192786
-
Activation of the pp60c-Src protein kinase is an early event in colonic carcinogenesis
-
C.A. Cartwright, A.I. Meisler, and W. Eckhart Activation of the pp60c-Src protein kinase is an early event in colonic carcinogenesis Proc Natl Acad Sci USA 87 1990 558 562
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 558-562
-
-
Cartwright, C.A.1
Meisler, A.I.2
Eckhart, W.3
-
17
-
-
0037080135
-
Activation of Src kinase in primary colorectal carcinoma: An indicator of poor clinical prognosis
-
H. Aligayer, D.D. Boyd, and M.M. Heiss et al. Activation of Src kinase in primary colorectal carcinoma: an indicator of poor clinical prognosis Cancer 94 2002 344 351
-
(2002)
Cancer
, vol.94
, pp. 344-351
-
-
Aligayer, H.1
Boyd, D.D.2
Heiss, M.M.3
-
18
-
-
32144460477
-
C-terminal Src kinase (csk) and csk-homologous kinase (chk) - Endogenous negative regulators of Src-family protein kinases
-
Y.P. Chong, T.D. Mulhern, and H.C. Cheng C-terminal Src kinase (csk) and csk-homologous kinase (chk) - endogenous negative regulators of Src-family protein kinases Growth Factors 23 2005 233 244
-
(2005)
Growth Factors
, vol.23
, pp. 233-244
-
-
Chong, Y.P.1
Mulhern, T.D.2
Cheng, H.C.3
-
19
-
-
33750214579
-
C-terminal Src kinase-homologous kinase (chk), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases
-
Y.P. Chong, A.S. Chan, and K.C. Chan et al. C-terminal Src kinase-homologous kinase (chk), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases J Biol Chem 281 2006 32988 32999
-
(2006)
J Biol Chem
, vol.281
, pp. 32988-32999
-
-
Chong, Y.P.1
Chan, A.S.2
Chan, K.C.3
-
20
-
-
29144452123
-
Endogenous and synthetic inhibitors of the Src-family protein tyrosine kinases
-
Y.P. Chong, K.K. Ia, and T.D. Mulhern et al. Endogenous and synthetic inhibitors of the Src-family protein tyrosine kinases Biochim Biophys Acta 1754 2005 210 220
-
(2005)
Biochim Biophys Acta
, vol.1754
, pp. 210-220
-
-
Chong, Y.P.1
Ia, K.K.2
Mulhern, T.D.3
-
21
-
-
33748423528
-
Csk-binding protein (cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation
-
L.Q. Jiang, X. Feng, and W. Zhou et al. Csk-binding protein (cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation Oncogene 25 2006 5495 5506
-
(2006)
Oncogene
, vol.25
, pp. 5495-5506
-
-
Jiang, L.Q.1
Feng, X.2
Zhou, W.3
-
22
-
-
0031962265
-
Sh2- and sh3-mediated interactions between focal adhesion kinase and Src
-
J.W. Thomas, B. Ellis, and R.J. Boerner et al. Sh2- and sh3-mediated interactions between focal adhesion kinase and Src J Biol Chem 273 1998 577 583
-
(1998)
J Biol Chem
, vol.273
, pp. 577-583
-
-
Thomas, J.W.1
Ellis, B.2
Boerner, R.J.3
-
23
-
-
0347991870
-
Pressure activates colon cancer cell adhesion by inside-out focal adhesion complex and actin cytoskeletal signaling
-
V. Thamilselvan, and M.D. Basson Pressure activates colon cancer cell adhesion by inside-out focal adhesion complex and actin cytoskeletal signaling Gastroenterology 126 2004 8 18
-
(2004)
Gastroenterology
, vol.126
, pp. 8-18
-
-
Thamilselvan, V.1
Basson, M.D.2
-
24
-
-
60449104053
-
Src activity alters alpha3 integrin expression in colon tumor cells
-
C.L. Kline, T.L. Olson, and R.B. Irby Src activity alters alpha3 integrin expression in colon tumor cells Clin Exp Metastasis 26 2009 77 87
-
(2009)
Clin Exp Metastasis
, vol.26
, pp. 77-87
-
-
Kline, C.L.1
Olson, T.L.2
Irby, R.B.3
-
25
-
-
70350574674
-
An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression
-
J.S. Desgrosellier, L.A. Barnes, and D.J. Shields et al. An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression Nat Med 15 2009 1163 1169
-
(2009)
Nat Med
, vol.15
, pp. 1163-1169
-
-
Desgrosellier, J.S.1
Barnes, L.A.2
Shields, D.J.3
-
26
-
-
72949119124
-
Integrins in cancer: Biological implications and therapeutic opportunities
-
J.S. Desgrosellier, and D.A. Cheresh Integrins in cancer: biological implications and therapeutic opportunities Nat Rev Cancer 10 2010 9 22
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 9-22
-
-
Desgrosellier, J.S.1
Cheresh, D.A.2
-
27
-
-
71349087632
-
Regulation of miRNA expression by Src and contact normalization: Effects on nonanchored cell growth and migration
-
X. Li, Y. Shen, and H. Ichikawa et al. Regulation of miRNA expression by Src and contact normalization: Effects on nonanchored cell growth and migration Oncogene 28 2009 4272 4283
-
(2009)
Oncogene
, vol.28
, pp. 4272-4283
-
-
Li, X.1
Shen, Y.2
Ichikawa, H.3
-
28
-
-
54449099588
-
The cell growth suppressor, mir-126, targets irs-1
-
J. Zhang, Y.Y. Du, and Y.F. Lin et al. The cell growth suppressor, mir-126, targets irs-1 Biochem Biophys Res Commun 377 2008 136 140
-
(2008)
Biochem Biophys Res Commun
, vol.377
, pp. 136-140
-
-
Zhang, J.1
Du, Y.Y.2
Lin, Y.F.3
-
29
-
-
52249096359
-
The noncoding RNA, mir-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers
-
C. Guo, J.F. Sah, and L. Beard et al. The noncoding RNA, mir-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers Genes Chromosomes Cancer 47 2008 939 946
-
(2008)
Genes Chromosomes Cancer
, vol.47
, pp. 939-946
-
-
Guo, C.1
Sah, J.F.2
Beard, L.3
-
30
-
-
0345138451
-
Functional implication of the interaction between EGF receptor and c-Src
-
T.H. Leu, and M.C. Maa Functional implication of the interaction between EGF receptor and c-Src Front Biosci 8 2003 s28 s38
-
(2003)
Front Biosci
, vol.8
-
-
Leu, T.H.1
Maa, M.C.2
-
31
-
-
0037429737
-
Epidermal growth factor receptor: Mechanisms of activation and signalling
-
