메뉴 건너뛰기




Volumn 63, Issue 3, 2014, Pages 947-959

Hepatic overexpression of ATP synthase β subunit activates PI3K/Akt pathway to ameliorate hyperglycemia of diabetic mice

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GLUCONEOGENESIS; HEP G2 CELLS; HUMANS; HYPERGLYCEMIA; LIVER; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STREPTOZOCIN;

EID: 84894458421     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-1096     Document Type: Article
Times cited : (52)

References (55)
  • 1
    • 73749083481 scopus 로고    scopus 로고
    • Global estimates of the prevalence of diabetes for 2010 and 2030
    • Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 2010;87:4-14
    • (2010) Diabetes Res Clin Pract , vol.87 , pp. 4-14
    • Shaw, J.E.1    Sicree, R.A.2    Zimmet, P.Z.3
  • 2
    • 33645982255 scopus 로고    scopus 로고
    • From mice to men: Insights into the insulin resistance syndromes
    • Biddinger SB, Kahn CR. From mice to men: insights into the insulin resistance syndromes. Annu Rev Physiol 2006;68:123-158
    • (2006) Annu Rev Physiol , vol.68 , pp. 123-158
    • Biddinger, S.B.1    Kahn, C.R.2
  • 3
    • 77951638914 scopus 로고    scopus 로고
    • Basal release of ATP: An autocrine-paracrine mechanism for cell regulation
    • Corriden R, Insel PA. Basal release of ATP: an autocrine-paracrine mechanism for cell regulation. Sci Signal 2010;3:re1
    • (2010) Sci Signal , vol.3
    • Corriden, R.1    Insel, P.A.2
  • 4
    • 19944426266 scopus 로고    scopus 로고
    • Leucine culture reveals that ATP synthase functions as a fuel sensor in pancreatic beta-cells
    • Yang J, Wong RK, Wang X, et al. Leucine culture reveals that ATP synthase functions as a fuel sensor in pancreatic beta-cells. J Biol Chem 2004;279: 53915-53923
    • (2004) J Biol Chem , vol.279 , pp. 53915-53923
    • Yang, J.1    Wong, R.K.2    Wang, X.3
  • 5
    • 33644753928 scopus 로고    scopus 로고
    • Leucine regulation of glucokinase and ATP synthase sensitizes glucose-induced insulin secretion in pancreatic betacells
    • Yang J, Wong RK, Park M, et al. Leucine regulation of glucokinase and ATP synthase sensitizes glucose-induced insulin secretion in pancreatic betacells. Diabetes 2006;55:193-201
    • (2006) Diabetes , vol.55 , pp. 193-201
    • Yang, J.1    Wong, R.K.2    Park, M.3
  • 6
    • 45749128962 scopus 로고    scopus 로고
    • Hepatic changes in adenine nucleotide levels and adenosine 39-monophosphate forming enzyme in streptozotocin-induced diabetic mice
    • Miyamoto A, Takeshita M, Pan-Hou H, Fujimori H. Hepatic changes in adenine nucleotide levels and adenosine 39-monophosphate forming enzyme in streptozotocin-induced diabetic mice. J Toxicol Sci 2008;33:209-217
    • (2008) J Toxicol Sci , vol.33 , pp. 209-217
    • Miyamoto, A.1    Takeshita, M.2    Pan-Hou, H.3    Fujimori, H.4
  • 7
    • 68849090270 scopus 로고    scopus 로고
    • Hepatic energy state is regulated by glucagon receptor signaling in mice
    • Berglund ED, Lee-Young RS, Lustig DG, et al. Hepatic energy state is regulated by glucagon receptor signaling in mice. J Clin Invest 2009;119: 2412-2422
    • (2009) J Clin Invest , vol.119 , pp. 2412-2422
    • Berglund, E.D.1    Lee-Young, R.S.2    Lustig, D.G.3
  • 8
    • 40749091283 scopus 로고    scopus 로고
