An intracellular signal pathway that regulates cancer cell adhesion in response to extracellular forces

Cancer Research

Volumn 68, Issue 1, 2008, Pages 2-4

  Basson, Marc D ^a,b  

^a WAYNE STATE UNIVERSITY   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; FOCAL ADHESION KINASE; INTEGRIN; PHOSPHATIDYLINOSITOL 3 KINASE; RAPAMYCIN; SMALL INTERFERING RNA; PHOSPHOTRANSFERASE;

AUTOPHOSPHORYLATION; BINDING AFFINITY; CANCER CELL CULTURE; CANCER GROWTH; CELL ADHESION; COLON CANCER; DRUG EFFECT; EXTRACELLULAR MATRIX; HUMAN; LAPAROSCOPIC SURGERY; MACROPHAGE; PHAGOCYTOSIS; PRIORITY JOURNAL; REVIEW; ENZYMOLOGY; METABOLISM; METASTASIS; NEOPLASM; PRESSURE; SIGNAL TRANSDUCTION;

ANTIGENS, CD29; CELL ADHESION; HUMANS; NEOPLASM METASTASIS; NEOPLASMS; PHOSPHOTRANSFERASES; PRESSURE; SIGNAL TRANSDUCTION;

EID: 39149122846     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-2992     Document Type: Review

References (21)

1. Basson MD, Yu CF, Herden-Kirchoff O, et al. Effects of increased ambient pressure on colon cancer cell adhesion. J Cell Biochem 2000;78:47-61.
2. Thamilselvan V, Basson MD. Pressure activates colon cancer cell adhesion by inside-out focal adhesion complex and actin cytoskeletal signaling. Gastroenterology 2004;126:8-18.
3. van der Voort van Zyp J, Thamilselvan V, Walsh M, Polin L, Basson MD. Extracellular pressure stimulates colon cancer cell adhesion in vitro and to surgical wounds by Src (sarcoma protein) activation. Am J Surg 2004;188:467-73.
4. von Sengbusch A, Gassmann P, Fisch KM, Enns A, Nicolson GL, Haier J. Focal adhesion kinase regulates metastatic adhesion of carcinoma cells within liver sinusoids. Am J Pathol 2005;166:585-96.
5. Lawler K, Meade G, O'Sullivan G, Kenny D. Shear stress modulates the interaction of platelet-secreted matrix proteins with tumor cells through the integrin αvβ3. Am J Physiol 2004;287:C1320-7.
6. Conway WC, Van der Voort van Zyp J, Thamilselvan V, Walsh MF, Crowe DL, Basson MD. Paxillin modulates squamous cancer cell adhesion and is important in pressure-augmented adhesion. J Cell Biochem 2006;98:1507-16.
7. van Zyp JV, Conway WC, Craig DH, van Zyp NV, Thamilselvan V, Basson MD. Extracellular pressure stimulates tumor cell adhesion in vitro by paxillin activation. Cancer Biol Ther 2006;5:1169-78.
8. Downey C, Alwan K, Thamilselvan V, et al. Pressure stimulates breast cancer cell adhesion independently of cell cycle and apoptosis regulatory protein (CARP)-1 regulation of focal adhesion kinase. Am J Surg 2006;192:631-5.
9. Thamilselvan V, Patel A, van der Voort van Zyp J, Basson MD. Colon cancer cell adhesion in response to Src kinase activation and actin-cytoskeleton by non-laminar shear stress. J Cell Biochem 2004;92:361-71.
10. Thamilselvan V, Basson MD. The role of the cytoskeleton in differentially regulating pressure-mediated effects on malignant colonocyte focal adhesion signaling and cell adhesion. Carcinogenesis 2005;26:1687-97.
11. Thamilselvan V, Craig DH, Basson MD. FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway. FASEB J 2007;21:1730-41.
12. Shiratsuchi H, Basson MD. Akt2, but not Akt1 or Akt3 mediates pressure-stimulated serum-opsonized latex bead phagocytosis through activating mTOR and p70 S6 kinase. J Cell Biochem 2007;102:353-67.
13. Wang S, Basson MD. Identification of functional domains in AKT responsible for distinct roles of AKT isoforms in pressure-stimulated cancer cell adhesion. Exp Cell Res. In press.
14. Basson MD. Paradigms for mechanical signal transduction in the intestinal epithelium. Category: molecular, cell, and developmental biology. Digestion 2003;68:217-25.
15. Diresta GR, Nathan SS, Manoso MW, et al. Cell proliferation of cultured human cancer cells are affected by the elevated tumor pressures that exist in vivo. Ann Biomed Eng 2005;33:1270-80.
16. Taghian AG, Abi-Raad R, Assaad SI, et al. Paclitaxel decreases the interstitial fluid pressure and improves oxygenation in breast cancers in patients treated with neoadjuvant chemotherapy: clinical implications. J Clin Oncol 2005;23:1951-61.
17. Baskaranathan S, Philips J, McCredden P, Solomon MJ. Free colorectal cancer cells on the peritoneal surface: correlation with pathologic variables and survival. Dis Colon Rectum 2004;47:2076-9.
18. Benoliel AM, Pirro N, Marin V, et al. Correlation between invasiveness of colorectal tumor cells and adhesive potential under flow. Anticancer Res 2003;23:4891-6.
19. Walsh MF, Woo RK, Gomez R, Basson MD. Extracellular pressure stimulates colon cancer cell proliferation via a mechanism requiring PKC and tyrosine kinase signals. Cell Prolif 2004;37:427-41.
20. Zhou GL, Tucker DF, Bae SS, Bhatheja K, Birnbaum MJ, Field J. Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration. J Biol Chem 2006;281:36443-53.
21. Somanath PR, Kandel ES, Hay N, Byzova TV. Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly. J Biol Chem 2007;282:22964-76.