R.N. Jorissen, F. Walker, and N. Pouliot et al. Epidermal growth factor receptor: mechanisms of activation and signalling Exp Cell Res 284 2003 31 53
-
(2003)
Exp Cell Res
, vol.284
, pp. 31-53
-
-
Jorissen, R.N.1
Walker, F.2
Pouliot, N.3
-
32
-
-
3543025709
-
Phosphorylation of y845 on the epidermal growth factor receptor mediates binding to the mitochondrial protein cytochrome c oxidase subunit ii
-
J.L. Boerner, M.L. Demory, and C. Silva et al. Phosphorylation of y845 on the epidermal growth factor receptor mediates binding to the mitochondrial protein cytochrome c oxidase subunit ii Mol Cell Biol 24 2004 7059 7071
-
(2004)
Mol Cell Biol
, vol.24
, pp. 7059-7071
-
-
Boerner, J.L.1
Demory, M.L.2
Silva, C.3
-
33
-
-
0028910667
-
Src activity increases and yes activity decreases during mitosis of human colon carcinoma cells
-
J. Park, and C.A. Cartwright Src activity increases and yes activity decreases during mitosis of human colon carcinoma cells Mol Cell Biol 15 1995 2374 2382
-
(1995)
Mol Cell Biol
, vol.15
, pp. 2374-2382
-
-
Park, J.1
Cartwright, C.A.2
-
34
-
-
79952081456
-
Specific oncogenic activity of the Src-family tyrosine kinase c-yes in colon carcinoma cells
-
F. Sancier, A. Dumont, and A. Sirvent et al. Specific oncogenic activity of the Src-family tyrosine kinase c-yes in colon carcinoma cells PLoS One 6 2011 e17237
-
(2011)
PLoS One
, vol.6
, pp. 17237
-
-
Sancier, F.1
Dumont, A.2
Sirvent, A.3
-
35
-
-
65549101582
-
Sonic hedgehog guides axons through a noncanonical, Src-family-kinase- dependent signaling pathway
-
P.T. Yam, S.D. Langlois, and S. Morin et al. Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway Neuron 62 2009 349 362
-
(2009)
Neuron
, vol.62
, pp. 349-362
-
-
Yam, P.T.1
Langlois, S.D.2
Morin, S.3
-
36
-
-
42549107360
-
The diverse functions of Src family kinases in macrophages
-
C.L. Abram, and C.A. Lowell The diverse functions of Src family kinases in macrophages Front Biosci 13 2008 4426 4450
-
(2008)
Front Biosci
, vol.13
, pp. 4426-4450
-
-
Abram, C.L.1
Lowell, C.A.2
-
37
-
-
0036632368
-
The phosphatidylinositol 3-kinase Akt pathway in human cancer
-
I. Vivanco, and C.L. Sawyers The phosphatidylinositol 3-kinase Akt pathway in human cancer Nat Rev Cancer 2 2002 489 501
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
38
-
-
0035920129
-
Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase
-
B.D. Cuevas, Y. Lu, and M. Mao et al. Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase J Biol Chem 276 2001 27455 27461
-
(2001)
J Biol Chem
, vol.276
, pp. 27455-27461
-
-
Cuevas, B.D.1
Lu, Y.2
Mao, M.3
-
39
-
-
0141994730
-
Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/Akt cascades
-
Y. Lu, Q. Yu, and J.H. Liu et al. Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/Akt cascades J Biol Chem 278 2003 40057 40066
-
(2003)
J Biol Chem
, vol.278
, pp. 40057-40066
-
-
Lu, Y.1
Yu, Q.2
Liu, J.H.3
-
40
-
-
0032486198
-
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
-
M. Tamura, J. Gu, and K. Matsumoto et al. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN Science 280 1998 1614 1617
-
(1998)
Science
, vol.280
, pp. 1614-1617
-
-
Tamura, M.1
Gu, J.2
Matsumoto, K.3
-
41
-
-
68249093818
-
Targeting the phosphoinositide 3-kinase pathway in cancer
-
P. Liu, H. Cheng, and T.M. Roberts et al. Targeting the phosphoinositide 3-kinase pathway in cancer Nat Rev Drug Discov 8 2009 627 644
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 627-644
-
-
Liu, P.1
Cheng, H.2
Roberts, T.M.3
-
42
-
-
0032978365
-
Transformation by v-Src: Ras-MAPK and PI3K-mTOR mediate parallel pathways
-
E. Penuel, and G.S. Martin Transformation by v-Src: Ras-MAPK and PI3K-mTOR mediate parallel pathways Mol Biol Cell 10 1999 1693 1703
-
(1999)
Mol Biol Cell
, vol.10
, pp. 1693-1703
-
-
Penuel, E.1
Martin, G.S.2
-
43
-
-
84860524342
-
Src-mediated aryl hydrocarbon and epidermal growth factor receptor cross talk stimulates colon cancer cell proliferation
-
G. Xie, Z. Peng, and J.P. Raufman Src-mediated aryl hydrocarbon and epidermal growth factor receptor cross talk stimulates colon cancer cell proliferation Am J Physiol Gastrointest Liver Physiol 302 2012 G1006 G1015
-
(2012)
Am J Physiol Gastrointest Liver Physiol
, vol.302
-
-
Xie, G.1
Peng, Z.2
Raufman, J.P.3
-
44
-
-
0022472990
-
Requirement for c-Ras proteins during viral oncogene transformation
-
M.R. Smith, S.J. DeGudicibus, and D.W. Stacey Requirement for c-Ras proteins during viral oncogene transformation Nature 320 1986 540 543
-
(1986)
Nature
, vol.320
, pp. 540-543
-
-
Smith, M.R.1
Degudicibus, S.J.2
Stacey, D.W.3
-
45
-
-
84865200796
-
Src tyrosine kinase inhibits apoptosis through the erk1/2- dependent degradation of the death accelerator Bik
-
J. Lopez, C. Hesling, and J. Prudent et al. Src tyrosine kinase inhibits apoptosis through the erk1/2- dependent degradation of the death accelerator Bik Cell Death Differ 19 2012 1459 1469
-
(2012)
Cell Death Differ
, vol.19
, pp. 1459-1469
-
-
Lopez, J.1
Hesling, C.2
Prudent, J.3
-
46
-
-
0028074316
-
Phosphatidylinositol-3-oh kinase as a direct target of Ras
-
P. Rodriguez-Viciana, P.H. Warne, and R. Dhand et al. Phosphatidylinositol-3-oh kinase as a direct target of Ras Nature 370 1994 527 532
-
(1994)
Nature
, vol.370
, pp. 527-532
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Dhand, R.3
-
47
-
-
0030911052
-
Role of phosphoinositide 3-oh kinase in cell transformation and control of the actin cytoskeleton by Ras
-
P. Rodriguez-Viciana, P.H. Warne, and A. Khwaja et al. Role of phosphoinositide 3-oh kinase in cell transformation and control of the actin cytoskeleton by Ras Cell 89 1997 457 467