    • Alterations of hepatic ATP homeostasis and respiratory chain during development of non-alcoholic steatohepatitis in a rodent model
    • Serviddio G, Bellanti F, Tamborra R, et al. Alterations of hepatic ATP homeostasis and respiratory chain during development of non-alcoholic steatohepatitis in a rodent model. Eur J Clin Invest 2008;38:245-252
    • (2008) Eur J Clin Invest , vol.38 , pp. 245-252
    • Serviddio, G.1    Bellanti, F.2    Tamborra, R.3
  • 9
    • 70350043496 scopus 로고    scopus 로고
    • Abnormal hepatic energy homeostasis in type 2 diabetes
    • Szendroedi J, Chmelik M, Schmid AI, et al. Abnormal hepatic energy homeostasis in type 2 diabetes. Hepatology 2009;50:1079-1086
    • (2009) Hepatology , vol.50 , pp. 1079-1086
    • Szendroedi, J.1    Chmelik, M.2    Schmid, A.I.3
  • 10
    • 79951697487 scopus 로고    scopus 로고
    • Liver ATP synthesis is lower and relates to insulin sensitivity in patients with type 2 diabetes
    • Schmid AI, Szendroedi J, Chmelik M, Krssák M, Moser E, Roden M. Liver ATP synthesis is lower and relates to insulin sensitivity in patients with type 2 diabetes. Diabetes Care 2011;34:448-453
    • (2011) Diabetes Care , vol.34 , pp. 448-453
    • Schmid, A.I.1    Szendroedi, J.2    Chmelik, M.3    Krssák, M.4    Moser, E.5    Roden, M.6
  • 11
    • 84888187278 scopus 로고    scopus 로고
    • The hepatic cannabinoid 1 receptor as a modulator of hepatic energy state and food intake
    • March 4 [Epub ahead of print]
    • Cooper ME, Regnell SE. The hepatic cannabinoid 1 receptor as a modulator of hepatic energy state and food intake. Br J Clin Pharmacol 2013 March 4 [Epub ahead of print]
    • (2013) Br J Clin Pharmacol
    • Cooper, M.E.1    Regnell, S.E.2
  • 12
    • 0037285725 scopus 로고    scopus 로고
    • Hepatic ATP reserve and efficiency of replenishing: Comparison between obese and nonobese normal individuals
    • Nair S, P Chacko V, Arnold C, Diehl AM. Hepatic ATP reserve and efficiency of replenishing: comparison between obese and nonobese normal individuals. Am J Gastroenterol 2003;98:466-470
    • (2003) Am J Gastroenterol , vol.98 , pp. 466-470
    • Nair, S.1    Chacko, V.P.2    Arnold, C.3    Diehl, A.M.4
  • 13
    • 50949085716 scopus 로고    scopus 로고
    • Pck1 gene silencing in the liver improves glycemia control, insulin sensitivity, and dyslipidemia in db/db mice
    • Gómez-Valadés AG, Méndez-Lucas A, Vidal-Alabró A, et al. Pck1 gene silencing in the liver improves glycemia control, insulin sensitivity, and dyslipidemia in db/db mice. Diabetes 2008;57:2199-2210
    • (2008) Diabetes , vol.57 , pp. 2199-2210
    • Gómez-Valadés, A.G.1    Méndez-Lucas, A.2    Vidal-Alabró, A.3
  • 15
    • 79957521884 scopus 로고    scopus 로고
    • Pancreatic-derived factor promotes lipogenesis in the mouse liver: Role of the Forkhead box 1 signaling pathway
    • Li J, Chi Y, Wang C, et al. Pancreatic-derived factor promotes lipogenesis in the mouse liver: role of the Forkhead box 1 signaling pathway. Hepatology 2011;53:1906-1916
    • (2011) Hepatology , vol.53 , pp. 1906-1916
    • Li, J.1    Chi, Y.2    Wang, C.3
  • 16
    • 33845947091 scopus 로고    scopus 로고
    • Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappaB in db/db mice
