-
1
-
-
15244351004
-
Overview of monoclonal antibodies in cancer therapy: Present and promise
-
Stern M, Herrmann R. Overview of monoclonal antibodies in cancer therapy: present and promise. Critical Reviews in Oncology Hematology 2005; 54:11-29.
-
(2005)
Critical Reviews in Oncology Hematology
, vol.54
, pp. 11-29
-
-
Stern, M.1
Herrmann, R.2
-
2
-
-
0016756272
-
Continuous cultures of fused cells secreting antibody of predefined specificity
-
Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975; 256:495-7.
-
(1975)
Nature
, vol.256
, pp. 495-497
-
-
Kohler, G.1
Milstein, C.2
-
3
-
-
0018971622
-
Serotherapy of a patient with a monoclonal antibody directed against a human lymphoma-associated antigen
-
Nadler LM, Stashenko P, Hardy R, Kaplan WD, Button LN, Kufe DW, et al. Serotherapy of a patient with a monoclonal antibody directed against a human lymphoma-associated antigen. Cancer Res 1980; 40:3147-54. (Pubitemid 10043516)
-
(1980)
Cancer Research
, vol.40
, Issue.9
, pp. 3147-3154
-
-
Nadler, L.M.1
Stashenko, P.2
Hardy, R.3
-
4
-
-
0022558297
-
Replacing the complementary determining regions in a human antibody with those from a mouse
-
Jones PT, Dear PH, Foote J, Neuberger MS, Winter G. Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature 1986; 321:522-5. (Pubitemid 16052256)
-
(1986)
Nature
, vol.321
, Issue.6069
, pp. 522-525
-
-
Jones, P.T.1
Dear, P.H.2
Foote, J.3
-
5
-
-
0026610881
-
Humanization of an anti-p185HER2 antibody for human cancer therapy
-
Carter P, Presta L, Gorman CM, Ridgway JB, Henner D, Wong WL, et al. Humanization of an anti-p185HER2 antibody for human cancer therapy. Proc Natl Acad Sci USA 1992; 89:4285-9.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 4285-4289
-
-
Carter, P.1
Presta, L.2
Gorman, C.M.3
Ridgway, J.B.4
Henner, D.5
Wong, W.L.6
-
6
-
-
35148851643
-
From XenoMouse technology to panitumumab, the first fully human antibody product from transgenic mice
-
Jakobovits A, Amado RG, Yang X, Roskos L, Schwab G. From XenoMouse technology to panitumumab, the first fully human antibody product from transgenic mice. Nat Biotechnol 2007; 25:1134-43.
-
(2007)
Nat Biotechnol
, vol.25
, pp. 1134-1143
-
-
Jakobovits, A.1
Amado, R.G.2
Yang, X.3
Roskos, L.4
Schwab, G.5
-
7
-
-
3342982829
-
A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women
-
Bekker PJ, Holloway DL, Rasmussen AS, Murphy R, Martin SW, Leese PT, et al. A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women. J Bone Miner Res 2004; 19:1059-66.
-
(2004)
J Bone Miner Res
, vol.19
, pp. 1059-1066
-
-
Bekker, P.J.1
Holloway, D.L.2
Rasmussen, A.S.3
Murphy, R.4
Martin, S.W.5
Leese, P.T.6
-
8
-
-
38449087414
-
The role of the EGFR signaling in tumor microenvironment
-
De Luca A, Carotenuto A, Rachiglio A, Gallo M, Maiello MR, Aldinucci D, et al. The role of the EGFR signaling in tumor microenvironment. J Cell Physiol 2008; 214:559-67.
-
(2008)
J Cell Physiol
, vol.214
, pp. 559-567
-
-
De Luca, A.1
Carotenuto, A.2
Rachiglio, A.3
Gallo, M.4
Maiello, M.R.5
Aldinucci, D.6
-
9
-
-
58149381635
-
A pan-HER approach for cancer therapy: Background, current status and future development
-
Huang Z, Brdlik C, Jin P, Shepard HM. A pan-HER approach for cancer therapy: background, current status and future development. Expert Opin Biol Ther 2009; 9:97-110.