-
(1997)
Cell
, vol.89
, pp. 457-467
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Khwaja, A.3
-
48
-
-
0035952638
-
G protein coupled receptor signaling through the Src and stat3 pathway: Role in proliferation and transformation
-
P.T. Ram, and R. Iyengar G protein coupled receptor signaling through the Src and stat3 pathway: Role in proliferation and transformation Oncogene 20 2001 1601 1606
-
(2001)
Oncogene
, vol.20
, pp. 1601-1606
-
-
Ram, P.T.1
Iyengar, R.2
-
49
-
-
0029069540
-
Enhanced DNA-binding activity of a stat3-related protein in cells transformed by the Src oncoprotein
-
C.L. Yu, D.J. Meyer, and G.S. Campbell et al. Enhanced DNA-binding activity of a stat3-related protein in cells transformed by the Src oncoprotein Science 269 1995 81 83
-
(1995)
Science
, vol.269
, pp. 81-83
-
-
Yu, C.L.1
Meyer, D.J.2
Campbell, G.S.3
-
50
-
-
7944233465
-
Role of stats as downstream signal transducers in Src family kinase-mediated tumorigenesis
-
C.M. Silva Role of stats as downstream signal transducers in Src family kinase-mediated tumorigenesis Oncogene 23 2004 8017 8023
-
(2004)
Oncogene
, vol.23
, pp. 8017-8023
-
-
Silva, C.M.1
-
51
-
-
24644457736
-
Targeting stat3 blocks both hif-1 and VEGF expression induced by multiple oncogenic growth signaling pathways
-
Q. Xu, J. Briggs, and S. Park et al. Targeting stat3 blocks both hif-1 and VEGF expression induced by multiple oncogenic growth signaling pathways Oncogene 24 2005 5552 5560
-
(2005)
Oncogene
, vol.24
, pp. 5552-5560
-
-
Xu, Q.1
Briggs, J.2
Park, S.3
-
52
-
-
85047695527
-
Constitutive stat3 activity up-regulates VEGF expression and tumor angiogenesis
-
G. Niu, K.L. Wright, and M. Huang et al. Constitutive stat3 activity up-regulates VEGF expression and tumor angiogenesis Oncogene 21 2002 2000 2008
-
(2002)
Oncogene
, vol.21
, pp. 2000-2008
-
-
Niu, G.1
Wright, K.L.2
Huang, M.3
-
53
-
-
30344460024
-
Ap23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes
-
J.M. Summy, J.G. Trevino, and D.P. Lesslie et al. Ap23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes Mol Cancer Ther 4 2005 1900 1911
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 1900-1911
-
-
Summy, J.M.1
Trevino, J.G.2
Lesslie, D.P.3
-
54
-
-
0031985127
-
Down-regulation of vascular endothelial growth factor in a human colon carcinoma cell line transfected with an antisense expression vector specific for c-Src
-
L.M. Ellis, C.A. Staley, and W. Liu et al. Down-regulation of vascular endothelial growth factor in a human colon carcinoma cell line transfected with an antisense expression vector specific for c-Src J Biol Chem 273 1998 1052 1057
-
(1998)
J Biol Chem
, vol.273
, pp. 1052-1057
-
-
Ellis, L.M.1
Staley, C.A.2
Liu, W.3
-
55
-
-
0024801035
-
Vascular permeability factor, an endothelial cell mitogen related to PDGF
-
P.J. Keck, S.D. Hauser, and G. Krivi et al. Vascular permeability factor, an endothelial cell mitogen related to PDGF Science 246 1989 1309 1312
-
(1989)
Science
, vol.246
, pp. 1309-1312
-
-
Keck, P.J.1
Hauser, S.D.2
Krivi, G.3
-
56
-
-
0024818355
-
Vascular endothelial growth factor is a secreted angiogenic mitogen
-
D.W. Leung, G. Cachianes, and W.J. Kuang et al. Vascular endothelial growth factor is a secreted angiogenic mitogen Science 246 1989 1306 1309
-
(1989)
Science
, vol.246
, pp. 1306-1309
-
-
Leung, D.W.1
Cachianes, G.2
Kuang, W.J.3
-
57
-
-
47949089077
-
VEGF-targeted therapy: Mechanisms of anti-tumour activity
-
L.M. Ellis, and D.J. Hicklin VEGF-targeted therapy: mechanisms of anti-tumour activity Nat Rev Cancer 8 2008 579 591
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 579-591
-
-
Ellis, L.M.1
Hicklin, D.J.2
-
58
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
H. Hurwitz, L. Fehrenbacher, and W. Novotny et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer N Engl J Med 350 2004 2335 2342
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
59
-
-
20944441857
-
Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells
-
F. Fan, J.S. Wey, and M.F. McCarty et al. Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells Oncogene 24 2005 2647 2653
-
(2005)
Oncogene
, vol.24
, pp. 2647-2653
-
-
Fan, F.1
Wey, J.S.2
McCarty, M.F.3
-
60
-
-
77953719787
-
Monoclonal antibodies for targeted therapy in colorectal cancer
-
S. Banerjee, and H. Flores-Rozas Monoclonal antibodies for targeted therapy in colorectal cancer Cancer Biol Ther 9 2010 563 571
-
(2010)
Cancer Biol Ther
, vol.9
, pp. 563-571
-
-
Banerjee, S.1
Flores-Rozas, H.2
-
61
-
-
0034849755
-
Interleukin-8 and human cancer biology
-
K. Xie Interleukin-8 and human cancer biology Cytokine Growth Factor Rev 12 2001 375 391
-
(2001)
Cytokine Growth Factor Rev
, vol.12
, pp. 375-391
-
-
Xie, K.1
-
62
-
-
58149232586
-
The interleukin-8 pathway in cancer
-
D.J. Waugh, and C. Wilson The interleukin-8 pathway in cancer Clin Cancer Res 14 21 2008 6735 6741
-
(2008)
Clin Cancer Res
, vol.14
, Issue.21
, pp. 6735-6741
-
-
Waugh, D.J.1
Wilson, C.2
-
63
-
-
79952471898
-
Interleukin-8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models
-
Y. Ning, P.C. Manegold, and Y.K. Hong et al. Interleukin-8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models Int J Cancer 128 2010 2038 2049
-
(2010)
Int J Cancer
, vol.128
, pp. 2038-2049
-
-
Ning, Y.1
Manegold, P.C.2
Hong, Y.K.3
-
64
-
-
44949181869
-
Is Src the key to understanding metastasis and developing new treatments for colon cancer?
