AMPK potentiates hypertonicity-induced apoptosis by suppressing NFκB/COX-2 in medullary interstitial cells

Journal of the American Society of Nephrology

Volumn 22, Issue 10, 2011, Pages 1897-1911

  Han, Qifei ^a,c   Zhang, Xiaoyan ^a,b,c   Xue, Rui ^a,c   Yang, Hang ^a,c   Zhou, Yunfeng ^a,c   Kong, Xiaomu ^a,c   Zhao, Pan ^a,c   Li, Jing ^a,c   Yang, Jichun ^a,c   Zhu, Yi ^a,c   Guan, Youfei ^a,b,c  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c Research Center for Obesity and Metabolic Diseases   (China)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENYLATE KINASE; ADENYLATE KINASE ACTIVATOR; ANTIDIABETIC AGENT; CYCLOOXYGENASE 2; ENZYME ACTIVATOR; HYPERTONIC SOLUTION; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DEHYDRATION; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME PHOSPHORYLATION; KIDNEY DYSFUNCTION; KIDNEY INTERSTITIUM; KIDNEY MEDULLA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; WATER DEPRIVATION;

EID: 80053507266     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2010080822     Document Type: Article

References (56)

1. Brezis M, Rosen S: Hypoxia of the renal medulla: Its implications for disease. N Engl J Med 332: 647-655, 1995
2. Neuhofer W, Beck FX: Cell survival in the hostile environment of the renal medulla. Annu Rev Physiol 67: 531-555, 2005 (Pubitemid 40404500)
3. Chou SY, Porush JG, Faubert PF: Renal medullary circulation: Hormonal control. Kidney Int 37: 1-13, 1990 (Pubitemid 20023760)
4. Beck FX, Schmolke M, Guder WG: Osmolytes. Curr Opin Nephrol Hypertens 1: 43-52, 1992
5. Burger-Kentischer A, Muller E, Marz J, Fraek ML, Thurau K, Beck FX: Hypertonicity-induced accumulation of organic osmolytes in papillary interstitial cells. Kidney Int 55: 1417-1425, 1999 (Pubitemid 29157140)
6. Na KY, Woo SK, Lee SD, Kwon HM: Silencing of TonEBP/NFAT5 transcriptional activator by RNA interference. J Am Soc Nephrol 14: 283-288, 2003 (Pubitemid 36150850)
7. Lopez-Rodriguez C, Antos CL, Shelton JM, Richardson JA, Lin F, Novobrantseva TI, Bronson RT, Igarashi P, Rao A, Olson EN: Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression. Proc Natl Acad Sci USA 101: 2392-2397, 2004 (Pubitemid 38269322)
8. Ohtaka A, Muto S, Nemoto J, Kawakami K, Nagano K, Asano Y: Hyperosmolality stimulates Na-K-ATPase gene expression in inner medullary collecting duct cells. Am J Physiol 270: F728-F738, 1996
9. Capasso JM, Rivard CJ, Berl T: Long-term adaptation of renal cells to hypertonicity: Role of MAP kinases and Na-K-ATPase. Am J Physiol Renal Physiol 280: F768-F776, 2001
10. Capasso JM, Rivard CJ, Enomoto LM, Berl T: Adaptation of murine inner medullary collecting duct (IMCD3) cell cultures to hypertonicity. Ann NY Acad Sci 986: 410-415, 2003 (Pubitemid 36584142)
11. Wang W, Guan KL: AMP-activated protein kinase and cancer. Acta Physiol 196: 55-63, 2009
12. Salt IP, Johnson G, Ashcroft SJ, Hardie DG: AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release. Biochem J 335: 533-539, 1998 (Pubitemid 28515405)
13. Musi N, Fujii N, Hirshman MF, Ekberg I, Froberg S, Ljungqvist O, Thorell A, Goodyear LJ: AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise. Diabetes 50: 921-927, 2001 (Pubitemid 32374520)
14. Mu J, Brozinick JT, Jr., Valladares O, Bucan M, Birnbaum MJ: A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle. Mol Cell 7: 1085-1094, 2001 (Pubitemid 32525754)
15. Fraser S, Mount P, Hill R, Levidiotis V, Katsis F, Stapleton D, Kemp BE, Power DA: Regulation of the energy sensor AMP-activated protein kinase in the kidney by dietary salt intake and osmolality. Am J Physiol Renal Physiol 288: F578-F586, 2005 (Pubitemid 40279465)
16. Okoshi R, Ozaki T, Yamamoto H, Ando K, Koida N, Ono S, Koda T, Kamijo T, Nakagawara A, Kizaki H: Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress. J Biol Chem 283: 3979-3987, 2008
17. Hwang JT, Ha J, Park OJ: Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways. Biochem Biophys Res Commun 332: 433-440, 2005 (Pubitemid 40731495)
