The molecular mechanism of B cell activation by toll-like receptor protein RP-105

Journal of Experimental Medicine

Volumn 188, Issue 1, 1998, Pages 93-101

  Chan, Vivien W F ^a   Mecklenbräuker, Ingrid ^b   Su, I Hsin ^b   Texido, Gemma ^b   Leitges, Michael ^c   Carsetti, Rita ^c   Lowell, Clifford A ^a   Rajewsky, Klaus ^b   Miyake, Kensuke ^d   Tarakhovsky, Alexander ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF COLOGNE   (Germany)

^c MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^d SAGA UNIVERSITY   (Japan)

Author keywords

B lymphocytes; Mice; RP 105; Signal transduction

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; RECEPTOR PROTEIN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; ENZYME ACTIVATION; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; B-LYMPHOCYTES; CALCIUM; CELL DIVISION; CELLS, CULTURED; DROSOPHILA PROTEINS; ENZYME ACTIVATION; FLOW CYTOMETRY; IMMUNOGLOBULIN M; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN KINASES; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; SPLEEN; SRC-FAMILY KINASES; TOLL-LIKE RECEPTORS;

EID: 2642708378     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.1.93     Document Type: Article

References (44)

1. Tooze, R.M., G.M. Doody, and D.T. Fearon. 1997. Counterregulation by the coreceptors CD19 and CD22 of MAP kinase activation by membrane immunoglobulin. Immunity. 7:59-67.
2. O'Rourke, L., R. Tooze, and D.T. Fearon. 1997. Co-receptors of B lymphocytes. Curr. Opin. Immunol. 9:324-329.
3. Medzhitov, R., and C.A. Janeway, Jr. 1997. Innate immunity: impact on the adaptive immune response. Curr. Opin. Immunol. 9:4-9.
4. Wright, S.D. 1995. CD14 and innate recognition of bacteria. J. Immunol. 155:6-8.
5. Rott, O., and E. Cash. 1994. Influenza virus hemagglutinin induces differentiation of mature resting B cells and growth arrest of immature WEHI-231 lymphoma cells. J. Immunol. 152:5381-5391.
6. Cash, E., J. Charreire, and O. Rott. 1996. B-cell activation by superstimulatory influenza virus hemagglutinin: a pathogenesis for autoimmunity? Immunol. Rev. 152:67-88.
7. Krieg, A.M. 1996. An innate immune defense mechanism based on the recognition of CpG motifs in microbial DNA. J. Lab. Clin. Med. 128:128-133.
8. Medzhitov, R., and C.A. Janeway, Jr. 1997. Innate immunity: the virtues of a nonclonal system of recognition. Cell. 91:295-298.
9. Medzhitov, R., P. Preston-Hurlburt, and C.A. Janeway, Jr. 1997. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature. 388:394-397.
10. Ferrero, E., C.L. Hsieh, U. Francke, and S.M. Goyert. 1990. CD14 is a member of the family of leucine-rich proteins and is encoded by a gene syntenic with multiple receptor genes. J. Immunol. 145:331-336.
11. Miyake, K., Y. Yamashita, M. Ogata, T. Sudo, and M. Kimoto. 1995. RP105, a novel B cell surface molecule implicated in B cell activation, is a member of the leucine-rich repeat protein family. J. Immunol. 154:3333-3340.
12. Miyake,K.,Y. Yamashita, Y. Hitoshi, K. Takatsu, and M. Kimoto. 1994. Murine B cell proliferation and protection from apoptosis with an antibody against a 105-kD molecule: unresponsivencss of X-linked immunodeficient B cells. J. Exp. Med. 180:1217-1224.
13. Miura, Y., K. Miyake, Y. Yamashita, R. Shimazu, N.G. Copeland, D.J. Gilbert, N.A. Jenkins, J. Inazawa, T. Abe, and M. Kimoto. 1996. Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64). Genomics. 38:299-304.
14. Fugier-Vivier, I., O. de Bouteiller, C. Guret, F. Fossiez, J. Banchereau, M.G. Mattei, S. Ait-Yahia, E. Garcia, S. Lebecque, and Y.J. Liu. 1997. Molecular cloning of human RP-105. Eur. J. Immunol. 27:1824-1827.
15. Yamashita, Y., K. Miyake, Y. Miura, Y. Kaneko, H. Yagita, T. Suda, S. Nagata. J. Nomura, N. Sakaguchi, and M. Kimoto. 1996. Activation mediated by RP105 but not CD40 makes normal B cells susceptible to anti-IgM-induced apoptosis: a role tor Fc receptor coligation. J. Exp. Med. 184: 113-120.
16. Chan, V.W.F., F. Meng, P. Soriano, A.L. DeFranco, and C.A. Lowell. 1997. Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity. 7:69-81.
17. Appleby, M.W., J.D. Kerner, S. Chien, C.R. Maliszewski, S. Bondada, R.M. Perlmutter, and S. Bondada. 1995. Involvement of p59fynT in interleukin-5 receptor signaling. J. Exp. Med. 182:811-820.
18. Leitges, M., C. Schmedt, R. Guinamard, J. Davoust, S. Schaal, S. Stabel, and A. Tarakhovsky. 1996. Immunodeficiency in protein kinase C β-deficient mice. Science. 273: 788-791.