-
J. Chen Is Src the key to understanding metastasis and developing new treatments for colon cancer? Nat Clin Pract Gastroenterol Hepatol 5 2008 306 307
-
(2008)
Nat Clin Pract Gastroenterol Hepatol
, vol.5
, pp. 306-307
-
-
Chen, J.1
-
65
-
-
34548129607
-
An active Src kinase-beta-actin association is linked to actin dynamics at the periphery of colon cancer cells
-
E. Avizienyte, M. Keppler, and E. Sandilands et al. An active Src kinase-beta-actin association is linked to actin dynamics at the periphery of colon cancer cells Exp Cell Res 313 2007 3175 3188
-
(2007)
Exp Cell Res
, vol.313
, pp. 3175-3188
-
-
Avizienyte, E.1
Keppler, M.2
Sandilands, E.3
-
66
-
-
38449123004
-
Activation of the Fak-src molecular scaffolds and p130Cas-JNK signaling cascades by alpha1-integrins during colon cancer cell invasion
-
S. Van Slambrouck, C. Grijelmo, and O. De Wever et al. Activation of the Fak-src molecular scaffolds and p130Cas-JNK signaling cascades by alpha1-integrins during colon cancer cell invasion Int J Oncol 3 2007 1501 1508
-
(2007)
Int J Oncol
, vol.3
, pp. 1501-1508
-
-
Van Slambrouck, S.1
Grijelmo, C.2
De Wever, O.3
-
67
-
-
63349085980
-
An essential role for p120-catenin in Src- and rac1-mediated anchorage-independent cell growth
-
M.R. Dohn, M.V. Brown, and A.B. Reynolds An essential role for p120-catenin in Src- and rac1-mediated anchorage-independent cell growth J Cell Biol 184 2009 437 450
-
(2009)
J Cell Biol
, vol.184
, pp. 437-450
-
-
Dohn, M.R.1
Brown, M.V.2
Reynolds, A.B.3
-
68
-
-
0034659526
-
Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism
-
W.T. Arthur, L.A. Petch, and K. Burridge Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism Curr Biol 10 2000 719 722
-
(2000)
Curr Biol
, vol.10
, pp. 719-722
-
-
Arthur, W.T.1
Petch, L.A.2
Burridge, K.3
-
69
-
-
24144458264
-
A Rac switch regulates random versus directionally persistent cell migration
-
R. Pankov, Y. Endo, and S. Even-Ram et al. A Rac switch regulates random versus directionally persistent cell migration J Cell Biol 170 2005 793 802
-
(2005)
J Cell Biol
, vol.170
, pp. 793-802
-
-
Pankov, R.1
Endo, Y.2
Even-Ram, S.3
-
70
-
-
33748086453
-
Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification
-
B.L. Rothschild, A.H. Shim, and A.G. Ammer et al. Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification Cancer Res 66 2006 8017 8025
-
(2006)
Cancer Res
, vol.66
, pp. 8017-8025
-
-
Rothschild, B.L.1
Shim, A.H.2
Ammer, A.G.3
-
71
-
-
78649864017
-
C-Src differentially regulates the functions of microtentacles and invadopodia
-
E.M. Balzer, R.A. Whipple, and K. Thompson et al. C-Src differentially regulates the functions of microtentacles and invadopodia Oncogene 29 2010 6402 6408
-
(2010)
Oncogene
, vol.29
, pp. 6402-6408
-
-
Balzer, E.M.1
Whipple, R.A.2
Thompson, K.3
-
72
-
-
77957374075
-
Microtubule-binding agents: A dynamic field of cancer therapeutics
-
C. Dumontet, and M.A. Jordan Microtubule-binding agents: A dynamic field of cancer therapeutics Nat Rev Drug Discov 9 2010 790 803
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 790-803
-
-
Dumontet, C.1
Jordan, M.A.2
-
73
-
-
84857127779
-
Src tyrosine kinase phosphorylation of nuclear receptor hnf4alpha correlates with isoform-specific loss of hnf4alpha in human colon cancer
-
K. Chellappa, L. Jankova, and J.M. Schnabl et al. Src tyrosine kinase phosphorylation of nuclear receptor hnf4alpha correlates with isoform-specific loss of hnf4alpha in human colon cancer Proc Natl Acad Sci USA 109 2012 2302 2307
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 2302-2307
-
-
Chellappa, K.1
Jankova, L.2
Schnabl, J.M.3
-
74
-
-
79955567067
-
Src kinase pathway is involved in nfat5-mediated s100a4 induction by hyperosmotic stress in colon cancer cells
-
M. Chen, S.K. Sastry, and K.L. O'Connor Src kinase pathway is involved in nfat5-mediated s100a4 induction by hyperosmotic stress in colon cancer cells Am J Physiol Cell Physiol 300 2011 C1155 C1163
-
(2011)
Am J Physiol Cell Physiol
, vol.300
-
-
Chen, M.1
Sastry, S.K.2
O'Connor, K.L.3
-
75
-
-
26844529710
-
Metastases and their microenvironments: Linking pathogenesis and therapy
-
A. Sierra Metastases and their microenvironments: linking pathogenesis and therapy Drug Resist Updat 8 2005 247 257
-
(2005)
Drug Resist Updat
, vol.8
, pp. 247-257
-
-
Sierra, A.1
-
78
-
-
0031909568
-
Elevated c-Src protein expression is an early event in colonic neoplasia
-
S. Iravani, W. Mao, and L. Fu et al. Elevated c-Src protein expression is an early event in colonic neoplasia Lab Invest 78 1998 365 371
-
(1998)
Lab Invest
, vol.78
, pp. 365-371
-
-
Iravani, S.1
Mao, W.2
Fu, L.3
-
79
-
-
0031952488
-
An epitope localized in c-Src negative regulatory domain is a potential marker in early stage of colonic neoplasms
-
T. Sakai, H. Kawakatsu, and M. Fujita et al. An epitope localized in c-Src negative regulatory domain is a potential marker in early stage of colonic neoplasms Lab Invest 78 1998 219 225
-
(1998)
Lab Invest
, vol.78
, pp. 219-225
-
-
Sakai, T.1
Kawakatsu, H.2
Fujita, M.3
-
80
-
-
0026612625
-
c-src activity in well and poorly differentiated human colon carcinomas and cell lines
-
c-src activity in well and poorly differentiated human colon carcinomas and cell lines J Clin Invest 90 1992 815 821
-