-
(2009)
Expert Opin Biol Ther
, vol.9
, pp. 97-110
-
-
Huang, Z.1
Brdlik, C.2
Jin, P.3
Shepard, H.M.4
-
10
-
-
67349143074
-
Anti-epidermal growth factor receptor monoclonal antibodies in cancer treatment
-
Capdevila J, Elez E, Macarulla T, Ramos FJ, Ruiz-Echarri M, Tabernero J. Anti-epidermal growth factor receptor monoclonal antibodies in cancer treatment. Cancer Treat Rev 2009.
-
(2009)
Cancer Treat Rev
-
-
Capdevila, J.1
Elez, E.2
Macarulla, T.3
Ramos, F.J.4
Ruiz-Echarri, M.5
Tabernero, J.6
-
11
-
-
36749086904
-
Targeting the epidermal growth factor receptor in metastatic colorectal cancer
-
Ng K, Zhu AX. Targeting the epidermal growth factor receptor in metastatic colorectal cancer. Crit Rev Oncol Hematol 2008; 65:8-20.
-
(2008)
Crit Rev Oncol Hematol
, vol.65
, pp. 8-20
-
-
Ng, K.1
Zhu, A.X.2
-
12
-
-
34548404210
-
Mechanisms for oncogenic activation of the epidermal growth factor receptor
-
Zandi R, Larsen AB, Andersen P, Stockhausen MT, Poulsen HS. Mechanisms for oncogenic activation of the epidermal growth factor receptor. Cell Signal 2007; 19:2013-23.
-
(2007)
Cell Signal
, vol.19
, pp. 2013-2023
-
-
Zandi, R.1
Larsen, A.B.2
Andersen, P.3
Stockhausen, M.T.4
Poulsen, H.S.5
-
13
-
-
17844362179
-
Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: A cohort study
-
Moroni M, Veronese S, Benvenuti S, Marrapese G, Sartore-Bianchi A, Di Nicolantonio F, et al. Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study. Lancet Oncol 2005; 6:279-86.
-
(2005)
Lancet Oncol
, vol.6
, pp. 279-286
-
-
Moroni, M.1
Veronese, S.2
Benvenuti, S.3
Marrapese, G.4
Sartore-Bianchi, A.5
Di Nicolantonio, F.6
-
14
-
-
63149108552
-
Mutations and response to epidermal growth factor receptor inhibitors
-
Laurent-Puig P, Lievre A, Blons H. Mutations and response to epidermal growth factor receptor inhibitors. Clin Cancer Res 2009; 15:1133-9.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 1133-1139
-
-
Laurent-Puig, P.1
Lievre, A.2
Blons, H.3
-
16
-
-
0026846928
-
The role of angiogenesis in tumor growth
-
Folkman J. The role of angiogenesis in tumor growth. Semin Cancer Biol 1992; 3:65-71.
-
(1992)
Semin Cancer Biol
, vol.3
, pp. 65-71
-
-
Folkman, J.1
-
17
-
-
58149150071
-
VEGF-1 expression in colorectal cancer is associated with disease localization, stage and long-term disease-specific survival
-
Bendardaf R, Buhmeida A, Hilska M, Laato M, Syrjanen S, Syrjanen K, et al. VEGF-1 expression in colorectal cancer is associated with disease localization, stage and long-term disease-specific survival. Anticancer Res 2008; 28:3865-70.