18. Khanal P, Oh WK, Thuong PT, Cho SD, Choi HS: 24-Hydroxyursolic acid from the leaves of the Diospyros kaki (Persimmon) induces apoptosis by activation of AMP-activated protein kinase. Planta Med 76: 689-693
19. Hao CM, Yull F, Blackwell T, Komhoff M, Davis LS, Breyer MD: Dehydration activates an NF-kappaB-driven, COX2-dependent survival mechanism in renal medullary interstitial cells. J Clin Invest 106: 973-982, 2000
20. Cacicedo JM, Yagihashi N, Keaney JF Jr, Ruderman NB, Ido Y: AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells. Biochem Biophys Res Commun 324: 1204-1209, 2004 (Pubitemid 40292150)
21. Burg MB, Ferraris JD, Dmitrieva NI: Cellular response to hyperosmotic stresses. Physiol Rev 87: 1441-1474, 2007 (Pubitemid 350033825)
22. Moeckel GW, Zhang L, Fogo AB, Hao CM, Pozzi A, Breyer MD: COX2 activity promotes organic osmolyte accumulation and adaptation of renal medullary interstitial cells to hypertonic stress. J Biol Chem 278: 19352-19357, 2003 (Pubitemid 36799330)
23. Sakoda H, Ogihara T, Anai M, Fujishiro M, Ono H, Onishi Y, Katagiri H, Abe M, Fukushima Y, Shojima N, Inukai K, Kikuchi M, Oka Y, Asano T: Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes. Am J Physiol Endocrinol Metab 282: E1239-E1244, 2002 (Pubitemid 34654692)
24. Chen ZP, McConell GK, Michell BJ, Snow RJ, Canny BJ, Kemp BE: AMPK signaling in contracting human skeletal muscle: Acetyl-CoA carboxylase and NO synthase phosphorylation. Am J Physiol Endocrinol Metab 279: E1202-E1206, 2000
25. Muoio DM, Seefeld K, Witters LA, Coleman RA: AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. Biochem J 338: 783-791, 1999 (Pubitemid 29140087)
26. Bergeron R, Previs SF, Cline GW, Perret P, Russell RR 3rd, Young LH, Shulman GI: Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats. Diabetes 50: 1076-1082, 2001 (Pubitemid 32374538)
27. Zhang BB, Zhou G, Li C: AMPK: An emerging drug target for diabetes and the metabolic syndrome. Cell Metab 9: 407-416, 2009
28. Hallows KR, Mount PF, Pastor-Soler NM, Power DA: Role of the energy sensor AMP-activated protein kinase in renal physiology and disease. Am J Physiol Renal Physiol 298: F1067-F1077, 2010
29. Carattino MD, Edinger RS, Grieser HJ, Wise R, Neumann D, Schlattner U, Johnson JP, Kleyman TR, Hallows KR: Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells. J Biol Chem 280: 17608-17616, 2005 (Pubitemid 41388995)
30. Lee MJ, Feliers D, Mariappan MM, Sataranatarajan K, Mahimainathan L, Musi N, Foretz M, Viollet B, Weinberg JM, Choudhury GG, Kasinath BS: A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy. Am J Physiol Renal Physiol 292: F617-F627, 2007 (Pubitemid 46220529)
31. Sharma K, Ramachandrarao S, Qiu G, Usui HK, Zhu Y, Dunn SR, Ouedraogo R, Hough K, McCue P, Chan L, Falkner B, Goldstein BJ: Adiponectin regulates albuminuria and podocyte function in mice. J Clin Invest 118: 1645-1656, 2008 (Pubitemid 351632369)
32. Miranda L, Carpentier S, Platek A, Hussain N, Gueuning MA, Vertommen D, Ozkan Y, Sid B, Hue L, Courtoy PJ, Rider MH, Horman S: AMP-activated protein kinase induces actin cytoskeleton reorganization in epithelial cells. Biochem Biophys Res Commun 396: 656-661
33. Krause MM, Brand MD, Krauss S, Meisel C, Vergin H, Burmester GR, Buttgereit F: Nonsteroidal antiinflammatory drugs and a selective cyclooxygenase 2 inhibitor uncouple mitochondria in intact cells. Arthritis Rheum 48: 1438-1444, 2003 (Pubitemid 36554544)
34. Yang T, Zhang A, Honeggar M, Kohan DE, Mizel D, Sanders K, Hoidal JR, Briggs JP, Schnermann JB: Hypertonic induction of COX-2 in collecting duct cells by reactive oxygen species of mitochondrial origin. J Biol Chem 280: 34966-34973, 2005 (Pubitemid 41504632)
35. Lamberts RR, Onderwater G, Hamdani N, Vreden MJ, Steenhuisen J, Eringa EC, Loer SA, Stienen GJ, Bouwman RA: Reactive oxygen species-induced stimulation of 5′AMP-activated protein kinase mediates sevoflurane-induced cardioprotection. Circulation 120: S10-S15, 2009
36. Yen CY, Lin MH, Liu SY, Chiang WF, Hsieh WF, Cheng YC, Hsu KC, Liu YC: Arecoline-mediated inhibition of AMP-activated protein kinase through reactive oxygen species is required for apoptosis induction. Oral Oncol 47: 345-351, 2011