(1992)
J Clin Invest
, vol.90
, pp. 815-821
-
-
Weber, T.K.1
Steele, G.2
Summerhayes, I.C.3
-
81
-
-
0028214877
-
Elevated c-Src tyrosine kinase activity in premalignant epithelia of ulcerative colitis
-
C.A. Cartwright, C.A. Coad, and B.M. Egbert Elevated c-Src tyrosine kinase activity in premalignant epithelia of ulcerative colitis J Clin Invest 93 1994 509 515
-
(1994)
J Clin Invest
, vol.93
, pp. 509-515
-
-
Cartwright, C.A.1
Coad, C.A.2
Egbert, B.M.3
-
82
-
-
0026509549
-
Oncogene-mediated transformation of fetal rat colon in vitro
-
S. Pories, K. Jaros, and G. Steele Jr. et al. Oncogene-mediated transformation of fetal rat colon in vitro Oncogene 7 1992 885 893
-
(1992)
Oncogene
, vol.7
, pp. 885-893
-
-
Pories, S.1
Jaros, K.2
Steele Jr., G.3
-
83
-
-
0037297508
-
Epidermal growth factor stimulation can substitute for c-Src overexpression in promoting breast carcinoma invasion
-
M. Lotz, H.H. Wang, and W. Cance et al. Epidermal growth factor stimulation can substitute for c-Src overexpression in promoting breast carcinoma invasion J Surg Res 109 2003 123 129
-
(2003)
J Surg Res
, vol.109
, pp. 123-129
-
-
Lotz, M.1
Wang, H.H.2
Cance, W.3
-
84
-
-
0033810059
-
Overexpression of the csk gene suppresses tumor metastasis in vivo
-
T. Nakagawa, S. Tanaka, and H. Suzuki et al. Overexpression of the csk gene suppresses tumor metastasis in vivo Int J Cancer 88 2000 384 391
-
(2000)
Int J Cancer
, vol.88
, pp. 384-391
-
-
Nakagawa, T.1
Tanaka, S.2
Suzuki, H.3
-
85
-
-
24044548332
-
Adhesion signaling by a novel mitotic substrate of Src kinases
-
A.S. Bhatt, H. Erdjument-Bromage, and P. Tempst et al. Adhesion signaling by a novel mitotic substrate of Src kinases Oncogene 24 2005 5333 5343
-
(2005)
Oncogene
, vol.24
, pp. 5333-5343
-
-
Bhatt, A.S.1
Erdjument-Bromage, H.2
Tempst, P.3
-
86
-
-
65249184413
-
Phosphorylation of the Src epithelial substrate trask is tightly regulated in normal epithelia but widespread in many human epithelial cancers
-
C.H. Wong, F.L. Baehner, and D.S. Spassov et al. Phosphorylation of the Src epithelial substrate trask is tightly regulated in normal epithelia but widespread in many human epithelial cancers Clin Cancer Res 15 2009 2311 2322
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2311-2322
-
-
Wong, C.H.1
Baehner, F.L.2
Spassov, D.S.3
-
87
-
-
77950931419
-
Matrix metalloproteinases: Regulators of the tumor microenvironment
-
K. Kessenbrock, V. Plaks, and Z. Werb Matrix metalloproteinases: Regulators of the tumor microenvironment Cell 141 2010 52 67
-
(2010)
Cell
, vol.141
, pp. 52-67
-
-
Kessenbrock, K.1
Plaks, V.2
Werb, Z.3
-
88
-
-
0037038686
-
Src activation regulates anoikis in human colon tumor cell lines
-
T.C. Windham, N.U. Parikh, and D.R. Siwak et al. Src activation regulates anoikis in human colon tumor cell lines Oncogene 21 2002 7797 7807
-
(2002)
Oncogene
, vol.21
, pp. 7797-7807
-
-
Windham, T.C.1
Parikh, N.U.2
Siwak, D.R.3
-
89
-
-
84870355576
-
Claudin-1 expression confers resistance to anoikis in colon cancer cells in a Src-dependent manner
-
A.B. Singh, A. Sharma, and P. Dhawan Claudin-1 expression confers resistance to anoikis in colon cancer cells in a Src-dependent manner Carcinogenesis 33 2012 2538 2547
-
(2012)
Carcinogenesis
, vol.33
, pp. 2538-2547
-
-
Singh, A.B.1
Sharma, A.2
Dhawan, P.3
-
90
-
-
77954240253
-
Dynamics and mechanism of p130cas localization to focal adhesions
-
D.M. Donato, L.M. Ryzhova, and L.M. Meenderink et al. Dynamics and mechanism of p130cas localization to focal adhesions J Biol Chem 285 2010 20769 20779
-
(2010)
J Biol Chem
, vol.285
, pp. 20769-20779
-
-
Donato, D.M.1
Ryzhova, L.M.2
Meenderink, L.M.3
-
91
-
-
77951233123
-
Src induces podoplanin expression to promote cell migration
-
Y. Shen, C.S. Chen, and H. Ichikawa et al. Src induces podoplanin expression to promote cell migration J Biol Chem 285 2010 9649 9656
-
(2010)
J Biol Chem
, vol.285
, pp. 9649-9656
-
-
Shen, Y.1
Chen, C.S.2
Ichikawa, H.3
-
92
-
-
78449266131
-
Prognostic impact of ERbeta and mmp7 expression on overall survival in colon cancer
-
Y.J. Fang, Z.H. Lu, and F. Wang et al. Prognostic impact of ERbeta and mmp7 expression on overall survival in colon cancer Tumour Biol 31 2010 651 658
-
(2010)
Tumour Biol
, vol.31
, pp. 651-658
-
-
Fang, Y.J.1
Lu, Z.H.2
Wang, F.3
-
93
-
-
77953313163
-
Phosphorylation of the cool-1/beta-pix protein serves as a regulatory signal for the migration and invasive activity of Src-transformed cells
-
Q. Feng, D. Baird, and S. Yoo et al. Phosphorylation of the cool-1/beta-pix protein serves as a regulatory signal for the migration and invasive activity of Src-transformed cells J Biol Chem 285 2010 18806 18816
-
(2010)
J Biol Chem
, vol.285
, pp. 18806-18816
-
-
Feng, Q.1
Baird, D.2
Yoo, S.3
-
94
-
-
78650109514
-
C-Src-mediated phosphorylation of noxa1 and tks4 induces the reactive oxygen species (Ros)-dependent formation of functional invadopodia in human colon cancer cells
-
D. Gianni, N. Taulet, and C. DerMardirossian et al. C-Src-mediated phosphorylation of noxa1 and tks4 induces the reactive oxygen species (Ros)-dependent formation of functional invadopodia in human colon cancer cells Mol Biol Cell 21 2010 4287 4298
-
(2010)
Mol Biol Cell
, vol.21
, pp. 4287-4298
-
-
Gianni, D.1
Taulet, N.2
Dermardirossian, C.3