    • Tamura Y, Ogihara T, Uchida T, et al. Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappaB in db/db mice. Diabetologia 2007;50:131-141
    • (2007) Diabetologia , vol.50 , pp. 131-141
    • Tamura, Y.1    Ogihara, T.2    Uchida, T.3
  • 17
    • 84872057896 scopus 로고    scopus 로고
    • Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
    • Kim KH, Jeong YT, Oh H, et al. Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nat Med 2013;19:83-92
    • (2013) Nat Med , vol.19 , pp. 83-92
    • Kim, K.H.1    Jeong, Y.T.2    Oh, H.3
  • 18
    • 78049314664 scopus 로고    scopus 로고
    • Pparg-P465L mutation worsens hyperglycemia in Ins2-Akita female mice via adipose-specific insulin resistance and storage dysfunction
    • Pendse AA, Johnson LA, Tsai YS, Maeda N. Pparg-P465L mutation worsens hyperglycemia in Ins2-Akita female mice via adipose-specific insulin resistance and storage dysfunction. Diabetes 2010;59:2890-2897
    • (2010) Diabetes , vol.59 , pp. 2890-2897
    • Pendse, A.A.1    Johnson, L.A.2    Tsai, Y.S.3    Maeda, N.4
  • 19
    • 33748463364 scopus 로고    scopus 로고
    • NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism
    • Pei L, Waki H, Vaitheesvaran B, Wilpitz DC, Kurland IJ, Tontonoz P. NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism. Nat Med 2006;12:1048-1055
    • (2006) Nat Med , vol.12 , pp. 1048-1055
    • Pei, L.1    Waki, H.2    Vaitheesvaran, B.3    Wilpitz, D.C.4    Kurland, I.J.5    Tontonoz, P.6
  • 20
    • 69949174739 scopus 로고    scopus 로고
    • PANDER binds to the liver cell membrane and inhibits insulin signaling in HepG2 cells
    • Yang J, Wang C, Li J, et al. PANDER binds to the liver cell membrane and inhibits insulin signaling in HepG2 cells. FEBS Lett 2009;583:3009-3015
    • (2009) FEBS Lett , vol.583 , pp. 3009-3015
    • Yang, J.1    Wang, C.2    Li, J.3
  • 21
    • 23944511121 scopus 로고    scopus 로고
    • Structure-function studies of PANDER, an islet specific cytokine inducing cell death of insulin-secreting beta cells
    • Yang J, Gao Z, Robert CE, et al. Structure-function studies of PANDER, an islet specific cytokine inducing cell death of insulin-secreting beta cells. Biochemistry 2005;44:11342-11352
    • (2005) Biochemistry , vol.44 , pp. 11342-11352
    • Yang, J.1    Gao, Z.2    Robert, C.E.3
  • 22
    • 53149138585 scopus 로고    scopus 로고
    • Deleterious action of FA metabolites on ATP synthesis: Possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance
    • Abdul-Ghani MA, Muller FL, Liu Y, et al. Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance. Am J Physiol Endocrinol Metab 2008; 295:E678-E685
    • (2008) Am J Physiol Endocrinol Metab , vol.295
    • Abdul-Ghani, M.A.1    Muller, F.L.2    Liu, Y.3
  • 23
    • 31144452713 scopus 로고    scopus 로고
    • Involvement of P2 receptors in the growth and survival of neurons in the CNS
    • Franke H, Illes P. Involvement of P2 receptors in the growth and survival of neurons in the CNS. Pharmacol Ther 2006;109:297-324
    • (2006) Pharmacol Ther , vol.109 , pp. 297-324
    • Franke, H.1    Illes, P.2
  • 24
    • 71149121137 scopus 로고    scopus 로고
    • ATP release after partial hepatectomy regulates liver regeneration in the rat