37. Karin M: How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex. Oncogene 18: 6867-6874, 1999
38. Hao CM, Redha R, Morrow J, Breyer MD: Peroxisome proliferator-activated receptor delta activation promotes cell survival following hypertonic stress. J Biol Chem 277: 21341-21345, 2002 (Pubitemid 34952273)
39. Neuhofer W, Steinert D, Fraek ML, Beck FX: Prostaglandin E2 stimulates expression of osmoprotective genes in MDCK cells and promotes survival under hypertonic conditions. J Physiol 583: 287-297, 2007 (Pubitemid 47244259)
40. Steinert D, Kuper C, Bartels H, Beck FX, Neuhofer W: PGE2 potentiates tonicity-induced COX-2 expression in renal medullary cells in a positive feedback loop involving EP2-cAMP-PKA signaling. Am J Physiol Cell Physiol 296: C75-C87, 2009
41. Greenberg MM: In vitro and in vivo effects of oxidative damage to deoxyguanosine. Biochem Soc Trans 32: 46-50, 2004
42. Levine RL, Wehr N, Williams JA, Stadtman ER, Shacter E: Determination of carbonyl groups in oxidized proteins. Methods Mol Biol 99: 15-24, 2000
43. Zhou X, Ferraris JD, Cai Q, Agarwal A, Burg MB: Increased reactive oxygen species contribute to high NaCl-induced activation of the osmoregulatory transcription factor TonEBP/OREBP. Am J Physiol Renal Physiol 289: F377-F385, 2005 (Pubitemid 41003667)
44. Zhang Z, Yang XY, Cohen DM: Urea-associated oxidative stress and Gadd153/CHOP induction. Am J Physiol 276: F786-F793, 1999 (Pubitemid 29249698)
45. Liu C, Liang B, Wang Q, Wu J, Zou MH: Activation of AMP-activated protein kinase alpha1 alleviates endothelial cell apoptosis by increasing the expression of anti-apoptotic proteins Bcl-2 and survivin. J Biol Chem 285: 15346-15355, 2010
46. Zhang WB, Wang Z, Shu F, Jin YH, Liu HY, Wang QJ, Yang Y: Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition. J Biol Chem 285: 40461-40471, 2010
47. Foretz M, Ancellin N, Andreelli F, Saintillan Y, Grondin P, Kahn A, Thorens B, Vaulont S, Viollet B: Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. Diabetes 54: 1331-1339, 2005 (Pubitemid 40586661)
48. He TC, Zhou S, Da Costa LT, Yu J, Kinzler KW, Vogelstein B: A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA 95: 2509-2514, 1998 (Pubitemid 28145972)
49. Muirhead EE, Brooks B, Pitcock JA, Stephenson P: Renomedullary antihypertensive function in accelerated (malignant) hypertension: Observations on renomedullary interstitial cells. J Clin Invest 51: 181-190, 1972
50. Vistica DT, Skehan P, Scudiero D, Monks A, Pittman A, Boyd MR: Tetrazolium-based assays for cellular viability: A critical examination of selected parameters affecting formazan production. Cancer Res 51: 2515-2520, 1991
51. Wang Y, Li J, Cui Y, Li T, Ng KM, Geng H, Li H, Shu XS, Li H, Liu W, Luo B, Zhang Q, Mok TS, Zheng W, Qiu X, Srivastava G, Yu J, Sung JJ, Chan AT, Ma D, Tao Q, Han W: CMTM3, located at the critical tumor suppressor locus 16q22.1, is silenced by CpG methylation in carcinomas and inhibits tumor cell growth through inducing apoptosis. Cancer Res 69: 5194-5201, 2009
52. Rao R, Hao CM, Breyer MD: Hypertonic stress activates glycogen synthase kinase 3beta-mediated apoptosis of renal medullary interstitial cells, suppressing an NFkappaB-driven cyclooxygenase-2-dependent survival pathway. J Biol Chem 279: 3949-3955, 2004 (Pubitemid 38198978)
53. Cheng HF, Zhang MZ, Harris RC: Nitric oxide stimulates cyclooxygenase-2 in cultured cTAL cells through a p38-dependent pathway. Am J Physiol Renal Physiol 290: F1391-F1397, 2006
54. Cornelussen RN, Gupta S, Knowlton AA: Regulation of prostaglandin A1-induced heat shock protein expression in isolated cardiomyocytes. J Mol Cell Cardiol 33: 1447-1454, 2001 (Pubitemid 32681663)
55. Guan Y, Hao C, Cha DR, Rao R, Lu W, Kohan DE, Magnuson MA, Redha R, Zhang Y, Breyer MD: Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption. Nat Med 11: 861-866, 2005 (Pubitemid 41161118)
56. Chen M, Li Y, Yang T, Wang Y, Bai Y, Xie X: ADMA induces monocyte adhesion via activation of chemokine receptors in cultured THP-1 cells. Cytokine 43: 149-159, 2008