-
95
-
-
80455160168
-
Lysophosphatidic acid induces a migratory phenotype through a crosstalk between RhoA-Rock and Src-FAK signalling in colon cancer cells
-
F. Leve, T.G. Marcondes, and L.G. Bastos et al. Lysophosphatidic acid induces a migratory phenotype through a crosstalk between RhoA-Rock and Src-FAK signalling in colon cancer cells Eur J Pharmacol 671 2011 7 17
-
(2011)
Eur J Pharmacol
, vol.671
, pp. 7-17
-
-
Leve, F.1
Marcondes, T.G.2
Bastos, L.G.3
-
96
-
-
68949186349
-
Integrin alpha9beta1 mediates enhanced cell migration through nitric oxide synthase activity regulated by Src tyrosine kinase
-
S.K. Gupta, and N.E. Vlahakis Integrin alpha9beta1 mediates enhanced cell migration through nitric oxide synthase activity regulated by Src tyrosine kinase J Cell Sci 122 2009 2043 2054
-
(2009)
J Cell Sci
, vol.122
, pp. 2043-2054
-
-
Gupta, S.K.1
Vlahakis, N.E.2
-
97
-
-
77953961680
-
Overexpression of integrin {beta}5 enhances the paracrine properties of circulating angiogenic cells via Src kinase-mediated activation of STAT3
-
M. Leifheit-Nestler, G. Conrad, and N.M. Heida et al. Overexpression of integrin {beta}5 enhances the paracrine properties of circulating angiogenic cells via Src kinase-mediated activation of STAT3 Arterioscler Thromb Vasc Biol 2010
-
(2010)
Arterioscler Thromb Vasc Biol
-
-
Leifheit-Nestler, M.1
Conrad, G.2
Heida, N.M.3
-
98
-
-
58149122747
-
Activated STAT3 is a mediator and biomarker of VEGF endothelial activation
-
S.H. Chen, D.A. Murphy, and W. Lassoued et al. Activated STAT3 is a mediator and biomarker of VEGF endothelial activation Cancer Biol Ther 7 2008 1994 2003
-
(2008)
Cancer Biol Ther
, vol.7
, pp. 1994-2003
-
-
Chen, S.H.1
Murphy, D.A.2
Lassoued, W.3
-
99
-
-
33846827051
-
Pyrazolo-pyrimidine-derived c-Src inhibitor reduces angiogenesis and survival of squamous carcinoma cells by suppressing vascular endothelial growth factor production and signaling
-
S. Donnini, M. Monti, and C. Castagnini et al. Pyrazolo-pyrimidine- derived c-Src inhibitor reduces angiogenesis and survival of squamous carcinoma cells by suppressing vascular endothelial growth factor production and signaling Int J Cancer 120 2007 995 1004
-
(2007)
Int J Cancer
, vol.120
, pp. 995-1004
-
-
Donnini, S.1
Monti, M.2
Castagnini, C.3
-
100
-
-
51349114614
-
Colchicine inhibits pressure-induced tumor cell implantation within surgical wounds and enhances tumor-free survival in mice
-
D.H. Craig, C.R. Owen, and W.C. Conway et al. Colchicine inhibits pressure-induced tumor cell implantation within surgical wounds and enhances tumor-free survival in mice J Clin Invest 118 2008 3170 3180
-
(2008)
J Clin Invest
, vol.118
, pp. 3170-3180
-
-
Craig, D.H.1
Owen, C.R.2
Conway, W.C.3
-
101
-
-
39149122846
-
An intracellular signal pathway that regulates cancer cell adhesion in response to extracellular forces
-
M.D. Basson An intracellular signal pathway that regulates cancer cell adhesion in response to extracellular forces Cancer Res 68 2008 2 4
-
(2008)
Cancer Res
, vol.68
, pp. 2-4
-
-
Basson, M.D.1
-
102
-
-
37149044827
-
Alpha-actinin-1 phosphorylation modulates pressure-induced colon cancer cell adhesion through regulation of focal adhesion kinase-Src interaction
-
D.H. Craig, B. Haimovich, and M.D. Basson Alpha-actinin-1 phosphorylation modulates pressure-induced colon cancer cell adhesion through regulation of focal adhesion kinase-Src interaction Am J Physiol Cell Physiol 293 2007 C1862 C1874
-
(2007)
Am J Physiol Cell Physiol
, vol.293
-
-
Craig, D.H.1
Haimovich, B.2
Basson, M.D.3
-
103
-
-
58349107266
-
Increased extracellular pressure enhances cancer cell integrin-binding affinity through phosphorylation of beta1-integrin at threonine 788/789
-
D.H. Craig, C.P. Gayer, and K.L. Schaubert et al. Increased extracellular pressure enhances cancer cell integrin-binding affinity through phosphorylation of beta1-integrin at threonine 788/789 Am J Physiol Cell Physiol 296 2009 C193 C204
-
(2009)
Am J Physiol Cell Physiol
, vol.296
-
-
Craig, D.H.1
Gayer, C.P.2
Schaubert, K.L.3
-
104
-
-
65949102791
-
Synergistic activity of the Src family kinase inhibitor dasatinib and oxaliplatin in colon carcinoma cells is mediated by oxidative stress
-
S. Kopetz, D.P. Lesslie, and N.A. Dallas et al. Synergistic activity of the Src family kinase inhibitor dasatinib and oxaliplatin in colon carcinoma cells is mediated by oxidative stress Cancer Res 69 2009 3842 3849
-
(2009)
Cancer Res
, vol.69
, pp. 3842-3849
-
-
Kopetz, S.1
Lesslie, D.P.2
Dallas, N.A.3
-
105
-
-
8544272554
-
Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis
-
G.J. Griffiths, M.Y. Koh, and V.G. Brunton et al. Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis J Biol Chem 279 2004 46113 46121
-
(2004)
J Biol Chem
, vol.279
, pp. 46113-46121
-
-
Griffiths, G.J.1
Koh, M.Y.2
Brunton, V.G.3
-
106
-
-
77956380733
-
Obesity hormone leptin induces growth and interferes with cytotoxic effects of 5-fluorouracil in colorectal tumor stem cells
-
M. Bartucci, S. Svensson, and L. Ricci-Vitiani et al. Obesity hormone leptin induces growth and interferes with cytotoxic effects of 5-fluorouracil in colorectal tumor stem cells Endocr Relat Cancer 17 2010 823 833
-
(2010)
Endocr Relat Cancer
, vol.17
, pp. 823-833
-
-
Bartucci, M.1
Svensson, S.2
