C-Src differentially regulates the functions of microtentacles and invadopodia

Oncogene

Volumn 29, Issue 48, 2010, Pages 6402-6408

  Balzer, E M ^a,b   Whipple, R A ^b   Thompson, K ^b   Boggs, A E ^a   Slovic, J ^a   Cho, E H ^a,b   Matrone, M A ^a,b   Yoneda, T ^c   Mueller, S C ^d   Martin, S S ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTER   (United States)

^c OSAKA UNIVERSITY   (Japan)

^d GEORGETOWN UNIVERSITY   (United States)

Author keywords

actin; breast cancer; invadopodia; microtentacle; microtubule; Src

Indexed keywords

2,3 DIHYDRO 2 OXO 3 (4,5,6,7 TETRAHYDRO 1H INDOL 2 YLMETHYLENE) 1H INDOLE 5 SULFONIC ACID DIMETHYLAMIDE; CORTACTIN; F ACTIN;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL FUNCTION; CELL MEMBRANE; CONTROLLED STUDY; CYTOSKELETON; DNA MODIFICATION; EXTRACELLULAR MATRIX; FIBROBLAST; GENE FUNCTION; GENE SILENCING; IN VITRO STUDY; IN VIVO STUDY; INVADOPODIA; LUNG CAPILLARY; MICROTENTACLE; MOUSE; NONHUMAN; ONCOGENE SRC; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR CELL;

3T3 CELLS; ACTINS; ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURFACE EXTENSIONS; CYTOSKELETON; EXTRACELLULAR MATRIX; FEMALE; HUMANS; MICE; MICROTUBULES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS;

EID: 78649864017     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.360     Document Type: Article

References (20)

1. Balzer EM, Whipple RA, Cho EH, Matrone MA, Martin SS. (2010). Antimitotic chemotherapeutics promote adhesive responses in detached and circulating tumor cells. Breast Cancer Res Treat 121: 65-78.
2. Blake RA, Broome MA, Liu X, Wu J, Gishizky M, Sun L et al. (2000). SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol Cell Biol 20: 9018-9027.
3. Buccione R, Caldieri G, Ayala I. (2009). Invadopodia: specialized tumor cell structures for the focal degradation of the extracellular matrix. Cancer Metastasis Rev 28: 137-149.
4. Buccione R, Orth JD, McNiven MA. (2004). Foot and mouth: podosomes, invadopodia and circular dorsal ruffles. Nat Rev Mol Cell Biol 5: 647-657.
5. Chambers AF, Groom AC, MacDonald IC. (2002). Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2: 563-572.
6. Clark ES, Weaver AM. (2008). A new role for cortactin in invadopodia: regulation of protease secretion. Eur J Cell Biol 87: 581-590.
7. Frame MC, Fincham VJ, Carragher NO, Wyke JA. (2002). v-Src's hold over actin and cell adhesions. Nat Rev Mol Cell Biol 3: 233-245.
8. Gupton SL, Gertler FB. (2007). Filopodia: the fingers that do the walking. Sci STKE 2007: re5.
9. Korb T, Schluter K, Enns A, Spiegel HU, Senninger N, Nicolson GL et al. (2004). Integrity of actin fibers and microtubules influences metastatic tumor cell adhesion. Exp Cell Res 299: 236-247.
10. Linder S. (2007). The matrix corroded: podosomes and invadopodia in extracellular matrix degradation. Trends Cell Biol 17: 107-117.
11. Linder S, Aepfelbacher M. (2003). Podosomes: adhesion hot-spots of invasive cells. Trends Cell Biol 13: 376-385.
12. Machesky LM. (2008). Lamellipodia and filopodia in metastasis and invasion. FEBS Lett 582: 2102-2111.
13. Mehlen P, Puisieux A. (2006). Metastasis: a question of life or death. Nat Rev Cancer 6: 449-458.
14. Mendoza M, Khanna C. (2009). Revisiting the seed and soil in cancer metastasis. Int J Biochem Cell Biol 41: 1452-1462.
15. Miles FL, Pruitt FL, Van Golen KL, Cooper CR. (2008). Stepping out of the flow: capillary extravasation in cancer metastasis. Clin Exp Metastasis 25: 305-324.
16. Mitra SK, Schlaepfer DD. (2006). Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol 18: 516-523.
17. Seals DF, Azucena Jr EF, Pass I, Tesfay L, Gordon R, Woodrow M et al. (2005). The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells. Cancer Cell 7: 155-165.
18. Whipple RA, Balzer EM, Cho EH, Matrone MA, Yoon JR, Martin SS. (2008). Vimentin filaments support extension of tubulin-based microtentacles in detached breast tumor cells. Cancer Res 68: 5678-5688.
19. Whipple RA, Cheung AM, Martin SS. (2007). Detyrosinated microtubule protrusions in suspended mammary epithelial cells promote reattachment. Exp Cell Res 313: 1326-1336.
20. Yilmaz M, Christofori G. (2009). EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev 28: 15-33.