    • Gonzales E, Julien B, Serrière-Lanneau V, et al. ATP release after partial hepatectomy regulates liver regeneration in the rat. J Hepatol 2010;52:54-62
    • (2010) J Hepatol , vol.52 , pp. 54-62
    • Gonzales, E.1    Julien, B.2    Serrière-Lanneau, V.3
  • 25
    • 33749253862 scopus 로고    scopus 로고
    • Clozapine, a neuroleptic agent, inhibits Akt by counteracting Ca2+/calmodulin in PTEN-negative U-87MG human glioblastoma cells
    • Shin SY, Choi BH, Ko J, Kim SH, Kim YS, Lee YH. Clozapine, a neuroleptic agent, inhibits Akt by counteracting Ca2+/calmodulin in PTEN-negative U-87MG human glioblastoma cells. Cell Signal 2006;18:1876-1886
    • (2006) Cell Signal , vol.18 , pp. 1876-1886
    • Shin, S.Y.1    Choi, B.H.2    Ko, J.3    Kim, S.H.4    Kim, Y.S.5    Lee, Y.H.6
  • 26
    • 80051792845 scopus 로고    scopus 로고
    • Activation of the PI3K/Akt signaling pathway through P2Y2 receptors by extracellular ATP is involved in osteoblastic cell proliferation
    • Katz S, Ayala V, Santillán G, Boland R. Activation of the PI3K/Akt signaling pathway through P2Y2 receptors by extracellular ATP is involved in osteoblastic cell proliferation. Arch Biochem Biophys 2011;513:144-152
    • (2011) Arch Biochem Biophys , vol.513 , pp. 144-152
    • Katz, S.1    Ayala, V.2    Santillán, G.3    Boland, R.4
  • 27
    • 79251557845 scopus 로고    scopus 로고
    • Targeting Forkhead box O1 from the concept to metabolic diseases: Lessons from mouse models
    • Cheng Z, White MF. Targeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models. Antioxid Redox Signal 2011;14:649-661
    • (2011) Antioxid Redox Signal , vol.14 , pp. 649-661
    • Cheng, Z.1    White, M.F.2
  • 28
    • 84877082028 scopus 로고    scopus 로고
    • Induction of ATP synthase b by H2O2 induces melanogenesis by activating PAH and cAMP/CREB/MITF signaling in melanoma cells
    • Kim HE, Lee SG. Induction of ATP synthase b by H2O2 induces melanogenesis by activating PAH and cAMP/CREB/MITF signaling in melanoma cells. Int J Biochem Cell Biol 2013;45:1217-1222
    • (2013) Int J Biochem Cell Biol , vol.45 , pp. 1217-1222
    • Kim, H.E.1    Lee, S.G.2
  • 29
    • 60449098150 scopus 로고    scopus 로고
    • Proteomic analysis of hepatic ischemia/ reperfusion injury and ischemic preconditioning in mice revealed the protective role of ATP5beta
    • Xu C, Zhang X, Yu C, et al. Proteomic analysis of hepatic ischemia/ reperfusion injury and ischemic preconditioning in mice revealed the protective role of ATP5beta. Proteomics 2009;9:409-419
    • (2009) Proteomics , vol.9 , pp. 409-419
    • Xu, C.1    Zhang, X.2    Yu, C.3
  • 30
    • 79960212462 scopus 로고    scopus 로고
    • Pannexin 3 functions as an ER Ca(2+) channel, hemichannel, and gap junction to promote osteoblast differentiation
    • Ishikawa M, Iwamoto T, Nakamura T, Doyle A, Fukumoto S, Yamada Y. Pannexin 3 functions as an ER Ca(2+) channel, hemichannel, and gap junction to promote osteoblast differentiation. J Cell Biol 2011;193:1257-1274
    • (2011) J Cell Biol , vol.193 , pp. 1257-1274
    • Ishikawa, M.1    Iwamoto, T.2    Nakamura, T.3    Doyle, A.4    Fukumoto, S.5    Yamada, Y.6
  • 31
    • 84876526228 scopus 로고    scopus 로고
    • Electrical stimuli release ATP to increase GLUT4 translocation and glucose uptake via PI3Kg-Akt-AS160 in skeletal muscle cells