-
(2008)
Anticancer Res
, vol.28
, pp. 3865-3870
-
-
Bendardaf, R.1
Buhmeida, A.2
Hilska, M.3
Laato, M.4
Syrjanen, S.5
Syrjanen, K.6
-
19
-
-
47949089077
-
VEGF-targeted therapy: Mechanisms of anti-tumour activity
-
Ellis LM, Hicklin DJ. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer 2008; 8:579-91.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 579-591
-
-
Ellis, L.M.1
Hicklin, D.J.2
-
20
-
-
37049032136
-
First-line use of anti-epidermal growth factor receptor monoclonal antibodies in metastatic colorectal cancer
-
Lee JJ, Chu E. First-line use of anti-epidermal growth factor receptor monoclonal antibodies in metastatic colorectal cancer. Clin Colorectal Cancer 2007; 6:42-6.
-
(2007)
Clin Colorectal Cancer
, vol.6
, pp. 42-46
-
-
Lee, J.J.1
Chu, E.2
-
21
-
-
0021254542
-
Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activity
-
Gill GN, Kawamoto T, Cochet C, Le A, Sato JD, Masui H, et al. Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activity. J Biol Chem 1984; 259:7755-60. (Pubitemid 14081190)
-
(1984)
Journal of Biological Chemistry
, vol.259
, Issue.12
, pp. 7755-7760
-
-
Gill, G.N.1
Kawamoto, T.2
Cochet, C.3
-
23
-
-
0029670014
-
Involvement of p27KIP1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody
-
Wu X, Rubin M, Fan Z, DeBlasio T, Soos T, Koff A, et al. Involvement of p27KIP1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody. Oncogene 1996; 12:1397-403.
-
(1996)
Oncogene
, vol.12
, pp. 1397-1403
-
-
Wu, X.1
Rubin, M.2
Fan, Z.3
DeBlasio, T.4
Soos, T.5
Koff, A.6
-
24
-
-
0034038282
-
Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity
-
Liu B, Fang M, Schmidt M, Lu Y, Mendelsohn J, Fan Z. Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity. Br J Cancer 2000; 82:1991-9. (Pubitemid 30326461)
-
(2000)
British Journal of Cancer
, vol.82
, Issue.12
, pp. 1991-1999
-
-
Liu, B.1
Fang, M.2
Schmidt, M.3
Lu, Y.4
Mendelsohn, J.5
Fan, Z.6
-
25
-
-
0032972944
-
Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice
-
Perrotte P, Matsumoto T, Inoue K, Kuniyasu H, Eve BY, Hicklin DJ, et al. Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clin Cancer Res 1999; 5:257-65. (Pubitemid 29085177)
-
(1999)
Clinical Cancer Research
, vol.5
, Issue.2
, pp. 257-265
-
-
Perrotte, P.1
Matsumoto, T.2
Inoue, K.3
Kuniyasu, H.4
Eve, B.Y.5
Hicklin, D.J.6
Radinsky, R.7
Dinney, C.P.N.8
-
26
-
-
63349086603
-
Cetuximab-mediated cellular cytotoxicity is inhibited by HLA-E membrane expression in colon cancer cells
-
Levy EM, Sycz G, Arriaga JM, Barrio MM, von Euw EM, Morales SB, et al. Cetuximab-mediated cellular cytotoxicity is inhibited by HLA-E membrane expression in colon cancer cells. Innate Immun 2009; 15:91-100.
-
(2009)
Innate Immun
, vol.15
, pp. 91-100
-
-
Levy, E.M.1
Sycz, G.2
Arriaga, J.M.3
Barrio, M.M.4
Von Euw, E.M.5
Morales, S.B.6
-
27
-
-
40849142102
-
Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-13- galactose
-
Chung CH, Mirakhur B, Chan E, Le QT, Berlin J, Morse M, et al. Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3- galactose. N Engl J Med 2008; 358:1109-17.
-
(2008)
N Engl J Med
, vol.358
, pp. 1109-1117
-
-
Chung, C.H.1
Mirakhur, B.2
Chan, E.3
Berlin J, L.Q.T.4
Morse, M.5
-
28
-
-
33645785843
-
Common side effects of anti-EGFR therapy: Acneform rash
-
Sipples R. Common side effects of anti-EGFR therapy: acneform rash. Semin Oncol Nurs 2006; 22:28-34.