Ricci-Vitiani, L.3
-
107
-
-
77951261957
-
Reduced drug accumulation is more important in acquired resistance against oxaliplatin than against cisplatin in isogenic colon cancer cells
-
L. Ekblad, J. Kjellstrom, and A. Johnsson Reduced drug accumulation is more important in acquired resistance against oxaliplatin than against cisplatin in isogenic colon cancer cells Anticancer Drugs 21 2010 523 531
-
(2010)
Anticancer Drugs
, vol.21
, pp. 523-531
-
-
Ekblad, L.1
Kjellstrom, J.2
Johnsson, A.3
-
108
-
-
33645038097
-
The PI3K inhibitor LY294002 blocks drug export from resistant colon carcinoma cells overexpressing MRP1
-
R. Abdul-Ghani, V. Serra, and B. Györffy et al. The PI3K inhibitor LY294002 blocks drug export from resistant colon carcinoma cells overexpressing MRP1 Oncogene 25 2006 1743 1752
-
(2006)
Oncogene
, vol.25
, pp. 1743-1752
-
-
Abdul-Ghani, R.1
Serra, V.2
Györffy, B.3
-
109
-
-
20444500171
-
SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models
-
J.M. Golas, J. Lucas, and C. Etienne et al. SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models Cancer Res 65 2005 5358 5364
-
(2005)
Cancer Res
, vol.65
, pp. 5358-5364
-
-
Golas, J.M.1
Lucas, J.2
Etienne, C.3
-
110
-
-
0041426730
-
Simultaneous inhibition of focal adhesion kinase and Src enhances detachment and apoptosis in colon cancer cell lines
-
V.M. Golubovskaya, S. Gross, and A.S. Kaur et al. Simultaneous inhibition of focal adhesion kinase and Src enhances detachment and apoptosis in colon cancer cell lines Mol Cancer Res 1 2003 755 764
-
(2003)
Mol Cancer Res
, vol.1
, pp. 755-764
-
-
Golubovskaya, V.M.1
Gross, S.2
Kaur, A.S.3
-
111
-
-
77954600200
-
Synergistic activity of the Src/Abl inhibitor bosutinib in combination with imatinib
-
S. Redaelli, F. Boschelli, and P. Perini et al. Synergistic activity of the Src/Abl inhibitor bosutinib in combination with imatinib Leukemia 24 2010 1223 1227
-
(2010)
Leukemia
, vol.24
, pp. 1223-1227
-
-
Redaelli, S.1
Boschelli, F.2
Perini, P.3
-
112
-
-
84873412467
-
Dual inhibition of alphaV integrins and Src kinase activity as a combination therapy strategy for colorectal cancer
-
J. Jia, A. Starodub, and I. Cushman et al. Dual inhibition of alphaV integrins and Src kinase activity as a combination therapy strategy for colorectal cancer Anticancer Drugs 24 2013 237 250
-
(2013)
Anticancer Drugs
, vol.24
, pp. 237-250
-
-
Jia, J.1
Starodub, A.2
Cushman, I.3
-
113
-
-
79955487784
-
Phase 2 study of dasatinib in the treatment of head and neck squamous cell carcinoma
-
H.D. Brooks, B.S. Glisson, and B.N. Bekele et al. Phase 2 study of dasatinib in the treatment of head and neck squamous cell carcinoma Cancer 117 2011 2112 2119
-
(2011)
Cancer
, vol.117
, pp. 2112-2119
-
-
Brooks, H.D.1
Glisson, B.S.2
Bekele, B.N.3
-
114
-
-
65749095573
-
Natural product inhibitors of protein-protein interactions mediated by Src-family sh2 domains
-
B. Sperl, M.H. Seifert, and T. Berg Natural product inhibitors of protein-protein interactions mediated by Src-family sh2 domains Bioorg Med Chem Lett 19 2009 3305 3309
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 3305-3309
-
-
Sperl, B.1
Seifert, M.H.2
Berg, T.3
-
115
-
-
77954213519
-
Discovery of novel purine derivatives with potent and selective inhibitory activity against c-Src tyrosine kinase
-
H. Huang, J. Ma, and J. Shi et al. Discovery of novel purine derivatives with potent and selective inhibitory activity against c-Src tyrosine kinase Bioorg Med Chem 18 2010 4615 4624
-
(2010)
Bioorg Med Chem
, vol.18
, pp. 4615-4624
-
-
Huang, H.1
Ma, J.2
Shi, J.3
-
116
-
-
0344962391
-
Direct inhibitory effect of curcumin on Src and focal adhesion kinase activity
-
T.H. Leu, S.L. Su, and Y.C. Chuang et al. Direct inhibitory effect of curcumin on Src and focal adhesion kinase activity Biochem Pharmacol 66 2003 2323 2331
-
(2003)
Biochem Pharmacol
, vol.66
, pp. 2323-2331
-
-
Leu, T.H.1
Su, S.L.2
Chuang, Y.C.3
-
118
-
-
43249096013
-
Dasatinib suppresses in vitro natural killer cell cytotoxicity
-
S.J. Blake, A. Bruce Lyons, and C.K. Fraser et al. Dasatinib suppresses in vitro natural killer cell cytotoxicity Blood 111 2008 4415 4416
-
(2008)
Blood
, vol.111
, pp. 4415-4416
-
-
Blake, S.J.1
Bruce Lyons, A.2
Fraser, C.K.3
-
119
-
-
26844476447
-
Differential regulation of monocyte/macrophage cytokine production by pressure
-
H. Shiratsuch, and M.D. Basson Differential regulation of monocyte/macrophage cytokine production by pressure Am J Surg 190 2005 757 762
-
(2005)
Am J Surg
, vol.190
, pp. 757-762
-
-
Shiratsuch, H.1
Basson, M.D.2
-
120
-
-
0242335086
-
Activation of Src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling ap-1 formation
-
G. Napolitani, N. Bortoletto, and L. Racioppi et al. Activation of Src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling ap-1 formation Eur J Immunol 33 2003 2832 2841
-
(2003)
Eur J Immunol
, vol.33
, pp. 2832-2841
-
-
Napolitani, G.1
Bortoletto, N.2
Racioppi, L.3
-
121
-
-
0032853934
-
Cutting edge: NKT cell development is selectively impaired in Fyn-deficient mice
-
G. Eberl, B. Lowin-Kropf, and H.R. MacDonald Cutting edge: NKT cell development is selectively impaired in Fyn-deficient mice J Immunol 163 1999 4091 4094
-
(1999)
J Immunol
, vol.163
, pp. 4091-4094
-
-
Eberl, G.1
Lowin-Kropf, B.2