    • Osorio-Fuentealba C, Contreras-Ferrat AE, Altamirano F, et al. Electrical stimuli release ATP to increase GLUT4 translocation and glucose uptake via PI3Kg-Akt-AS160 in skeletal muscle cells. Diabetes 2013;62:1519-1526
    • (2013) Diabetes , vol.62 , pp. 1519-1526
    • Osorio-Fuentealba, C.1    Contreras-Ferrat, A.E.2    Altamirano, F.3
  • 32
    • 84865388591 scopus 로고    scopus 로고
    • Extracellular ATP attenuates ischemia-induced caspase-3 cleavage in human endothelial cells
    • Urban D, Härtel FV, Gadiraju K, et al. Extracellular ATP attenuates ischemia-induced caspase-3 cleavage in human endothelial cells. Biochem Biophys Res Commun 2012;425:230-236
    • (2012) Biochem Biophys Res Commun , vol.425 , pp. 230-236
    • Urban, D.1    Härtel, F.V.2    Gadiraju, K.3
  • 33
    • 39549091300 scopus 로고    scopus 로고
    • Characterization of ionotrophic purinergic receptors in hepatocytes
    • Emmett DS, Feranchak A, Kilic G, et al. Characterization of ionotrophic purinergic receptors in hepatocytes. Hepatology 2008;47:698-705
    • (2008) Hepatology , vol.47 , pp. 698-705
    • Emmett, D.S.1    Feranchak, A.2    Kilic, G.3
  • 34
    • 0033913902 scopus 로고    scopus 로고
    • Volume-sensitive purinergic signaling in human hepatocytes
    • Feranchak AP, Fitz JG, Roman RM. Volume-sensitive purinergic signaling in human hepatocytes. J Hepatol 2000;33:174-182
    • (2000) J Hepatol , vol.33 , pp. 174-182
    • Feranchak, A.P.1    Fitz, J.G.2    Roman, R.M.3
  • 35
    • 84875642466 scopus 로고    scopus 로고
    • Altered responsiveness to extracellular ATP enhances acetaminophen hepatotoxicity
    • Amaral SS, Oliveira AG, Marques PE, et al. Altered responsiveness to extracellular ATP enhances acetaminophen hepatotoxicity. Cell Commun Signal 2013;11:10
    • (2013) Cell Commun Signal , vol.11 , pp. 10
    • Amaral, S.S.1    Oliveira, A.G.2    Marques, P.E.3
  • 36
    • 0034670388 scopus 로고    scopus 로고
    • Changes in intracellular Ca2+ by activation of P2 receptors in submucosal neurons in short-term cultures
    • Barajas-López C, Espinosa-Luna R, Christofi FL. Changes in intracellular Ca2+ by activation of P2 receptors in submucosal neurons in short-term cultures. Eur J Pharmacol 2000;409:243-257
    • (2000) Eur J Pharmacol , vol.409 , pp. 243-257
    • Barajas-López, C.1    Espinosa-Luna, R.2    Christofi, F.L.3
  • 37
    • 0037470163 scopus 로고    scopus 로고
    • Calmodulin mediates brain-derived neurotrophic factor cell survival signaling upstream of Akt kinase in embryonic neocortical neurons
    • Cheng A, Wang S, Yang D, Xiao R, Mattson MP. Calmodulin mediates brain-derived neurotrophic factor cell survival signaling upstream of Akt kinase in embryonic neocortical neurons. J Biol Chem 2003;278:7591-7599
    • (2003) J Biol Chem , vol.278 , pp. 7591-7599
    • Cheng, A.1    Wang, S.2    Yang, D.3    Xiao, R.4    Mattson, M.P.5
  • 38
    • 77249100829 scopus 로고    scopus 로고
    • Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation
    • Sopasakis VR, Liu P, Suzuki R, et al. Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation. Cell Metab 2010;11:220-230
    • (2010) Cell Metab , vol.11 , pp. 220-230
    • Sopasakis, V.R.1    Liu, P.2    Suzuki, R.3