-
(2006)
Semin Oncol Nurs
, vol.22
, pp. 28-34
-
-
Sipples, R.1
-
29
-
-
67349083594
-
Skin toxicities associated with epidermal growth factor receptor inhibitors
-
Li T, Perez-Soler R. Skin toxicities associated with epidermal growth factor receptor inhibitors. Target Oncol 2009; 4:107-19.
-
(2009)
Target Oncol
, vol.4
, pp. 107-119
-
-
Li, T.1
Perez-Soler, R.2
-
30
-
-
45349097237
-
Panitumumab: Human monoclonal antibody against epidermal growth factor receptors for the treatment of metastatic colorectal cancer
-
Wu M, Rivkin A, Pham T. Panitumumab: Human monoclonal antibody against epidermal growth factor receptors for the treatment of metastatic colorectal cancer. Clin Ther 2008; 30:14-30.
-
(2008)
Clin Ther
, vol.30
, pp. 14-30
-
-
Wu, M.1
Rivkin, A.2
Pham, T.3
-
32
-
-
34147103678
-
Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy- refractory metastatic colorectal cancer
-
Van Cutsem E, Peeters M, Siena S, Humblet Y, Hendlisz A, Neyns B, et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol 2007; 25:1658-64.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1658-1664
-
-
Van Cutsem, E.1
Peeters, M.2
Siena, S.3
Humblet, Y.4
Hendlisz, A.5
Neyns, B.6
-
33
-
-
63449142391
-
Association of progression-free survival, overall survival and patient-reported outcomes by skin toxicity and KRAS status in patients receiving panitumumab monotherapy
-
Peeters M, Siena S, Van Cutsem E, Sobrero A, Hendlisz A, Cascinu S, et al. Association of progression-free survival, overall survival and patient-reported outcomes by skin toxicity and KRAS status in patients receiving panitumumab monotherapy. Cancer 2009; 115:1544-54.
-
(2009)
Cancer
, vol.115
, pp. 1544-1554
-
-
Peeters, M.1
Siena, S.2
Van Cutsem, E.3
Sobrero, A.4
Hendlisz, A.5
Cascinu, S.6
-
34
-
-
33750818148
-
Panitumumab in colon cancer: A review and summary of ongoing trials
-
Wainberg Z, Hecht JR. Panitumumab in colon cancer: a review and summary of ongoing trials. Expert Opin Biol Ther 2006; 6:1229-35.
-
(2006)
Expert Opin Biol Ther
, vol.6
, pp. 1229-1235
-
-
Wainberg, Z.1
Hecht, J.R.2
-
35
-
-
2142641698
-
Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
-
Saltz LB, Meropol NJ, Loehrer PJ Sr, Needle MN, Kopit J, Mayer RJ. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 2004; 22:1201-8.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1201-1208
-
-
Saltz, L.B.1
Meropol, N.J.2
Loehrer Sr., P.J.3
Needle, M.N.4
Kopit, J.5
Mayer, R.J.6
-
37
-
-
55549102649
-
Clinical use of anti-vascular endothelial growth factor monoclonal antibodies in metastatic colorectal cancer
-
Chase JL. Clinical use of anti-vascular endothelial growth factor monoclonal antibodies in metastatic colorectal cancer. Pharmacotherapy 2008; 28:23-30.
-
(2008)
Pharmacotherapy
, vol.28
, pp. 23-30
-
-
Chase, J.L.1
-
39
-
-
59749091477
-
Chemotherapy bevacizumab and cetuximab in metastatic colorectal cancer
-
Tol J, Koopman M, Cats A, Rodenburg CJ, Creemers GJ, Schrama JG, et al. Chemotherapy, bevacizumab and cetuximab in metastatic colorectal cancer. N Engl J Med 2009; 360:563-72.