Macdonald, H.R.3
-
122
-
-
0036210733
-
A role for the Src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors
-
B. Lowin-Kropf, B. Kunz, and P. Schneider et al. A role for the Src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors Eur J Immunol 32 2002 773 782
-
(2002)
Eur J Immunol
, vol.32
, pp. 773-782
-
-
Lowin-Kropf, B.1
Kunz, B.2
Schneider, P.3
-
123
-
-
0027330894
-
Fc gamma RIIIA-mediated signaling involves Src-family Lck in human natural killer cells
-
C. Pignata, K.V. Prasad, and M.J. Robertson et al. Fc gamma RIIIA-mediated signaling involves Src-family Lck in human natural killer cells J Immunol 151 1993 6794 6800
-
(1993)
J Immunol
, vol.151
, pp. 6794-6800
-
-
Pignata, C.1
Prasad, K.V.2
Robertson, M.J.3
-
124
-
-
9444249908
-
Natural killer cell signaling pathways
-
E. Vivier, J.A. Nunes, and F. Vely Natural killer cell signaling pathways Science 306 2004 1517 1519
-
(2004)
Science
, vol.306
, pp. 1517-1519
-
-
Vivier, E.1
Nunes, J.A.2
Vely, F.3
-
125
-
-
0028828062
-
Phosphorylation of Src family Lck tyrosine kinase following interleukin-12 activation of human natural killer cells
-
C. Pignata, K.V. Prasad, and M. Hallek et al. Phosphorylation of Src family Lck tyrosine kinase following interleukin-12 activation of human natural killer cells Cell Immunol 165 1995 211 216
-
(1995)
Cell Immunol
, vol.165
, pp. 211-216
-
-
Pignata, C.1
Prasad, K.V.2
Hallek, M.3
-
126
-
-
61849128182
-
T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance
-
R.J. Salmond, A. Filby, and I. Qureshi et al. T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance Immunol Rev 228 2009 9 22
-
(2009)
Immunol Rev
, vol.228
, pp. 9-22
-
-
Salmond, R.J.1
Filby, A.2
Qureshi, I.3
-
127
-
-
77953995931
-
The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation
-
S. Beer-Hammer, E. Zebedin, and M. von Holleben et al. The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation J Leukoc Biol 87 2010 1083 1095
-
(2010)
J Leukoc Biol
, vol.87
, pp. 1083-1095
-
-
Beer-Hammer, S.1
Zebedin, E.2
Von Holleben, M.3
-
128
-
-
0032478805
-
Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells
-
E.A. Feshchenko, W.Y. Langdon, and A.Y. Tsygankov Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells J Biol Chem 273 1998 8323 8331
-
(1998)
J Biol Chem
, vol.273
, pp. 8323-8331
-
-
Feshchenko, E.A.1
Langdon, W.Y.2
Tsygankov, A.Y.3
-
129
-
-
6944241415
-
Activation of naive CD4 T cells by anti-CD3 reveals an important role for Fyn in Lck-mediated signaling
-
K. Sugie, M.S. Jeon, and H.M. Grey Activation of naive CD4 T cells by anti-CD3 reveals an important role for Fyn in Lck-mediated signaling Proc Natl Acad Sci USA 101 2004 14859 14864
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 14859-14864
-
-
Sugie, K.1
Jeon, M.S.2
Grey, H.M.3
-
130
-
-
29144464371
-
Advances in the structural biology, design and clinical development of Bcr-Abl kinase inhibitors for the treatment of chronic myeloid leukaemia
-
P.W. Manley, S.W. Cowan-Jacob, and J. Mestan Advances in the structural biology, design and clinical development of Bcr-Abl kinase inhibitors for the treatment of chronic myeloid leukaemia Biochim Biophys Acta 1754 2005 3 13
-
(2005)
Biochim Biophys Acta
, vol.1754
, pp. 3-13
-
-
Manley, P.W.1
Cowan-Jacob, S.W.2
Mestan, J.3
-
131
-
-
38949210227
-
Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits t-cell activation and proliferation
-
A.E. Schade, G.L. Schieven, and R. Townsend et al. Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits t-cell activation and proliferation Blood 111 2008 1366 1377
-
(2008)
Blood
, vol.111
, pp. 1366-1377
-
-
Schade, A.E.1
Schieven, G.L.2
Townsend, R.3
-
132
-
-
45449102076
-
The Src/Abl kinase inhibitor dasatinib (bms-354825) inhibits function of normal human T-lymphocytes in vitro
-
S. Blake, T.P. Hughes, and G. Mayrhofer et al. The Src/Abl kinase inhibitor dasatinib (bms-354825) inhibits function of normal human T-lymphocytes in vitro Clin Immunol 127 2008 330 339
-
(2008)
Clin Immunol
, vol.127
, pp. 330-339
-
-
Blake, S.1
Hughes, T.P.2
Mayrhofer, G.3
-
133
-
-
58149181387
-
Dasatinib inhibits recombinant viral antigen-specific murine CD4+ and CD8+ T-cell responses and NK-cell cytolytic activity in vitro and in vivo
-
C.K. Fraser, S.J. Blake, and K.R. Diener et al. Dasatinib inhibits recombinant viral antigen-specific murine CD4+ and CD8+ T-cell responses and NK-cell cytolytic activity in vitro and in vivo Exp Hematol 37 2009 256 265
-
(2009)
Exp Hematol
, vol.37
, pp. 256-265
-
-
Fraser, C.K.1
Blake, S.J.2
Diener, K.R.3
-
134
-
-
2642708378
-
The molecular mechanism of B cell activation by toll-like receptor protein Rp-105
-
V.W. Chan, I. Mecklenbrauker, and I. Su et al. The molecular mechanism of B cell activation by toll-like receptor protein Rp-105 J Exp Med 188 1998 93 101
-
(1998)
J Exp Med
, vol.188
, pp. 93-101
-
-
Chan, V.W.1
Mecklenbrauker, I.2
Su, I.3
-
135
-
-
70449467570
-
Immunosuppression and atypical infections in CML patients treated with dasatinib at 140 mg daily
-
C. Sillaber, H. Herrmann, and K. Bennett et al. Immunosuppression and atypical infections in CML patients treated with dasatinib at 140 mg daily Eur J Clin Invest 39 2009 1098 1109
-
(2009)
Eur J Clin Invest
, vol.39
, pp. 1098-1109
-
-
Sillaber, C.1
Herrmann, H.2
Bennett, K.3
|