  • 39
    • 0033546717 scopus 로고    scopus 로고
    • Glibenclamide induces apoptosis through inhibition of cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channels and intracellular Ca(2+) release in HepG2 human hepatoblastoma cells
    • Kim JA, Kang YS, Lee SH, Lee EH, Yoo BH, Lee YS. Glibenclamide induces apoptosis through inhibition of cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channels and intracellular Ca(2+) release in HepG2 human hepatoblastoma cells. Biochem Biophys Res Commun 1999;261: 682-688
    • (1999) Biochem Biophys Res Commun , vol.261 , pp. 682-688
    • Kim, J.A.1    Kang, Y.S.2    Lee, S.H.3    Lee, E.H.4    Yoo, B.H.5    Lee, Y.S.6
  • 40
    • 84875063009 scopus 로고    scopus 로고
    • Genipin stimulates glucose transport in C2C12 myotubes via an IRS-1 and calcium-dependent mechanism
    • Ma CJ, Nie AF, Zhang ZJ, et al. Genipin stimulates glucose transport in C2C12 myotubes via an IRS-1 and calcium-dependent mechanism. J Endocrinol 2013;216:353-362
    • (2013) J Endocrinol , vol.216 , pp. 353-362
    • Ma, C.J.1    Nie, A.F.2    Zhang, Z.J.3
  • 42
    • 77949272758 scopus 로고    scopus 로고
    • Human ATP synthase beta is phosphorylated at multiple sites and shows abnormal phosphorylation at specific sites in insulin-resistant muscle
    • Højlund K, Yi Z, Lefort N, et al. Human ATP synthase beta is phosphorylated at multiple sites and shows abnormal phosphorylation at specific sites in insulin-resistant muscle. Diabetologia 2010;53:541-551
    • (2010) Diabetologia , vol.53 , pp. 541-551
    • Højlund, K.1    Yi, Z.2    Lefort, N.3
  • 43
    • 0038576291 scopus 로고    scopus 로고
    • Proteome analysis reveals phosphorylation of ATP synthase beta-subunit in human skeletal muscle and proteins with potential roles in type 2 diabetes
    • Højlund K, Wrzesinski K, Larsen PM, et al. Proteome analysis reveals phosphorylation of ATP synthase beta-subunit in human skeletal muscle and proteins with potential roles in type 2 diabetes. J Biol Chem 2003;278: 10436-10442
    • (2003) J Biol Chem , vol.278 , pp. 10436-10442
    • Højlund, K.1    Wrzesinski, K.2    Larsen, P.M.3
  • 44
    • 73949160860 scopus 로고    scopus 로고
    • Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells
    • Hirabara SM, Curi R, Maechler P. Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells. J Cell Physiol 2010;222:187-194
    • (2010) J Cell Physiol , vol.222 , pp. 187-194
    • Hirabara, S.M.1    Curi, R.2    Maechler, P.3
  • 45
    • 84879885429 scopus 로고    scopus 로고
    • Amelioration of palmitate-induced insulin resistance in C2C12 muscle cells by rooibos (Aspalathus linearis)
    • Mazibuko SE, Muller CJ, Joubert E, et al. Amelioration of palmitate-induced insulin resistance in C2C12 muscle cells by rooibos (Aspalathus linearis). Phytomedicine 2013;20:813-819
    • (2013) Phytomedicine , vol.20 , pp. 813-819
    • Mazibuko, S.E.1    Muller, C.J.2    Joubert, E.3
  • 46
    • 34250021550 scopus 로고    scopus 로고
    • Insulin resistance and the mitochondrial link. Lessons from cultured human myotubes
    • Gaster M. Insulin resistance and the mitochondrial link. Lessons from cultured human myotubes. Biochim Biophys Acta 2007;1772:755-765
    • (2007) Biochim Biophys Acta , vol.1772 , pp. 755-765