-
(2009)
N Engl J Med
, vol.360
, pp. 563-572
-
-
Tol, J.1
Koopman, M.2
Cats, A.3
Rodenburg, C.J.4
Creemers, G.J.5
Schrama, J.G.6
-
40
-
-
59949102930
-
A randomized phase IIIB trial of chemotherapy bevacizumab and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
-
Hecht JR, Mitchell E, Chidiac T, Scroggin C, Hagenstad C, Spigel D, et al. A randomized phase IIIB trial of chemotherapy, bevacizumab and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol 2009; 27:672-80.
-
(2009)
J Clin Oncol
, vol.27
, pp. 672-680
-
-
Hecht, J.R.1
Mitchell, E.2
Chidiac, T.3
Scroggin, C.4
Hagenstad, C.5
Spigel, D.6
-
41
-
-
73449100517
-
Vascular Endothelial Growth Factor plus Epidermal Growth Factor Receptor Dual Targeted Therapy in Metastatic Colorectal Cancer: Synergy or Antagonism?
-
Marshall JL. Vascular Endothelial Growth Factor plus Epidermal Growth Factor Receptor Dual Targeted Therapy in Metastatic Colorectal Cancer: Synergy or Antagonism? J Oncol 2009; 2009:937305.
-
(2009)
J Oncol
, vol.2009
, pp. 937305
-
-
Marshall, J.L.1
-
42
-
-
70450195266
-
Implications for KRAS status and EGFR-targeted therapies in metastatic CRC
-
Normanno N, Tejpar S, Morgillo F, De Luca A, Van Cutsem E, Ciardiello F. Implications for KRAS status and EGFR-targeted therapies in metastatic CRC. Nat Rev Clin Oncol 2009; 6:519-27.
-
(2009)
Nat Rev Clin Oncol
, vol.6
, pp. 519-527
-
-
Normanno, N.1
Tejpar, S.2
Morgillo, F.3
De Luca, A.4
Van Cutsem, E.5
Ciardiello, F.6
-
43
-
-
20144381957
-
Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry
-
Chung KY, Shia J, Kemeny NE, Shah M, Schwartz GK, Tse A, et al. Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J Clin Oncol 2005; 23:1803-10.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1803-1810
-
-
Chung, K.Y.1
Shia, J.2
Kemeny, N.E.3
Shah, M.4
Schwartz, G.K.5
Tse, A.6
-
44
-
-
42649145667
-
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
-
Amado RG, Wolf M, Peeters M, Van Cutsem E, Siena S, Freeman DJ, et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008; 26:1626-34.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
Van Cutsem, E.4
Siena, S.5
Freeman, D.J.6
-
45
-
-
65349189958
-
American Society of Clinical Oncology Provisional Clinical Opinion: Testing for KRAS Gene Mutations in Patients with Metastatic Colorectal Carcinoma to Predict Response to Anti-Epidermal Growth Factor Receptor Monoclonal Antibody Therapy
-
Allegra CJ, Jessup JM, Somerfield MR, Hamilton SR, Hammond EH, Hayes DF, et al. American Society of Clinical Oncology Provisional Clinical Opinion: Testing for KRAS Gene Mutations in Patients With Metastatic Colorectal Carcinoma to Predict Response to Anti-Epidermal Growth Factor Receptor Monoclonal Antibody Therapy. J Clin Oncol 2009.
-
(2009)
J Clin Oncol
-
-
Allegra, C.J.1
Jessup, J.M.2
Somerfield, M.R.3
Hamilton, S.R.4
Hammond, E.H.5
Hayes, D.F.6
-
46
-
-
61449202998
-
The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: Analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer
-
Hurwitz HI, Yi J, Ince W, Novotny WF, Rosen O. The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer. Oncologist 2009; 14:22-8.