19. Law, D.A., V.W.F. Chan, S.K. Datta, and A.L. DeFranco. 1993. B-cell antigen receptor motifs have abundant signaling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn. Curr. Biol. 3:645-657.
20. Richards, J.D., M.R. Gold, S.L. Hourihane, A.L. DeFranco, and L. Matsuuchi. 1996. Reconstitution of B cell antigen-receptor induced signaling events in a nonlymphoid cell line by expressing the syk protein-tyrosine kinase. J. Biol. Chem. 271:6458-6466.
21. Chan, V.W.F., C.A. Lowell, and A.L. DeFranco. 1998. Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes. Curr. Biol. 8:545-553.
22. Lowell, C.A., P. Soriano, and H.E. Varmus. 1994. Functional overlap in the Src gene family: inactivation of hck and fgr impairs natural immunity. Genes Dev. 8:387-398.
23. Weiss, A., and D.R. Littman. 1994. Signal transduction by lymphocyte antigen receptors. Cell. 76:263-274.
24. Jensen, W.A., C.M. Pleiman, and J.C. Cambier. 1996. Molecular mechanisms of signal transduction by B cell receptors. In Weir's handbook of experimental immunology. L.A. Herzenberg, D.M. Weir, L.A. Herzenberg, C. Blackwell, editors. Blackwell Science, Cambridge, MA. 88.1-88.12.
25. Wicker, L.S., R. Boltz, Jr., V. Matt, E.A. Nichols, L.B. Peterson, and N.H. Sigal. 1990. Suppression of B cell activation by cyclosporin A, FK506 and rapamycin. Eur. J. Immunol. 20:2277-2283.
26. Klaus, G.G., M.S. Choi, and M. Holman. 1994. Properties of mouse CD40. Ligation of CD40 activates B cells via a Ca(++)-dependent, FK506-sensitive pathway. Eur. J. Immunol. 24:3229-3232.
27. Lund, F.E., N. Yu, K.M. Kim, M. Reth, and M.C. Howard. 1996. Signaling through CD38 augments B cell antigen receptor (BCR) responses and is dependent on BCR expression. J. Immunol. 157:1455-1467.
28. Schreiber, S.L., and G.R. Crabtree. 1992. The mechanism of action of cyclosporin A and FK506. Immunol. Today. 13: 136-142.
29. Choi, M.S., R.D. Brines, M.J. Holman, and G.G. Klaus. 1994. Induction of NF-AT in normal B lymphocytes by antiimmunoglobulin or CD40 ligand in conjunction with IL-4. Immunity. 1:179-187.
30. Li, Y.Y., M. Baccam, S.B. Waters, J.E. Hessin, G.A. Bishop, and G.A. Koretzky. 1996. CD40 ligation results in protein kinase C-independent activation of ERK and JNK in resting niurine splenic B cells. J. Immunol. 157:1440-1447.
31. Rawlings, D.J., A.M. Scharenberg, H. Park, M.I. Wahl, S. Lin, R.M. Kato, A.C. Fluckiger, O.N. Witte, and J.P. Kinet. 1996. Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. Science. 271:822-825.
32. Wahl, M.I., A.C. Fluckiger, R.M. Kato, H. Park, O.N. Witte, and D.J. Rawlings. 1997. Phosphorylation of two regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors. Proc. Natl. Acad. Sci. USA. 94:11526-11533.
33. Burkhardt, A.L., M. Brunswick, J.B. Bolen, and J.J. Mond. 1991. Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases. Proc. Natl. Acad. Sci. USA. 88:7410-7414.
34. Cambier, J.C., and K.S. Campbell. 1992. Membrane immunoglobulin and its accomplices: new lessons from an old receptor. FASEB J. 6:3207-3217.
35. DeFranco, A.L., J.D. Richards, J.H. Blum, T.L. Stevens, D.A. Law, V.W. Chan, S.K. Datra, S.P. Foy, S.L. Hourihane, M.R. Gold et al. 1995. Signal transduction by the B-cell antigen receptor. Ann. NY. Acad Sci. 766:195-201.
36. Yao, L., Y. Kawakami, and T. Kawakami. 1994. The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C. Proc. Natl. Acad. Sci. USA. 91:9175-9179.
37. Marshall, C.J. 1995. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell. 80:179-185.
38. Yamanashi, Y., T. Kakiuchi, J. Mizuguchi, T. Yamamoto, and K. Toyoshima. 1991. Association of B cell antigen receptor with protein tyrosine kinase Lyn. Science. 251:192-194.
39. van Noesel, C.J., A.C. Lankester, G.M. van Schijndel, and R.A. van Lier. 1993. The CR2/CD19 complex on human B cells contains the src-family kinase Lyn. Int. Immunol. 5:699-705.
40. Nishizuka, Y. 1992. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science. 258: 607-614.
41. Marais, R.M., and P.J. Parker. 1989. Purification and characterisation of bovine brain protein kinase C isotypes α, β, and γ. Eur. J. Biochem. 182:129-137.
42. Baixeras, E., G. Kroemer, E. Cuende, C. Marquez, L. Bosca, J.E. Ales Martinez, and C. Martinez. 1993. Signal transduction pathways involved in B-cell induction. Immunol. Rev. 132:607-614.
43. Su, B., and M. Karin. 1996. Mitogen-activated protein kinase cascades and regulation of gene expression. Curr. Opin. Immunol. 8:402-411.
44. Treisman, R. 1996. Regulation of transcription by MAP kinase cascades. Curr. Opin. Cell. Biol. 8:205-213.