    • Gaster, M.1
  • 47
    • 77956921023 scopus 로고    scopus 로고
    • The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways
    • Gao D, Nong S, Huang X, et al. The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways. J Biol Chem 2010;285: 29965-29973
    • (2010) J Biol Chem , vol.285 , pp. 29965-29973
    • Gao, D.1    Nong, S.2    Huang, X.3
  • 48
    • 84874806070 scopus 로고    scopus 로고
    • Mechanisms of insulin resistance in obesity
    • Ye J. Mechanisms of insulin resistance in obesity. Front Med 2013;7:14-24
    • (2013) Front Med , vol.7 , pp. 14-24
    • Ye, J.1
  • 49
    • 65349177200 scopus 로고    scopus 로고
    • AMPK: An emerging drug target for diabetes and the metabolic syndrome
    • Zhang BB, Zhou G, Li C. AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell Metab 2009;9:407-416
    • (2009) Cell Metab , vol.9 , pp. 407-416
    • Zhang, B.B.1    Zhou, G.2    Li, C.3
  • 50
    • 77954933558 scopus 로고    scopus 로고
    • Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
    • Foretz M, Hébrard S, Leclerc J, et al. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J Clin Invest 2010;120:2355-2369
    • (2010) J Clin Invest , vol.120 , pp. 2355-2369
    • Foretz, M.1    Hébrard, S.2    Leclerc, J.3
  • 51
    • 12144291275 scopus 로고    scopus 로고
    • Thiazolidinediones, like metformin, inhibit respiratory complex I: A common mechanism contributing to their antidiabetic actions?
    • Brunmair B, Staniek K, Gras F, et al. Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions? Diabetes 2004;53:1052-1059
    • (2004) Diabetes , vol.53 , pp. 1052-1059
    • Brunmair, B.1    Staniek, K.2    Gras, F.3
  • 52
    • 82455209029 scopus 로고    scopus 로고
    • Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status
    • Stephenne X, Foretz M, Taleux N, et al. Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status. Diabetologia 2011;54:3101-3110
    • (2011) Diabetologia , vol.54 , pp. 3101-3110
    • Stephenne, X.1    Foretz, M.2    Taleux, N.3
  • 53
    • 77951298589 scopus 로고    scopus 로고
    • Ghrelin inhibits insulin secretion through the AMPK-UCP2 pathway in beta cells
    • Wang Y, Nishi M, Doi A, et al. Ghrelin inhibits insulin secretion through the AMPK-UCP2 pathway in beta cells. FEBS Lett 2010;584:1503-1508
    • (2010) FEBS Lett , vol.584 , pp. 1503-1508
    • Wang, Y.1    Nishi, M.2    Doi, A.3
  • 54
    • 33847009048 scopus 로고    scopus 로고
    • AICAR potentiates ROS production induced by chronic high glucose: Roles of AMPK in pancreatic beta-cell apoptosis
    • Kim WH, Lee JW, Suh YH, et al. AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis. Cell Signal 2007;19:791-805
    • (2007) Cell Signal , vol.19 , pp. 791-805
    • Kim, W.H.1    Lee, J.W.2    Suh, Y.H.3
  • 55
    • 80053507266 scopus 로고    scopus 로고
    • AMPK potentiates hypertonicity-induced apoptosis by suppressing NFkB/COX-2 in medullary interstitial cells
    • Han Q, Zhang X, Xue R, et al. AMPK potentiates hypertonicity-induced apoptosis by suppressing NFkB/COX-2 in medullary interstitial cells. J Am Soc Nephrol 2011;22:1897-1911
    • (2011) J Am Soc Nephrol , vol.22 , pp. 1897-1911
    • Han, Q.1    Zhang, X.2    Xue, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.