-
(2009)
Oncologist
, vol.14
, pp. 22-28
-
-
Hurwitz, H.I.1
Yi, J.2
Ince, W.3
Novotny, W.F.4
Rosen, O.5
-
47
-
-
57449095367
-
Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
-
Di Nicolantonio F, Martini M, Molinari F, Sartore-Bianchi A, Arena S, Saletti P, et al. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol 2008; 26:5705-12.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5705-5712
-
-
Di Nicolantonio, F.1
Martini, M.2
Molinari, F.3
Sartore-Bianchi, A.4
Arena, S.5
Saletti, P.6
-
48
-
-
28844448182
-
Oncogenic PI3K deregulates transcription and translation
-
Bader AG, Kang S, Zhao L, Vogt PK. Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer 2005; 5:921-9.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 921-929
-
-
Bader, A.G.1
Kang, S.2
Zhao, L.3
Vogt, P.K.4
-
50
-
-
73349094741
-
Analysis of PTEN BRAF and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer
-
Laurent-Puig P, Cayre A, Manceau G, Buc E, Bachet JB, Lecomte T, et al. Analysis of PTEN, BRAF and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer. J Clin Oncol 2009; 27:5924-30.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5924-5930
-
-
Laurent-Puig, P.1
Cayre, A.2
Manceau, G.3
Buc, E.4
Bachet, J.B.5
Lecomte, T.6
-
51
-
-
62449302407
-
PIK3CA Mutations in Colorectal Cancer Are Associated with Clinical Resistance to EGFR-Targeted Monoclonal Antibodies
-
Sartore-Bianchi A, Martini M, Molinari F, Veronese S, Nichelatti M, Artale S, et al. PIK3CA Mutations in Colorectal Cancer Are Associated with Clinical Resistance to EGFR-Targeted Monoclonal Antibodies. Cancer Res 2009.
-
(2009)
Cancer Res
-
-
Sartore-Bianchi, A.1
Martini, M.2
Molinari, F.3
Veronese, S.4
Nichelatti, M.5
Artale, S.6
-
52
-
-
65649086786
-
PIK3CA Mutations Are Not a Major Determinant of Resistance to the Epidermal Growth Factor Receptor Inhibitor Cetuximab in Metastatic Colorectal Cancer
-
Prenen H, De Schutter J, Jacobs B, De Roock W, Biesmans B, Claes B, et al. PIK3CA Mutations Are Not a Major Determinant of Resistance to the Epidermal Growth Factor Receptor Inhibitor Cetuximab in Metastatic Colorectal Cancer. Clin Cancer Res 2009.
-
(2009)
Clin Cancer Res
-
-
Prenen, H.1
De Schutter, J.2
Jacobs, B.3
De Roock, W.4
Biesmans, B.5
Claes, B.6
-
53
-
-
68949146819
-
Nimotuzumab: A novel anti-EGFR monoclonal antibody that retains anti-EGFR activity while minimizing skin toxicity
-
Boland WK, Bebb G. Nimotuzumab: a novel anti-EGFR monoclonal antibody that retains anti-EGFR activity while minimizing skin toxicity. Expert Opin Biol Ther 2009; 9:1199-206.
-
(2009)
Expert Opin Biol Ther
, vol.9
, pp. 1199-1206
-
-
Boland, W.K.1
Bebb, G.2
-
54
-
-
77953712023
-
A phase II clinical trial of nimotuzumab, an EGFR monoclonal antibody, in metastatic colorectal cancer
-
Shah AMCE, Jonker D, Zibdawi I, Mackenzie M, Walde D, Siddiqui J, et al. A phase II clinical trial of nimotuzumab, an EGFR monoclonal antibody, in metastatic colorectal cancer. 2009 Gastrointestinal Cancers Symposium. http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst-detail- view&confID=63&abstractID=10679, 2009.
-
(2009)
2009 Gastrointestinal Cancers Symposium
-
-
Shah, A.M.C.E.1
Jonker, D.2
Zibdawi, I.3
Mackenzie, M.4
Walde, D.5
Siddiqui, J.6
-
55
-
-
70349685092
-
CEACAM5-targeted therapy of human colonic and pancreatic cancer xenografts with potent labetuzumab-SN-38 immunoconjugates
-
Govindan SV, Cardillo TM, Moon SJ, Hansen HJ, Goldenberg DM. CEACAM5-targeted therapy of human colonic and pancreatic cancer xenografts with potent labetuzumab-SN-38 immunoconjugates. Clin Cancer Res 2009; 15:6052-61.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6052-6061
-
-
Govindan, S.V.1
Cardillo, T.M.2
Moon, S.J.3
Hansen, H.J.4
Goldenberg, D.M.5
-
56
-
-
10744222441
-
EphB2 as a therapeutic antibody drug target for the treatment of colorectal cancer
-
Mao W, Luis E, Ross S, Silva J, Tan C, Crowley C, et al. EphB2 as a therapeutic antibody drug target for the treatment of colorectal cancer. Cancer Res 2004; 64:781-8.
-
(2004)
Cancer Res
, vol.64
, pp. 781-788
-
-
Mao, W.1
Luis, E.2
Ross, S.3
Silva, J.4
Tan, C.5
Crowley, C.6
-
57
-
-
63549094211
-
Tumor-targeted nanomedicines: Enhanced antitumor efficacy in vivo of doxorubicin-loaded, long-circulating liposomes modified with cancer-specific monoclonal antibody
-
ElBayoumi TA, Torchilin VP. Tumor-targeted nanomedicines: enhanced antitumor efficacy in vivo of doxorubicin-loaded, long-circulating liposomes modified with cancer-specific monoclonal antibody. Clin Cancer Res 2009; 15:1973-80.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 1973-1980
-
-
ElBayoumi, T.A.1
Torchilin, V.P.2
-
59
-
-
48749119784
-
Cetuximab in combination with weekly 5-fluorouracil/folinic acid and oxaliplatin (FUFOX) in untreated patients with advanced colorectal cancer: A phase Ib/II study of the AIO GI Group
-
Arnold D, Hohler T, Dittrich C, Lordick F, Seufferlein T, Riemann J, et al. Cetuximab in combination with weekly 5-fluorouracil/folinic acid and oxaliplatin (FUFOX) in untreated patients with advanced colorectal cancer: a phase Ib/II study of the AIO GI Group. Ann Oncol 2008; 19:1442-9.
-
(2008)
Ann Oncol
, vol.19
, pp. 1442-1449
-
-
Arnold, D.1
Hohler, T.2
Dittrich, C.3
Lordick, F.4
Seufferlein, T.5
Riemann, J.6
-
60
-
-
65649086838
-
Cetuximab in combination with irinotecan/5-fluorouracil/folinic acid (FOLFIRI) in the initial treatment of metastatic colorectal cancer: A multicentre two-part phase I/II study
-
Raoul JL, Van Laethem JL, Peeters M, Brezault C, Husseini F, Cals L, et al. Cetuximab in combination with irinotecan/5-fluorouracil/folinic acid (FOLFIRI) in the initial treatment of metastatic colorectal cancer: a multicentre two-part phase I/II study. BMC Cancer 2009; 9:112.
-
(2009)
BMC Cancer
, vol.9
, pp. 112
-
-
Raoul, J.L.1
Van Laethem, J.L.2
Peeters, M.3
Brezault, C.4
Husseini, F.5
Cals, L.6
-
61
-
-
36749067866
-
Phase II trial of cetuximab in combination with fluorouracil, leucovorin and oxaliplatin in the first-line treatment of metastatic colorectal cancer
-
Tabernero J, Van Cutsem E, Diaz-Rubio E, Cervantes A, Humblet Y, Andre T, et al. Phase II trial of cetuximab in combination with fluorouracil, leucovorin and oxaliplatin in the first-line treatment of metastatic colorectal cancer. J Clin Oncol 2007; 25:5225-32.
-
(2007)
J Clin Oncol
, vol.25
, pp. 5225-5232
-
-
Tabernero, J.1
Van Cutsem, E.2
Diaz-Rubio, E.3
Cervantes, A.4
Humblet, Y.5
Andre, T.6
-
62
-
-
44249111440
-
EPIC: Phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer
-
Sobrero AF, Maurel J, Fehrenbacher L, Scheithauer W, Abubakr YA, Lutz MP, et al. EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer. J Clin Oncol 2008; 26:2311-9.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2311-2319
-
-
Sobrero, A.F.1
Maurel, J.2
Fehrenbacher, L.3
Scheithauer, W.4
Abubakr, Y.A.5
Lutz, M.P.6
-
63
-
-
34548147248
-
Panitumumab monotherapy in patients with previously treated metastatic colorectal cancer
-
Hecht JR, Patnaik A, Berlin J, Venook A, Malik L, Tchekmedyian S, et al. Panitumumab monotherapy in patients with previously treated metastatic colorectal cancer. Cancer 2007; 110:980-8.
-
(2007)
Cancer
, vol.110
, pp. 980-988
-
-
Hecht, J.R.1
Patnaik, A.2
Berlin, J.3
Venook, A.4
Malik, L.5
Tchekmedyian, S.6
-
64
-
-
34247480064
-
Panitumumab with irinotecan/leucovorin/5-fluorouracil for first-line treatment of metastatic colorectal cancer
-
Berlin J, Posey J, Tchekmedyian S, Hu E, Chan D, Malik I, et al. Panitumumab with irinotecan/leucovorin/5-fluorouracil for first-line treatment of metastatic colorectal cancer. Clin Colorectal Cancer 2007; 6:427-32.
-
(2007)
Clin Colorectal Cancer
, vol.6
, pp. 427-432
-
-
Berlin, J.1
Posey, J.2
Tchekmedyian, S.3
Hu, E.4
Chan, D.5
Malik, I.6
-
65
-
-
70350103864
-
Bevacizumab in association with de Gramont 5-fluorouracil/folinic acid in patients with oxaliplatin-, irinotecan- and cetuximab-refractory colorectal cancer: A single-center phase 2 trial
-
Vincenzi B, Santini D, Russo A, Spoto C, Venditti O, Gasparro S, et al. Bevacizumab in association with de Gramont 5-fluorouracil/folinic acid in patients with oxaliplatin-, irinotecan- and cetuximab-refractory colorectal cancer: a single-center phase 2 trial. Cancer 2009; 115:4849-56.
-
(2009)
Cancer
, vol.115
, pp. 4849-4856
-
-
Vincenzi, B.1
Santini, D.2
Russo, A.3
Spoto, C.4
Venditti, O.5
Gasparro, S.6
-
66
-
-
42949149159
-
Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
-
Saltz LB, Clarke S, Diaz-Rubio E, Scheithauer W, Figer A, Wong R, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol 2008; 26:2013-9.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2013-2019
-
-
Saltz, L.B.1
Clarke, S.2
Diaz-Rubio, E.3
Scheithauer, W.4
Figer, A.5
Wong, R.6
-
67
-
-
35648941728
-
Randomized phase II trial of cetuximab, bevacizumab and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: The BOND-2 study
-
Saltz LB, Lenz HJ, Kindler HL, Hochster HS, Wadler S, Hoff PM, et al. Randomized phase II trial of cetuximab, bevacizumab and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: the BOND-2 study. J Clin Oncol 2007; 25:4557-61.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4557-4561
-
-
Saltz, L.B.1
Lenz, H.J.2
Kindler, H.L.3
Hochster, H.S.4
Wadler, S.5
Hoff, P.M.6
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